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China's CRISPR Twins Might Have Had Their Brains Inadvertently Enhanced (technologyreview.com)
An anonymous reader quotes a report from MIT Technology Review: The brains of two genetically-edited girls born in China last year may have been changed in ways that enhance cognition and memory, scientists say. The twins, called Lulu and Nana, were modified using CRISPR, a new gene-editing tool, by a Chinese scientific team to make the girls immune to infection by HIV, the virus that causes AIDS. Now, new research shows the same genetic alteration introduced into the girls' DNA, to a gene called CCR5, not only makes mice smarter, but also improves human brain recovery after stroke, and could be linked to greater success in school.
"The answer is likely yes, it did affect their brains," says Alcino J. Silva, a neurobiologist at the University of California, Los Angeles. Silva's lab lab has been uncovering a major new role for the CCR5 gene in memory formation and the brain's ability to form new connections. "The simplest interpretation is that those mutations will probably have an impact on cognitive function in the twins," says Silva. He says the exact effect on the girls cognition is impossible to predict and "that is why it should not be done." The Chinese designer babies were created to be resistant to HIV. A team in Shenzhen, China, led by Southern University of Science and Technology He Jiankui used the gene-editing tool CRISPR to delete a single gene, called CCR5, from human embryos, some of which were later used to create pregnancies. The virus that causes AIDS requires the CCR5 gene to enter human blood cells. The scientist, He Jiankui of the Southern University of Science and Technology in Shenzhen, China, has been fired from the university as He is under investigation in China. There is no evidence that He actually set out to modify the twins' intelligence.
"The answer is likely yes, it did affect their brains," says Alcino J. Silva, a neurobiologist at the University of California, Los Angeles. Silva's lab lab has been uncovering a major new role for the CCR5 gene in memory formation and the brain's ability to form new connections. "The simplest interpretation is that those mutations will probably have an impact on cognitive function in the twins," says Silva. He says the exact effect on the girls cognition is impossible to predict and "that is why it should not be done." The Chinese designer babies were created to be resistant to HIV. A team in Shenzhen, China, led by Southern University of Science and Technology He Jiankui used the gene-editing tool CRISPR to delete a single gene, called CCR5, from human embryos, some of which were later used to create pregnancies. The virus that causes AIDS requires the CCR5 gene to enter human blood cells. The scientist, He Jiankui of the Southern University of Science and Technology in Shenzhen, China, has been fired from the university as He is under investigation in China. There is no evidence that He actually set out to modify the twins' intelligence.
If only we could get some politicians to undergo this procedure...
Of course youâ(TM)re polish - you love hosts files and screen doors on submarines, you say you have the gene and then say you donâ(TM)t have it, you babble idiocy constantly, and you write idiot essays nobody reads.
If they do, it'll be the best god damned sandwich you will ever taste.
I've had two girls make me a bologna sandwich. I was the bologna.
You are welcome on my lawn.
That's not fair to rocks, at least they have millions of years of experience.