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In First, Doctors Treat Rare Genetic Disorder With an Injection In Utero (arstechnica.com)
An anonymous reader quotes a report from Ars Technica: Three babies with a rare genetic disorder have been spared the worst effects of their condition thanks to an experimental injection they received in utero, researchers report this week in The New England Journal of Medicine. The success marks the first time a genetic disorder has been partially reversed by such a treatment prior to birth. The in utero injections treated a rare, recessive genetic condition called X-linked hypohidrotic ectodermal dysplasia (XLHED), which affects the development of skin, hair, nails, and teeth. People with the disorder have sparse body and head hair, dry eyes, mouths, and airways, and few teeth, which are usually pointy. But most dangerously, the condition also disrupts development of sweat glands throughout the body. People with XLHED have fewer sweat glands and/or poorly functioning ones. This leaves individuals vulnerable to high fevers and over-heating (hyperthermia), which can be life-threatening and lead to medical complications.
For the new experimental treatment, the researchers realized that it all came down to timing. Humans develop sweat glands much earlier in their development, generally between the 20th and 30th week of pregnancy. To prevent XLHED from wreaking havoc, the researchers needed to deliver the protein prior to birth. After testing the idea for safety and efficacy in mice and monkeys, doctors in Germany got a compassionate-use approval to try it in a 38-year-old pregnant woman. She had a family history of XLHED, a young son with the condition, and was found to be carrying twin boys with it, too. [...] The researchers will track the babies' development to see if the effects are permanent, but data from animals suggests that they will be.
For the new experimental treatment, the researchers realized that it all came down to timing. Humans develop sweat glands much earlier in their development, generally between the 20th and 30th week of pregnancy. To prevent XLHED from wreaking havoc, the researchers needed to deliver the protein prior to birth. After testing the idea for safety and efficacy in mice and monkeys, doctors in Germany got a compassionate-use approval to try it in a 38-year-old pregnant woman. She had a family history of XLHED, a young son with the condition, and was found to be carrying twin boys with it, too. [...] The researchers will track the babies' development to see if the effects are permanent, but data from animals suggests that they will be.
Defective people are not "encouraged" to breed, they are just not prohibited from doing so. The reason is that governments powerful and coercive enough to impose reproductive mandates tend to do plenty of other nasty things. It isn't worth it. Freedom doesn't lead to perfection, but it is better than the alternatives.
Anyway, now that we can edit-out the defects (and soon edit-in some upgrades), it doesn't matter as much who breeds.
"Anyway, now that we can edit-out the defects" yes like dark hair and eyes /duck
Go watch GATTACA, or the Star Trek episodes that talk about Eugenics Wars, specifically Doctor Bashir, I Presume IIRC.
The danger is that it might become a slippery slope:
1. Only the rich will be able to afford,
2. It could lead to reverse discrimination and job profiling,
i.e. I'm sorry, your Johnny wasn't born with _X_, he isn't allowed to do _Y_
3. Loss of genetic diversity.
Show me ANY tech that man hasn't abused the fuck out? And while that isn't reason enough we need to proceed with caution instead a naive "full steam ahead".
Go read Eugenics for more details.
She had a family history of XLHED, a young son with the condition, and was found to be carrying twin boys with it, too.
I think it's terrible that despite having a life's worth of warning about the outcome that the parents decided to go ahead and burden children with their own genetic shortcomings. There are orphans that need adopting but despite that they decided to pass on their problems to an entirely new generation. The selfishness of humans really just blows my mind.
I'm all for science but I can't help but scorn people who insist on having their own children while knowing the price their progeny will have to pay.
Anons need not reply. Questions end with a question mark.
NO, that is only the most minor effect. They also have only 4 or 5 teeth, all abnormal. But more seriously, no sweat glands. That means they seriously overheat at the slightest provocation. As in medical emergency, not need to sit down for a minute.
As genetic diseases go, it's not the worst of the lot, but it's a lot more than missing hair.