Actually, Apple customers are big MS Office customers, Microsoft even admits that their Mac version has an adoption rate comparable to the Windows version.
They've been working on iCloud betas since before the public announcement over the summer, I'm sure it will be done in time. That Billion-dollar-datacenter was started years ago.
Unfortunately both parties have fallen prey to the lobbying and money. Democrats are closer to Hollywood and thus more supportive of stronger copyright laws, and Republicans are hardly better.
ONE exec and one company would be unhappy, but the rest would be very happy that now they can legally manufacture it and compete. Novartis and Warrick and others can't wait to manufacture Pfizer's medications without having to pay any licensing fees to them.
Whoever told you this sounds overly optimistic or uninformed. Phase III trials are the longest phase in any study, especially in therapies for chronic conditions. The FDA usually requires at least 2 successful phase III trials before they certify a drug, and since this medication is slightly more controversial you know they're going to do that. While in most cases they can start marketing it while it's in the trial, I don't think the FDA is under any particular pressure to let this one out to market prematurely.
Well in that case, marijuana is not free either. You still have to provide fertilizer, water, pots for the plants, and even some grow farms use artificial light. If you want to sell it, the FDA is going to require you to run chemical purity and bioassay tests on the lot. All of that's going to cost more than one cent per pill.
Again, read what I said earlier in this thread, drug companies do not "hate ANY drug not covered by a patent they hold." More than half the drugs in any pharmacy are generic and have patents that expired. Rather than repeat an old myth, show me proof where a drug company has openly stated its hatred.
Rakaur, you need to calm down and take a deep breath. Sure you're passionate about the topic, but you need to stop insulting those who disagree with you and trying to insult me in every post. Ad hominem attacks only hurt your own case.
Go call any local CVS Pharmacy in your area and ask the pharmacist what they'd recommend. You sound like a medical professional, so you should be well-aware that not all antiemetics have severe side effects as you claim. Meclizine (brand name Antivert) or Benadryl (diphenhydramine) for example are generally considered to be a safe drug and is sold OTC. The first-line antiemetics are Compazine and Zofran, as well as scopolamine, along with meclizine, promethazine, and hydroxyzine then you can go down the list to Reglan (Metoclopramide) and if those still aren't working then you move into the controlled medications like Marinol, and benzodiazepines like lorazepam.
I'd give you sources in the medical literature, but I don't know if the links like UpToDate's will work for you if you do not have access to a medical library's subscriptions.
Well there are better antiemetics than marinol or cannaboids. Those can cause changes in perception, dizziness, and loss of coordination. Any doctor would give something like Zofran (Ondansetron) or Compazine (Prochlorperazine) instead, then all the patient has to worry about is Dry Mouth. Any more excuses to secretly get high?
CI doesn't really affect research. The FDA actually has a stockpile of legal marijuana for this purpose, and the pharmacokinetics of THC are understood as a result of said research. They're even doing more research in order to approve the new THC/CBD drug Sativex.
No drug is without side effects, even water can kill you if you have too much or too little of it. But there's a reason marijuana isn't considered a valid therapy by doctors for most conditions, since it has bigger side effects than existing mediations, and with less benefits.
I think you're exaggerating; aspirin is so popular that it's now being recommended to senior citizens as a daily medication along with vitamins (particularly low-dose or baby-aspirin). There are dozens of medications that put aspirin in with their formulations, like Percodan (oxycodone+aspirin) and Fiorinal (butalbital+aspirin+caffeine).
Pharmaceuticals love aspirin because it's cheap, has no patents, can be sold Over-the-counter (way more sales), and proven (so no lawsuits). Viagra may be more profitable but sells less and has legal issues that aspirin doesn't..
Actually, Sativex doesn't have FDA approval. The company is applying for it but it's still years away.
You're changing your argument, first arguing in favor of purified extracts and now backing off, saying it's the (natural) balance in cannabis? Take your own advice and come back when you actually have a full understanding of pharmacology
Marijuana is at CI because Marinol (a CIV medication) is far more medically effective as an anti-emetic and analgesic. Marijuana is carcinogenic, while Marinol is not. Marinol is purified THC in pill form, which the FDA has licensed. Marijuana "has for the most part been superseded by synthetic alternatives" as the parent poster said.
Yes, the marinol medication (purified THC) lasts longer in the body, but the Glaucoma Foundation says that its effects are "not impressive."
The effects of Marinol on glaucoma are not impressive.
To date, no studies have shown that marijuana— or any of its approximately 400 chemical components—can safely and effectively lower intraocular pressure better than the variety of drugs currently on the market.
Currently, there are no National Eye Institute studies in the United States concerning the use of marijuana to treat glaucoma.
The Glaucoma Research Foundation will continue to monitor the research community for any new and well-designed studies regarding the use of marijuana to effectively treat glaucoma.
An April 1986 product insert from Roxane warned that Marinol elicits "disturbing psychiatric symptoms," and that even patients on low doses might experience "a full-blown picture of psychosis." The latter phrase has disappeared from recent product inserts, but experts say nothing has changed.
"It's way too psychoactive," says Robert Randall, the glaucoma patient who was the first American to obtain marijuana legally from the government. "When I took Marinol, I found it anxiety-provoking and intense, like I had wandered into a short story by Flannery O'Connor."
Yet more proof that marijuana, even the purified Marinol, has far more side effects than simple effective eye drops, and is why the AMA and FDA refuse to license it.
I keep hearing this canard, but I don't think there's any truth to it. It's a convenient scapegoat, but it doesn't make sense.
Aspirin is cheap too, but the pharma companies love it; it's one of the best-selling drugs in the US. Many trademarks are out there: in the US there's Bayer, Excedrin, Anacin, Ecotrin, Midol, St.Joseph, Alka-Seltzer Plus, Rite-Aid brand, CVS brand, Duane Reade, Walgreens, etc. Clearly cannabis is generally illegal for other reasons than cost.
False analogy. Cocaine is used only for nasal and lacrimal duct surgery, because it's a potent vasoconstrictor (meaning it cuts down on bleeding during surgery). The systemic effect of cocaine is actually a downside for any other surgery (vasoconstriction increases risk of necrosis), which is why doctors use synthetics from the same family; like lidocaine, xylocaine, novocaine, and tetracaine.
Can you please show me some peer-reviewed scientific studies of the subject to prove your claim? Studies have shown a reduction of IOP in glaucoma patients who smoke cannabis, but the effects are generally short-lived. Since it can also decrease blood flow to the optic nerve (causing a potential worsening of the condition), it's not recommended by physicians when eye drops are such low-risk. Ask any licensed pharmacist or doctor.
Slashdot Mirror
So Google is finally copying Bing's features?
I don't quite mind, if Google starts copying Wolfram Alpha we may get LCARS one day.
Kittenman? Are you a kitten with the muscle structure of a man? Or a man with soft body and spirit of a kitten? .
Actually, Apple customers are big MS Office customers, Microsoft even admits that their Mac version has an adoption rate comparable to the Windows version.
They've been working on iCloud betas since before the public announcement over the summer, I'm sure it will be done in time. That Billion-dollar-datacenter was started years ago.
Fortunately, the iCloud betas from Apple allow you to download apps that were even yanked from the App Store, provided you already purchased them.
Yes! There was even a robot Turtle. A very simple language, Logo and LogoWriter.
Perfect for 2nd graders.
Unfortunately both parties have fallen prey to the lobbying and money. Democrats are closer to Hollywood and thus more supportive of stronger copyright laws, and Republicans are hardly better.
"Provoke cancer?" Your sources?
Looks like no Mac version yet. Anyone able to report how it plays in Crossover?
The Left was so used to condemning the Iraq war that they failed to see the important differences.
Top 10 Myths about the Libya war
Is it ok, plot-wise, if I ignored the sequels and went straight from Deus Ex to Human Revolution? Does the game make a lot of references to the past?
ONE exec and one company would be unhappy, but the rest would be very happy that now they can legally manufacture it and compete. Novartis and Warrick and others can't wait to manufacture Pfizer's medications without having to pay any licensing fees to them.
Whoever told you this sounds overly optimistic or uninformed. Phase III trials are the longest phase in any study, especially in therapies for chronic conditions. The FDA usually requires at least 2 successful phase III trials before they certify a drug, and since this medication is slightly more controversial you know they're going to do that. While in most cases they can start marketing it while it's in the trial, I don't think the FDA is under any particular pressure to let this one out to market prematurely.
Well in that case, marijuana is not free either. You still have to provide fertilizer, water, pots for the plants, and even some grow farms use artificial light. If you want to sell it, the FDA is going to require you to run chemical purity and bioassay tests on the lot. All of that's going to cost more than one cent per pill.
Again, read what I said earlier in this thread, drug companies do not "hate ANY drug not covered by a patent they hold." More than half the drugs in any pharmacy are generic and have patents that expired. Rather than repeat an old myth, show me proof where a drug company has openly stated its hatred.
Rakaur, you need to calm down and take a deep breath. Sure you're passionate about the topic, but you need to stop insulting those who disagree with you and trying to insult me in every post. Ad hominem attacks only hurt your own case.
Go call any local CVS Pharmacy in your area and ask the pharmacist what they'd recommend. You sound like a medical professional, so you should be well-aware that not all antiemetics have severe side effects as you claim. Meclizine (brand name Antivert) or Benadryl (diphenhydramine) for example are generally considered to be a safe drug and is sold OTC. The first-line antiemetics are Compazine and Zofran, as well as scopolamine, along with meclizine, promethazine, and hydroxyzine then you can go down the list to Reglan (Metoclopramide) and if those still aren't working then you move into the controlled medications like Marinol, and benzodiazepines like lorazepam.
I'd give you sources in the medical literature, but I don't know if the links like UpToDate's will work for you if you do not have access to a medical library's subscriptions.
Well there are better antiemetics than marinol or cannaboids. Those can cause changes in perception, dizziness, and loss of coordination. Any doctor would give something like Zofran (Ondansetron) or Compazine (Prochlorperazine) instead, then all the patient has to worry about is Dry Mouth. Any more excuses to secretly get high?
CI doesn't really affect research. The FDA actually has a stockpile of legal marijuana for this purpose, and the pharmacokinetics of THC are understood as a result of said research. They're even doing more research in order to approve the new THC/CBD drug Sativex.
No drug is without side effects, even water can kill you if you have too much or too little of it. But there's a reason marijuana isn't considered a valid therapy by doctors for most conditions, since it has bigger side effects than existing mediations, and with less benefits.
I think you're exaggerating; aspirin is so popular that it's now being recommended to senior citizens as a daily medication along with vitamins (particularly low-dose or baby-aspirin). There are dozens of medications that put aspirin in with their formulations, like Percodan (oxycodone+aspirin) and Fiorinal (butalbital+aspirin+caffeine).
Pharmaceuticals love aspirin because it's cheap, has no patents, can be sold Over-the-counter (way more sales), and proven (so no lawsuits). Viagra may be more profitable but sells less and has legal issues that aspirin doesn't..
Actually, Sativex doesn't have FDA approval. The company is applying for it but it's still years away.
You're changing your argument, first arguing in favor of purified extracts and now backing off, saying it's the (natural) balance in cannabis? Take your own advice and come back when you actually have a full understanding of pharmacology
Marijuana is at CI because Marinol (a CIV medication) is far more medically effective as an anti-emetic and analgesic. Marijuana is carcinogenic, while Marinol is not. Marinol is purified THC in pill form, which the FDA has licensed. Marijuana "has for the most part been superseded by synthetic alternatives" as the parent poster said.
Yes, the marinol medication (purified THC) lasts longer in the body, but the Glaucoma Foundation says that its effects are "not impressive."
Heck, even High Times came out against it:
Yet more proof that marijuana, even the purified Marinol, has far more side effects than simple effective eye drops, and is why the AMA and FDA refuse to license it.
I keep hearing this canard, but I don't think there's any truth to it. It's a convenient scapegoat, but it doesn't make sense.
Aspirin is cheap too, but the pharma companies love it; it's one of the best-selling drugs in the US. Many trademarks are out there: in the US there's Bayer, Excedrin, Anacin, Ecotrin, Midol, St.Joseph, Alka-Seltzer Plus, Rite-Aid brand, CVS brand, Duane Reade, Walgreens, etc. Clearly cannabis is generally illegal for other reasons than cost.
False analogy. Cocaine is used only for nasal and lacrimal duct surgery, because it's a potent vasoconstrictor (meaning it cuts down on bleeding during surgery). The systemic effect of cocaine is actually a downside for any other surgery (vasoconstriction increases risk of necrosis), which is why doctors use synthetics from the same family; like lidocaine, xylocaine, novocaine, and tetracaine.
whoops, I meant to say Marinol (Dronabinol).
Can you please show me some peer-reviewed scientific studies of the subject to prove your claim? Studies have shown a reduction of IOP in glaucoma patients who smoke cannabis, but the effects are generally short-lived. Since it can also decrease blood flow to the optic nerve (causing a potential worsening of the condition), it's not recommended by physicians when eye drops are such low-risk. Ask any licensed pharmacist or doctor.