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Researchers 3D-Print Heart From Human Patient's Cells

Researchers have 3D-printed a heart using a patient's cells, providing hope that the technique could be used to heal hearts or engineer new ones for transplants. "This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers," Professor Tal Dvir of Tel Aviv University's School of Molecular Cell Biology and Biotechnology said in a statement. Dvir is senior author of the research, published Monday in the journal Advanced Science. CNN reports: The process of printing the heart involved a biopsy of the fatty tissue that surrounds abdominal organs. Researchers separated the cells in the tissue from the rest of the contents, namely the extracellular matrix linking the cells. The cells were reprogrammed to become stem cells with the ability to differentiate into heart cells; the matrix was processed into a personalized hydrogel that served as the printing "ink."

The cells and hydrogel were first used to create heart patches with blood vessels and, from there, an entire heart. Next, the researchers plan to train the hearts to behave like hearts, Dvir explained. "The cells need to form a pumping ability; they can currently contract, but we need them to work together." If researchers are successful, they plan to transplant the 3D-printed heart in animal models and, after that, humans.

74 comments

  1. "Let's set the IPO for noon tomorrow" by Anonymous Coward · · Score: 0

    "If researchers are successful, they plan to transplant the 3D-printed heart in animal models and, after that, humans." Yeah or you could perfect it first, whichever.

    1. Re:"Let's set the IPO for noon tomorrow" by Anonymous Coward · · Score: 0

      Are you being stupid or is this some joke?

    2. Re: "Let's set the IPO for noon tomorrow" by Anonymous Coward · · Score: 0

      When do they insert the soul? Oh wait, it's only ancient religions that believed the soul was in the heart.

    3. Re:"Let's set the IPO for noon tomorrow" by jellomizer · · Score: 2

      Perfection is often a goal to disaster.
      Good Enough is actually a better goal. Then with improvements later on.
      Lets say this new 3d heard will work 75% as well as a healthy human heart transplant. So the patient may not be able to run sprints or marathons, but it is better then their own heart that is working at 25% of normal.

      Animal Testing then human trials are part of the course. I am not sure what you are expecting a 100% effective human heart to be implanted perfectly without any testing?

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    4. Re:"Let's set the IPO for noon tomorrow" by Anonymous Coward · · Score: 0

      I'm expecting them to perfect their design flows before they think it's ready for human/animal testing, as opposed to be rushing to bring it to market for corporate purposes like companies do exclusively now.

      I'm sorry you couldn't get that.

    5. Re:"Let's set the IPO for noon tomorrow" by Anonymous Coward · · Score: 0

      I'm sorry you couldn't get that.

      No need to be a snotty little shit, bro.

  2. Netanyahu or his masters? by Anonymous Coward · · Score: 0

    Or a Saudi Royal (is the former king still alive?)

  3. Re:Interesting... by Anonymous Coward · · Score: 0, Insightful

    why do you have to turn everything into political mess.

  4. Screw that noise! Gimme full conversion! by Anonymous Coward · · Score: 0

    Invent a sturdy sustainable way to hook up the brain to a computer already! (Maybe 3d-print organic connectors for the nerves?)

    I want my ass to be 40% titanium!

    1. Re: Screw that noise! Gimme full conversion! by Anonymous Coward · · Score: 0

      You do realize that 99.999% of people, including scientists, can't tell the difference between the warranty contract on a stove and a love note.

    2. Re:Screw that noise! Gimme full conversion! by Micah+NC · · Score: 1

      Given that the life expectancy of a computer is 3 to 5 years ... would this be an advantage?

  5. Re: Interesting... by Anonymous Coward · · Score: 1

    âoewhy do you have to turn everything into political mess.â

    Because there are mentally ill people out there who obsess over things like this.

  6. Re: Interesting... by Anonymous Coward · · Score: 0

    Call me when the EU gets sensible leadership and I'll listen to your complaints about trump. I'll even write you a litany.

  7. Magic by Anonymous Coward · · Score: 0

    This sounds like pure magic.

    1. Re: Magic by Anonymous Coward · · Score: 0

      Time travel would be magic. Nobody reasonable would call tissue printing magic.

    2. Re: Magic by Anonymous Coward · · Score: 0

      If you believe in magic I am certain you can be convinced to believe it again unless you are sensible

    3. Re:Magic by Anonymous Coward · · Score: 0

      Except that no real functional heart was 3D printed. You want magic? Try to understand how a single cell becomes an animal.
      There's magic.
      Every stray cat you see out there is more magical than this stupid story.

    4. Re: Magic by Micah+NC · · Score: 1

      Says the person whose heart is not dying.

  8. Re: Interesting... by Anonymous Coward · · Score: 0

    Try again. Not even in the neighborhood of acceptable thought.

  9. Re: Interesting... by Anonymous Coward · · Score: 0

    Only the ones I disagree with.

  10. Re: Any sufficiently advanced technology is indis by Anonymous Coward · · Score: 0

    You must have a lot of paperbacks and time on your hands

  11. Excellent! by Gravis+Zero · · Score: 0, Offtopic

    Now that we've helped Tin Man, maybe there is hope for President Scarecrow. ;)

    --
    Anons need not reply. Questions end with a question mark.
    1. Re: Excellent! by Anonymous Coward · · Score: 0

      It's not you. The crazies took over the asylum and the guards are MIA.

    2. Re:Excellent! by Anonymous Coward · · Score: 0

      This story has nothing to do with politics. Why are you working hard, to make every story about politics?

      Slashdot should have a new moderator tag. "About politics -> -50".

  12. Re:Interesting... by Anonymous Coward · · Score: 0

    Think Shakespeare. Shylock wants his pound of flesh. Soon he may get it and the debtor can in Israel BUY a printed heart. With interest etc, Soon the modern day shylocks can ply their trade, and can say one kidney, and some bone marrow, and we will sell you a heart.

  13. An interesting first step. by pslytely+psycho · · Score: 4, Informative

    I see they haven't figured out how to print nerves yet.
    After I wrote that sentence, I thought, how the hell does a heart transplant work since all the nerves had been cut. Apparently, the nerves degenerate immediately and the heart just runs on autopilot. They can't feel angina or other heart problems.
    Just about 70% will eventually see new nerve growth however over a long period of time.
    So yeah, they have to learn to print nerves unless they intend this to be bio-mechanical in some way.

    The article I read after writing the initial sentence, it's a bit out of most of our fields, but is still fairly easy to interpret. I found it a fascinating read on a subject I have only passing familiarity with. (Once trained as a Medical Assistant. Then Hillary Clinton, the day Bill was elected said "health care reform." No one knew what it would entail, and the jobs dried up for about two years and I became a mechanic instead. My tale of woe for your entertainment)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210323/

    --
    Donald Trump, on a crusade to make Nixon look respectable
  14. Re: Interesting... by Anonymous Coward · · Score: 0

    Only the ones I disagree with.

    I thought standard alt-right/Nazi policy was to throw everybody you disagree with into an oven?

  15. Re: Interesting... by Anonymous Coward · · Score: 0

    Call me when the EU gets sensible leadership and I'll listen to your complaints about trump. I'll even write you a litany.

    It already has a leadership that is by orders of magnitude more intelligent than Trump, now call me when the orange one grows a brain.

  16. Re:Interesting... by Anonymous Coward · · Score: 0

    The point is, it has nothing to do with this story. Further, you're clearly reading stories, and doing your best to try to find a way, any way, to link it to politics.

    You know that 50 years ago, people thought about the president of a country, the prime minister, monthly maybe? Stop watching 24 hour news channels, of any type. Stop reading political stories hourly. Maybe read them weekly, or monthly.

    Stop being a slave to the 24x7 news cycle, and their need for you to read the same story over, and over, and over.

  17. Re: Interesting... by Freischutz · · Score: 0

    Try again. Not even in the neighborhood of acceptable thought.

    What? Retrofitting sociopath politicians with a moral compass is unacceptable thought? Why? Being a a greedy and corrupt sociopath incapable of empathy (Bibi) is due to an malfunction in the circuitry of the human brain as is narcissism and dementia (Trump). If we can 3D print a heart, surely we can 3D print replacement neural circuitry and retroactively install a moral compass in these people using the 10 commandments as a basis for the design. I may be an atheist but the 10 commandments are pretty sensible rules to live by for the most part. As an atheist I don't really care about the idolatry part and banning coveting seems pretty harsh (a guy or girl l can dream) but not doing blasphemy, murder, adultery, theft and general dishonesty sounds like a plan

  18. Re:Interesting... by Anonymous Coward · · Score: 0

    Snowflake alert!

  19. Re:Interesting... by Anonymous Coward · · Score: 0

    Think Shakespeare. Shylock wants his pound of flesh. Soon he may get it and the debtor can in Israel BUY a printed heart. With interest etc, Soon the modern day shylocks can ply their trade, and can say one kidney, and some bone marrow, and we will sell you a heart.

    Well, at least with 3D printed organs they won't have to carve poor people up for parts anymore: https://www.haaretz.com/israel...

  20. Re: Interesting... by Anonymous Coward · · Score: 0

    The orange one is the only one with a brain in my estimation

    So you are suffering from dementia too? Sad! ... very, very sad!

  21. Re: Interesting... by Freischutz · · Score: 1, Insightful

    Only the ones I disagree with.

    And here I thought you conservatives valued the 1st amendment? ... apparently it only applies to people you agree with.

  22. Re:Interesting... by Freischutz · · Score: 1

    The point is, it has nothing to do with this story. Further, you're clearly reading stories, and doing your best to try to find a way, any way, to link it to politics.

    You know that 50 years ago, people thought about the president of a country, the prime minister, monthly maybe? Stop watching 24 hour news channels, of any type. Stop reading political stories hourly. Maybe read them weekly, or monthly.

    Stop being a slave to the 24x7 news cycle, and their need for you to read the same story over, and over, and over.

    If you want to be an uninformed rube that is your choice. I, however, welcome any technology that allows us to retroactively upgrade our leaders to be less of a bunch of greedy selfish ass-holes than they currently are.

  23. That's nice by Anonymous Coward · · Score: 0

    But if it isn't useful for anything, honestly: who cares? Research didn't used to be about scientists impressing themselves. :/

    1. Re:That's nice by Dunbal · · Score: 2

      A guy puts wings on a bicycle and it's pretty useless. Until a few months later he decides to put a gasoline engine and a propeller on it too. Science is often done in iterations...

      --
      Seven puppies were harmed during the making of this post.
  24. Re: Interesting... by Anonymous Coward · · Score: 0

    Oh stop making so much sense. You're just gonna confuse everyone. And the people who don't like what you say are never gonna like it. Most people don't start agreeing unless its profitable. Most people don't help unless its profitable, no matter what is claimed to the contrary.

  25. Adult vs. Embryonic Stem Cells? by Anonymous Coward · · Score: 0

    Am I missing something or has all the major stem cell breakthroughs been with Adult Stem Cell (from patient's own body) instead of Embryonic stem cells? Hmm. I wonder how that impacts the political discussion on that topic.

    1. Re:Adult vs. Embryonic Stem Cells? by Anonymous Coward · · Score: 0

      Have there been *any* major breakthroughs with Embrionic stem cells?

    2. Re:Adult vs. Embryonic Stem Cells? by Anonymous Coward · · Score: 0

      They have been used to justify the killing of thousands of babies for "research".
      So if you are pro-killing babies (basically a DNC member) there is that going for you.

      Other than that, no.

    3. Re:Adult vs. Embryonic Stem Cells? by Anonymous Coward · · Score: 0

      The truth is that there are multiple sites they've learned to siphon stem cells from.

      Whether or not they're still using embryonic ones regardless in some non-permission given way, well... your guess is as good as mine, but if they aren't explicitly asking, it should be wrong to just take.

      Apparently they already take the discarded foreskins after circumcisions, too. No compensation or permission and they're used for beauty products. No source, but hey, I wouldn't be surprised if in medicine they make use of all "discarded" human bits and make some money quietly on it on the side.

    4. Re:Adult vs. Embryonic Stem Cells? by Dunbal · · Score: 1

      Stem cells are stem cells. Since they're not differentiated it doesn't really matter where they came from. The breakthrough was being able to take regular differentiated cells and turn them back into undifferentiated stem cells.

      --
      Seven puppies were harmed during the making of this post.
    5. Re:Adult vs. Embryonic Stem Cells? by Anonymous Coward · · Score: 0

      "Stem cells are stem cells. Since they're not differentiated it doesn't really matter where they came from."

      Sigh. Wrong. You have pluripotent and totipotent stem cells. If you don't know, keep quiet.

    6. Re: Adult vs. Embryonic Stem Cells? by Anonymous Coward · · Score: 0

      All of those âoebabiesâ were leftover medical waste from in vitro fertilization. They were destined for an incinerator. In the real world, the majority of embryos never become babies. If the âoepro-lifeâ set actually were pro-life (or, letâ(TM)s be fair, they might actually be pro-life but just not rational) they wouldnâ(TM)t be throwing away their efforts on trying to ban abortion, they would be working on improving the US healthcare system so that it no longer has the highest infant mortality rate in the developed world. Approximately a third as many pregnancies that are aborted end up with a preventable infant death, maybe more. Having decent social services would also probably prevent half or more of those abortions in the first place.

    7. Re:Adult vs. Embryonic Stem Cells? by Anonymous Coward · · Score: 0

      Well, you're probably missing that figuring out how to grow a heart from stem cells would have included a lot of trial and error in stages where there was no possibility of producing a working heart yet so they wouldn't have had a patent to harvest stem cells from, but still needed to get a bunch of them to try things with.

      The utility of embryonic stem cells was't that cells from a fetus are better, but that aborted fetuses were a trove of stem cells that wasn't otherwise going to be used for anything.

  26. Re: Interesting... by Anonymous Coward · · Score: 0

    Not true, reading the news can actually reduce your knowledge of the world.

  27. without paywall by ltcdata · · Score: 2

    Link without paywall: https://onlinelibrary.wiley.co... (paper is open access)

  28. Re:Interesting... by jellomizer · · Score: 0

    Would it be the moral compass of the voters that need to be fixed?
    The problem is we are trying to find a politician who will solve all our problems, so we keep on voting in bozos who try to solve all our problems, and often will fail miserably because our problems are diverse and will conflict with others problems.

    We really need to solve most of our own problems, and for bigger ones, it should be up to the local governments, and giving national government the least amount of problems to solve. Because a national sweeping change, is going to hurt a lot of people.

    --
    If something is so important that you feel the need to post it on the internet... It probably isn't that important.
  29. Now I need a maker space by goombah99 · · Score: 1

    to make my pace makers

    --
    Some drink at the fountain of knowledge. Others just gargle.
  30. Re:Interesting... by squiggleslash · · Score: 0

    I think many voters gave up on finding politicians who will solve their problems a while ago. Now, for at least half the electorate, it's a tribal thing. Which of the problems ordinary Republicans have are being addressed by any serious Republican candidates? At the last election... maybe Jeb and Rubio kinda sorta, but even then only for a small number of groups.

    The problem with the "local is best" mentality is it tends to assume that most problems aren't national and it also provides people with ways to have their cake and eat it. If my city decided it was going to solve the healthcare crisis for its inhabitants, it'd get swamped pretty quickly by people who live outside the city, benefiting from not having to pay for the city's services, moving in only once they require the services.

    Nor can a city in the middle of nowhere expect to make macroeconomic policy changes that'd encourage business investment.

    The reality is most politics needs to be national. In most countries, this is a given and it works. In the US, there's a good argument for suggesting the current constitutional structure is never going to work again, but that's not going to be fixed by making politics "local" or giving power to institutions like the States that have historically abused it in certain regions.

    --
    You are not alone. This is not normal. None of this is normal.
  31. Re:No left wing by Anonymous Coward · · Score: 0

    I thought standard alt-right/Nazi policy was to throw everybody you disagree with into an oven?

    No, that was a Sanders supporter that decided shooting politicians was acceptable. Its a left-wing thing, which the DNC is also currently supporting anti-Semitism and a KKK member, so they are much more Nazi like.

    So why did I hear a bunch of right wingers shout those exact words in my face at Charlottesville? ... and then hear POTUS call them 'good people' a little later.

  32. Re:Interesting... by Anonymous Coward · · Score: 0

    You think you're moral and anyone who doesn't agree with you is immoral. I think it's you that needs a new compass printed and perhaps a sense of circumspection too.

  33. Re: Interesting... by Anonymous Coward · · Score: 0, Informative

    The Nazis were leftist. And there were just as many non-Jews in the socialist work camps. They all had to take delousing showers and they were all burned in the garbage incinerator when they died. Use some critical thinking, gas chambers are air tight for a good reason.

    Yeah, that's why the Nazis made common cause with right wing oligarchs and killed all those social-democrats and communists. You need to put some serious work into your trolling skills, that or start taking your medication again, depending on which of those ailments caused you to write that post.

  34. Re:Interesting... by Freischutz · · Score: 1

    You think you're moral and anyone who doesn't agree with you is immoral. I think it's you that needs a new compass printed and perhaps a sense of circumspection too.

    No, I think that being elected into office rots your soul and the first thing to rot away is your moral compass. I don't care whether your name is Mitch McConnell or Nancy Pelosi. I watched the both of them give interviews recently and I knew the two of them were rotten, but I had somewhat underestimated just how rotten they have become and while I was not surprised at just how completely the two of them have sold out their ideals I was somewhat surprised that the two of them seem to genuine believe that the people elected them to be this corrupt. I'm sure that at some point they really believed in them but nowadays they McConnell and Pelosi are just husks of their former selves who think they were elected to take bribes from corporations, banks and special interest groups. This story just made me muse about how things would be if we could update the moral software of our leaders so I posted my OP as a kind of a sarcastic joke which everybody seems to be taking waaaaaaaaaaaayyyy to seriously. I keep forgetting that if you don't suffix your sarcasm with the word 'Zinger!' many Americans *will* take you literally.

  35. Another failure for BDS by Anonymous Coward · · Score: 1

    I sincerely hope that all those that advocate for the antisemitic BDS movement never get to benefit from these, and other potentially life saving breakthroughs that have originated in Israel.

  36. EDITORS: the link to the journal article is broken by blind+biker · · Score: 1

    I am pretty sure the editors just copy/pasted the broken link from the CNN article. Obviously, that's a wrongheaded way of doing... editing.

    --
    "The agriculture ministry is not in charge of Gundam" - Japanese ministry official.
  37. Used heart by Anonymous Coward · · Score: 0

    "...they plan to transplant the 3D-printed heart in animal models and, after that, humans."

    After the heart has been in an animal model, I don't think I would want it anymore. But that's just me...
    (Sorry for the lame joke.)

  38. Re: Interesting... by GLMDesigns · · Score: 1

    IF you're going to limit your discussion to a left-right dichotomy then you can say the Nazis are on the left.

    If Right means limited, small-government and the left means state control of economy and subjects (think monarchy, fascism, socialism) then the Nazi's are on the left.

    If the Nazi's are on the Right. And the Socialists are on the Left. Then where do monarchists go? Where do Libertarians go?

    The problem is in the ill-defined Left-Right scale.

    --
    If you're scared of your govt then you need to further restrict its powers
    Vote 3rd Party in 2016 and beyond
  39. Re: Interesting... by Anonymous Coward · · Score: 0

    yeah sure it cant be they are russian trolls because they only troll elections right?

  40. Re: Interesting... by Anonymous Coward · · Score: 0

    not us screaming to shut folks down at free speech events. fact check yourself by doing something other than listen to your buddies and favorite twitter feed.

  41. Re: Interesting... by Anonymous Coward · · Score: 0

    oh look at this: grooming.

  42. Re:Interesting... by Anonymous Coward · · Score: 0

    If you want to be an uninformed rube that is your choice. I, however, welcome any technology that allows us to retroactively upgrade our leaders to be less of a bunch of greedy selfish ass-holes than they currently are.

    By your words you want technology to advance. Yet you trumpblock the discussion of technology. 4D chess?