Yea, I like your thinking. I always say the only meaning of life is to make more like yourself and most people don't get it. Its too simple of an explanation and they'd wanna have some obscure or unattainable meaning to strive for. Most people act on it anyway... without the feeling of fulfillment though.
Nope. Spreading Ideas (ie memes) can be just as much an accomplishment as spreading genes. If the population is big enough it may even be more of an accomplishment. Theres no reason you can't do both though.
Erroneus... there is no such thing as 100% safety. Don't even say it. I am probably on your side in this debate. Anyway, I'm no expert in energy making, but I know not to listen to people who say that. Your 100% safety means that under conditions XYZ nothing bad happened. Theres always condition ZZ.
"This fifinding suggests that even though modern social networks help us to log all the people with whom we meet and interact, they are unable to overcome the biological and physical constraints that limit stable social relations," say Goncalves and co.
They used viruses to add four extra genes in as DNA. This DNA encoded the four proteins they mention. While these genes were already present in the skin cells, they were not active (ie not being used to make Proteins). One way to make the already present versions of the genes active could be adding the right mix of growth factors. Your body really doesnt want this to happen easily though, since it would easily lead to cancer.
Instead of that, they added in new copies of the genes designed so that they will be made into proteins by the skin cells. These proteins then go on to change whats going on in the cell to change it to look and act like a neuron.
Normally the growth factors would cause a signal at the cell surface that eventually changed the amount of various neuronal genes being expressed.They skipped that step here by using viruses to insert extra copies of the neuronal genes into the skin cells. I should note that the neuronal genes are still present in the skin cells but are being suppressed. What this process does is insert extra, non-suppressed copies of those genes.
Nature. 2011 May 26. [Epub ahead of print] Induction of human neuronal cells by defined transcription factors. Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M. Source
1] Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA [2]. Abstract
Somatic cell nuclear transfer, cell fusion, or expression of lineage-specific factors have been shown to induce cell-fate changes in diverse somatic cell types. We recently observed that forced expression of a combination of three transcription factors, Brn2 (also known as Pou3f2), Ascl1 and Myt1l, can efficiently convert mouse fibroblasts into functional induced neuronal (iN) cells. Here we show that the same three factors can generate functional neurons from human pluripotent stem cells as early as 6days after transgene activation. When combined with the basic helix-loop-helix transcription factor NeuroD1, these factors could also convert fetal and postnatal human fibroblasts into iN cells showing typical neuronal morphologies and expressing multiple neuronal markers, even after downregulation of the exogenous transcription factors. Importantly, the vast majority of human iN cells were able to generate action potentials and many matured to receive synaptic contacts when co-cultured with primary mouse cortical neurons. Our data demonstrate that non-neural human somatic cells, as well as pluripotent stem cells, can be converted directly into neurons by lineage-determining transcription factors. These methods may facilitate robust generation of patient-specific human neurons for in vitro disease modelling or future applications in regenerative medicine.
To be fair, Womprat didn't say ionizing radiation though. Microwaves are at energy levels to disrupt hydrogen bonds (obviously, thats why your food gets cooked), which could disrupt DNA helices, or the hydration shells of proteins or signaling molecules, maybe even mess with ion channels (push out some Mg2+ in the case of NMDA channels). So now we gotta calculate how much radiation penetrates different tissues and where that energy goes. Its probably mostly spinning solvent H2O around harmlessly, but we don't really know. I personally doubt its a big deal, but really we don't know... or at least I'm not familiar with the literature. As far as I can tell, if someone shouts in the next room ERK gets phosphorylated though. At least in vitro.
I should also note that as I've grown up all the girls I know have one by one started to make these loud clonking noises as they walk around. Also, if you happen to be at hospital at the right time of year you can witness whole packs of these clonk walkers traveling the campus together as they interview for medical school.
So are the shoes a gender thing or sex thing? I've never been outside of US and Europe so just wondering... I think yahoo answers, my usual source of info, has a selection bias.
I follow and agree with you (actually 100%), but still... what makes you think those principles you have aren't determined by your own self interest? Like do you actually live consistently by them? I'm thinking about Kholbergs moral hierarchy here.
Slashdot Mirror
What the hell? Now even the people submitting articles aren't reading them. Or even the entire title. Here is the full title:
'Anonymous' cyberattack arrests made in Spain
Accused not involved in April PlayStation Network intrusion
Theres always a next generation of people who think itll be profitable that you can sell access to.
So are you in favor of this happening or not?
Yea, I like your thinking. I always say the only meaning of life is to make more like yourself and most people don't get it. Its too simple of an explanation and they'd wanna have some obscure or unattainable meaning to strive for. Most people act on it anyway... without the feeling of fulfillment though.
Nope. Spreading Ideas (ie memes) can be just as much an accomplishment as spreading genes. If the population is big enough it may even be more of an accomplishment. Theres no reason you can't do both though.
Erroneus... there is no such thing as 100% safety. Don't even say it. I am probably on your side in this debate. Anyway, I'm no expert in energy making, but I know not to listen to people who say that. Your 100% safety means that under conditions XYZ nothing bad happened. Theres always condition ZZ.
"This fifinding suggests that even though modern social networks help us to log all the people with whom we meet and interact, they are unable to overcome the biological and physical constraints that limit stable social relations," say Goncalves and co.
A, C, B?
They used viruses to add four extra genes in as DNA. This DNA encoded the four proteins they mention. While these genes were already present in the skin cells, they were not active (ie not being used to make Proteins). One way to make the already present versions of the genes active could be adding the right mix of growth factors. Your body really doesnt want this to happen easily though, since it would easily lead to cancer.
Instead of that, they added in new copies of the genes designed so that they will be made into proteins by the skin cells. These proteins then go on to change whats going on in the cell to change it to look and act like a neuron.
Normally the growth factors would cause a signal at the cell surface that eventually changed the amount of various neuronal genes being expressed.They skipped that step here by using viruses to insert extra copies of the neuronal genes into the skin cells. I should note that the neuronal genes are still present in the skin cells but are being suppressed. What this process does is insert extra, non-suppressed copies of those genes.
Nature. 2011 May 26. [Epub ahead of print]
Induction of human neuronal cells by defined transcription factors.
Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M.
Source
1] Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA [2].
Abstract
Somatic cell nuclear transfer, cell fusion, or expression of lineage-specific factors have been shown to induce cell-fate changes in diverse somatic cell types. We recently observed that forced expression of a combination of three transcription factors, Brn2 (also known as Pou3f2), Ascl1 and Myt1l, can efficiently convert mouse fibroblasts into functional induced neuronal (iN) cells. Here we show that the same three factors can generate functional neurons from human pluripotent stem cells as early as 6days after transgene activation. When combined with the basic helix-loop-helix transcription factor NeuroD1, these factors could also convert fetal and postnatal human fibroblasts into iN cells showing typical neuronal morphologies and expressing multiple neuronal markers, even after downregulation of the exogenous transcription factors. Importantly, the vast majority of human iN cells were able to generate action potentials and many matured to receive synaptic contacts when co-cultured with primary mouse cortical neurons. Our data demonstrate that non-neural human somatic cells, as well as pluripotent stem cells, can be converted directly into neurons by lineage-determining transcription factors. These methods may facilitate robust generation of patient-specific human neurons for in vitro disease modelling or future applications in regenerative medicine.
http://www.ncbi.nlm.nih.gov/pubmed/21617644
sorry for all the sentences ending in "oh"
To be fair, Womprat didn't say ionizing radiation though. Microwaves are at energy levels to disrupt hydrogen bonds (obviously, thats why your food gets cooked), which could disrupt DNA helices, or the hydration shells of proteins or signaling molecules, maybe even mess with ion channels (push out some Mg2+ in the case of NMDA channels). So now we gotta calculate how much radiation penetrates different tissues and where that energy goes. Its probably mostly spinning solvent H2O around harmlessly, but we don't really know. I personally doubt its a big deal, but really we don't know... or at least I'm not familiar with the literature. As far as I can tell, if someone shouts in the next room ERK gets phosphorylated though. At least in vitro.
I should also note that as I've grown up all the girls I know have one by one started to make these loud clonking noises as they walk around. Also, if you happen to be at hospital at the right time of year you can witness whole packs of these clonk walkers traveling the campus together as they interview for medical school.
So are the shoes a gender thing or sex thing? I've never been outside of US and Europe so just wondering... I think yahoo answers, my usual source of info, has a selection bias.
http://answers.yahoo.com/question/index?qid=20070407112648AAB9WHV
Haha, there's a wargames gap
I follow and agree with you (actually 100%), but still... what makes you think those principles you have aren't determined by your own self interest? Like do you actually live consistently by them? I'm thinking about Kholbergs moral hierarchy here.
The USSR landed on venus and found plastic. It turned out to be the lenscap from the probe's camera. At least that was the official story.
so you're saying they happened to be listening in on all those people randomly?
But if theres enough of them its bound to happen once in awhile. If only there was a way to calculate how often...
nah look up two photon microscopy, or just:
http://en.wikipedia.org/wiki/Two-photon_absorption
Who uses books and pencils anymore?
If God's already done what hes going to do and not intervening in anything then who cares if he exists or not?
I'm pretty sure physicists see that as a problem...
A cell being created in a lab wouldnt prove anything about the origins of the universe to me.