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Method For Fooling Cancer Cells Into Fat Cells Can Stop Cancer's Spread (technologynetworks.com)
Researchers from the University of Basel in Switzerland have discovered that they can prevent the formation of metastases by fooling breast cancer cells into fat cells. The proof-of-concept study was published in the journal Cancer Cell. Technology Networks reports: Malignant cells can rapidly respond and adapt to changing microenvironmental conditions, by reactivating a cellular process called epithelial-mesenchymal transition (EMT), enabling them to alter their molecular properties and transdifferentiate into a different type of cell (cellular plasticity). Cancer cells can exploit EMT -- a process that is usually associated with the development of organs during embryogenesis -- in order to migrate away from the primary tumor and form secondary metastases. Cellular plasticity is linked to cancer survival, invasion, tumor heterogeneity and resistance to both chemo and targeted therapies. In addition, EMT and the inverse process termed mesenchymal-epithelial transition (MET) both play a role in a cancer cell's ability to metastasize.
Using mouse models of both murine and human breast cancer the team investigated whether they could therapeutically target cancer cells during the process of EMT -- whilst the cells are in a highly plastic state. When the mice were administered Rosiglitazone in combination with MEK inhibitors it provoked the transformation of the cancer cells into post-mitotic and functional adipocytes (fat cells). In addition, primary tumor growth was suppressed and metastasis was prevented. Since both drugs used in the preclinical study were FDA-approved the team are hopeful that it may be possible to translate this therapeutic approach to the clinic.
Using mouse models of both murine and human breast cancer the team investigated whether they could therapeutically target cancer cells during the process of EMT -- whilst the cells are in a highly plastic state. When the mice were administered Rosiglitazone in combination with MEK inhibitors it provoked the transformation of the cancer cells into post-mitotic and functional adipocytes (fat cells). In addition, primary tumor growth was suppressed and metastasis was prevented. Since both drugs used in the preclinical study were FDA-approved the team are hopeful that it may be possible to translate this therapeutic approach to the clinic.
Nice Post Thanks for sharing Instagram Captions
That's my transmogrifying butt cancer.
English as a fifteenth language, or just the vocabulary of a screaming monkey?
I would be richer now than the cancer of Steve Jobs.
On to something much worse now, on to Trump's Disease.
I think they mean 'turning'.
Fascinating science in the actual article - really odd use of language in the article. 'Fooling' is kind of anthropomorphizing the cancer cells - they're changing based on mechanisms, they never really make decisions to be fooled on, and that's why the actual study doesn't really use the word.
Ryan Fenton
a variety of poisons on the 'menu', & now a way to survive stuff that we/our spawn aren't designed to have in us in the first place? what a story? not this one. just more deep voodoo & chicken feathers?
I would call it hacking. They are hacking the process started by the cancer cells. Just like digital hackers, biohackers can be good guys.
Nae king! Nae laird! Nae yurrupiean pressedent! We willna be fooled again!
Cancers that are turned into fat later
just as likely we'll grow the gossamer like wings?
Instead of runaway cancer, you get runaway obesity? Then you die of a massive coronary.
FAIL
How about some opensource news for nerds: https://slashdot.org/submissio... Why do these cancer medicines never cure cancer? Ever? I've been hearing this stuff all of my life.
unbelievable clickage #s.. no imported or 'loaded' turds allowed.. may the best moms win.. see you there
Fat-cancer rates explode.
In other news, obscenely fat people are now walking tanks with their tumor-armor.
Hollywood saw to that. And it's the law now: "Computer hacking" is criminal, even though the law doesn't say what "hacking" is. Since this "hacking" indubitably involves computers somehow, it must be "computer hacking" and therefore criminal. Don't go "but the law doesn't mean that" on me, you doofus. If the prosecutor feels like it, he can use it that way. That makes it bad law, but it is a law in force, and thus almost anything anyone would care to call "hacking" can get prosecuted.
You can thank the security s'kiddies for that. And hollywood.
...You mean Trump Derangement Syndrome?
It's not like cancer sees some environmental stimulus and says "oh hey look at that, let me just to make more random mutations to my DNA that just happen to make me do this other thing."
Cancer isn't a sentient being, so let's stop talking about it like it is. Cancer doesn't exploit anything, or take affirmative action to a particular result. It, like any other cell, responds to environmental stimuli exactly as its program defines.
fat? :)
Serious question - I understand everyone has fat cells, just that in obese people, they are larger than in lean people. However, if we turn cancer cells into fat cells, and that person adopts a healthy lifestyle to reduce the size of the fat cell, is that a win-win? Or is this a different type of fat cell that has other consequences?
Because Basel is a major center for pharma research, with several major firms headquartered there, it nurtures a university/manufacturing complex that makes it the Silicon Valley of the drug trade. Switzerland has its own regulatory apparatus that is notably faster and more responsive than our FDA, with the same high standards. And as a non-EU country, Switzerland is not subject to regulatory luddism from Brussels. If genetic engineering turns out to be part of the next big cancer treatment, it will flourish in Switzerland.
https://www.pharmaceutical-tec...
While excited. I hope it works out.
So can we fool fat cells into being cancer for a few weeks and then fool them back to fat?
Turn cancer cells into fat cells
Good news for everyone except Hollywood starlets, who'd rather have the cancer.
(-1: Post disagrees with my already-settled worldview) is not a valid mod option.
That will get cured on November 3, 2020.
I am a bit suspicious of the value of studies that have not been replicated for more than one case. This is one of those. It is very clever work but I don't think the chances that it will lead to a cancer therapy are particularly high. The idea behind the work is that cells from breast cancer are one type (epithelial), but they need to convert into another type (mesenchymal) so they can leave the tumor and form metastasis. The clever part is that they nudge the mesenchymal cells to convert to fat cells and stop dividing. The problem is that the occurrence of the epithelial to mesenchymal transition in tumors is a bit of a controversial topic. The idea has a devoted cult following, but it has not been convincingly shown to be true. We know that the breast cancer tumors are epithelial and we know that their metastasis are epithelial. Genetic tagging to detect the transition in actual tumors so far have failed to do so and have shown that you don't need this transition to form metastasis. We also can see epithelial cells leaving the tumor without the need to convert to a different cell type. In the work, they use cell lines (cell cultured in a dish) that either readily undergo the epithelial to mesenchymal transition when exposed to a hormone that is abundant in the tissue and the blood (TGF-Beta), or a cell line that is mesenchymal (MDA-MB-231). These experiments show that when you inject these cell lines in a mouse you can reprogram them into fat cells. To make sure the reprogramming also works on tumors they use a human patient derived tumor that is grown in mice. Here is where my major problem with the work is. There are hundreds of these patient derived tumors that are available but they do the experiments on just one. Why just one? Why this particular one? If you are developing a cancer therapy one of the major questions is what are the chances that it will work. You answer that question by testing as many tumors as you can.
Fat cancer sounds terrifying.
Not only does the person who has the cancer get cured but they get some bigger titties in the process. Maybe not so good for the male breast cancer suffers which is very tiny percentage but hey bigger titties are bigger titties and that's a win-win in my book :)
....hello converted cancer cells.
So, this "biohacking" can be used to grow someone's breast fat to make them "naturally" bigger?
No, don''t get up, I'll show myself out
+Raider of the lost BBS
But cancer wants to become fat cells, it just can't remember how without our helpful hints.
All my cancer cells turned into fat!
Oh wait... Americans. Illiterate cretins. You really do have a problem with prepositions in the U.S.A., don't you.
Just insert a random preposition if you don't know the correct one to use!
Like "named for" - which should be "named after", and "in the death of", which should be "FOR the death of". "Mr. Smith was arrested FOR the death of John Jones."
Be cancer free with bigger breasts?
Ducks...
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