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James P Allison and Tasuku Honjo Win Nobel Prize For Medicine (theguardian.com)

An American and a Japanese scientist have won the 2018 Nobel prize in physiology or medicine for discovery of a revolutionary approach to cancer treatment. The Institute -- 50 professors at the Stockholm facility -- chose the winners of the prize honoring research into the microscopic mechanisms of life and ways to fend off invaders that cut it short. From a report: James Allison and Tasuku Honjo will share the 9m Swedish kronor (roughly $1 million) prize, announced by the Nobel Assembly at the Karolinska Institute in Stockholm. The two scientists have been awarded the prize for their discovery that the body's immune system can be harnessed to attack cancer cells.

The immune system normally seeks out and destroys mutated cells, but cancer cells find sophisticated ways to hide from immune attacks, allowing them to thrive and grow. Many types of cancer do this by ramping up a braking mechanism that keeps immune cells in check. The discovery is transforming cancer treatments and has led to a new class of drugs that work by switching off the braking mechanism, prompting the immune cells to attack cancer cells. The drugs have significant side effects, but have been shown to be effective -- including, in some cases, against late-stage cancers that were previously untreatable.
The physics prize is to be announced Tuesday, followed by chemistry. The winner of the Nobel Peace Prize will be named Friday. No literature prize is being given this year.

54 comments

  1. Re:You ain't seen nothing yet! by 50000BTU_barbecue · · Score: 1

    When did cdreimer become Slashdot's whipping boy?

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    Mostly random stuff.
  2. Re:You ain't seen nothing yet! by Anonymous Coward · · Score: 0

    Ask and you shall receive brother!

    Here is the latest news about creimer being played for almost 2 years now. Look towards the bottom of the thread for informative stuff:
    https://slashdot.org/comments....

  3. Re:You ain't seen nothing yet! by Anonymous Coward · · Score: 1

    When a bunch of retarded trolls with too much time on their hands decided to bully him, and the rest of slashdot, including moderators, decided to either idly stand by or participate.

    The continued allowance of campaigns like this is one of the signs of how slashdot has turned into a far right cesspool of stupidity.

    Captcha; "predicts". Yeah "-1 I hate you and while I have no arguments, I have modpoints", here we come.

  4. Re: You ain't seen nothing yet! by Anonymous Coward · · Score: 0

    I don't believe that the real creimer even posts here any longer. My understanding is that he had his fill of the trolling and left. Apparently that hasn't been enough for some trolls to declare their victory and move on. Instead, they are now posting copy & paste fake creimer comments and replying with attacks. Anyone who criticizes the trolls is accused of creimer. They impersonated other people to attack creimer, including a UC-Berkeley psychology professor. It's highly unethical because there could be serious consequences for the people they've impersonated. These trolls are beyond pathetic in the lengths they've gone to for amusement.

  5. Re:You ain't seen nothing yet! by Anonymous Coward · · Score: 0

    Just FTR, you're not talking to the person you think you're talking to.

    You know, there still exist decent people in this world who think scum like you should get a whipping and have your Internet access revoked? There are things called limits, which you're not supposed to cross no matter how poorly you might think of someone. You're crossing just about all of them, which btw doesn't make you "cool", it makes you subhuman trash.

  6. Re: You ain't seen nothing yet! by Anonymous Coward · · Score: 0

    The actual creimer doesn't post here any longer and actually left awhile back. Accept your victory and STFU. The sheer volume of your spam posts makes you more insidious than creimer ever was. You won; he's gone. That's your cue to leave, too.

  7. Re: You ain't seen nothing yet! by Anonymous Coward · · Score: 0

    They know you're not creimer. They don't care. The actual creimer left Slashdot months ago, so they pretend others are creimer and also impersonate him.

  8. find sophisticated by markdavis · · Score: 2

    >"The immune system normally seeks out and destroys mutated cells, but cancer cells find sophisticated ways to hide from immune attacks"

    That is strange wording. Cancer cells are not autonomous, learning, clever, and planning. They are just mutations that "happen", randomly due to replication errors and external events (like radiation, viruses, and chemicals). Sometimes there just happen to be cells that mutate in a way that the immune system doesn't recognize. We all have cancer cells in our bodies, probably all the time, and normally they are caught and killed by our immune systems. The above statement makes it sound like they are planning something with a "will" :)

    1. Re: find sophisticated by Anonymous Coward · · Score: 0

      Are genetic algorithms a form of machine learning? Such algorithms mimic the process of natural selection. If genetic algorithms constitute a form of learning, couldn't one suggest that the cancer is learning to evade the immune system?

    2. Re:find sophisticated by Nidi62 · · Score: 1

      >"The immune system normally seeks out and destroys mutated cells, but cancer cells find sophisticated ways to hide from immune attacks"

      That is strange wording. Cancer cells are not autonomous, learning, clever, and planning. They are just mutations that "happen", randomly due to replication errors and external events (like radiation, viruses, and chemicals). Sometimes there just happen to be cells that mutate in a way that the immune system doesn't recognize. We all have cancer cells in our bodies, probably all the time, and normally they are caught and killed by our immune systems. The above statement makes it sound like they are planning something with a "will" :)

      Look at "find" not in the sense of "seeking out", but rather "stumbled upon". As you say, we have mutated or cancerous cells in us all the time, but our body kills most of them. Only the ones that hit the mutation lottery get the chance to kill us. Although, as for having a will, since some cancers can be made up of cells from all over the body (gotta love those pictures of tumors with hair, teeth, etc), if one develops with brain tissue is there a chance for some rudimentary brain activity?

      --
      The only thing necessary for evil to triumph is for it to be pitted against a slightly greater evil
    3. Re:find sophisticated by Tx · · Score: 1

      Seems fine to me.

      Sophisticated
      adjective
      1. [...]
      2.(of a machine, system, or technique) developed to a high degree of complexity.

      The method only has to be complicated to be appropriately described as "sophisticated", it does not matter how the aforesaid complex method was arrived at; intelligence is not required. Evolution comes up with plenty of sophisticated solutions without using intelligence.

      --
      Oh no... it's the future.
    4. Re: find sophisticated by drewsup · · Score: 1

      Sounds like a good start to a Sci fi movie where the cancer brain is able to take over cognitive functions and starts screaming at the cancer clinic " Stop trying to kill me!" :0

    5. Re:find sophisticated by Anonymous Coward · · Score: 0

      That is strange wording.

      Not to mention it sounds very dangerous.

      Cancer cells are "immune" from the immune system's search because they present the same protein markers as the rest of the body. The immune system is trained to ignore cells that present those protein markers. One of the causes of autoimmune diseases, such as rheumatoid arthritis, is a failure to recognize the correct protein markers as "self" by the immune system. In this state the immune system attacks the body's own cells in error.

      As such there isn't a "braking mechanism" that cancer can "ramp up" to avoid detection. It's actually doing what the original non-mutated cell is supposed to do. Cancer is just a mutation of yourself after all. It had the markers to begin with, assuming the genetic code that makes them wasn't part of the mutation.

      The dangerous part of this summary comes from this:

      a new class of drugs that work by switching off the braking mechanism, prompting the immune cells to attack cancer cells.

      That implies that the drugs are creating a situation where the immune system ignores the body's own protein markers. If true, this would mean that the body's immune system would not only attack cancerous cells, but healthy ones as well.

      The drugs have significant side effects

      Yeah, no shit Sherlock. You gave these people a whole host of new auto-immune diseases in exchange for killing their cancer. Which now also requires medical treatment and can cause permanent damage to other organs even if the effects of the drugs are temporary. Way to go.

    6. Re:find sophisticated by hcs_$reboot · · Score: 1

      Too bad I already posted something. This is a +1 insightful .

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    7. Re:find sophisticated by Anonymous Coward · · Score: 0

      Strange that they all behave the same then, isn't it? That's not very random.

      It is just as random as all except one behaving the same, or half one way and the other half another.
      Randomness isn't the same thing as statistically distributed, the coin can end up with the same face up all the time.

    8. Re: find sophisticated by Anonymous Coward · · Score: 0

      It's just a matter of phrasing and terminology. It's just cancer cells have the same tools and use them

    9. Re: find sophisticated by Anonymous Coward · · Score: 0

      It is a valid way to look at it. It's an abstract concept, making it difficult to say yes or no. An individual cell does not try to become cancerous, it either is or it is not. I want to say that it is not correct to say that it is "trying" because I've been convinced that entropy is not "trying" to reach equilibrium. It's an interesting statistical phenomena caused by the law of large numbers.

      A certain aspect of saying that cancer is trying to be cancerous is similar to life finding a way. Kind of an observation selection effect.

  9. Re: You ain't seen nothing yet! by Anonymous Coward · · Score: 0
  10. Re: You ain't seen nothing yet! by Anonymous Coward · · Score: 0

    Again, creimer doesn't post here any longer. Neither should you. GTFO.

  11. Re:You ain't seen nothing yet! by Anonymous Coward · · Score: 0
  12. Re: You ain't seen nothing yet! by Anonymous Coward · · Score: 0

    The fact that this kind of behaviour is tolerated speaks volumes of slashdot itself. Ip bans should have been on the menu a long time ago.

  13. The really big news is no Lit. Price this year by Terje+Mathisen · · Score: 1

    This morning they announced a two year prison sentence for rape, against the husband of one of the Swedish Academy members, that scandal is the reason there will be no Literature price this year.

    Terje

    --
    "almost all programming can be viewed as an exercise in caching"
    1. Re:The really big news is no Lit. Price this year by Anonymous Coward · · Score: 1

      No, the reason is that the Academy which gives out the literature award has been infested by petty, arrogant academics who have been institutionalized to the point where they've lost sight of anything other than their own egos.

      It will be interesting to see if this conviction could possibly clear things up. In a reasonable world it would weaken Horace Engdahl - who have defended Arnault to the death and pretty much is the entire reason for the gridlock - enough to make him take his leave. Unfortunately without the Academy, Engdahl is a nobody and he knows that, so I'm not optimistic.

      All that said, all of this has nothing to do with the medicine award. Let's celebrate these gents and not rain on their parade with tangential crap.

  14. Re:You ain't seen nothing yet! by Anonymous Coward · · Score: 0

    I first found out about him when he made a blatantly false statement and I called him out on it. He couldn't possibly defend his position and knew it, so he resorted to threatening to shoot me.

    I made fun of him for making such a stupid threat, and was pretty relentless for a couple weeks about it (he never admitted threating to shoot someone was wrong of him). I thought such a threat was unacceptable. He responded by then threatening to sue me for "mental trauma" or something for pointing out he threatened to shoot me. So I then made fun of him for that and pointed out assault with a deadly weapon would likely be brought up in such a case and it might not work out well for him.

    About that time a number of other people began harassing him with gay porn pictures that looked like him amongst other things. I limited my harassment to making fun of his threatening me with shooting, calling police on me, suing me, and even threatened to have the FBI investigate me. No one ever called me. Most other who saw his post, he frequently linked to it, also came to the conclusion he was threatening to shoot me.

    I'm not aware of anyone making fun of him before he began threatening people. It became obvious he wasn't mentally stable and they went crazy. I haven't responded to him in years, usually he has 12 posts ridiculing him by the time I see he posted anything.

  15. Sophisticated does not require planning by sjbe · · Score: 4, Insightful

    That is strange wording. Cancer cells are not autonomous, learning, clever, and planning.

    It's not strange wording at all. Sophistication is a statement of what something is, not how it was arrived at. Things don't have to have intelligent thought behind them to be sophisticated. Trees do not have what we regard as intelligence but you'd be hard pressed to argue that a tree leaf isn't an astonishingly sophisticated thing. Enormous sophistication and complexity can arise from very simple processes and evolution - no clever learning or planning required.

    1. Re:Sophisticated does not require planning by markdavis · · Score: 1

      >It's not strange wording at all. Sophistication is a statement of

      I was more targeting the word "find" as odd, not "sophisticated." "Find" implies it was looking or trying. It is more like "happen" or "occur" or something like that.

  16. Literature by hcs_$reboot · · Score: 1

    No literature prize is being given this year

    They should really start reading slashdot.

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    Slashdot, fix the reply notifications... You won't get away with it...
  17. Zero on topic posts by DCFusor · · Score: 2
    What's the point of mod points when an entire article has zero on-topic posts? An argument between sock puppets, probably the same idiot, someone else whining about another prize, or lack of, and nothing about the guys who won the prize for doing something decent - and difficult, which might save lives.
    .

    What a bunch of losers. Which I at least know how to spell.
    .

    How about some info on how they managed to get immune system to discriminate well enough between cancer and normal cells (which have nearly the same DNA) well enough to make this more good than harmful? What about reasoned discussion of this and alternate approaches? Not here. Disgusting.

    --
    Why guess when you can know? Measure!
    1. Re:Zero on topic posts by Anonymous Coward · · Score: 1

      How about some info on how they managed to get immune system to discriminate well enough between cancer and normal cells

      The Nobel prize is typically awarded long after the science around it is hyped. It is not even uncommon that the academy awards people for "the wrong research" if the groundbreaking research was too controversial.

      If you are interested in the subject you should check the older Slashdot articles about it where people who knows more about the subject have posted their comments:
      Drug Turns Immune System Against All Tumor Types (2012)
      Killing Cancer By Retraining the Patient's Immune System (2013)
      'Living Drug' That Fights Cancer By Harnessing The Immune System Clears Key Hurdle (2017)

      Or go to Can our own immune system defeat cancer? if you want to read about this research in particular.

    2. Re:Zero on topic posts by jeff4747 · · Score: 2

      Not here. Disgusting.

      And here you are, adding to the problem.

      You want info? Google's right over there. Look it up and supply a comment that actually helps fix the problem you are so upset about.

  18. What dead writer was considered? by tepples · · Score: 0

    I saw "no literature prize" and wondered what dead writer the Norwegian Nobel Institute was considering. The Institute doesn't award posthumous prizes, which is why it withheld its Peace Prize in 1948 in memory of Mohandas Gandhi.

    1. Re:What dead writer was considered? by Anonymous Coward · · Score: 1

      I saw "no literature prize" and wondered what dead writer the Norwegian Nobel Institute was considering. The Institute doesn't award posthumous prizes, which is why it withheld its Peace Prize in 1948 in memory of Mohandas Gandhi.

      Well, the Norwegian Institute doesn't award the literature prize so it doesn't really matter who they consider.
      Besides, there have been other occasions when no prize was awarded, sometimes for the reason that they didn't think anyone deserved it.

  19. Should be no prizes till the fucking cure somethin by Seven+Spirals · · Score: 0

    Can medicine not actually *cure* anything anymore? This seems like something someone should have got a pat on the head and a "good job" from their research lead on, not a fuxxoring Nobel Prize. Note that they didn't give one in literature this year. Good. When there aren't Nobel-worth advances, then there shouldn't be Nobel prizes. Giving them out anyway waters them down (as if the stupid Peace Prizes to genocidal politicians weren't bad enough). From my lay perspective medical advances in the last 30 years have been weak, AF. They haven't really cured anything or significantly made people healthier or live longer. The only thing they seem to have become really really good at is billing.

  20. Re:Should be no prizes till the fucking cure somet by ShanghaiBill · · Score: 2

    From my lay perspective medical advances in the last 30 years have been weak, AF.

    Over the last 30 years, average live expectancy has gone up by 5 years.

    The only thing they seem to have become really really good at is billing.

    That is an American problem. It doesn't much affect the other 95% of the world.

  21. Re:Should be no prizes till the fucking cure somet by Anonymous Coward · · Score: 0

    I'm sorry, but that is such an uninformed statement, that it borders on deliberate trolling.

    Do you have any idea that the therapies they are talking about with the immune system being modified to specifically target and eradicate leukemia are actually the bright spots in medicine, with 'cure' being the most appropriate word?
    See for example:
    https://www.nejm.org/doi/full/10.1056/NEJMoa1407222
    These were people with leukemia that was not responding to the best in standard treatments, and they used these personalized T-cell immunotherapy treatments and basically cured these people. No ongoing treatments. Just the one time treatment.

    Honestly. What is the difference between willful ignorance and trolling at this point?
    Please - if you are uninformed and can't even bother to do some basic investigating, please shut the hell up, stay off the internet, and stop making the world a worse place with your whining, tangential logic, and misinformation, because you are not helping the world in any way.
    Stay off of Slashdot!

  22. c6gunner IMPERSONATING me again? by Anonymous Coward · · Score: 0

    See subject: his FAKEname on a post impersonating me https://linux.slashdot.org/com... & altering /.er's words.

    c6gunner tried to mock me 1st https://linux.slashdot.org/com...

    So I challenge c6gunner to show he did better work than mine & he CAN'T!

    YOU DEMAND PROOF of others here?

    "I've yet to see you provide any evidence of that." by c6gunner on Monday March 15, 2010 @10:02PM (#31490942) ?

    So now I DEMAND IT OF YOU & YOU FAIL!

    c6gunner = "Run, Forrest: RUN!!!

    * c6gunner's LYING saying I did a MacOS X one - I haven't yet & c6gunner's LYING impersonating me hosts work vs. Intel CPU issues (spectre/meltdown).

    APK

    P.S.=> You say hosts = shit here https://slashdot.org/comments.... ?

    FACTS: /.ers & security pros + RESULTS say DIFFERENT:

    1st: /.ers https://slashdot.org/comments.... https://slashdot.org/comments.... https://slashdot.org/comments.... https://slashdot.org/comments.... https://slashdot.org/comments.... https://slashdot.org/comments....

    2nd: SECURITY PROS https://slashdot.org/comments....

    3rd: REAL RESULTS w/ hosts vs. threats https://slashdot.org/comments....

    EAT YOUR WORDS!!!

  23. Re:Should be no prizes till the fucking cure somet by DigiShaman · · Score: 1

    Bull shit! 95% of the world is paying for it already, transparently through increased taxation.

    Healthcare isn't free. It never was. Anyone that says otherwise is either lying, ignorant, or both.

    --
    Life is not for the lazy.
  24. Re:Should be no prizes till the fucking cure somet by Seven+Spirals · · Score: 1

    So, they cured cancer/malaria/AIDS in Europe? Oh, wait, you spouted some ridiculous bullshit about "life expectancy" instead of any real evidence or thought. I've lived in Europe before myself (Norway). I remember people waiting months to see a specialist, in the second richest country (per capita) in Europe. So, yeah, they couldn't figure out the billing or the actual care, either. I'm not exactly itching to sign onto that garbage. The only difference between strutting doctors that are full of shit over their non-accomplishments in the USA versus Europe is how much less they have to work in Europe.

  25. Re:Should be no prizes till the fucking cure somet by Seven+Spirals · · Score: 1

    First off, fuck you. Second, that study is all you got after throwing all those grenades? What a load of shit, Coward. That fucking study has 30 people in it. What about the other 174,200 people in the USA alone that aren't getting your wonder-cure? If it's a cure, why didn't anyone else pick up on that, or is everyone else just not as smart as you? It's full of shit AC's like you that need to stay the fuck off the cain and /.