Considering that the WebOS team at HP is facing almost certain doom, I think it's more likely a disgruntled (or altruistic) engineer somewhere inside decide to slip a few units out the door. If nothing else, to make sure their work didn't go completely to waste.
Is it because since the patterns NEVER repeat so it is impossible (or extremely unlikely) for two surfaces to "lock" together?
I was thinking the same thing. If lack of periodicity is a key, would a metallic glass have the same non-stick properties as a quasi-crystal metal? Well, did some Googling and found this: Lunac 1 Metallic Glass coating.
Dunno if it applies to mobiles w/ GPS's, but I have heard that handheld GPS's are disabled (if legal at all) when in China...
Due to a combination of paranoia and market-protectionism, uncensored maps are considered some sort of state secret and not allowed to be exported. Instead, if you buy any GPS sold outside the PRC with maps of that country, you're stuck with censored maps that have offsets and distortions introduced -- so while your unit might give you the right coordinates, you'll be looking at the wrong spot on the map.
Supposedly there are "fixed" maps floating around for some GPS brands, but they're probably quite illegal to bring into China.
How could a phase 1 trial (http://en.wikipedia.org/wiki/Clinical_trial#Phase_I) show 90% effectiveness? Phase 1 trials are about the safety of the drug, not its effectiveness.
They mean 90% vs. a "biomarker" -- a measurable physical change used as a benchmark. In this case, production of anti-HIV antibodies.
I am not expecting anything impressive from actual in-vivo protection; your typical humoral immune response to HIV (like the kind achieved by this vaccine) is not protective. This is an example of an over-hyped press release.
However generating a long lasting response against future attacks truly renders the vaccine effective.
A longer-lasting non-protective response is still non-protective. As someone who has previously participated in HIV vaccine research, I still see nothing in this vaccine to suggest it will overcome the very large obstacles that have caused so many previous ones to fail.
HIV vaccine in which 90% of volunteers developed an immunological response against the virus.
This is an absolutely meaningless measure; seroconversion against HIV is easy to achieve, and typically worthless. The elicited antibodies end up being targeted to highly variable regions, and have little long-term neutralizing power.
Although a handful of unusual broadly neutralizing antibodies have been found among "elite controllers", it is extremely rare for typical individuals to generate them. There's been some speculation it might be possible to create an effective vaccine by directing the response away from decoy regions, and towards the handful of areas targeted by such elite antibodies. Thus far, nobody has managed such a feat, unfortunately.
I have also lived in both countries and can attest that Brasil has a much higher concentration of hot women than the USA does - speaking in general
I have no problem believing this, the difference between our populations is obvious (2010 Int. Obesity Taskforce). Note that the rates aren't directly comparable, as Brasil also has a more youthful population distribution which skews obesity numbers -- but I suppose that plays into the "hotness" distribution too: Obesity Rates: Brazil: M 8.9% | F 13.1% USA: M 32.3% | F 35.5%
"Nations have passed away and left no trace, and history gives the naked cause of it-- one single, simple reason in all cases; they fell because their people were not fit."
-- Rudyard Kipling
* The DEA wants reformulated Primatene to include additional ingredients that (supposedly) won't affect asthmatic users, but will taint the ephedrine so it can't be used for meth production.
Primatene Mist contains Epinephrine, not Ephedrine (Primatene tablets contain Ephedrine).
Well, I'll take a shot at it. Please excuse me if I miss a decimal point somewhere, corrections are welcome.
About 14g of material in a Primatene Mist Inhaler. Non-propellant mass is ascorbic acid, dehydrated alcohol (34%), hydrochloric acid, nitric acid, purified water (actual mass of drug is negligible). Don't know the breakdown, but guesstimating about 4g of CFC-12 and CFC-114 propellant per inhaler, since alcohol is ~1/3 mass, and ascorbic acid is listed before the alcohol (ingredients should be listed in order of descending weight, so at least 1/3 ascorbic acid).
In one of the recent news interviews about this, FDA spokesman estimated 1-2 million Primatene Mist users out there. Let's say 12 vials per year * 2mil users (I don't really know how many vials an asthmatic goes through), and call it 20 million vials. That would be 24,000kg of CFCs per year, or 24 metric tons.
For reference, reported peak production of CFC-12 was reached in 1988, at 421,002 metric tons (1000kg in a metric ton), and 8,938 metric tons in 2004 (last reported year). So total usage is not tiny, but still a small fraction of the overall CFC usage.
Anyone that has asthma will tell you that things dramatically changed for them in 2010 when their old albuterol (fast-acting, for emergencies) inhalers were reformulated to not include CFCs (dubbed HFA, aka Hydrofluoroalkane) . Most HFA-using patients state that they cannot "feel" the aerosol or that it doesn't work nearly as well as the CFC-based ones.*
There are a number of significant differences between CFC and HFC inhalers. One is that most drugs are less soluble in HFCs than CFCs; newer HFCs inhalers are generally formulated using a suspension of solid particles in propellant (this may have something to do with the clogging & self-depletion problems reported with HFC inhalers). There might also be issues given the density differences between CFCs and HFCs -- I would expect the heavier gas would do a better job carrying the medication deeper down into the lungs.
I'm going to have a hard time believing this, until we get a couple more labs to replicate the findings.
Just about every animal on earth, including us, produces copious amounts of RNAse, an enzyme that shreds RNA molecules. And while most enzymes are rather fragile, RNAse is unusally robust -- you can boil some RNAses for hours, and they will retain their activity. They're everywhere, on your skin, in your body -- and it's a pain in the butt when you're working with RNA (you put RNAse inhibitors in everything to keep them from chewing up your material).
It's almost as if it were being produced as some kind of defense mechanism against... hmm....
I agree. However I remember that Apple also patented the discussed DC jack, and doesn't probably want to license it for less than 100% of your laptop's price.
Yup. There was a company that tried to make some external add-on battery for Macbooks, and they had to resort to buying Apple adapters and chopping off the connector to use on their product, because Apple would not license at any price (or the per-unit price was more than a new power adapter).
One of these researchers said it was hard to find the psyochopaths. Oh really? I can pick them out almost instantly.
I can believe that.
Resesarchers and Psychologists? It's important for a psychopath to fool them, whether to pass through a screening, or for the sheer "I'm smarter than you" game. If you can pick them out easily, you clearly must be of no use to them.
Perhaps the population could be coaxed into premature senesence (sp? I am tired...) by carefully regulated injections of refined trigger protein? The idea is to get the memory population to spike and exhaust the longevity of the population.
Well, nobody knows yet if the leukemia has been permanently eliminated, or is instead being continually suppressed by the constant T-cell response.
However, I believe the researchers involved have stated they would like to include a kill-switch (as a long-term goal), both to be able to turn off the attack when therapy is concluded (assuming it can ever be concluded). and as a safeguard against T-cell leukemia that might possibly be induced by the therapy.
I did not know T cells underwent mitosis. I thought they were produced as needed by their progenitor cells in the bone marrow, similarly to red cells.
Yes, that's correct, there are T-cell progenitors in the bone marrow that generate new T-cells. However, experienced T-cells are maintained in a population of circulating "memory" cells that persist long-term, and undergo rapid expansion upon encountering their triggering antigen.
Indescriminate destruction of B cells is a very bad thing and would make the patient extremely immune suppressed following the initial "thermonuclear" immune response, as the patient's immune system would effectively be given a lobotomy and would forget every pathogen it had encountered, and would remain that way until new B cells are produced.
Yes, these patients are currently on IVIG (Intravenous Immunoglobulin - antibodies collected and pooled from donors), and will be for a long time, possibly for the rest of their lives. Very expensive.
This treatment could be adapted for other types of cancer besides this flavor of leukemia, just as long as there is a reasonably reliable target for the t cells to go after.
Yes, I believe one of the next targets they are going after with this technique will be mesothelin-expressing tumors (found in certain ovarian/mesothelioma/pancreatic tumors). Will probably be messy, as it is expressed in certain populations of normal mesothelial cells.
I am currently a candidate for an experimental treatment that does just that - plasma collection at start, then they convince the white blood cells to reproduce like mad, then put them back into me at weekly intervals.
I've heard of some trials of autologous immune therapies that were going on -- Dendreon (Prostate), Genesis/Lonza (Melanoma), and Sloan-Kettering Memorial (Ovarian & Leukemia) were supposedly doing some. Any chance you're in one of these?
A killer T cell is an end product cell type. It does not divide.
T-cells are differentiated cells, but they most certainly do undergo clonal expansion.
(T cells destroy pathogens, but they also pass antigen information on to B cells, which "remember" previous infectious agents, and mass replicate antibodies in the hystamine cycle. This mechanism is how vaccination works.
Huh? "Histamine Cycle"?
Deactivated virus is introduced, white cells engage, destroy, and then present the debris to B cells, which produce antibodies. When the real virus comes along, the immine system reacts with a flood of antibody production, which greatly inhibits proliferation of the pathogen
This description relates to the humoral branch of the adaptive immune system, but is irrelevant here. The treatment in question primarily operates via a cell-mediated mechanism.
In this case, researchers would have to be VERY careful what cellular membrane cues they program their new mutant superhero T cells to go after, or else the body may become sensitized against its own cellular membranes, resulting in runaway autoimmune reactions.)
Target cue was CD19, a B-cell specific receptor (but not cancer-specific receptor). Hence the patient's ensuing state of hypo-gammaglobulinemia, due to indiscriminant destruction of antibody-producing cells.
Moderators, please refrain from moderation when not sufficiently versed in a field to accurately gauge the value of a post.
"Japan is not just the #1 exporter of nuclear reactors, they are the ONLY exporter"
I think Idou's referring to Japan being the only manufacturer of single-piece reactor containtment vessels (used in all modern designs) -- other non-Japanese companies purchase them from Japan Steel Works. Just do a Google for something like "Japan containment vessel monopoly".
For those who didn't read the link, the problem is, "How do you glue the ends of a tiny blood vessel together without gluing the lumen of the vessel shut?" Answer is that you need a temporary plug that sits inside and joins the two ends together, while propping it open until the glue sets.
The clever part was finding a material (the polaxamer) that is solid enough to do the job, but melts away at the right speed afterwards, without toxicity.
Smoke from any burning organic matter is a carcinogen.
This may be true, but unburnt tobacco is carcinogenic to begin with (hence the high rate of oralpharyngeal cancers in chewing tobacco users).
Interestingly, much of the carcinogen load is generated during the curing process -- steam-cured tobaccos apparently are much safer, but tobacco companies are prohibited from advertising this.
Already out this morning at all the local stores (Walmart, Staples, Best Buy, etc...), well before noon. Suppose we might start seeing these things on Ebay soon, being flipped for a quick profit.
Anyway, wondering if we'll see an Android ROM for it anytime soon. I've heard WebOS is great, but developers are going to be leaving in droves.
Slashdot Mirror
Considering that the WebOS team at HP is facing almost certain doom, I think it's more likely a disgruntled (or altruistic) engineer somewhere inside decide to slip a few units out the door. If nothing else, to make sure their work didn't go completely to waste.
Is it because since the patterns NEVER repeat so it is impossible (or extremely unlikely) for two surfaces to "lock" together?
I was thinking the same thing. If lack of periodicity is a key, would a metallic glass have the same non-stick properties as a quasi-crystal metal? Well, did some Googling and found this: Lunac 1 Metallic Glass coating.
So, I think there's a connection.
Dunno if it applies to mobiles w/ GPS's, but I have heard that handheld GPS's are disabled (if legal at all) when in China...
Due to a combination of paranoia and market-protectionism, uncensored maps are considered some sort of state secret and not allowed to be exported. Instead, if you buy any GPS sold outside the PRC with maps of that country, you're stuck with censored maps that have offsets and distortions introduced -- so while your unit might give you the right coordinates, you'll be looking at the wrong spot on the map.
Supposedly there are "fixed" maps floating around for some GPS brands, but they're probably quite illegal to bring into China.
always made me think people have a few taste buds in their anus.
Funny, but the GI tract actually does have taste receptors, at least for sweet, bitter, and possibly umami.
How could a phase 1 trial (http://en.wikipedia.org/wiki/Clinical_trial#Phase_I) show 90% effectiveness? Phase 1 trials are about the safety of the drug, not its effectiveness.
They mean 90% vs. a "biomarker" -- a measurable physical change used as a benchmark. In this case, production of anti-HIV antibodies.
I am not expecting anything impressive from actual in-vivo protection; your typical humoral immune response to HIV (like the kind achieved by this vaccine) is not protective. This is an example of an over-hyped press release.
However generating a long lasting response against future attacks truly renders the vaccine effective.
A longer-lasting non-protective response is still non-protective. As someone who has previously participated in HIV vaccine research, I still see nothing in this vaccine to suggest it will overcome the very large obstacles that have caused so many previous ones to fail.
HIV vaccine in which 90% of volunteers developed an immunological response against the virus.
This is an absolutely meaningless measure; seroconversion against HIV is easy to achieve, and typically worthless. The elicited antibodies end up being targeted to highly variable regions, and have little long-term neutralizing power.
Although a handful of unusual broadly neutralizing antibodies have been found among "elite controllers", it is extremely rare for typical individuals to generate them. There's been some speculation it might be possible to create an effective vaccine by directing the response away from decoy regions, and towards the handful of areas targeted by such elite antibodies. Thus far, nobody has managed such a feat, unfortunately.
I have also lived in both countries and can attest that Brasil has a much higher concentration of hot women than the USA does - speaking in general
I have no problem believing this, the difference between our populations is obvious (2010 Int. Obesity Taskforce). Note that the rates aren't directly comparable, as Brasil also has a more youthful population distribution which skews obesity numbers -- but I suppose that plays into the "hotness" distribution too:
Obesity Rates:
Brazil: M 8.9% | F 13.1%
USA: M 32.3% | F 35.5%
"Nations have passed away and left no trace,
and history gives the naked cause of it--
one single, simple reason in all cases;
they fell because their people were not fit."
-- Rudyard Kipling
* The DEA wants reformulated Primatene to include additional ingredients that (supposedly) won't affect asthmatic users, but will taint the ephedrine so it can't be used for meth production.
Primatene Mist contains Epinephrine, not Ephedrine (Primatene tablets contain Ephedrine).
Quantitative proof or GTFO.
Well, I'll take a shot at it. Please excuse me if I miss a decimal point somewhere, corrections are welcome.
About 14g of material in a Primatene Mist Inhaler. Non-propellant mass is ascorbic acid, dehydrated alcohol (34%), hydrochloric acid, nitric acid, purified water (actual mass of drug is negligible). Don't know the breakdown, but guesstimating about 4g of CFC-12 and CFC-114 propellant per inhaler, since alcohol is ~1/3 mass, and ascorbic acid is listed before the alcohol (ingredients should be listed in order of descending weight, so at least 1/3 ascorbic acid).
In one of the recent news interviews about this, FDA spokesman estimated 1-2 million Primatene Mist users out there. Let's say 12 vials per year * 2mil users (I don't really know how many vials an asthmatic goes through), and call it 20 million vials. That would be 24,000kg of CFCs per year, or 24 metric tons.
For reference, reported peak production of CFC-12 was reached in 1988, at 421,002 metric tons (1000kg in a metric ton), and 8,938 metric tons in 2004 (last reported year). So total usage is not tiny, but still a small fraction of the overall CFC usage.
Anyone that has asthma will tell you that things dramatically changed for them in 2010 when their old albuterol (fast-acting, for emergencies) inhalers were reformulated to not include CFCs (dubbed HFA, aka Hydrofluoroalkane) . Most HFA-using patients state that they cannot "feel" the aerosol or that it doesn't work nearly as well as the CFC-based ones.*
There are a number of significant differences between CFC and HFC inhalers. One is that most drugs are less soluble in HFCs than CFCs; newer HFCs inhalers are generally formulated using a suspension of solid particles in propellant (this may have something to do with the clogging & self-depletion problems reported with HFC inhalers). There might also be issues given the density differences between CFCs and HFCs -- I would expect the heavier gas would do a better job carrying the medication deeper down into the lungs.
I'm going to have a hard time believing this, until we get a couple more labs to replicate the findings.
Just about every animal on earth, including us, produces copious amounts of RNAse, an enzyme that shreds RNA molecules. And while most enzymes are rather fragile, RNAse is unusally robust -- you can boil some RNAses for hours, and they will retain their activity. They're everywhere, on your skin, in your body -- and it's a pain in the butt when you're working with RNA (you put RNAse inhibitors in everything to keep them from chewing up your material).
It's almost as if it were being produced as some kind of defense mechanism against... hmm....
I agree. However I remember that Apple also patented the discussed DC jack, and doesn't probably want to license it for less than 100% of your laptop's price.
Yup. There was a company that tried to make some external add-on battery for Macbooks, and they had to resort to buying Apple adapters and chopping off the connector to use on their product, because Apple would not license at any price (or the per-unit price was more than a new power adapter).
One of these researchers said it was hard to find the psyochopaths. Oh really? I can pick them out almost instantly.
I can believe that.
Resesarchers and Psychologists? It's important for a psychopath to fool them, whether to pass through a screening, or for the sheer "I'm smarter than you" game. If you can pick them out easily, you clearly must be of no use to them.
Perhaps the population could be coaxed into premature senesence (sp? I am tired...) by carefully regulated injections of refined trigger protein? The idea is to get the memory population to spike and exhaust the longevity of the population.
Well, nobody knows yet if the leukemia has been permanently eliminated, or is instead being continually suppressed by the constant T-cell response.
However, I believe the researchers involved have stated they would like to include a kill-switch (as a long-term goal), both to be able to turn off the attack when therapy is concluded (assuming it can ever be concluded). and as a safeguard against T-cell leukemia that might possibly be induced by the therapy.
I did not know T cells underwent mitosis. I thought they were produced as needed by their progenitor cells in the bone marrow, similarly to red cells.
Yes, that's correct, there are T-cell progenitors in the bone marrow that generate new T-cells. However, experienced T-cells are maintained in a population of circulating "memory" cells that persist long-term, and undergo rapid expansion upon encountering their triggering antigen.
Indescriminate destruction of B cells is a very bad thing and would make the patient extremely immune suppressed following the initial "thermonuclear" immune response, as the patient's immune system would effectively be given a lobotomy and would forget every pathogen it had encountered, and would remain that way until new B cells are produced.
Yes, these patients are currently on IVIG (Intravenous Immunoglobulin - antibodies collected and pooled from donors), and will be for a long time, possibly for the rest of their lives. Very expensive.
This treatment could be adapted for other types of cancer besides this flavor of leukemia, just as long as there is a reasonably reliable target for the t cells to go after.
Yes, I believe one of the next targets they are going after with this technique will be mesothelin-expressing tumors (found in certain ovarian/mesothelioma/pancreatic tumors). Will probably be messy, as it is expressed in certain populations of normal mesothelial cells.
I am currently a candidate for an experimental treatment that does just that - plasma collection at start, then they convince the white blood cells to reproduce like mad, then put them back into me at weekly intervals.
I've heard of some trials of autologous immune therapies that were going on -- Dendreon (Prostate), Genesis/Lonza (Melanoma), and Sloan-Kettering Memorial (Ovarian & Leukemia) were supposedly doing some. Any chance you're in one of these?
A killer T cell is an end product cell type. It does not divide.
T-cells are differentiated cells, but they most certainly do undergo clonal expansion.
(T cells destroy pathogens, but they also pass antigen information on to B cells, which "remember" previous infectious agents, and mass replicate antibodies in the hystamine cycle. This mechanism is how vaccination works.
Huh? "Histamine Cycle"?
Deactivated virus is introduced, white cells engage, destroy, and then present the debris to B cells, which produce antibodies. When the real virus comes along, the immine system reacts with a flood of antibody production, which greatly inhibits proliferation of the pathogen
This description relates to the humoral branch of the adaptive immune system, but is irrelevant here. The treatment in question primarily operates via a cell-mediated mechanism.
In this case, researchers would have to be VERY careful what cellular membrane cues they program their new mutant superhero T cells to go after, or else the body may become sensitized against its own cellular membranes, resulting in runaway autoimmune reactions.)
Target cue was CD19, a B-cell specific receptor (but not cancer-specific receptor). Hence the patient's ensuing state of hypo-gammaglobulinemia, due to indiscriminant destruction of antibody-producing cells.
Moderators, please refrain from moderation when not sufficiently versed in a field to accurately gauge the value of a post.
It will be a Religious War, a sort of Christian Jihad
I could not help but notice there already is a term for that -- Crusade.
"Japan is not just the #1 exporter of nuclear reactors, they are the ONLY exporter"
I think Idou's referring to Japan being the only manufacturer of single-piece reactor containtment vessels (used in all modern designs) -- other non-Japanese companies purchase them from Japan Steel Works. Just do a Google for something like "Japan containment vessel monopoly".
For those who didn't read the link, the problem is, "How do you glue the ends of a tiny blood vessel together without gluing the lumen of the vessel shut?" Answer is that you need a temporary plug that sits inside and joins the two ends together, while propping it open until the glue sets.
The clever part was finding a material (the polaxamer) that is solid enough to do the job, but melts away at the right speed afterwards, without toxicity.
You seriously want the government to be your ISP?
Hell yes. Unlike our local Comcast and AT&T monopolies, our local officials actually have to answer to the electorate.
Smoke from any burning organic matter is a carcinogen.
This may be true, but unburnt tobacco is carcinogenic to begin with (hence the high rate of oralpharyngeal cancers in chewing tobacco users).
Interestingly, much of the carcinogen load is generated during the curing process -- steam-cured tobaccos apparently are much safer, but tobacco companies are prohibited from advertising this.
As I said earlier, contact me about your stocks of the TX series. Forget TouchPad, Android and iOS. the TX series was THE tablet.
What's your opinion of the newer TM2 series? Same form-factor, but a lot of little changes to the hardware.
Already out this morning at all the local stores (Walmart, Staples, Best Buy, etc...), well before noon. Suppose we might start seeing these things on Ebay soon, being flipped for a quick profit.
Anyway, wondering if we'll see an Android ROM for it anytime soon. I've heard WebOS is great, but developers are going to be leaving in droves.