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Can Two Injections of Tuberculosis Vaccine Cure Diabetes? (fortune.com)
An anonymous reader quotes Fortune:
The causes of Type 1 diabetes can be significantly reversed over several years with just two injections of a common tuberculosis vaccine injected a few weeks apart, researchers at Massachusetts General Hospital announced Thursday in a paper published in the journal Nature. Researchers found a substantial reduction in the blood-sugar marker HbA1c that is used to diagnose diabetes.
All subjects with diabetes who received the vaccine had a 10% reduction after three years and 18% after four years, bringing them below the cutoff point for a clinical diagnosis. Those subjects followed for a full eight years retained most of the reduction. Participants who received a placebo or were in a reference group that followed normal diabetic management saw their blood sugar measurement rise by a few percentage points during the same periods followed... A 10% reduction in Hb1Ac reduces the risk of death as a result of diabetes by 21%, and drops by 37% other complications, like blindness and loss of feeling in hands and feet, according to a 2000 study.
All subjects with diabetes who received the vaccine had a 10% reduction after three years and 18% after four years, bringing them below the cutoff point for a clinical diagnosis. Those subjects followed for a full eight years retained most of the reduction. Participants who received a placebo or were in a reference group that followed normal diabetic management saw their blood sugar measurement rise by a few percentage points during the same periods followed... A 10% reduction in Hb1Ac reduces the risk of death as a result of diabetes by 21%, and drops by 37% other complications, like blindness and loss of feeling in hands and feet, according to a 2000 study.
Or maybe scientists and researchers should have some ethics to make sure their studies are valid and repeatable before pushing claims?
Would this work for type 2? I am on 2 medications that are low dosages for it, but if I could get this done and take less medicine or maybe even none that would be awesome. Although it sounds like avoiding as much sugar as possible would still be a good idea.
How's that working for the ex-Google employees who refused to work on gubmint programs?
It little behooves the best of us to comment on the rest of us.
It strikes me as though there is a large number of oral medications and injectables all geared toward "managing" diabetes. That's a lot of revenue for somebody. Now to have something that (if it's true) can reduce the need for diabetic medications seems like it would make those drug manufacturers very unhappy.
An effective "democracy" creates the illusion the people have a say in their government.
In this case it's the "The study relied on the bacillus Calmette-Guérin (BCG) vaccine" which has been in use since 1921.
All you need to do if you have Diabetes type 1 is to find a vaccination clinic which has the vaccine in question.
So take your pick. Vaccines are bad ok?
To be clear, the intervention is not a cure for type I diabetes mellitus. The authors go out of there way to prove and explain this:
"In this study we observe the long term and stable lowering of blood sugars in humans after BCG vaccinations. In the human, this stable blood sugar control was not driven primarily in these human subjects by pancreas recovery or regeneration. The human pancreas after BCG even at four years after repeat vaccinations did not secrete significant insulin as clinically measured by C-peptide. The mechanism for lowered HbA1c values was not equivalent to the NOD diabetic mouse pancreas regeneration after BCG treatment, despite equally restored and long term improved blood sugar control. The BCG-treated type 1 diabetic subjects at year 4 after glucagon challenge had a negligible to no return of clinically significant C-peptide. The C-peptide values after glucagon were in the range of 2–3 pmol/L of C-peptide (Fig. 1c), but with no known clinical significance. Therefore we concluded that BCG vaccinations did not induce a clinically meaningful return of C-peptide levels in the pancreas by regeneration, as observed in the NOD mouse model of diabetes17,18 Thus pancreas rescue or regeneration could not fully account for the persistent and long term HbA1c lowering in humans receiving BCG."
The study didn't include type 2 so we really can't say how this intervention will work on that group; however, I don't see a reason to think it wouldn't be effective in this group.
This is a really interesting study. I've been heavily involved in the past with diabetes mellitus management. This is a novel approach as far as I know. This may revolutionize the approach to treatment for many with diabetes mellitus.
There probably are several new medicines that will cure or alleviate symptoms for all manner of things developed each month. Sometimes the news is a bit premature as the drug hasn't even been tried in humans yet. Once further testing is done some of these are found to cause all manner of nasty side effects, some worse than what they cure. Sometimes the FDA approves it anyhow if the side effects don't appear to be life threatening, even as off-putting as they may be.
The answer to this stoopid libtard question, as always, is no. But thanks for asking.
AE911Truth org
Or maybe scientists and researchers should have some ethics to make sure their studies are valid and repeatable before pushing claims?
Sure
Certainly though, a societal trend seems to have developed that indicate getting your possibly inaccurate scoop out there trumps carefully researching your data.
Happiness in intelligent people is the rarest thing I know.
Ernest Hemingway
Are you just shittin on Demos cause he shat on Pubtards? Type 1 diabetes is inherited, it is not from germ phobia.
The article refers to type one diabetes, not the far more common (and epidemic) type two.
Nice, but not as useful
Type 1 diabetes is inherited, it is not from germ phobia.
Type 1 diabetes, like many other autoimmune disorders, is correlated with excessive cleanliness.
Both Type 1 and Type 2 have a genetic component, but it is actually stronger for type 2. The heritability for type 1 is about 3% if you mother has it, and about 5% if your father has it. For some Native American tribes, such as the Pima people, the type 2 rate is nearly 40%, nearly all of which is heritable because their genetic heritage isn't adapted to a modern diet.
BCG is hard to find in the US. Vaccination with it will cause a person to have a positive PPD (tuberculosis test), and the rate of TB is low enough that public health policymakers would rather have a very accurate and simple test than vaccinate everyone. The only use for it in the US that I’m aware of is in treatment of bladder cancer.
Alright, you're trying to make this a dig about Republicans all being fat, and it's working, but you don't have to go that far for the punch line here. The truth is that this is about religious fanaticism more than party lines. The (+80% Christian) Republicans think type 1 diabetes is punishment from God, because you're born with it. That is why they care less about it than type 2.
Seems like it's possible to find at clinics which specialize in travel vaccines. (granted the research done was a couple of googles.)
I'm pretty sure none of us will be around to feel stupid. --Captain Obvious
like the US does, so a lot of good basic research is getting done over there. Eventually it makes it's way over the pond.
Hi! I make Firefox Plug-ins. Check 'em out @ https://addons.mozilla.org/en-US/firefox/addon/youtube-mp3-podcaster/
Given that I am a conservative, and a medical researcher, working on pancreatic disease issues at a class 1 research medical school and that the vast majority of my team is not only conservative, but religious and of a strain you would wrongly call fundamentalist all I can say is: What you talking about Willis. I do not know any Christian's who think type 1 diabetes is a curse on the individual or a punishment.
But, if you really think as you do and are thus smoking that much crack, maybe you should go get a nice naltrexone injection, say 150 mg?
Native tribes and gypsies are not known for excessive cleanliness. So the germophobia link is likely pure BS.
Good thing is that they have a new assay, quantiferon gold that will tell you if you have actual TB vs antibodies to the vaccine.
BCG is pretty much useless for TB, but they still give it out to everyone in the philippines. They should instead work on quarantining people that are sick.
Please share some of what you're smoking. That's done dank shit.
It's probably under patent any longer.
Big Pharma is hard at work on new, patentable therapies for diabetes.
Pharma and the medical community wont push for this.
Since getting those injections does no harm why not test responses tor type 2 diabetes?
If you think that an opioid antagonist is going to have an effect on a dopamine agonist, maybe you should go retake some of your med school classes?
I don't trust atoms -- they make up stuff.
I'll try and identify a few of them.
First up: define what a Type 1 diabetic is.
We had this come up some weeks back, when some Scandinavian doctors came up with the conclusion that the several thousand diabetics they studied did not fall neatly into 2 groups ie. Type 1 & 2. Instead they identified some half a dozen groups.
I angrily posted about this at the time because this was known over 20 years ago. What was worse is that I (a diabetic who needs insulin) wasn't covered in their groupings and neither was somebody with gestational diabetes or ....etc.
There's also the problem of what an American doctor diagnoses as a "Type 1" might be somewhat different to what a British or Japanese or Ugandan doctor does. It may even subtly vary among the doctors in just one hospital.
Treatment regimens will vary also: human or analog insulin? Which analog? Short acting, long acting, mix? Pump, pen, syringe? Which pump running what software?
The authors of this paper obviously start with the assumption that all the "Type 1 diabetics" they studied were as a result of this mysterious auto-immune disease, a disease whose pathology or very existence is entirely unclear.
They say in the paper that their cohort had all been diagnosed as "Type 1" as if it's a choice between black or white. It's not, because that term is undefined and in clinical practice covers a significant spectrum of people.
The Machine stops.
Pretty much useless, but somehow still managed to all but wipe out TB in the UK in the 50s? I may have a small scar from my BCG vaccination, but I'm still very happy to have had it. TB is back on the rise in the UK, largely because the BCG vaccination program was phased out 15 years ago.
Or maybe scientists and researchers should have some ethics to make sure their studies are valid and repeatable before pushing claims?
Scientists don't publish claims, they publish results. The media publishes claims.
They vaccinated a total of 9 people. Cannot possibly be valid.
"BCG is pretty much useless for TB, but they still give it out to everyone in the philippines."
So Type 1 diabetes is pretty much unknown in the Philippines?
You can't see ANYTHING from a car, You've got to get out of the goddamned contraption and walk...Edward Abbey
Type 2 is a lifestyle choice, srsly, at least for 95% of humans.
Switch to a mostly veggie diet (by bulk) with reduced carbs and walk fast for 1 hr a day, 5 days a week.
Reduce rice, potatoes, breads, especially for the first month.
No need to be no-carb or even lo-carb, but by reducing carb-based calories to less than 30% of the total, it is amazing the changes most people will see. I dropped 50 lbs, which freaked me out. It freaked out my doctor too.
But it won't work for everyone. Some people need to drop below 20% calories from carbs to get results. Different bodies are .... different.
My libido is much higher/larger/bigger now too, since reducing the carbs.
And forget the whole "net-carbs" crap.
They do and did. The real work is being done by Dr. Faustmann's lab at Mass. General Hospital, and I've been keeping an eye on it. It also requires tight blood sugar control for the month of the treatment, which is why at first other laboratories could not reproduce the results in lab animals. Tight blood sugar control for Type 1 diabetics requires many blood glucose tests and careful diet, schedule, etc. And it costs a lot more in personnel to do the animal care and the blood glucose test strips are $1/each, it really raises the cost of the lab animals. So other labs failed to replicate the work until they did a "laying on of hands", sending personnel from Dr. Faustmann's lab to other groups to see what the issue might be. This is startlingly common in research and science: unstated, implicit components, such as the frequency of blood glucose testing and quality of lab animal care, are not automatically spelled out in even a good scientific paper.
There was a similar, not so well documented and published study at University of West Virginia more than 20 years ago. I was never able to find what the chemical treatment was, only that they had encouraging lab animal results. Eli Lilly took, owner of insulin production around the world, over their funding: as best I can tell, they've never published anything useful again. Don't know if the approach failed, or the manufacturers of insulin helped poison the research to protect a market. Mass. General Hospital, fortunately, is big enough and has enough political pull and political savvy to avoid that trick.
If this works, and works well, but gets held up by at the FDA for decades more of human testing, I expect medical tourism to India, or even Cuba, to balloon with Type 1 diabetics like me taking badly needed month long vacations for a cure. A month or so of complete dietary control, daily exercise at the beach or the gym, and very attentive diabetic treatment to keep things right during the cure are *much* cheaper than a year of Type 1 diabetic supplies. With 6 test strips daily at $1/each, Humalog short-acting insulin at $25/day, insulin pump or insulin pump supplies adding a few more bucks a day, $2000/month is pretty reasonable for us Type 1 diabetics even if we're stable.
I'd do it in a *heartbeat* once I have a sense of the doses. The trick for me would be keeping tight blood sugar for the whole month, especially avoiding hypoglycemia as my insulin production improves and I'm still using an insulin pump. That's tricky, like any general lifestyle change for us Type 1 diabetics.
I've worked in US communities with a very high concentration of Philippino immigrants and their recent offspring. My anecdotal observation of Type I diabetes rates in this community is that it's markedly lower than what I'm used to seeing in areas of the US with predominantly European genetic stock. World health statistics also show that the Philippines has significantly lower rates of diabetes than the US.
"No, no, no. Don't tug on that. You never know what it might be attached to."
2 things:
a) You don't need "intensive exercise" - 1 hr daily of fast walking. How fast is fast? As fast as you can go, based on your current conditioning. Waddle if you must. Stroll when that becomes easy. Walk when strolling is too east. And keep going faster and slower for the hour until you are walking the full hr as fast as a fit 18 yr old crossing a huge University campus. Add in hills, then mountains,if you can.
b) each fewer carbs. Get your carbs from veggies only the first month. Drastically reduce potatoes, bread, rice for the first month. Cake is gone. Then you can add back a little over the week - perhaps 1-2 sandwiches and 1 sweet potato. Try to stay below 30% carbs by calories. That means you'll be eating more healthy fats and proteins. Just don't go crazy on the fats. Too many nuts is a bad thing when dropping weight and getting fit is the goal. Eat food that looks like nature made it. Anything that doesn't look that way, should be drastically removed from your eating plan. I've never seen a Cheez-It on a tree.
It really is that simple. The added fats solve most hunger issues. I always have a handful in my daypak. I used to be starving by 10am before when eating 70+% of my calories from carbs. It becomes easier over time as you learn all the new possibilities.
No need for most people to go low-carb (under 20%), but perhaps 2% of a population won't see the results without going low-carb. I'm lucky, below 30% works well for me.
And be certain to have protein at every meal. Something about protein+ fats takes away hunger. If I need to skip a meal, it isn't a big deal. I wouldn't have believed that was possible last year.
After eating this way since Sept, I've dropped 80 lbs. After the first few months, I was able to add back "splurges" for 1-2 special situations a month. Mostly for social things like birthdays. About a month into my efforts, I started doing a 2K ft vertical mountain trail a few times a week nearby. That took more than 1 hour, but the top was beautiful and satisfying to achieve.
Make the decision and do it. Start tonight with a walk. I like walking early in the morning, before everyone else is awake.
If you do this, your type-2 problems will go away, quickly. You can even fall off the wagon for vacations and not have type-2 issues after the first 3 months. Just be certain to get back on the plan.
Type-1 is completely different, but type-2 is truly a lifestyle choice.
When I was a kid in the UK in the '60s I was vaccinated with BCG. TB was still common enough then, that even though I lived in a 'well-to-do' town, you'd see these large white vans parked up on occasion which contained an X-ray machine. The idea was to X-ray people's chests and look for TB lesions. I last saw one of those vans in the mid-70s.
TB is still diagnosed over here but mainly in immigrants from 3rd world countries. I've no idea if kids still routinely get BCG (it used to be done at school).
The Machine stops.
naltrexone also blocks certain endorphines
Apocalypse Cancelled, Sorry, No Ticket Refunds
Does Bayes play here? https://www.google.com/search?... I don't have access to PubMed but others here might. Would those May 2017 research articles suggest the area of research around treatment that is now publishing?
I'm a lot better since I apply some evidenced based medicine and started using crystals. Any crystal will do. I like amethyst, because I think their pretty. Here is the Rx:
Fill your pockets with 20 pounds of crystals. Speed walk 2 miles a day.
This will increase your physical fitness over speed walking without crystals.
BTW, I don't like to microwave food. I'm afraid it will get contaminated with all those little micros.
according to a 2000 study.
Does this mean this study was done in 2000?
Or, is the data from this study compared to a different study in 2000?
Self-importance and self-indulgence is the root of ALL evil.
Dude. Go on a ketogenic diet. Eat as little carbs as possible, supplying your body with energy the other ways (read up). It's possible then to live on basal alone. What they don't want you to know....
When I was a toddler in the 1960s, my granny died of TB. Unsurprisingly, when I got my TB test in the 1970s, I was positive - I'd been exposed to the bacterium enough that my immune system had a response to a challenge dose. So I didn't get BCG'd, because I was already immune. Since then I've worked in TB clinics (test on joining, test on leaving) and I've had three call backs to be re-tested because someone at my workspace has come back from working abroad and then developed TB (XDR, fatal in one case if the grapevine is correct).
TB is expected to become endemic again in the UK in the near future as drug resistance spreads. It certainly remains a quite common diagnosis. If they've stopped vaccinating schoolkids, then that's a false economy. My immunisations passport remains up to date.
Birds are not dinosaur descendants;birds are dinosaurs, for all useful meanings of "birds", "are" and "dinosaurs"
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