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Scientists Grow Sheep Embryos Containing Human Cells (theguardian.com)

An anonymous reader quotes a report from The Guardian: Scientists say growing human organs inside animals could not only increase supply, but also offer the possibility of genetically tailoring the organs to be compatible with the immune system of the patient receiving them, by using the patient's own cells in the procedure, removing the possibility of rejection. "Even today the best matched organs, except if they come from identical twins, don't last very long because with time the immune system continuously is attacking them," said Dr Pablo Ross from the University of California, Davis, who is part of the team working towards growing human organs in other species. Ross added that if it does become possible to grow human organs inside other species, it might be that organ transplants become a possibility beyond critical conditions.

Ross and colleagues have recently reported a major breakthrough for our own species, revealing they were able to introduce human stem cells into early pig embryos, producing embryos for which about one in every 100,000 cells were human. These chimeras -- a term adopted from Greek mythology -- were only allowed to develop for 28 days. Now, at this week's meeting of the American Association for the Advancement of Science in Austin, Texas, the team have announced that they have managed a similar feat with sheep embryos, achieving an even higher ratio of human to animal cells. "About one in 10,000 cells in these sheep embryos are human," said Ross. The team are currently allowed to let the chimeric embryos develop for 28 days, 21 of which are in the sheep. While that might be sufficient to see the development of the missing organ when human cells are eventually combined with the genetically modified embryo, Dr Hiro Nakauchi of Stanford University, who is part of the team, said a longer experiment, perhaps up to 70 days, would be more convincing, although that would require additional permission from institutional review boards.

51 comments

  1. Sheeples by tonique · · Score: 1

    Is this how real sheeples are born?

    1. Re:Sheeples by nucrash · · Score: 1

      WAKE UP SHEEPLE!

      --
      Place something witty here
    2. Re:Sheeples by Hal_Porter · · Score: 1

      That's baaaaaaad.

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
  2. That's nothing... by Oswald+McWeany · · Score: 4, Funny

    That's nothing... Back home in Britain the Welsh have been combining human and sheep DNA for centuries.

    --
    "That's the way to do it" - Punch
    1. Re: That's nothing... by peragrin · · Score: 1

      The joke is that combination was so loved that England made them Kinga and queens.

      Hence the Welsh got the last lyygh.

      --
      i thought once I was found, but it was only a dream.
    2. Re:That's nothing... by XxtraLarGe · · Score: 1

      That's nothing... Back home in Britain the Welsh have been combining human and sheep DNA for centuries.

      Sheepboy says "Thaaaat's my daaaaad!"

      --
      Taking guns away from the 99% gives the 1% 100% of the power.
    3. Re:That's nothing... by Hal_Porter · · Score: 3

      The Arabs invented the condom in 700 BC, using a goat's lower intestine. In 1873 the British somewhat refined the idea by taking the intestine out of the goat first.

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
    4. Re:That's nothing... by skids · · Score: 1

      We've seen how that story ends.

  3. Re:Just like today's college students? by Anonymous Coward · · Score: 0

    I will get an extremely high paying job, and then use it as a cover to implement a Logan's Run type society where old people are 'retired.'

  4. I'm Delicious by Anonymous Coward · · Score: 0

    But do the scientists have the chops to prevent cannibalism?

  5. The anti abortion crowd is by mark_reh · · Score: 1

    going to go nuts over this.
    How many cells does it take to make a human?
    How many angels can dance on the head of a pin?

    1. Re:The anti abortion crowd is by PolygamousRanchKid+ · · Score: 1

      going to go nuts over this.

      Let them go nuts. We'll just mix up the DNA of an ornery crazy-ass Rocky Mountain bighorn sheep with the DNA of Conor McGregor, and set that monstrosity loose on the the anti abortion crowd.

      --
      Schroedinger's Brexit: The UK is both in and out of the EU at the same time!
    2. Re:The anti abortion crowd is by The-Ixian · · Score: 1

      That brings up another good point.

      If we slaughter the animals for food, is it considered cannibalism?

      --
      My eyes reflect the stars and a smile lights up my face.
    3. Re:The anti abortion crowd is by mnemotronic · · Score: 1

      going to go nuts over this ... snipsnip ....

      I'd prefer a curry mint sauce.

      --
      The Russians have won. They have made the world a cesspool of distrust, greed, fear and hate.
    4. Re:The anti abortion crowd is by Anonymous Coward · · Score: 0

      going to go nuts over this.

      Not to mention PETA.

  6. Re:Just like today's college students? by Anonymous Coward · · Score: 1

    I will get an extremely high paying job, and then use it as a cover to implement a Logan's Run type society where old people are 'retired.'

    Yeah, you keep telling yourself that.

    Although, now that the Obama "recovery" is over, you might be able to get some of Trump's CRUMBS!!!

  7. Re:Are they fuckable? by Anonymous Coward · · Score: 0

    How exactly do you know normal sheep feel any different?

  8. Problem, lambs now play video games all day by jfdavis668 · · Score: 1

    The lambs produced won't move out of the basement and spend all day playing video games.

  9. and they call them by Anonymous Coward · · Score: 0

    Trump voters.

    1. Re:and they call them by Anonymous Coward · · Score: 0

      Transgender, meet Trans-species.

      They can vote too.

  10. Incredibly dangerous, should be regulated by hydrodog · · Score: 1

    It seems incredible to me that this was done without public comment and regulation. This is extremely dangerous. First, it's a potential vector for diseases to jump inter-species. Second, it's a way to grow more unquestioning trump supporters.

    1. Re:Incredibly dangerous, should be regulated by Eloking · · Score: 2

      It seems incredible to me that this was done without public comment and regulation.
      This is extremely dangerous. First, it's a potential vector for diseases to jump inter-species.
      Second, it's a way to grow more unquestioning trump supporters.

      I fail to understand the logic behind your two assumptions.

      Please, entertain us and explain yourself.

      --
      Elok
    2. Re: Incredibly dangerous, should be regulated by Anonymous Coward · · Score: 0

      He read some science fiction once.

    3. Re:Incredibly dangerous, should be regulated by iggymanz · · Score: 1

      every year a flu or two or three jumps inter-species to humans. humans get bit by animals and get rabies. my my diseases have been jumping species to primates since the dawn of primates! too bad you weren't there when we could have stayed tree shrews!

  11. BeauHD's replacement? by Anonymous Coward · · Score: 0

    /. is attempting to create a BeauHD replacement to mindlessly bleat "Russia! Russia! Russia!"

    1. Re:BeauHD's replacement? by mnemotronic · · Score: 1

      Don't blame me. I voted for the baaaaaastard.

      --
      The Russians have won. They have made the world a cesspool of distrust, greed, fear and hate.
  12. The planet of the sheep by ndato · · Score: 1

    New idea for Hollywood

  13. Shotgun Approach by drunken_boxer777 · · Score: 0

    While not trying to be dismissive, it's unclear that this would ever be a viable approach. It's really just a shotgun approach: put human cells in an early stage sheep blastocyst, and human cells are scattered throughout the tissues of the embryo. There's no selective approach to trying to only grow a heart from human cells, for instance. This means that the organ will still contain sheep cells, and therefore have the possibility of being rejected by the transplant recipient's body. Their work with mouse-rat chimeras was far more targeted, but that's because the techniques exist to do so in those species.

    Absent developing the techniques available in rat and mouse model systems, I'd rather see them try to entirely replace one of the germ layers with human cells; the endoderm for instance. You'd basically get a sheep with a human digestive tract. You'd also avoid the problem of getting human cells in the sheep's central nervous system (e.g., brain), which probably happens with their current approach, and which they said would cause them to stop if it was significant.

    1. Re:Shotgun Approach by HiThere · · Score: 1

      IFAIKT the interesting part here is that the immune system didn't reject them. OTOH, since it's only 28 days in the embryo, of which only 21 are within the sheep, this may not prove much. (I'm not sure when embryo cells start making it through the placental barrier.)

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    2. Re:Shotgun Approach by drunken_boxer777 · · Score: 1

      Embryos don't have immune systems. They use the mother's immune system. You'd have to wait post partum to see if there are markers of increased immune activity, particularly at the chimeric organs, as well as general markers of immune hyperactivity. One approach for such animals would be to remove MHC genes so that the animal doesn't recognize the chimeric organs as "non-self". (It's more complicated, but I'd be interested in seeing how this might play out.)

  14. Re: Are they fuckable? by Anonymous Coward · · Score: 0

    He's first on the list for QA.

  15. Re:Just like today's college students? by Hal_Porter · · Score: 3, Funny

    Yeah, I'd like fries with that. Thanks.

    --
    echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
  16. As the punchline goes by Greyfox · · Score: 2

    But you f**k just ONE goat...

    --

    I'm trying to teach myself to set people on fire with my mind... Is it hot in here?

  17. A new brand, a new day by Anonymous Coward · · Score: 0

    At last. a new brand of sheeple to increase the ranks of Republican politicians.

  18. Big deal ... by Anonymous Coward · · Score: 0

    (Grounds-keeper Willie voice) ... every Scottish person does it!

  19. Q: SNOWDEN is CIA plant in war with the NSA by Anonymous Coward · · Score: 0

    http://qanonposts.com/

    !UW.yye1fxoQ5997a0
    180445
    >>180316
    HK allowed his passport to clear customs WITH THE CLOWNS IN AMERICA AND DEPT OF DEFENSE PUTTING A NAT SEC HOLD WW?
    How does he clear customs?
    How does he end up in Russia?
    Coincidence?
    Who was the 1st agency he worked for?
    Who taught him the game?
    Who assigned him w/ foreign ops?
    Why is this relevant?
    Future unlocks past.
    Watch the news.
    Spider web.
    Stop taking the sleeping pill.
    Q

    Feb 18 2018 20:41:03
    !UW.yye1fxoQ
    104
    @SNOWDEN
    WHERE ARE YOU?
    NOT RUSSIA.
    [EYES ON]
    YOU ARE NOW A LIABILITY.
    HELPING @JACK?
    PROJECT DEEPDREAMv2[A]].
    WE WILL NEVER FORGET.
    ES FAILED.
    WHERE IS ES?
    JOHN PERRY BARLOW.
    DEFINE THE END?
    THE DAY OF RECKONING IS UPON US.
    JOHN 3:16
    Q

    Q: Total take down of the deep state in progress

    https://twitter.com/hashtag/qa...

    13,000 sealed indictments sent in 3 months (Prior Average 1k a year) Cells for 13,000 inmates being built in Guantanamo Don't believe? check current flight records to Gitmo Contractors flying #qanon #thegreatawakening

    https://pbs.twimg.com/media/DW...

    https://pbs.twimg.com/media/DW...

  20. Go forth and bleet by Anonymous Coward · · Score: 0

    Dr Hiro Nakauchi of Stanford University, who is part of the team, said a longer experiment, perhaps up to 70 days, would be more convincing, although that would require additional permission from the gods.

    /bah

  21. I'll get my coat by bmo · · Score: 1

    "So I guess they really did find the cock for Dolly"

    --
    BMO

  22. more demoncrate voters by Anonymous Coward · · Score: 0

    build stupid voters who will vote for another obama... ooga booga

  23. ManBearPig by Anonymous Coward · · Score: 0

    https://en.wikipedia.org/wiki/ManBearPig

  24. Apple by Anonymous Coward · · Score: 0

    should be happy

  25. How did they do that?!? by Anonymous Coward · · Score: 0

    How did they get HUMAN cells into a sheep embry-oooooh... I know how they did it.

    To quote Cleveland Brown, "that's nasty."

  26. OMG...The Guardian has Gone full Alex Jones by Anonymous Coward · · Score: 0

    Of course Alex is quite often correct given enough time.

  27. 28 Days Later by DarthVain · · Score: 1

    This is how it all starts...

  28. Calling Doctor Moreau... by Mike+Van+Pelt · · Score: 1

    All ba(aaa)d jokes aside, some of this kind of research should really squick everyone out.

  29. Re:Just like today's college students? by Anonymous Coward · · Score: 0

    everything is a joke!! hahahahahahahahahhahahahahaa let's all make jokes because nothing is serious!!!! hahahahaha