Proteins are typically characterized through X-ray crystallography. The drawback with X-ray analysis is that the protein must be in a crystallized form--this typically means that millions of occurences of the same protein are crystallized together. The shape that a protein takes such that it can form a crystal may not be the shape that the crystal takes when in the heterogenous solution of a cell. Fesik, at Abbott Laboratories, made ground breaking advances in the realm of solution phase study of the shape of proteins--SAR by NMR analysis. Still concerns remain because the solutions used to lend to NMR analysis are not the same as the heterogenous environment within a cell.
This creates a much larger problem in drug design. The medicinal chemists design molecules to fit active sites of proteins and enzymes but the shape of that active site is only determined from Xray, NMR, or computer generated lowest energy conformations. It is no surprise then that 3/4 of molecules which are advanced to clinical trials fail efficacy studies: in short, they simply do not work. Looking back it's quite logical that they do not work because they were designed to fit a shape that was not a proper representation of the shape which the protein takes within the actual cells, in vivo.
Making note of this was usually received with extreme vitriol by the management.
think yourself better than I. Any day you would like to live, side-by-side, dollar for dollar, on the same fixed income, paying the exact same rent, with the exact same network connection and the exact same toys, to verify this I'll be more than happy to show up. Any time, any where.
You might want to consider what you truly believe in life and decide if Christianity really preaches the ideals you practice God exists. That was the point of my original post.
Not a possible cause of autism Spare us the BS. You were dropped on your head. That explains your whining about headaches.
I'm now faithfully married I feel sorry for the victim of your daily abuse.
have NO extramarital s3xual interests Due to your mental disorder you probably have a lack of intramarital s3xual interest.
AND have a child I pity the poor child who grows up under the supervision of a self-admitted youth s3x offender and a compulsive verbal abuser such as yourself. Every cent of your taxpayer leeched money will be necessary to ensure that the kid isn't reviled throughout their life.
until my brain finished maturing at 25 As evidenced by your chosen path of discourse, in which you fail to maintain thorough continuity across subjects, your brain will never mature.
I was treating the g1rls I went out with before then the way I wanted to be treated. Did that include the constant verbal degradation which you've clearly demonstrated on Slashdot?
I've treated you the *exact* same way I expect to be treated and debated with Except that, when I dish back the insults and abuse which you've dished, you cop out. I've demonstrated that, no matter how ludicrous and incongruous your arguments are, I'm willing to patiently continue an attempt at discourse. Well, until today that is. I decided to try an experiment to see how you would receive the same crap which you give on a daily basis. You fail it.
there is no reason to hide feelings behind a false polticial correctness with an If that is true then the level of disrespect which you've shown me is worthy of 4dult-calibre punishment (and no hiding behind desperate proclamations of "I'm autistic! I can't help it!"). You should be in prison or, at least, barred from internet use.
> you're just another nutjob whose reasoning boils down to "because I said so"
Maybe you missed my original post in this article. I'm not surprised that a lower class debate reject like you couldn't be bothered to remember where the discourse began.
> After all, what's more important, voting or money?
Which one was it that contributed to your ability to foist your personal madness on the rest of the world with impossible regularity and without challenge?
The same major investors in WiFi companies are the same major investors in Telcos are the same major investors in a majority portion of the stock market.
The only thing which is happening here is the creation of an illusion in order to exploit the American consumer's inability to keep up with the markets as well as the major investors.
one can "simply" look at the drive from a clean system Maybe I've written a rootkit based upon an unknown exploit in the code for the library which reads and writes to the file system used by the partition. Then what would you do? So much for the clean system.
Do you know everything? Do you know anyone who knows everything? Is it possible for you to know everything? (Theoretically, maybe, but empirically over ten thousand years--no) Is it possible for anyone to know everything? (Theoretically, maybe, but empirically over ten thousand years--no) If something exists then nothing cannot be everything. If nobody knows everything then what knows everything?
If there is something (indicating that nothing is not everything) then there must be something which knows everything.
Once you believe that something does exist (and therefore nothing cannot be everything) then everything after that--which religion, which set of rituals, which particular prayers, which actions necessary for appeasement--is just personal preference.
There is a God, he does exist, and it doesn't have to have anything to do with DNA. The simple fact of existence indicates (strongly) God.
I can see that If this were true then, given the demonstrated level of skill for misrepresenting the facts, his next position may be as a PR news release editor for a major presidential campaign.
Because then you could use non-Microsoft products to access your mail. Is that in an RFC as a sign of the end of the world? How is that possibly a Bad Thing?
One could write a shell script to negotiate the HTTP transactions with wget and pipe the resulting pages through a series of filters to strip away the page cruft (ads, navbars, menus, etc.) and the HTML tags and leave only the message text which could be inserted into standard system/var/mail files. After the shell script was sufficiently defined one could use the source code of wget, the source code of HTML libs, the source code of a mail daemon, and a little innovative C glue and write a formal local Windows Live Mail retrieval tool. Once the custom tool achieves any sort of popularity, though, then MS will begin to change the page formats subtly to confound the stripping filters. Then it'll be another radar race.
Why can't they just offer POP service to those who want it?
Changes are ONLY going to take place through efficient lobbying Efficient lobbying does nothing to cut the government off from their supply of money. History has shown that if the citizens rise up and protest then a subcommittee is formed to resolve the differences in opinion. The major talking points of the public protest are identified and the bill is restructured to neatly sidestep those issues. Five years later the same proposal is reintroduced with the modifications necessary to negate the debate points of any public protest.
The only real solution is to quit funding those fools. Try telling your employer you would like to withhold your taxes as a patriotic assertion of citizen's rights.
Re:Disingenious backronym
on
Define - /etc?
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· Score: 1
Keep in mind that pathname.com is only a decade old, and the FHS even newer That is what prompted me to include a direct link to the portion of the FHS where acknowledgements are made. The text in the FHS contains many historical caveats and references to predecessors.
Slashdot Mirror
Proteins are typically characterized through X-ray crystallography. The drawback with X-ray analysis is that the protein must be in a crystallized form--this typically means that millions of occurences of the same protein are crystallized together. The shape that a protein takes such that it can form a crystal may not be the shape that the crystal takes when in the heterogenous solution of a cell. Fesik, at Abbott Laboratories, made ground breaking advances in the realm of solution phase study of the shape of proteins--SAR by NMR analysis. Still concerns remain because the solutions used to lend to NMR analysis are not the same as the heterogenous environment within a cell.
This creates a much larger problem in drug design. The medicinal chemists design molecules to fit active sites of proteins and enzymes but the shape of that active site is only determined from Xray, NMR, or computer generated lowest energy conformations. It is no surprise then that 3/4 of molecules which are advanced to clinical trials fail efficacy studies: in short, they simply do not work. Looking back it's quite logical that they do not work because they were designed to fit a shape that was not a proper representation of the shape which the protein takes within the actual cells, in vivo.
Making note of this was usually received with extreme vitriol by the management.
You're a mentally compromised social reject.
> The cause of my autism is still unknown
You were dropped on your head.
> I find my sexual maturation
Or positive lack thereof since you seem to have an inner need to witness debasement.
> I had parents who cared to correct me
They failed.
> will never fully understand Church teaching on the subject
Which is what? "Do unto others" is somehow, in your mind, exempted in the course of discussion?
> you're just another nutjob whose reasoning boils down to "because I said so"
Maybe you missed my original post in this article. I'm not surprised that a lower class debate reject like you couldn't be bothered to remember where the discourse began.
> Money
Spoiled little rich retard.
> The other part was having parents who were actually FAITHFULL Catholics
Are those the ones you credit with your autism, or the events which caused you to be a self-proclaimed sexual abuser in your childhood?
> Give me evidence
I'm not giving you the sweat off my nutsack, buttercupcake. Give me evidence that God doesn't exist and then you might have a leg to stand on.
> After all, what's more important, voting or money?
Which one was it that contributed to your ability to foist your personal madness on the rest of the world with impossible regularity and without challenge?
> The Universe knows nothing
The universe knows everything
You're baggin' on the homeless guy because you are a pathetic piece of turtle dung.
The same major investors in WiFi companies are the same major investors in Telcos are the same major investors in a majority portion of the stock market.
The only thing which is happening here is the creation of an illusion in order to exploit the American consumer's inability to keep up with the markets as well as the major investors.
In short: We're being milked.
How do you know the difference? The hypothesis is that reaction is an expression of knowing. Prove it wrong.
The universe knows itself--thus the claim over all of history, across all religions, that God is everything.
Keep your crap-hole planet. I have the earth.
Do you know everything?
Do you know anyone who knows everything?
Is it possible for you to know everything? (Theoretically, maybe, but empirically over ten thousand years--no)
Is it possible for anyone to know everything? (Theoretically, maybe, but empirically over ten thousand years--no)
If something exists then nothing cannot be everything.
If nobody knows everything then what knows everything?
If there is something (indicating that nothing is not everything) then there must be something which knows everything.
Once you believe that something does exist (and therefore nothing cannot be everything) then everything after that--which religion, which set of rituals, which particular prayers, which actions necessary for appeasement--is just personal preference.
There is a God, he does exist, and it doesn't have to have anything to do with DNA. The simple fact of existence indicates (strongly) God.
One could write a shell script to negotiate the HTTP transactions with wget and pipe the resulting pages through a series of filters to strip away the page cruft (ads, navbars, menus, etc.) and the HTML tags and leave only the message text which could be inserted into standard system /var/mail files. After the shell script was sufficiently defined one could use the source code of wget, the source code of HTML libs, the source code of a mail daemon, and a little innovative C glue and write a formal local Windows Live Mail retrieval tool. Once the custom tool achieves any sort of popularity, though, then MS will begin to change the page formats subtly to confound the stripping filters. Then it'll be another radar race.
Why can't they just offer POP service to those who want it?
The only real solution is to quit funding those fools. Try telling your employer you would like to withhold your taxes as a patriotic assertion of citizen's rights.