There was a story ten or fifteen years ago about a lady who had epileptic seizures when Entertainment Tonight came on. Eventually they pinned the actual trigger on the voice of Mary Hart.
It made perfect sense to me. I'm sure we've all had seizures caused by Entertainment Tonight coming on TV.
Anyway they made hostile jokes about this woman on that show; to her credit Mary Hart wanted to call the woman to apologize.
I'm not sure but I think Piracetam has been asociated with anxiety and irritability, although it's generally considered to have minor side effects.
I took another one of the racetams (Levetiracetam, trade name Keppra) for epileptic seizures. Besides being an anti-epileptic drug, Levetiracetam is considered a nootropic, and I do remember feeling that it made me a little sharper. It's structurally similar to piracetam- it has an extra ethyl group. But I can't imagine anyone wanting to take this stuff to get more intelligence. The psychological side effects are just too nasty.
Not everyone reacts to it the way I did. Some people experience no side effects at all, and really like it. But for me this was an amazing drug. I would take it, note the time, and brace for it. After 20 minutes, thoughts would start to fill my head- first reflective thoughts, then bittersweet thoughts, becoming morose ones, and an hour later it was a full blown depression. It felt like I was being crushed by a little pill, if that makes any sense.
I actually was able to focus well on this drug, but I was really pissed the whole time. I was angry that I had to do whatever I was doing, even if I could do it well. I did more chores and resented every minute of it. At work I would snap at people and have to apologize an hour later. That got old really fast. I gave things to my wife and asked her to hide them from me, because I would get overwhelmed by sudden impulses to smash whatever I was holding against the floor. It changed the importance I attributed to things- so that I would get incredibly annoyed by the stupidest little stuff. If something was even a little annoying without Keppra, it became intolerable under its influence. This is a well-known symptom; it even has a name: "Kepp-rage". I caused a lot of trouble.
After months of this my emotions sort of dulled out and faded away, except for occasional hostile impulses that I was able to recognize as the drug. It was a little helpful with the seizures. But then I went to my next doctor appointment and as soon as he saw me he took me off of it. "I can see you have a flattened affect." No kidding, it was flatter than Kansas.
It's a canned approach that worked for other people, so it is guaranteed to work for you.
You all meet once a day in these meetings that are referred to as "scrums".:P Then, various feature additions, major refactorings etc. are labeled as "stories", and each "story" is further broken up into "tasks" which are also meticulously labeled and tracked. Every piece of code is pounded by unit tests that nobody has any time to write because of the proliferation of stories. There's a lot more BS to be found on the web about it, most of which boils down to a set of formally prescribed methodologies that have a significant overlap with basic common sense but with some omissions and extras.
The best thing Agile has going for it IMHO is that it is not Six Sigma. I worked at a Six Sigma company for over a year and I still couldn't describe it to you. Nobody had the faintest idea what it was.
> "In other words, heredity can flow through a second channel" This is not heredity unless these molecules self-replicate.
The article uses the cytosine methylation as an example all throughout, but it talks about it in this popularized way that doesn't make a lot of sense. Your DNA is full of crap like dormant viruses and transposons and other little vicious stretches of nucleic acid, and if it's left sitting around for the transcription machinery to find, you'll generally end up with undesirable RNA and undesirable proteins.
Methyl groups on cytosine bases will jam all this stuff up, so even if the DNA is somehow hostile, it can still be "commented out" by cytosine methylation. But cytosine methylation doesn't give you/* */ comments for your DNA- it's more like a// comment mechanism in that to comment out a region you can't just stick methyl groups at the ends; you have to carpet the whole stretch of DNA with methyl groups on all the cytosines.
When a cell divides, both strands of its DNA have methylated cytosines in the same regions. After the DNA replicates you have two methylated daughter strands, each coupled with a brand new complimentary strand. This complimentary strand has no methyl groups on it, which is a problem. So a clever enzyme comes along, DNA methyltransferase. It has a regulatory domain and a catalytic domain. The regulatory domain runs across the DNA feeling it for methyl groups. If it finds them on one strand, the catalytic domain deposits methyl groups on nearby cytosines on the other strand. That way, the stretch of DNA can be marked and disabled in a way that is heritable. The cytosine methylation signal is propagating on a separate channel of the DNA than the one that carries the actual DNA base sequence. Both are shaped by natural selection.
I discovered the uselessness of nitrogen triiodide as a high explosive in my home lab.
Other findings:
- It will explode if left underwater, but can be kept for long periods of time under ammonia - It's difficult to get a good report because you can't clump it- the crystals are continuously letting off little explosions as it dries - Clumping kitty litter gets around this nicely - After very long periods of time under ammonia the crystals change color from black to a very bright orange- for reasons that are not clear from the literature - If it gets on you or your clothes you can expect to be snapping and fizzling all day - Try not to make too much
They will NOT ignore the Court at the end of a countdown. They do these things with signing statements, not descending lists of numbers like they might have done before. You can't cite a countdown in a legal brief explaining why you're blowing off a law passed by Congress.
There's this American penchant for trying to fix voting problems with signing statements, starting a few years ago. No president publicly issued signing statements, an idea imported from Lord knows where, until quite early in the 21st century.
I'm taking actin and will soon kick your ass. I will crush you with my contractile system and force feed you ATP with my sliding filaments as I hurl you in toward my M line.
Actually thinking about it a little, the reentry is only going to create electron-poor compounds, just because the Earth has an oxidizing atmosphere and electron-rich compounds are unlikely to form at 100 mph. It's mostly going to turn into mostly just water vapor and copious amounts of nitrogen oxides. And of course there's metal oxides and crap from the fridge itself as it burns up.
But the point about tax policy remains- you can claim your own house if you file maintaining the legal fiction that the refrigerator is going to fly over the official Governor's Residence at some point during the tax year. Then if it flies over, which will satisfy them, then great, otherwise, you file the form to amend the previous year's return. Unless you're really unlucky and this refrigerator skedoodles past never getting closer than a few miles. In that case the standard you have to meet is that you need to be able to see the refrigerator from your house when it flies over.
It will turn into probably a "toxic" mixture of nitrous oxide- a substance that makes one more of a man with its cumulative damage as an inhalant. If you truly love your country you'll be willing to expose yourself to it. Along with other fun combinations of nitrogen and oxygen, plus a little hydrazine (especially if it actually reaches water), when this thing finally lands. If this refrigerator fell on your head you'd be qualified for the presidency, my friends- just like if Vladimir Putin himself were riding it over your Governor's Mansion. Actually you wouldn't actually have to live there if he were to also fly over your other house.
That means for this you can claim your own house on your taxes, hang out there, and wait for the refrigerator to show up.
This is truly a momentous moment in world history. Nobody has ever hurled a f---in REFRIGERATOR for TWO HUNDRED MILES in their inertial frame with their bare hands. It should surely go in the record books- it will take the economies of the other spacefaring nations at least a few more years before their economies collapse to the point where they're hurling refrigerators directly downward as well.
Let's hope they don't beat our distance record- at least we were the FIRST refrigerator hurlers- in fact, yeah, we invented the sport of refrigerator hurling.
I like how she's careful to include that obviously rehearsed "Paris, France" barb. First of all there's still this negative attitude toward France for trying to warn us against a disastrous war. Second there's this implicit mockery of the fact that we're investigating an invasive species from the Mediterranean at a research facility in liberal FRANCE instead of one in the Good Old USA where the flies can escape to infest surrounding areas.
If this trend keeps up, all the liberals will end up in the ghetto, and the conservatives' property values will go up, leaving them in rich neighborhoods. Man won't it be sweet when that happens!?
Slashdot Mirror
There was a story ten or fifteen years ago about a lady who had epileptic seizures when Entertainment Tonight came on. Eventually they pinned the actual trigger on the voice of Mary Hart.
It made perfect sense to me. I'm sure we've all had seizures caused by Entertainment Tonight coming on TV.
Anyway they made hostile jokes about this woman on that show; to her credit Mary Hart wanted to call the woman to apologize.
I keep a gun at work. My manager is aware of the weapon.
Not my manager. Sweetness is hiding in my desk waiting for her big day.
I'm not sure but I think Piracetam has been asociated with anxiety and irritability, although it's generally considered to have minor side effects.
I took another one of the racetams (Levetiracetam, trade name Keppra) for epileptic seizures. Besides being an anti-epileptic drug, Levetiracetam is considered a nootropic, and I do remember feeling that it made me a little sharper. It's structurally similar to piracetam- it has an extra ethyl group. But I can't imagine anyone wanting to take this stuff to get more intelligence. The psychological side effects are just too nasty.
Not everyone reacts to it the way I did. Some people experience no side effects at all, and really like it. But for me this was an amazing drug. I would take it, note the time, and brace for it. After 20 minutes, thoughts would start to fill my head- first reflective thoughts, then bittersweet thoughts, becoming morose ones, and an hour later it was a full blown depression. It felt like I was being crushed by a little pill, if that makes any sense.
I actually was able to focus well on this drug, but I was really pissed the whole time. I was angry that I had to do whatever I was doing, even if I could do it well. I did more chores and resented every minute of it. At work I would snap at people and have to apologize an hour later. That got old really fast. I gave things to my wife and asked her to hide them from me, because I would get overwhelmed by sudden impulses to smash whatever I was holding against the floor. It changed the importance I attributed to things- so that I would get incredibly annoyed by the stupidest little stuff. If something was even a little annoying without Keppra, it became intolerable under its influence. This is a well-known symptom; it even has a name: "Kepp-rage". I caused a lot of trouble.
After months of this my emotions sort of dulled out and faded away, except for occasional hostile impulses that I was able to recognize as the drug. It was a little helpful with the seizures. But then I went to my next doctor appointment and as soon as he saw me he took me off of it. "I can see you have a flattened affect." No kidding, it was flatter than Kansas.
I wonder where all my money went.
It's a canned approach that worked for other people, so it is guaranteed to work for you.
You all meet once a day in these meetings that are referred to as "scrums". :P Then, various feature additions, major refactorings etc. are labeled as "stories", and each "story" is further broken up into "tasks" which are also meticulously labeled and tracked. Every piece of code is pounded by unit tests that nobody has any time to write because of the proliferation of stories. There's a lot more BS to be found on the web about it, most of which boils down to a set of formally prescribed methodologies that have a significant overlap with basic common sense but with some omissions and extras.
The best thing Agile has going for it IMHO is that it is not Six Sigma. I worked at a Six Sigma company for over a year and I still couldn't describe it to you. Nobody had the faintest idea what it was.
The article uses the cytosine methylation as an example all throughout, but it talks about it in this popularized way that doesn't make a lot of sense. Your DNA is full of crap like dormant viruses and transposons and other little vicious stretches of nucleic acid, and if it's left sitting around for the transcription machinery to find, you'll generally end up with undesirable RNA and undesirable proteins.
Methyl groups on cytosine bases will jam all this stuff up, so even if the DNA is somehow hostile, it can still be "commented out" by cytosine methylation. But cytosine methylation doesn't give you /* */ comments for your DNA- it's more like a // comment mechanism in that to comment out a region you can't just stick methyl groups at the ends; you have to carpet the whole stretch of DNA with methyl groups on all the cytosines.
When a cell divides, both strands of its DNA have methylated cytosines in the same regions. After the DNA replicates you have two methylated daughter strands, each coupled with a brand new complimentary strand. This complimentary strand has no methyl groups on it, which is a problem. So a clever enzyme comes along, DNA methyltransferase. It has a regulatory domain and a catalytic domain. The regulatory domain runs across the DNA feeling it for methyl groups. If it finds them on one strand, the catalytic domain deposits methyl groups on nearby cytosines on the other strand. That way, the stretch of DNA can be marked and disabled in a way that is heritable. The cytosine methylation signal is propagating on a separate channel of the DNA than the one that carries the actual DNA base sequence. Both are shaped by natural selection.
I discovered the uselessness of nitrogen triiodide as a high explosive in my home lab.
Other findings:
- It will explode if left underwater, but can be kept for long periods of time under ammonia
- It's difficult to get a good report because you can't clump it- the crystals are continuously letting off little explosions as it dries
- Clumping kitty litter gets around this nicely
- After very long periods of time under ammonia the crystals change color from black to a very bright orange- for reasons that are not clear from the literature
- If it gets on you or your clothes you can expect to be snapping and fizzling all day
- Try not to make too much
It was the Golden Age of Ballooning.
They will NOT ignore the Court at the end of a countdown. They do these things with signing statements, not descending lists of numbers like they might have done before. You can't cite a countdown in a legal brief explaining why you're blowing off a law passed by Congress.
There's this American penchant for trying to fix voting problems with signing statements, starting a few years ago. No president publicly issued signing statements, an idea imported from Lord knows where, until quite early in the 21st century.
I'm taking actin and will soon kick your ass. I will crush you with my contractile system and force feed you ATP with my sliding filaments as I hurl you in toward my M line.
Actually thinking about it a little, the reentry is only going to create electron-poor compounds, just because the Earth has an oxidizing atmosphere and electron-rich compounds are unlikely to form at 100 mph. It's mostly going to turn into mostly just water vapor and copious amounts of nitrogen oxides. And of course there's metal oxides and crap from the fridge itself as it burns up.
But the point about tax policy remains- you can claim your own house if you file maintaining the legal fiction that the refrigerator is going to fly over the official Governor's Residence at some point during the tax year. Then if it flies over, which will satisfy them, then great, otherwise, you file the form to amend the previous year's return. Unless you're really unlucky and this refrigerator skedoodles past never getting closer than a few miles. In that case the standard you have to meet is that you need to be able to see the refrigerator from your house when it flies over.
It will turn into probably a "toxic" mixture of nitrous oxide- a substance that makes one more of a man with its cumulative damage as an inhalant. If you truly love your country you'll be willing to expose yourself to it. Along with other fun combinations of nitrogen and oxygen, plus a little hydrazine (especially if it actually reaches water), when this thing finally lands. If this refrigerator fell on your head you'd be qualified for the presidency, my friends- just like if Vladimir Putin himself were riding it over your Governor's Mansion. Actually you wouldn't actually have to live there if he were to also fly over your other house.
That means for this you can claim your own house on your taxes, hang out there, and wait for the refrigerator to show up.
This is truly a momentous moment in world history. Nobody has ever hurled a f---in REFRIGERATOR for TWO HUNDRED MILES in their inertial frame with their bare hands. It should surely go in the record books- it will take the economies of the other spacefaring nations at least a few more years before their economies collapse to the point where they're hurling refrigerators directly downward as well.
Let's hope they don't beat our distance record- at least we were the FIRST refrigerator hurlers- in fact, yeah, we invented the sport of refrigerator hurling.
I like how she's careful to include that obviously rehearsed "Paris, France" barb. First of all there's still this negative attitude toward France for trying to warn us against a disastrous war. Second there's this implicit mockery of the fact that we're investigating an invasive species from the Mediterranean at a research facility in liberal FRANCE instead of one in the Good Old USA where the flies can escape to infest surrounding areas.
I'm really going to miss this lady.
Great... so the U.S. will soon become another Canada - universal free everything, and good at nothing.
Such as regulating banks?
Yeah the DOJ JavaScript Library continually sends AJAX requests to the FBI and the NSA in the background while your page is open.
I'm going to specifically ask during the interview if I can be put in charge of the "un-witnessed searches".
RNA world hypothesis
People have been trying to recreate life from the conditions on earth for a very long time.
I'd be surprised if anyone ever even considered seriously attempting this.
You can get an electronic fish that turns its head outwards and wiggles on its trophy plaque while singing kitschy cover songs.
If this trend keeps up, all the liberals will end up in the ghetto, and the conservatives' property values will go up, leaving them in rich neighborhoods. Man won't it be sweet when that happens!?
2005 just called... they want you back.
What, you don't play golf?
As opposed to your boy hero who just nationalized the banks.
What does it mean if they're dimly lit and well decorated with drug paraphernalia?
wow, especially being a US citizen this _really_ makes you sound dumb
That's what I was going for... but I couldn't have made it sound really dumb without "Joe the Plumber".
Yeah it does but we did it first.