Strangely, I was going to say the same thing with the polarities flipped. There's a lot of extremism out there and a lot of extremists who seem to delight more in their policies being rammed down "the opposition"'s throats rather than convincing them to compromise.
You want a cite? Start with the link you posted! See the part on MONAMINE OXIDASE. YOU read that, didn't you?
Of course, the entire article is ABOUT the role of nicotine in sustaining the behavior of SMOKING. OP is looking for information on nicotine not consumed as part of tobacco consumption.
As for your second link reading the non-paywalled part, it is about nicotine in smokers and a long list of references to other works about nicotine in the context of smoking. In other words, nothing about nicotine not in the context of smoking.
You say it's easy to find, but you failed.
Try this one. They administered nicotine as a freebase to rats. One group got just nicotine and the other got nicotine and MAOI. The second group showed a dramatically increased habituation. Guess which group smokers are in? Now guess which group vapers are in.
So yeah, there is a real question about how addictive nicotine is when divorced from the MAOIs present in cigarette smoke.
It's not actually a bad question. Following your link, they manage to conflate smoking and nicotine consumption in every single paragraph. Cigarette smoke is known to contain MAO inhibitors that potentiate the effects of nicotine, particularly the addictive characteristics.
While I doubt nicotine alone has zero addictive qualities, it almost certainly has a much weaker addictive effect by itself. It's nearly impossible to find any study on harmful effects of "nicotine" that don't turn out to actually mean smoking or occasionally chewing tobacco. So difficult, in fact, that OP's question isn't actually unreasonable at all.
The science is sloppy to say the least and drips of a deep awareness that the funding agencies are deeply interested in the "right" answers to all the questions.
Naturally, the tobacco industry's sponsored "research" is no better and certainly it isn't interested in nicotine ingestion other than by smoking or chewing either.
Your coworker may be habituated, or it's just not "out of his system" yet.
Cigarettes include a MAO inhibitor that potentiates nicotine and maximizes it's addictive qualities. e-juice doesn't have it, so after a while the desire for nicotine becomes much less urgent as well as less frequent.
When first switching, the biggest mistake people make is going too low on the nicotine level. That just perpetuates the problem and makes going back to smoking more likely.
It works best when you go high on the nicotine to start (compensating for no longer having a MAOI potentiating it) , then taper down.
It may also be that work sux and he has found an excuse for a break that the boss accepts.
It seems to me that teens are likely to use nicotine now, just as they have for centuries. It also seems that it's better if they do it by vaping rather than smoking.
Funny thing there. We now know that nicotine is one of the few substances that does any good whatsoever with the negative symptoms of schizophrenia. It is now thought that is an explaination for the fact that the mentally ill are vastly more likely to smoke than other demographics.
Are you SURE they were acting against their own well being by taking the one substance that treated this otherwise untreated cluster of symptoms?
So sure that you are ready to infantalize them by overriding their own judgement with yours?
It is also known to be protective against various cognitive declines and memory problems. Smoking and vaping are probably both useful as stress management tools (the former with a much larger downside than the latter).
Even worse, are you sure it's a good idea to ban a fairly benign means of administration, forcing people to the most harmful known method of administration?
If anything, we should discourage cigarettes and make e-cigs as cheap and easy to acquire as possible.
There's ample reason to ban public cologne and perfume as well, but it hasn't happened. At least the vapers stop emitting the vape when they go inside.
It's been coming to boil for a while, but it's now the new fashionable moral panic in the U.S.
It sounds like your doctor totally missed your diagnosis. Depending on the pain, a doctor might prescribe a moderate dose of opiates for breakthrough pain (especially if the pain is interfering with sleep), but would mostly focus on the exercises, a cane if needed, and NSAIDS.
Let me get this right, you actively WANT a government censor to read your every message and come arrest you if they don't like what they see for any reason?
Sure, but those things don't do the watching. They don't even passively control your use of them. Some uses are against the law, but it is up to law enforcement to detect those uses based on physical effects and prosecute specifically the unlawful uses.
If instead of murder, you chop onions with your knife, there isn't a cop looking in and deciding that's OK. No logic in the knife decides to extend the blade when it sees that you're approaching an onion rather than someone's chest.
Likewise, the camera doesn't forward a copy of your photo to "standards and practices" to see if they need to airbrush a figleaf on it or call the cops.
Most of us around the world somehow manage to use the knife, the camera, and messaging for positive purposes.
But they don't. WhatsApp is end to end encryption. Facebook cannot read your messages, nor would we want them to. Their job, like the fence is to provide a place where people can voluntarily communicate with each other. It doesn't know what is being said and it doesn't make you type anything at all. It neither puts words in your mouth nor takes them out.
This. It seems like any efficient communications system including reliable carrier pigeons would have the same effect. The answer is not shooting the pigeons down.
Medicine is still art as well as science and doctors are far from perfect. But I do know that cops who have never even met your loved one and legislators who show no sign of ever having felt pain worse than a paper cut (neither apparently care if people scream in agony for a week) are not remotely qualified to make the decision.
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Strangely, I was going to say the same thing with the polarities flipped. There's a lot of extremism out there and a lot of extremists who seem to delight more in their policies being rammed down "the opposition"'s throats rather than convincing them to compromise.
You want a cite? Start with the link you posted! See the part on MONAMINE OXIDASE. YOU read that, didn't you?
Of course, the entire article is ABOUT the role of nicotine in sustaining the behavior of SMOKING. OP is looking for information on nicotine not consumed as part of tobacco consumption.
As for your second link reading the non-paywalled part, it is about nicotine in smokers and a long list of references to other works about nicotine in the context of smoking. In other words, nothing about nicotine not in the context of smoking.
You say it's easy to find, but you failed.
Try this one. They administered nicotine as a freebase to rats. One group got just nicotine and the other got nicotine and MAOI. The second group showed a dramatically increased habituation. Guess which group smokers are in? Now guess which group vapers are in.
So yeah, there is a real question about how addictive nicotine is when divorced from the MAOIs present in cigarette smoke.
In Georgia, some care very much. Some "don't notice" if the customer is sneaky, and some just don't give a crap.
I wasn't able to vape for 4 days once and didn't have much of a problem either.
It's not actually a bad question. Following your link, they manage to conflate smoking and nicotine consumption in every single paragraph. Cigarette smoke is known to contain MAO inhibitors that potentiate the effects of nicotine, particularly the addictive characteristics.
While I doubt nicotine alone has zero addictive qualities, it almost certainly has a much weaker addictive effect by itself. It's nearly impossible to find any study on harmful effects of "nicotine" that don't turn out to actually mean smoking or occasionally chewing tobacco. So difficult, in fact, that OP's question isn't actually unreasonable at all.
The science is sloppy to say the least and drips of a deep awareness that the funding agencies are deeply interested in the "right" answers to all the questions.
Naturally, the tobacco industry's sponsored "research" is no better and certainly it isn't interested in nicotine ingestion other than by smoking or chewing either.
Your coworker may be habituated, or it's just not "out of his system" yet.
Cigarettes include a MAO inhibitor that potentiates nicotine and maximizes it's addictive qualities. e-juice doesn't have it, so after a while the desire for nicotine becomes much less urgent as well as less frequent.
When first switching, the biggest mistake people make is going too low on the nicotine level. That just perpetuates the problem and makes going back to smoking more likely.
It works best when you go high on the nicotine to start (compensating for no longer having a MAOI potentiating it) , then taper down.
It may also be that work sux and he has found an excuse for a break that the boss accepts.
It seems to me that teens are likely to use nicotine now, just as they have for centuries. It also seems that it's better if they do it by vaping rather than smoking.
Funny thing there. We now know that nicotine is one of the few substances that does any good whatsoever with the negative symptoms of schizophrenia. It is now thought that is an explaination for the fact that the mentally ill are vastly more likely to smoke than other demographics.
Are you SURE they were acting against their own well being by taking the one substance that treated this otherwise untreated cluster of symptoms?
So sure that you are ready to infantalize them by overriding their own judgement with yours?
It is also known to be protective against various cognitive declines and memory problems. Smoking and vaping are probably both useful as stress management tools (the former with a much larger downside than the latter).
Even worse, are you sure it's a good idea to ban a fairly benign means of administration, forcing people to the most harmful known method of administration?
If anything, we should discourage cigarettes and make e-cigs as cheap and easy to acquire as possible.
Or, more likely, not. Depending on exactly how much the restaurant cared.
Sure, but the chemical and your body don't know that so you can apply the research more generally.
Your vices, on the other hand are God given rights, amireight?
Actually, OSHA does.
Imagine if, e-cigs being unavailable, he was sneaking cigarettes instead.
There's ample reason to ban public cologne and perfume as well, but it hasn't happened. At least the vapers stop emitting the vape when they go inside.
Perhaps it's time to invoke the public interest clause in their corporate charter.
I made a couple attempts to clarify terminology but you were too busy looking for an excuse to make an ass of yourself to notice.
It's been coming to boil for a while, but it's now the new fashionable moral panic in the U.S.
It sounds like your doctor totally missed your diagnosis. Depending on the pain, a doctor might prescribe a moderate dose of opiates for breakthrough pain (especially if the pain is interfering with sleep), but would mostly focus on the exercises, a cane if needed, and NSAIDS.
Why? He's not in office!
Let me get this right, you actively WANT a government censor to read your every message and come arrest you if they don't like what they see for any reason?
Sure, but those things don't do the watching. They don't even passively control your use of them. Some uses are against the law, but it is up to law enforcement to detect those uses based on physical effects and prosecute specifically the unlawful uses.
If instead of murder, you chop onions with your knife, there isn't a cop looking in and deciding that's OK. No logic in the knife decides to extend the blade when it sees that you're approaching an onion rather than someone's chest.
Likewise, the camera doesn't forward a copy of your photo to "standards and practices" to see if they need to airbrush a figleaf on it or call the cops.
Most of us around the world somehow manage to use the knife, the camera, and messaging for positive purposes.
But they don't. WhatsApp is end to end encryption. Facebook cannot read your messages, nor would we want them to. Their job, like the fence is to provide a place where people can voluntarily communicate with each other. It doesn't know what is being said and it doesn't make you type anything at all. It neither puts words in your mouth nor takes them out.
This. It seems like any efficient communications system including reliable carrier pigeons would have the same effect. The answer is not shooting the pigeons down.
Medicine is still art as well as science and doctors are far from perfect. But I do know that cops who have never even met your loved one and legislators who show no sign of ever having felt pain worse than a paper cut (neither apparently care if people scream in agony for a week) are not remotely qualified to make the decision.
That just means it's hard to know if any particular incident is linked to a particular data breech.
"Heavy Duty " != "compute intensive". Say what you mean or don't complain when people disagree.