The crooked, multi-level, high-markup drug industry deserves disruption.
Not just to play Devil's advocate, but they already have disruption, that's why they do what they do. It effectively plays out like this:
A researcher or a few get an idea for a medicine or where to look for a medicine, they get funded from friends and family to the tune of 5-6 figures to fuel their research.
If the research proves successful they start seeking higher levels of investment for animal trials, somewhere from 7-8 figures, this tends to come from VC.
If the animal trials work out they're effectively at a federal roadblock, because the regulations ensure Human trials cost on the high end of 9 figures, sometimes even 10. This means the only option is to aim for a buyout from one of about 70 major pharmaceuticals to have the research completed.
Those ~70 major pharmaceuticals have long since given up their own internal R&D operations because it isn't profitable, because the lifetime of something which actually makes it to becoming a drug goes roughly like:
Drug is created for 9-10 figures in all.
Company has a monopoly on that drug for a bit under 20 years (usually 12-14 because the drug needs to be patented before clinical trials which usually run 6-8 years when they don't get stopped short due to it not working out.
Combine that with the cost of drugs which don't make it to market and you have the actual costs of the R&D effort (which thanks to the thousands of little companies each aiming for 1 specific thing, does reduce the R&D cost to a manageable level, but still not significantly.)
After that monopoly period expires everyone and their brother can take on the minimal manufacturing costs (usually about a fraction of a penny for a month supply of whatever it is for one person) and compete to drive the price down to basically include manufacture and distribution with little to no overhead depending on their business strategy.
This equates to one simple thing: They have at best 12-14 years to make up hundreds of millions of dollars to billions of dollars in R&D costs for every single drug they make. If they don't do that they go out of business and make zero drugs, it's that simple.
If you want to look at the parts of this process where you might actually get the costs down, look at the regulations - that's where most of the money actually goes.
Any advance in tech is from a development in physics or math fundamentally. "Technology" is too vague a term.
I agree with this sentiment. If there's a technology Nobel Prize it will just be Google or Apple or Microsoft or IBM or Samsung for the first few years, then once they see the marketing value they will corrupt it more than it already is (much like the Peace and Economics prizes which were added,) then before long, because there are so many technology companies clamoring for PR, you will end up with every prize going to some stupid Apple patent like "for the geometric construct of a rounded button" because of some long-winded fluff which boils down to "people like round shiny things."
I agree, but I think you might have misread the comment a bit. We need to plan around being able to recover materials after a collapse because even with savings like what SpaceX is aiming for it is going to be very expensive to ship equipment. If the people are lost the equipment should still be usable for the next group to salvage - things like CNCs, foundries, lathes, 3D printers, and ideally even the greenhouses. You don't get that reusability if things are meant to float in the atmosphere and come crashing down, but you do if they're already on the ground, barring events like a direct hit by an asteroid.
There's a sweet spot you have to balance on on Venus - too low and you crash, too high and you burn up. This is due to material constraints - you're pretty much limited to teflon and other plastics as coatings due to the sulfuric acid atmosphere. Metals would corrode. If you go to high the plastics melt (or at least will become soft allowing any stresses in the hull to crack them open. If components of the structure bump into eachother good luck with that because a scratch on the coating will likewise cause corrosion of the inner materials in a matter of days. The plastics themselves will have a lifetime of about 20-30 years at best in those conditions even if nothing goes wrong, so you will have to constant be recoating everything to keep it stable, and as far as I am aware there are no hydrocarbons on venus to make more. All this equates to: if the colony fails for whatever reason there will certainly be political issues lasting upwards of a half-decade preventing another attempt, then you're shit is corroded and destroyed leaving you to start fresh when/if it gets restarted. On Mars it could all go to Hell, politicians could bicker about whether or not to allow it to happen again for another several decades, and if they finally restart it most of the equipment will need at most the dust wiped off and some welding to function again. Every colonization attempt in Human history has had some massive collapse associated with it, it's not a matter of if it happens but when for something as complex as colonizing another planet, therefore that must be built into the plan. Venus is not within our current technological capabilities (Hell, for that matter Mars isn't either given we still crack water for O2 and the plan on Mars is to crack Iron Oxide for O2, but at least that provides building materials as a byproduct and there's a viable pathway to it.) Venus is a much more difficult place than Mars.
The point still stands. On Mars if something goes to utter shit and everyone dies you can at least go back and start with almost the same resources before it failed. On Venus it just sinks to the surface, and the sulfuric acid rain ensures anything that cracks on impact is destroyed.
I think everyone knows by now that ISIS is full of shit.
Most people who follow the situation over time know that ISIS are CIA puppets (they were actually formed when Obama sent McCain over to do an arms deal, which set them up with all their firepower - just after Obama was elected the media spun it for weeks straight as a massive bipartisan act of cooperation.)
Though using the term "puppet" might suggest too much control, if it was ISIS then more like it was a CIA op for a gun grab and pinning it on ISIS doesn't fit the desired narrative, even if they did facilitate it. So you would end up with people investigating claiming it was unrelated and ISIS claiming it was them because they genuinely believe it was, even though they were just unwittingly following the orders of their handlers who found them the best way to get it done.
It would take over 1,000 of these Vegas events EVERY DAY to even approach the threat of repealing high power weaponry.
In the course of Human history the biggest threat to a population has always been its own government, and the first thing they do before a genocide is to revoke weapons in the hands of citizens, this dates back to when weapons were swords through the modern day.
What's worse? 50,000 people slaughtered a day or a new holocaust? Because the numbers for the holocaust alone show that we would have to have 52,812 deaths PER DAY to even match the damage of a disarmed population of our size (and the holocaust was actually one of the milder genocides in Human history, though makes for a good example being both recent and well-known, there are some ongoing ones in the world today but people tend not to pay attention to them so I went the Godwin's law route.)
I have basic cable because it was cheaper (they were the only source of internet for me aside from super slow satellite providers.) The only use of it I make is sometimes logging in to stream something on Fox (though CBS not allowing this for my provider is absurd because CBS is included with the basic package.) I think it's like $70/mo for the internet connection and I probably do another $300/mo on movies, binge watching shows, etc mostly via Amazon. Definitely paying more than a full $175 cable package (for my area) but it's still much higher quality content, I don't need 500 channels I'll never watch and my schedule doesn't allow me to sit down at the same time every week to catch something (regardless of whenever that time might be.)
It's more globalism than anything else - trickle down economics is shit, but it was stable for awhile. The issue is the people doing the trickling realized they could outsource things more cheaply and started lobbying for open borders, free trade, etc to build global corporations which move to wherever the cheapest labor is at a given time. Nations have borders for a reason, it's more than just for defense.
The mix of companies counting and not counting lunch hours plus the labor standards being set at 40 hours a week they increased it to fill out a full 40 hours accounting for the federally-mandated 1-hour lunch break. Meanwhile sticking to that with rush hour as the GP suggested means you get about 2-4 hours of personal time a day if you get ready like mad in the morning and pass out 8 hours prior - just enough time to have dinner and a beer before passing out. Nobody can live like that, hence you end up missing sleep and the author of TFA is a fucking sheltered retard for believing the issue is lacking productivity when people don't get enough sleep - either that or a shill aiming for a slave population which works and gets just enough rest to be efficient without any personal development or personal life whatsoever.
It'll pass, there's a fixed amount people can spend on entertainment so they will end up stepping on eachother's toes at some price point, then they will start competing with eachother on price.
Things don't get cheaper, they get more expensive and inflation goes up, but this part is already priced in - what people were paying for cable is what it will level out at.
The issue was allowing poor people to have disposable income, there's not putting genie back in the bottle.
The explosions came from lights on the consoles. In sci-fi anything which lights up is a stand-in for some fantastical technology which doesn't yet exist - most of which can explode because as a basic rule glowing things make brighter glowing things.
How about we just throw the VIM and EMACS people into a pit to fight to the death, winner gets eaten by a lion - that way we can end this stupid debate once and for all while using real IDEs?
please, just one topic without this, please. can we just have some fun, please?
The fun starts in the backlash of Nov 4th (Antifa are plotting to slaughter white people because racism and anti-Trump sentiment, which is sure to make commie-bashing fashionable again.)
C'mon this is supposed to be the bright future. Maybe they have the bugs worked out of Windows 10 by then. Now that I think about it, CBS and Microsoft missed a golden opportunity for marketing synergy. They could rebrand Windows 10 Enterprise, to Windows 10 Discovery
That's like saying "maybe beetles, worms, and flies will have the bugs worked out by then." You can't work a bug out when the thing is the bug.
The thing is, we already have a "National ID", and it's the SSN. The problem is that this particular national ID can, in the wrong hands, wreak havoc on one's financial health, because it doubles as form of authorization.
The choices aren't between "National ID" and "no National ID". The choices are between "National ID that doubles as authorization" and "separate National ID and National Financial Authorization Number".
Realistically we should keep SSNs as the id and just add a password component which changes every 6 months, has a minimum length of 8 characters, minimum of 2 upper case, 2 lower case, 2 special characters, and two numbers, and has a password history to prevent reuse of old passwords. Maybe even make the requirements change slightly from use-to-use (e.g. if you're logging into a bank you can't use the character %. if you log into a credit card company you can't use *, if you log into the IRS you can't use $, if you log into some other government system you can't use #, etc - that way it gets people to pick unique passwords.)
Ah fuck it, let's just give everyone implanted RFID chips, who cares if they cause cancer, this is MONEY we're talking about - the most tangible thing in all of existence.
No reason domain veto rights should rest in the hands of a group inclusive of repressive regimes ranging from 3rd world dictators to China to the UK. It's the American internet, Obama's worst move in terms of the internet was pushing to have censorship authority transferred out of the US.
Slashdot Mirror
The crooked, multi-level, high-markup drug industry deserves disruption.
Not just to play Devil's advocate, but they already have disruption, that's why they do what they do. It effectively plays out like this:
Those ~70 major pharmaceuticals have long since given up their own internal R&D operations because it isn't profitable, because the lifetime of something which actually makes it to becoming a drug goes roughly like:
This equates to one simple thing: They have at best 12-14 years to make up hundreds of millions of dollars to billions of dollars in R&D costs for every single drug they make. If they don't do that they go out of business and make zero drugs, it's that simple.
If you want to look at the parts of this process where you might actually get the costs down, look at the regulations - that's where most of the money actually goes.
Any advance in tech is from a development in physics or math fundamentally. "Technology" is too vague a term.
I agree with this sentiment. If there's a technology Nobel Prize it will just be Google or Apple or Microsoft or IBM or Samsung for the first few years, then once they see the marketing value they will corrupt it more than it already is (much like the Peace and Economics prizes which were added,) then before long, because there are so many technology companies clamoring for PR, you will end up with every prize going to some stupid Apple patent like "for the geometric construct of a rounded button" because of some long-winded fluff which boils down to "people like round shiny things."
I agree, but I think you might have misread the comment a bit. We need to plan around being able to recover materials after a collapse because even with savings like what SpaceX is aiming for it is going to be very expensive to ship equipment. If the people are lost the equipment should still be usable for the next group to salvage - things like CNCs, foundries, lathes, 3D printers, and ideally even the greenhouses. You don't get that reusability if things are meant to float in the atmosphere and come crashing down, but you do if they're already on the ground, barring events like a direct hit by an asteroid.
There's a sweet spot you have to balance on on Venus - too low and you crash, too high and you burn up. This is due to material constraints - you're pretty much limited to teflon and other plastics as coatings due to the sulfuric acid atmosphere. Metals would corrode. If you go to high the plastics melt (or at least will become soft allowing any stresses in the hull to crack them open. If components of the structure bump into eachother good luck with that because a scratch on the coating will likewise cause corrosion of the inner materials in a matter of days. The plastics themselves will have a lifetime of about 20-30 years at best in those conditions even if nothing goes wrong, so you will have to constant be recoating everything to keep it stable, and as far as I am aware there are no hydrocarbons on venus to make more. All this equates to: if the colony fails for whatever reason there will certainly be political issues lasting upwards of a half-decade preventing another attempt, then you're shit is corroded and destroyed leaving you to start fresh when/if it gets restarted. On Mars it could all go to Hell, politicians could bicker about whether or not to allow it to happen again for another several decades, and if they finally restart it most of the equipment will need at most the dust wiped off and some welding to function again. Every colonization attempt in Human history has had some massive collapse associated with it, it's not a matter of if it happens but when for something as complex as colonizing another planet, therefore that must be built into the plan. Venus is not within our current technological capabilities (Hell, for that matter Mars isn't either given we still crack water for O2 and the plan on Mars is to crack Iron Oxide for O2, but at least that provides building materials as a byproduct and there's a viable pathway to it.) Venus is a much more difficult place than Mars.
The point still stands. On Mars if something goes to utter shit and everyone dies you can at least go back and start with almost the same resources before it failed. On Venus it just sinks to the surface, and the sulfuric acid rain ensures anything that cracks on impact is destroyed.
I think everyone knows by now that ISIS is full of shit.
Most people who follow the situation over time know that ISIS are CIA puppets (they were actually formed when Obama sent McCain over to do an arms deal, which set them up with all their firepower - just after Obama was elected the media spun it for weeks straight as a massive bipartisan act of cooperation.)
Though using the term "puppet" might suggest too much control, if it was ISIS then more like it was a CIA op for a gun grab and pinning it on ISIS doesn't fit the desired narrative, even if they did facilitate it. So you would end up with people investigating claiming it was unrelated and ISIS claiming it was them because they genuinely believe it was, even though they were just unwittingly following the orders of their handlers who found them the best way to get it done.
It would take over 1,000 of these Vegas events EVERY DAY to even approach the threat of repealing high power weaponry.
In the course of Human history the biggest threat to a population has always been its own government, and the first thing they do before a genocide is to revoke weapons in the hands of citizens, this dates back to when weapons were swords through the modern day.
What's worse? 50,000 people slaughtered a day or a new holocaust? Because the numbers for the holocaust alone show that we would have to have 52,812 deaths PER DAY to even match the damage of a disarmed population of our size (and the holocaust was actually one of the milder genocides in Human history, though makes for a good example being both recent and well-known, there are some ongoing ones in the world today but people tend not to pay attention to them so I went the Godwin's law route.)
ISIS claims they radicalized him. If we glassed the whole of the mideast this would never have happened.
I have basic cable because it was cheaper (they were the only source of internet for me aside from super slow satellite providers.) The only use of it I make is sometimes logging in to stream something on Fox (though CBS not allowing this for my provider is absurd because CBS is included with the basic package.) I think it's like $70/mo for the internet connection and I probably do another $300/mo on movies, binge watching shows, etc mostly via Amazon. Definitely paying more than a full $175 cable package (for my area) but it's still much higher quality content, I don't need 500 channels I'll never watch and my schedule doesn't allow me to sit down at the same time every week to catch something (regardless of whenever that time might be.)
It's more globalism than anything else - trickle down economics is shit, but it was stable for awhile. The issue is the people doing the trickling realized they could outsource things more cheaply and started lobbying for open borders, free trade, etc to build global corporations which move to wherever the cheapest labor is at a given time. Nations have borders for a reason, it's more than just for defense.
No, I don't. None of this resonates with my experience. I've been doing great and I started working AFTER the wages stagnated. /shrug
Not knowing anything different isn't living better.
The mix of companies counting and not counting lunch hours plus the labor standards being set at 40 hours a week they increased it to fill out a full 40 hours accounting for the federally-mandated 1-hour lunch break. Meanwhile sticking to that with rush hour as the GP suggested means you get about 2-4 hours of personal time a day if you get ready like mad in the morning and pass out 8 hours prior - just enough time to have dinner and a beer before passing out. Nobody can live like that, hence you end up missing sleep and the author of TFA is a fucking sheltered retard for believing the issue is lacking productivity when people don't get enough sleep - either that or a shill aiming for a slave population which works and gets just enough rest to be efficient without any personal development or personal life whatsoever.
It'll pass, there's a fixed amount people can spend on entertainment so they will end up stepping on eachother's toes at some price point, then they will start competing with eachother on price.
Things don't get cheaper, they get more expensive and inflation goes up, but this part is already priced in - what people were paying for cable is what it will level out at.
The issue was allowing poor people to have disposable income, there's not putting genie back in the bottle.
The explosions came from lights on the consoles. In sci-fi anything which lights up is a stand-in for some fantastical technology which doesn't yet exist - most of which can explode because as a basic rule glowing things make brighter glowing things.
How about we just throw the VIM and EMACS people into a pit to fight to the death, winner gets eaten by a lion - that way we can end this stupid debate once and for all while using real IDEs?
please, just one topic without this, please. can we just have some fun, please?
The fun starts in the backlash of Nov 4th (Antifa are plotting to slaughter white people because racism and anti-Trump sentiment, which is sure to make commie-bashing fashionable again.)
Anyone paying for CBS to watch this is doing the rest of us a massive disservice.
You mean I get to piss off nerds WHILE WATCHING STARTREK? Sign me up.
C'mon this is supposed to be the bright future. Maybe they have the bugs worked out of Windows 10 by then. Now that I think about it, CBS and Microsoft missed a golden opportunity for marketing synergy. They could rebrand Windows 10 Enterprise, to Windows 10 Discovery
That's like saying "maybe beetles, worms, and flies will have the bugs worked out by then." You can't work a bug out when the thing is the bug.
Why do starship designers love to route plasma conduits behind control panels?
Collusion with the Romulan Star Empire.
But node.js+RFID implanted hand chips are the way of the future (the forehead is also acceptable.)
The thing is, we already have a "National ID", and it's the SSN. The problem is that this particular national ID can, in the wrong hands, wreak havoc on one's financial health, because it doubles as form of authorization.
The choices aren't between "National ID" and "no National ID". The choices are between "National ID that doubles as authorization" and "separate National ID and National Financial Authorization Number".
Realistically we should keep SSNs as the id and just add a password component which changes every 6 months, has a minimum length of 8 characters, minimum of 2 upper case, 2 lower case, 2 special characters, and two numbers, and has a password history to prevent reuse of old passwords. Maybe even make the requirements change slightly from use-to-use (e.g. if you're logging into a bank you can't use the character %. if you log into a credit card company you can't use *, if you log into the IRS you can't use $, if you log into some other government system you can't use #, etc - that way it gets people to pick unique passwords.)
Ah fuck it, let's just give everyone implanted RFID chips, who cares if they cause cancer, this is MONEY we're talking about - the most tangible thing in all of existence.
"and" == "."
Therefore the number of the beast is 660.6
No reason domain veto rights should rest in the hands of a group inclusive of repressive regimes ranging from 3rd world dictators to China to the UK. It's the American internet, Obama's worst move in terms of the internet was pushing to have censorship authority transferred out of the US.
He jumped the firewall, he's using one of those international keyboards with unicode.
Because guns have done such a good job preventing that.
I know that's sarcasm, but they have. As far as corrupt governments go measured over a historical scale, ours is relatively nice.