Researchers already knew that mice models were far from perfect. Anyone paying any attention to biomedical research knows that if some amazing cure is demonstrated in mice, it will likely never be heard of again since it didn't pan out. It's important to realize if one hadn't already that mice weren't perfect models for humans, but it's also important to realize that drug testing in mice IS necessary.
This isn't directed at you, but I don't understand the logic, and never will, where you can use an animal with a DNA model that is different from the animal that will be using the drug. Sure, it can show some serious negative effects or positive ones, but the DNA difference can also give you a laboratory set where one animal has 130 side effects (including death or worse), and the other has zero or one.
Chemistry is a little more complicated with animals than it is with test tubes.
So, any word on how we managed to get from 'researchers identify class of conditions for which mice are an unexpectedly lousy model' to 'drug testing in mice may be a waste of time'?
Honestly, that sounds like another way of saying "we don't know what to effing do now. We have no test Humans!"
You know, capital punishment should include the obligatory 'island of murder/rape/pedophile criminals', but instead of serving time ad nauseam, you get to be randomly picked for drug trials.
Is so-called 'objective reality' also a social construct?
The parent comment is why teachers want you to "show your work", objective reality is where teachers lose consciousness with a bottle of booze in front of the television, or, you know, just give you a C- for the hell of it because they TOTALLY understood your non-linear thought.;)
Side effects in mice: Congenital defects, swelling of the urethra, kidney failure, liver failure, seizures, heightened blood pressure with occasional heart attacks, loss of vision and motor function, death.
As a technical troubleshooter I can not believe how they try to say it was not caused by the grand surge of electricity needed. Maybe the device saw the usage as abnormal and just did it's job a little bit late. Just admit it, you didn't think it would draw that much amps/be a problem with stage over-hype.
First thing I did after seeing it was check solar activity. Once I saw that it was nominal and not CLOSE to a major power fluctuation event, I determined it was caused by Human Error. Don't fucking care what the error was - people will fix broken shit. It was just an error.
I travel a lot and it's good to have a console with you
Do you bring the TV too? Or do you just trust that you'll be staying in a hotel that 1. allows guests to connect their own video sources without paying an extra fee, and 2. supports the same TV system (if you cross the Atlantic)? I think that's why phone gaming and handheld gaming took off.
Wha? When I'm traveling, one of the last things on my mind is playing games. Well, business 'games' aside, of course.
I think this is a dick move by MS. Games, like college textbooks, are fricking expensive and it's nice to know you can recoup some of your money when you're done with them via the used games market. I travel a lot and it's good to have a console with you...don't always know if I'll have Internet where I'm at and I don't know if I give a crap about hooking it up just to play a game I bought legally.
MS needs to rethink this..maybe copy the Steam model where you buy the game once and can play it anywhere would work.
Now to be blunt or anything... but if it's a "dick move," Microsoft will definitely succeed and rub everyone's face in it, only to enhance their success 10 fold.
The main problem I see with this is the ability to lend games to friends, or have friends lend games to me! This is what hooked me in with COD 4 and the reason I purchased an Xbox. My mate lent me his copy for a day and boom I was hooked.
That wont be happening again I guess....
Amen.
I can see the same problem as COA with Windows popping up in no time. Their "cool customer support" staff will increase by 200,000%.
Wait, this will bring our unemployment rate out of the gutter! Unless they offshore it. Aw, rats.
**NO** college has experience with it, currently. You don't think that they're going to hire subject matter specialists to help them build their curriculum and teaching materials, and probably teach the program? I don't know anything about that particular college, but they'd have to be run by utter incompetents if they didn't. From their campus locations I can see that they have plenty of opportunity to find the correct people.
Damn. I'd better sue them for patent infringement ASAP. Starting a college program from my own head is MY IDEA.
...Much though I'd enjoy burning these morons at the stake you can't burn your customers alive and expect them to keep buying from you. ( Unless you are Microsoft. )...
That works fine until the CEO misses an email from a prospective client.
Unless you plan to profit from stupidity, that prospective client is worthless if they can't even set up a functional SPF record. Either you're too stupid to know about SPF or you do it right. Everything else is dumb beyond reason.
The logic behind what you're saying is good in nature, but bad in execution; I can with 100% surety say that I have lost business from people with tons of money to blow because someone who doesn't know how to configure their IT environment properly got them to blow tons of money on them.
Translation: I lose money when I don't get email from 'the ignorant'.
No, because you send the NDR to a adress, which was detected by SPF as NOT being the source of the message. So you reach the wrong person. So instead you should just send nothing, if you filter based on SPF, because the whole point in spf is, when you filter it, you do it because you do not know the source (and the pretended source-adress is wrong)
It's an administrative degree, not an engineering degree. Yes, they will need people who know what paperwork needs to be file when the FAA approve flight plan has to be changed, who know whether they have to re-file their patent application when the alloy for the rocket exhaust nozzle changes, or if the scope of work for a subcontractor covers all the elements actually required. Those aren't things that a normal MBA prepares students for, and if they drop a regular MBA into that position it's going to take them years and dozens of mistakes to learn them.
Yeah, because all of this information is certifiably understood and taught by a college that has no experience with it at all.
This is like giving someone with an MBA a job in biological science because they "know how 'business' works."
Give me a break. You really want to try and play devil's advocate on this one?
I heard the (community) college down the street is offering a "Degree in Space Medicine." Are you telling me that this isn't a valid and widely accepted degree?
Now THAT'S a way to get a bunch of filthy rich people with dreams of venturing to space to pay you butt-loads of money for a degree that isn't officially notably accepted.
In what universe does someone consider an iPad to be a personal computer?
Not to sound simplistic, but it's a computer and it's personal. It's not an IBM PC, but now we're grabbing at straws for a definition accepted and used by all of Humanity.
Slashdot Mirror
Researchers already knew that mice models were far from perfect. Anyone paying any attention to biomedical research knows that if some amazing cure is demonstrated in mice, it will likely never be heard of again since it didn't pan out. It's important to realize if one hadn't already that mice weren't perfect models for humans, but it's also important to realize that drug testing in mice IS necessary.
This isn't directed at you, but I don't understand the logic, and never will, where you can use an animal with a DNA model that is different from the animal that will be using the drug. Sure, it can show some serious negative effects or positive ones, but the DNA difference can also give you a laboratory set where one animal has 130 side effects (including death or worse), and the other has zero or one.
Chemistry is a little more complicated with animals than it is with test tubes.
So, any word on how we managed to get from 'researchers identify class of conditions for which mice are an unexpectedly lousy model' to 'drug testing in mice may be a waste of time'?
Honestly, that sounds like another way of saying "we don't know what to effing do now. We have no test Humans!"
You know, capital punishment should include the obligatory 'island of murder/rape/pedophile criminals', but instead of serving time ad nauseam, you get to be randomly picked for drug trials.
Only to those people who find objective reality gets in the way of the reality they prefer.
If you can convince the rubes that objective reality is just an opinion, you can have any job in education you wish.
Tidied that up just a hair. :)
Is so-called 'objective reality' also a social construct?
The parent comment is why teachers want you to "show your work", objective reality is where teachers lose consciousness with a bottle of booze in front of the television, or, you know, just give you a C- for the hell of it because they TOTALLY understood your non-linear thought. ;)
I often wonder how many drugs we reject long before human trials because some researcher used the wrong animal to test.
Also an obligatory SMBC comic
No kidding.
Trial Drug 1035832B:
Side effects in mice: Congenital defects, swelling of the urethra, kidney failure, liver failure, seizures, heightened blood pressure with occasional heart attacks, loss of vision and motor function, death.
Side effects in Humans: Occasional diarrhea.
Almost everything gets rejected by Nature and Science. The article notes Science only accepts about 7% of the papers it receives.
Accepts, or 7% it bothers to mention that it accepts? Hey, I'm just being scientific. Har. :)
PNAS isn't exactly some chickenshit vanity press...
No, it's a bodily organ which urine is disposed through. Also used for sexual purposes.
Are they using synthetic urine to pass their tests now, too?
Have to. Their pH is insane!
A mouse can't even roll a joint, much less handle a lighter. Nor do they make syringes that small.
Why was anyone suspecting their mice of using drugs in the first place?
I work for a background screening and drug testing company. Now ^^^ that's ^^^ funny, right there!
As a technical troubleshooter I can not believe how they try to say it was not caused by the grand surge of electricity needed.
Maybe the device saw the usage as abnormal and just did it's job a little bit late.
Just admit it, you didn't think it would draw that much amps/be a problem with stage over-hype.
First thing I did after seeing it was check solar activity. Once I saw that it was nominal and not CLOSE to a major power fluctuation event, I determined it was caused by Human Error. Don't fucking care what the error was - people will fix broken shit. It was just an error.
That's why I stopped using UPS's on my home computers. I was having more failures caused by the UPS's than if I didn't have them in my system.
I think the turning point was when journaling file systems came to Linux.
I think it was a turning point when journaling file systems came to be -PERIOD-.
I travel a lot and it's good to have a console with you
Do you bring the TV too? Or do you just trust that you'll be staying in a hotel that 1. allows guests to connect their own video sources without paying an extra fee, and 2. supports the same TV system (if you cross the Atlantic)? I think that's why phone gaming and handheld gaming took off.
Wha? When I'm traveling, one of the last things on my mind is playing games. Well, business 'games' aside, of course.
I think this is a dick move by MS. Games, like college textbooks, are fricking expensive and it's nice to know you can recoup some of your money when you're done with them via the used games market. I travel a lot and it's good to have a console with you...don't always know if I'll have Internet where I'm at and I don't know if I give a crap about hooking it up just to play a game I bought legally.
MS needs to rethink this..maybe copy the Steam model where you buy the game once and can play it anywhere would work.
Now to be blunt or anything... but if it's a "dick move," Microsoft will definitely succeed and rub everyone's face in it, only to enhance their success 10 fold.
Always on always turns me off.
The main problem I see with this is the ability to lend games to friends, or have friends lend games to me! This is what hooked me in with COD 4 and the reason I purchased an Xbox. My mate lent me his copy for a day and boom I was hooked.
That wont be happening again I guess....
Amen.
I can see the same problem as COA with Windows popping up in no time. Their "cool customer support" staff will increase by 200,000%.
Wait, this will bring our unemployment rate out of the gutter! Unless they offshore it. Aw, rats.
**NO** college has experience with it, currently. You don't think that they're going to hire subject matter specialists to help them build their curriculum and teaching materials, and probably teach the program? I don't know anything about that particular college, but they'd have to be run by utter incompetents if they didn't. From their campus locations I can see that they have plenty of opportunity to find the correct people.
Damn. I'd better sue them for patent infringement ASAP. Starting a college program from my own head is MY IDEA.
...Much though I'd enjoy burning these morons at the stake you can't burn your customers alive and expect them to keep buying from you. ( Unless you are Microsoft. )...
Ooooooh Burn! And Bravo! :)
That works fine until the CEO misses an email from a prospective client.
Unless you plan to profit from stupidity, that prospective client is worthless if they can't even set up a functional SPF record. Either you're too stupid to know about SPF or you do it right. Everything else is dumb beyond reason.
The logic behind what you're saying is good in nature, but bad in execution; I can with 100% surety say that I have lost business from people with tons of money to blow because someone who doesn't know how to configure their IT environment properly got them to blow tons of money on them.
Translation: I lose money when I don't get email from 'the ignorant'.
No, because you send the NDR to a adress, which was detected by SPF as NOT being the source of the message. So you reach the wrong person. So instead you should just send nothing, if you filter based on SPF, because the whole point in spf is, when you filter it, you do it because you do not know the source (and the pretended source-adress is wrong)
So you're saying there is no solution?
Wow, Microsoft. Really?
So you're saying that we can solve all of our problems with malware by simply.... becoming richer?
We never thought about that. Thanks for informing us! We'll get right on that immediately!
It's an administrative degree, not an engineering degree. Yes, they will need people who know what paperwork needs to be file when the FAA approve flight plan has to be changed, who know whether they have to re-file their patent application when the alloy for the rocket exhaust nozzle changes, or if the scope of work for a subcontractor covers all the elements actually required. Those aren't things that a normal MBA prepares students for, and if they drop a regular MBA into that position it's going to take them years and dozens of mistakes to learn them.
Yeah, because all of this information is certifiably understood and taught by a college that has no experience with it at all.
This is like giving someone with an MBA a job in biological science because they "know how 'business' works."
Give me a break. You really want to try and play devil's advocate on this one?
Hey, now!
I heard the (community) college down the street is offering a "Degree in Space Medicine." Are you telling me that this isn't a valid and widely accepted degree?
;>
Blasphemer!
Now THAT'S a way to get a bunch of filthy rich people with dreams of venturing to space to pay you butt-loads of money for a degree that isn't officially notably accepted.
That's sales. Bravo! :)
In what universe does someone consider an iPad to be a personal computer?
Not to sound simplistic, but it's a computer and it's personal. It's not an IBM PC, but now we're grabbing at straws for a definition accepted and used by all of Humanity.
Now, should we praise Nintendo as one of the leaders in PC market?
Yes... In the segment of the industry of video game console manufacturers that begin with the letters N-Z.
Then we should treat game consoles, both home and portable, as PCs too. So that makes, for example, Nintendo rather significant PC vendor.~
May as well throw Blu-Ray players in to boot, given the firmware and network connectivity. I'm not kidding.