It is far more complex than that. There is a lot of doubt about the research but making stem cells is a process that is VERY hard to do even with protocols that we have fully diagnosed. With other techniques for induced pluripotent stem cells the results are usually 1% or less of the cells make the changes you want. Even if the paper had written down EVERYTHING that was done for the STAP cells there is no guarantee that it would work effectively for someone else until the protocol is nailed down better.
It does seem unlikely that the STAP research is correct but it is too soon to say that for sure and there is no way we can walk away from this kind of advance if it is at all possible.
The worst outcome would be if the STAP cells really do exist but was the result of sloppy technique and sloppy experimental documentation while having the paper also involve fraud. Under those conditions nobody else would be able to reproduce it since they would not make the same mistakes and the fraud involved would mean that it would be very hard for others to try similar experiments to figure out what really happened. If all we had was a shoddy experiment that happened to work but not fraud involved then there would be a LOT of work to figure out what really happened. This is why I hate all the cheating in scientific papers, not only does it damage that paper it also damages that entire line of inquiry.
So it has been gone for 13 years. Did you really expect the antivac groups to understand that already? At the rate they process change it will need to be gone for at least a hundred years before they are willing to accept that it is not in the vaccines anymore.
Trust me. No articles are very correct it is just that you are not an expert in the other fields that other articles discuss. Yes this article is wrong but so are the articles on genetic engineering, hard drives, SSD, memory, CPUs, gravity, dark matter and every other subject you could imagine.
Wouldn't one of the limits be on the oscillations allowed? Even when designing process controllers for industry for chemical reactors there are limits like that. There should be no input to these devices you can give which would endanger the patient.
What is already happening is these devices are getting hard coded safety envelopes. You would be able to give them commands within that envelope but that would be it. It is not a problem but the medical device companies though they would have to deal with but they seem to be working on the problem pretty efficiently. So you could tell the heart to speed up a little or slow down a little but there would be hard coded controls so that you could not make it stop, run too fast, run too slow, run for very long at an altered setting etc. Insulin pumps etc are doing the same thing.
This is a problem that is taking care of itself fairly quickly. There will not be many vulnerable devices and those will be replaced fairly quickly.
Simulink is a graphical programming language designed for engineers to use. That is pretty much the only audience of it. However, if your problem is very complex, it still becomes a horrible mess to read very very quickly. In the end visual programming just does not work very well. Especially in engineering since all of our stuff is math equations anyways.
As soon as the differential equations get very complex is becomes massively easier to just write them in code than to use Simulink. I don't think that Simulink is bad in any way just that if you have a complex problem it becomes at least as hard to read as any code is. I have a problem I am working on right now that is about 7 coupled differential equations and probably another 10 regular functions. Doing it in simulink just does not seem like a good idea.
I think we would be better if we could do this at a societal level instead of private companies but the system we have is private companies. Many of these ideas actually take close to 10 years to get to market and the FDA is only a small part of that. These new DNA and protein based medications are HARD to make. I don't think the average person has any clue how hard it is to make. If you had an entire swimming pool filled with your raw materials the amount of drug you can get out of that is about the size of a marble.
Worse just getting it is not enough, you also have to purify it, remove all contaminants etc. 2 years is just not enough time to do that.
There is nothing for them to compete with. These are the first medicines of their type EVER. The problem is that it is so expensive to develop and make these drugs that if the patent only lasted 2 years it would be 8 years before you where even ready to make it that the patent expired and your competitors would be able to work on making it also but at a tiny fraction of the cost.
DNA, protein and nanotech type drugs are so hard to make that from discovery it often takes about 10 years to put them into production. We are at a point right now where we have figured out a way to make something in a lab but not how to make it at an industrial scale. If you lowered patents to 2 years for this stuff you would stop all work on it.
We have also just started using stuff like CRISPR-CAS to do DNA editing on humans. It is likely to take at least 10 years just to get something approved and that does not cover figure out how to actually make it at scale.
I used to think that drugs should have much shorter protections but since actually taking classes in how to make them, how to get them approved etc and how hard they are to make my views have changed. Sure the short molecule drugs that most traditional pharmaceuticals are may be almost trivially easy to make but the newer biotech types ones are HARD. I mean insanely mind mindbogglingly hard. Many of the protein based drugs start with a 10,000L vat and end up at the end with 4 kg of product. Overall to make that 4 kg takes many millions of dollars for each batch and it does not help many people. However if you ever want that technology to improve then the patents on it have to last long enough to justify what it takes to make it.
However if those libraries are already installed on your system it should be fairly easy to update them. For zope 2.x the changes in python product code have been fairly minimal across all versions and the python changes from 1.5 to 2.7 are pretty easy to change also. The only big issue I can see is if the system used zclasses and I thought that could still be installed in a modern zope version, just heavily recommended against. However zclasses are normally fairly easy to rebuild as a pure python product.
I wonder why you can't migrate stuff from Zope 2.5.1 to newer versions? I started with applications from Zope 2.0 and migrated them step by step to 2.1, 2.2, 2.3 etc up through 2.13 and each step was usually a few hours of work or less.
Zope 2.x continues to be updated and maintained. It was zope 3.x which was abandoned. You can go to https://pypi.python.org/pypi/Zope2/2.13.21 and download the latest version of zope. It was even discussed to rename zope 2.x to zope 4.x but that was dropped since they thought it would be even more confusing. Zope 2.x has also run on the python 2.7 for a very long time now and so far I have upgraded apps written in zope 2.0 all the way up through 2.13 over the years with very few problems.
I would like to see full disclosure of ALL ingredients. The full chemical information for every single one. Just saying that something has GMO in it is darn close to worthless. What if you know that some GMO tomato variant is very good for you but some corn variant is bad. If all you have is GMO yes or no that tells you nothing. If I know the food has XXX GMO tomato varient, yyy natural strain corn, zzz GMO variant potato etc then that is useful.
Based on the professional scientists I have worked with they can't do it either. Based on the level of fraud in scientific papers that have been found for new drugs it seems that very very few actually can do it to those thresholds. Sure they can lie at that level but they can't do science at that level.
What is worse is that those clueless people have cratered the market for people that actually know what they are doing. I have had customers try to outsource something, fail but then come back and try to negotiate a price in the ballpark of what they outsourced the project for even though the outsourced project did not work. They try to argue that they at least have a ballpark estimate to work from. Even had one customer turn off the ordering system on their site that tied into the inventory tracking system because the new system was just about to go online... that was about 3 years ago and the new system never did get online at all.
That is a major reason I went back to school to change fields. Well that and how do you get something more exciting than DNA editing to cure diseases?
However works on the galaxy note series of items so long as you are using the spen. However what I have learned is to mostly work on removing hover wherever possible since it is non-obvious to many people. The bootstrap menus do a nice job of making a menu that works without hover and is immediately obvious what it does and how it works.
We don't even know what you see now. We don't know if we see the same colors the same things etc. Remember we are taught that a certain color is red. So long as what you see is consistent we both have the same name for the same color but we don't know if they look the same to both of us. In the end so long as it works that is all that really matters.
Amazon seems to use both. Sometimes it starts with the flash player and sometimes a silverlight player. I have not figured out any pattern to it so I suspect it is some kind of a test. The silverlight player though works MUCH better than the flash player does. This is true for netflix also.
I would say that all the presidents have been getting better at it. I would imagine our next one will be even better at it. A large part of the problem is our 24 hour news cycle. They are always jumping on the next new thing. Nixon had to deal with watergate for a long time. Current presidents only have to give lib service to the issue for about a week at most before the public is on to another issue and they forget the previous one. As a result no momentum is created and maintained to really do anything. It is wrong and it is evil but geeze it is hard as hell to fight.
Just trying to deal with things on a state and city level are hard enough much less dealing with the federal level. I wish things were not this way and that there was a better way to change this but so far I don't have any real ideas to fix it. That doesn't mean I will stop trying but I also have to realize how large the problem is.
You absolutely should try and do something to stop it. My point is that the parent comment had an extremely rosy view of this country and how much it followed the constitution which was NOT true.
Just look at the abuses of J Edgar Hoover with the FBI to see that warrant-less wiretaps did occur and were used to abuse specific people. Sure it was not on the scale we have not but that is a difference in scale not in kind.
One of the biggest problems I see is actually with citzens united ruling. In my state many people worked for a long time to get laws changed regarding campaign finance, state budget etc and with a single ruling the supreme court wiped that out. In the very next election almost all the officials were pro fracking since those companies outspent everyone else by a landside. How do you really get good people in office that do what the voters want when elections are almost purely defined by money and under citizen's united corporations can spend unlimited funds on elections?
My city even voted to start its own renewable power system for a lot of reasons. The local power company is spending more than my city is worth to fight it. They managed to spend enough money to get a new ballot issue put on that would basically stop the process and most people polled that signed that ballot measure thought it was to help the city create its own utility not destroy it. They did not even realize that the current power company was behind it. How do you really fight against corporations on that scale? If you can't fight those corporations how can you get any change in the government?
I try to view the world as it is not as what I want it to be. Only through seeing what is out there and accepting the way the world is can you figure out how to change it. In the 70s the dirty laundry was better kept away from the public but this country still did not follow the constitution and value freedom, it only claimed to.
I am pretty sure our leaders have been ignoring the constitution for over 100 years. Just because you did not notice that it was corrupted and ignored when you came here in the 1970s does not change that.
Warrant-less wiretaps is certainly a very old thing.
I don't think that Obama has been any better or worse than previous presidents at following the constitution.
They will be held accountable to shareholders where they will be given a huge bonus for doing this.:(
As for being accountable to us or to the laws they broke? Not a chance. I give better odds on Santa Claus existing than these guys being actually held accountable to a court.
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It is far more complex than that. There is a lot of doubt about the research but making stem cells is a process that is VERY hard to do even with protocols that we have fully diagnosed. With other techniques for induced pluripotent stem cells the results are usually 1% or less of the cells make the changes you want. Even if the paper had written down EVERYTHING that was done for the STAP cells there is no guarantee that it would work effectively for someone else until the protocol is nailed down better.
It does seem unlikely that the STAP research is correct but it is too soon to say that for sure and there is no way we can walk away from this kind of advance if it is at all possible.
The worst outcome would be if the STAP cells really do exist but was the result of sloppy technique and sloppy experimental documentation while having the paper also involve fraud. Under those conditions nobody else would be able to reproduce it since they would not make the same mistakes and the fraud involved would mean that it would be very hard for others to try similar experiments to figure out what really happened. If all we had was a shoddy experiment that happened to work but not fraud involved then there would be a LOT of work to figure out what really happened. This is why I hate all the cheating in scientific papers, not only does it damage that paper it also damages that entire line of inquiry.
So it has been gone for 13 years. Did you really expect the antivac groups to understand that already? At the rate they process change it will need to be gone for at least a hundred years before they are willing to accept that it is not in the vaccines anymore.
Trust me. No articles are very correct it is just that you are not an expert in the other fields that other articles discuss. Yes this article is wrong but so are the articles on genetic engineering, hard drives, SSD, memory, CPUs, gravity, dark matter and every other subject you could imagine.
Wouldn't one of the limits be on the oscillations allowed? Even when designing process controllers for industry for chemical reactors there are limits like that. There should be no input to these devices you can give which would endanger the patient.
What is already happening is these devices are getting hard coded safety envelopes. You would be able to give them commands within that envelope but that would be it. It is not a problem but the medical device companies though they would have to deal with but they seem to be working on the problem pretty efficiently. So you could tell the heart to speed up a little or slow down a little but there would be hard coded controls so that you could not make it stop, run too fast, run too slow, run for very long at an altered setting etc. Insulin pumps etc are doing the same thing.
This is a problem that is taking care of itself fairly quickly. There will not be many vulnerable devices and those will be replaced fairly quickly.
Simulink is a graphical programming language designed for engineers to use. That is pretty much the only audience of it. However, if your problem is very complex, it still becomes a horrible mess to read very very quickly. In the end visual programming just does not work very well. Especially in engineering since all of our stuff is math equations anyways.
As soon as the differential equations get very complex is becomes massively easier to just write them in code than to use Simulink. I don't think that Simulink is bad in any way just that if you have a complex problem it becomes at least as hard to read as any code is. I have a problem I am working on right now that is about 7 coupled differential equations and probably another 10 regular functions. Doing it in simulink just does not seem like a good idea.
I think we would be better if we could do this at a societal level instead of private companies but the system we have is private companies. Many of these ideas actually take close to 10 years to get to market and the FDA is only a small part of that. These new DNA and protein based medications are HARD to make. I don't think the average person has any clue how hard it is to make. If you had an entire swimming pool filled with your raw materials the amount of drug you can get out of that is about the size of a marble.
Worse just getting it is not enough, you also have to purify it, remove all contaminants etc. 2 years is just not enough time to do that.
There is nothing for them to compete with. These are the first medicines of their type EVER. The problem is that it is so expensive to develop and make these drugs that if the patent only lasted 2 years it would be 8 years before you where even ready to make it that the patent expired and your competitors would be able to work on making it also but at a tiny fraction of the cost.
DNA, protein and nanotech type drugs are so hard to make that from discovery it often takes about 10 years to put them into production. We are at a point right now where we have figured out a way to make something in a lab but not how to make it at an industrial scale. If you lowered patents to 2 years for this stuff you would stop all work on it.
We have also just started using stuff like CRISPR-CAS to do DNA editing on humans. It is likely to take at least 10 years just to get something approved and that does not cover figure out how to actually make it at scale.
I used to think that drugs should have much shorter protections but since actually taking classes in how to make them, how to get them approved etc and how hard they are to make my views have changed. Sure the short molecule drugs that most traditional pharmaceuticals are may be almost trivially easy to make but the newer biotech types ones are HARD. I mean insanely mind mindbogglingly hard. Many of the protein based drugs start with a 10,000L vat and end up at the end with 4 kg of product. Overall to make that 4 kg takes many millions of dollars for each batch and it does not help many people. However if you ever want that technology to improve then the patents on it have to last long enough to justify what it takes to make it.
However if those libraries are already installed on your system it should be fairly easy to update them. For zope 2.x the changes in python product code have been fairly minimal across all versions and the python changes from 1.5 to 2.7 are pretty easy to change also. The only big issue I can see is if the system used zclasses and I thought that could still be installed in a modern zope version, just heavily recommended against. However zclasses are normally fairly easy to rebuild as a pure python product.
I wonder why you can't migrate stuff from Zope 2.5.1 to newer versions? I started with applications from Zope 2.0 and migrated them step by step to 2.1, 2.2, 2.3 etc up through 2.13 and each step was usually a few hours of work or less.
Zope 2.x continues to be updated and maintained. It was zope 3.x which was abandoned. You can go to https://pypi.python.org/pypi/Zope2/2.13.21 and download the latest version of zope. It was even discussed to rename zope 2.x to zope 4.x but that was dropped since they thought it would be even more confusing. Zope 2.x has also run on the python 2.7 for a very long time now and so far I have upgraded apps written in zope 2.0 all the way up through 2.13 over the years with very few problems.
I would like to see full disclosure of ALL ingredients. The full chemical information for every single one. Just saying that something has GMO in it is darn close to worthless. What if you know that some GMO tomato variant is very good for you but some corn variant is bad. If all you have is GMO yes or no that tells you nothing. If I know the food has XXX GMO tomato varient, yyy natural strain corn, zzz GMO variant potato etc then that is useful.
Based on the professional scientists I have worked with they can't do it either. Based on the level of fraud in scientific papers that have been found for new drugs it seems that very very few actually can do it to those thresholds. Sure they can lie at that level but they can't do science at that level.
What is worse is that those clueless people have cratered the market for people that actually know what they are doing. I have had customers try to outsource something, fail but then come back and try to negotiate a price in the ballpark of what they outsourced the project for even though the outsourced project did not work. They try to argue that they at least have a ballpark estimate to work from. Even had one customer turn off the ordering system on their site that tied into the inventory tracking system because the new system was just about to go online ... that was about 3 years ago and the new system never did get online at all.
That is a major reason I went back to school to change fields. Well that and how do you get something more exciting than DNA editing to cure diseases?
However works on the galaxy note series of items so long as you are using the spen. However what I have learned is to mostly work on removing hover wherever possible since it is non-obvious to many people. The bootstrap menus do a nice job of making a menu that works without hover and is immediately obvious what it does and how it works.
We don't even know what you see now. We don't know if we see the same colors the same things etc. Remember we are taught that a certain color is red. So long as what you see is consistent we both have the same name for the same color but we don't know if they look the same to both of us. In the end so long as it works that is all that really matters.
Amazon seems to use both. Sometimes it starts with the flash player and sometimes a silverlight player. I have not figured out any pattern to it so I suspect it is some kind of a test. The silverlight player though works MUCH better than the flash player does. This is true for netflix also.
I would say that all the presidents have been getting better at it. I would imagine our next one will be even better at it. A large part of the problem is our 24 hour news cycle. They are always jumping on the next new thing. Nixon had to deal with watergate for a long time. Current presidents only have to give lib service to the issue for about a week at most before the public is on to another issue and they forget the previous one. As a result no momentum is created and maintained to really do anything. It is wrong and it is evil but geeze it is hard as hell to fight.
Just trying to deal with things on a state and city level are hard enough much less dealing with the federal level. I wish things were not this way and that there was a better way to change this but so far I don't have any real ideas to fix it. That doesn't mean I will stop trying but I also have to realize how large the problem is.
You absolutely should try and do something to stop it. My point is that the parent comment had an extremely rosy view of this country and how much it followed the constitution which was NOT true.
Just look at the abuses of J Edgar Hoover with the FBI to see that warrant-less wiretaps did occur and were used to abuse specific people. Sure it was not on the scale we have not but that is a difference in scale not in kind.
One of the biggest problems I see is actually with citzens united ruling. In my state many people worked for a long time to get laws changed regarding campaign finance, state budget etc and with a single ruling the supreme court wiped that out. In the very next election almost all the officials were pro fracking since those companies outspent everyone else by a landside. How do you really get good people in office that do what the voters want when elections are almost purely defined by money and under citizen's united corporations can spend unlimited funds on elections?
My city even voted to start its own renewable power system for a lot of reasons. The local power company is spending more than my city is worth to fight it. They managed to spend enough money to get a new ballot issue put on that would basically stop the process and most people polled that signed that ballot measure thought it was to help the city create its own utility not destroy it. They did not even realize that the current power company was behind it. How do you really fight against corporations on that scale? If you can't fight those corporations how can you get any change in the government?
I try to view the world as it is not as what I want it to be. Only through seeing what is out there and accepting the way the world is can you figure out how to change it. In the 70s the dirty laundry was better kept away from the public but this country still did not follow the constitution and value freedom, it only claimed to.
I just find it strange that there is anyone (other than those doing the searches) that supports warrant-less searches and secret evidence.
How can you have anything remotely like an honest court if you can't see all the evidence against you and how it was obtained?
Hmm humans with guns vs drones .....
Somehow I don't see the 2nd amendment as being very useful. Sorry but its time has passed. It can't protect you against the government or each other.
I am pretty sure our leaders have been ignoring the constitution for over 100 years. Just because you did not notice that it was corrupted and ignored when you came here in the 1970s does not change that.
Warrant-less wiretaps is certainly a very old thing.
I don't think that Obama has been any better or worse than previous presidents at following the constitution.
They will be held accountable to shareholders where they will be given a huge bonus for doing this. :(
As for being accountable to us or to the laws they broke? Not a chance. I give better odds on Santa Claus existing than these guys being actually held accountable to a court.