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Scientists Reawaken Cells From a 28,000-Year-Old Mammoth (vice.com)
Cells from a woolly mammoth that died more than 28,000 years ago have been partially reactivated inside of mouse egg cells, according to a study published Monday in Scientific Reports. "The achievement shows that biological activity can be induced in the cells of long-dead creatures, but that does not mean that scientists will be resurrecting extinct animals like mammoths any time soon," reports Motherboard. From the report: A team led by Kazuo Yamagata, a biologist at Kindai University in Japan, extracted cells from the remains of "Yuka," a young female mammoth discovered in 2010 on the coast of the Dmitry Laptev Strait in the Russian Far East. Yuka was entombed in permafrost, a frozen ground layer that can often keep the skin, fur, brains, and other softer tissues of dead animals intact. Because Yuka is in particularly great condition, Yamagata's team was able to extract 88 nucleus-like structures from her preserved muscle tissues. The mammoth cells were implanted into mouse oocytes, which are ovarian cells involved in embryonic development. The researchers also implanted elephant cells into mouse eggs to provide a control sample.
Once the cell nuclei were incubated, they seemed to reawaken -- but only slightly. The cells did not divide, but completed some steps that precede cell division. For instance, the mammoth nuclei performed a process called "spindle assembly," which ensures that chromosomes are correctly attached to microscopic spindle structures before a parent cell breaks into two daughter cells. The fact that Yuka's cells were able to spring back into partial action is both an exciting and challenging development for scientists interested in cloning extinct animals. On one hand, some degree of cellular reactivation is clearly possible. But Yuka is also an exceptionally pristine specimen, and even her cells were not able to complete cell division -- a major hurdle that scientists must clear to accomplish de-extinction.
Once the cell nuclei were incubated, they seemed to reawaken -- but only slightly. The cells did not divide, but completed some steps that precede cell division. For instance, the mammoth nuclei performed a process called "spindle assembly," which ensures that chromosomes are correctly attached to microscopic spindle structures before a parent cell breaks into two daughter cells. The fact that Yuka's cells were able to spring back into partial action is both an exciting and challenging development for scientists interested in cloning extinct animals. On one hand, some degree of cellular reactivation is clearly possible. But Yuka is also an exceptionally pristine specimen, and even her cells were not able to complete cell division -- a major hurdle that scientists must clear to accomplish de-extinction.
Next Step: Mouse pregnant with mammoth embryo.
"Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should..."
> there is no "quickening"...
Juan Villa-Lobosh Ramireszh would dishagree.
"Wait. Something's happening. It's opening up! My God, it's full of apricots!"
Probably because just cranking out endangered species would not really solve the problem. Most of them are endangered due to habitat destruction. Yes there are some exceptions like Wolves in North America where over hunting is to blame. There would be no point for example in release a bunch of endangered cats in Asia with no way for them to eek out a living.
Repeal the 17th Amendment TODAY! Also Please Read http://www.gnu.org/philosophy/right-to-read.html
I honestly don't know why we aren't already "manufacturing" endangered species.
Because it is expensive. Do you volunteer to fund it?
It would impress me, but far less than the mouse who can give birth to a woolly mammoth!
Seven puppies were harmed during the making of this post.
Maiya looked out wistfully over the horizon at the valley below. She leaned heavily on her walking stick carved from a mammoth shin bone and pulled back her sabertoothed tiger cowl. What changes this valley had seen over the past few decades. A few paces back, her son finally caught up with her and joined her in the view. "What was it like before they resurrected all the dinosaurs and ancient animals?" Maiya sighed heavily, eying the overgrowth that had swallowed a city that used to be called 'L.A.' She could hear in the distance the howls and screams of something fighting for its life. "Well, for one, we stepped in a lot less T-Rex shit."
You can reawaken me after 28000 years.
You think 28,000 years is long enough- but when you awake they'll still be singing "baby shark" and you'll immediately go back to sleep again.
"That's the way to do it" - Punch
Cells from a woolly mammoth that died more than 28,000 years ago have been partially reactivated inside of mouse egg cells
BRAINZZZZZ .... and cheese.
So, errr, like, what do you use -- a mousetrap? A mammoth trap? And it kills them? But, but they're already dead.
More like you'd get 'em more pissed than they were already. A mammoth-sized mouse is now upset with you. And here you thought your day was bad enough already.
If the universe is someone's simulation -- does that mean the stars are just stuck pixels?
No it is Holocene Park.
If something is so important that you feel the need to post it on the internet... It probably isn't that important.
It seems to me from this experiment they will learn a whole lot more about how to preserve cells for a long period of time than how to reawaken them.
12:50 - press return.
... get to be desirable, even when it comes to reviving mammoths. After all, what would be the point of reviving an old male ?
These cats are frightening.
The mouse became scared of itself.
"Evil will always triumph over good, because good is dumb." - Dark Helmet (Spaceballs)
"A mammoth-sized mouse"
The rodents of unusual size? I don't believe they exist.
Eloi are stupid, throw morlocks at them!
Will the world end in Parasite Eve, Skynet, or Heavy Weather?
"You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
Finally someone has made exciting advancements in the field. I propose we being to pool efforts to advance this quickly due to it's amazing medical applications. We can start by putting all the scientists in one major facility and managing them under a single Umbrella Corporation.
De-extinction is rife with seemingly intractable problems. Going to locate and clone a sufficient number of unique preserved specimens to avoid inbreeding? What about reproducing its entire exterior/interior microbiome - especially the essential gut flora?
I am not a number - I am a free man!