Yes, it's created a lot of interest but that's pretty standard for a molecule that hits a relatively unique molecular pathway. What has happened in the past is that as soon as the basic science gets firmed up, the drug companies wander it and start trailing slightly different molecules (which are patentable). That's where the big money goes.
By explicitly opening up access to the molecule early, you might find more applications faster and perhaps get more people working on the same receptor system, but the end result is that the drug that treats multiple myeloma will look slightly different from the one that treats heart failure or is used as a male contraceptive. The drug makers will work hard to make them as task specific as possible so they can charge more and control things better. The only possible 'good' outcome (for the open source concept here) would be that the 'generic' bromodomain receptor blocker (JQ1) works equally well for all, doesn't do anything bad in humans (an unlikely scenario - most promising drug candidates die here along with countless dogs, monkeys and other critters) and can be reasonably easily synthesized by the Indian and Chinese generic drug manufacturers and they make a shitload of it.
Which will get blocked at the border so save us from commie chemicals.
With 3D printing edging into device manufacturing space, just about everything is going to face free/public competition, not the least of which will be energy production. Big business with its dependency on having the public dependent on them has its days numbered. I look forward to those days... I wonder if I will live that long?
No you won't.
Because 3D printing isn't going to replace anything much beyond the utensil selection in Walmart for the foreseeable future. Hell, you'll be lucky if you can shoot yourself in head with a 3D printed object in your lifetime. You'd be most likely to blow up your hand and have to go the the hospital and get treated with stuff that's been woven, extruded, grown, spun or glued.
Naval nuc reactors are designed and maintained under very different standards (and cost constraints) than civilian light water reactors. For a number of reasons, the Navy system doesn't scale to commercial sizes.
But this is exactly my point: we can make nuclear power safe (as soon as we figure out what to do with the waste - that's political, not technical), we just haven't done so. And we don't seem to be making the effort to do so. The nuclear power industry at times is it's own worst enemy. They've been caught trying to cheap it out numerous times. They've been caught pants down in terms of security. They've been caught fudging pretty much everything they can fudge.
The big problem with commercial nuclear power these days is that it's too expensive. Even solar and wind and a shitload of batteries can out compete it.
Ah, you must be new here. Slashdot HTML is based on RFC documents stored in the bottom of a locked filing cabinet stuck in a disused lavatory with a sign on the door saying 'Beware of the Leopard'."
Yes, short term, natural gas is cheap, easy to configure ("just" drag a couple of 30 foot tall turbines to the site), well understood. Unfortunately it's not really clean - TLDR but natural gas extraction and burning may produce just as much CO2 as coal - just think about what happens to nat gas when in oxidizes - it turns into - wait for it- CO2!. And unfortunately our glut of nat gas is likely to be relatively short lived (on the order of a few decades).
Now, nuc plants are not necessarily clean (Fukashima) but could be made to be fairly safe. And nuc plants aren't really long term (each plant lasts a couple of decades) and we still have to figure out what to do with the waste. That's a political, not a technical problem but anybody who doesn''t think that politics can be problematic needs to wake up a bit.\
So neither nucs nor nat gas (nor coal) can get you out of dealing with longer term issues but our current society doesn't seem to want to do any of the hard stuff (planning, conservation, planning) so yep, drag those turbines in....
"Printing" your own PCBs is about at the level of 3D printers today - eminently practical for a limited number of users. I use a modified laminator and heat sensitive resistive paper and stick the exposed board in some moderately nasty oxidizer. Takes about 4 hours start to finish but about a year of fiddling with the all of the workflow bits.
You can get one or two off PCBs from a number of mail in houses. Just like 3D printers.
I think the 3D printer world will actually look like the low volume PCB manufacturers in a couple of years: The occasional DIYer with their own, the easy accessibility of small shops to send for one off bits. I can''t see 3D printers in my neigbor''s house - they've yet to keep a 2D inkjet alive for more than a couple of months.
You know? That's America's problem. Heroes. You've gotten so used to having heroes do this, do that, that when something bad happens, you stick your head in the sand and wait for a "hero" to take care of it.
Solve your own damned problems instead of blaming others and just watching from the sidelines. It's your country, nobody elses, and unless you don't want that to change, you better act fast.
The problem is that there aren't any more telephone booths and we've cleaned up our radiation pollution to the point where getting bit by contaminated insects isn't very likely. Sort of a dilemma , it is.
I was excited about that product until I looked at the reviews. Not accurate, buggy, proprietary. In other words, typical Wacom. So close, yet so far away.....
Look, people around here would buy ANYTHING with a CPU, memory and screen for pennies on the dollar if they get to take it apart and stare at the innards.
Announcing that a Slashdot user would buy any particular device is the Kiss of Electronic Death to mass markets. Remember the iPod? Lame, eh? Remember the HP tablet? Fantastic?.
Shorting anything that the Slashdot hive mind likes is a good way to make money. You're weird and you know it.
Hollywood and the rest of the graphics industry went to Windows (for individual stuff) and Linux (for heavy lifting) long ago.
Yes, there is a OS X presence, it's just a pale shadow of it's former glory. Apple squandered their lead about a decade ago with their dick waving contest with Adobe (may their soul rot in hell) and the loss of the X server.
If you trust ANY advertising / marketing company, you're in for a world of hurt.
Yep, Nokia got caught on that one but it's just One More Lie. Why it was only yesterday, I believe, that Google was caught hiding the USB power cord on the Chromedealywhopper thing.
And let's not get started about Apple. Or Microsoft. Or Lotus Notes (god, let's NOT get started on Lotus Notes).
I basically don't get it. The Navy has developed a new test for Influenza that (apparently) doesn't need the typical surface markers that other tests do. Cool. But TFA just drops that and wanders around the US government's attempt at creating a more unified / functional bio-surveillance program but then complains we don't have the money or expertise to do it.
OK. Fine. Another first world Problem.
I'd like to know more about the test. I'm well aware of the Government's inability to organize anything more complex than an egg coloring contest.
Slashdot Mirror
No, the insecure parts are the users.
Always has been, always will be.
Get rid of the humans and everything should be just peachy.
Is it going to help or hurt?
Yes, it's created a lot of interest but that's pretty standard for a molecule that hits a relatively unique molecular pathway. What has happened in the past is that as soon as the basic science gets firmed up, the drug companies wander it and start trailing slightly different molecules (which are patentable). That's where the big money goes.
By explicitly opening up access to the molecule early, you might find more applications faster and perhaps get more people working on the same receptor system, but the end result is that the drug that treats multiple myeloma will look slightly different from the one that treats heart failure or is used as a male contraceptive. The drug makers will work hard to make them as task specific as possible so they can charge more and control things better. The only possible 'good' outcome (for the open source concept here) would be that the 'generic' bromodomain receptor blocker (JQ1) works equally well for all, doesn't do anything bad in humans (an unlikely scenario - most promising drug candidates die here along with countless dogs, monkeys and other critters) and can be reasonably easily synthesized by the Indian and Chinese generic drug manufacturers and they make a shitload of it.
Which will get blocked at the border so save us from commie chemicals.
Grump again.
With 3D printing edging into device manufacturing space, just about everything is going to face free/public competition, not the least of which will be energy production. Big business with its dependency on having the public dependent on them has its days numbered. I look forward to those days... I wonder if I will live that long?
No you won't.
Because 3D printing isn't going to replace anything much beyond the utensil selection in Walmart for the foreseeable future. Hell, you'll be lucky if you can shoot yourself in head with a 3D printed object in your lifetime. You'd be most likely to blow up your hand and have to go the the hospital and get treated with stuff that's been woven, extruded, grown, spun or glued.
Take my wif(i), please.
Naval nuc reactors are designed and maintained under very different standards (and cost constraints) than civilian light water reactors. For a number of reasons, the Navy system doesn't scale to commercial sizes.
But this is exactly my point: we can make nuclear power safe (as soon as we figure out what to do with the waste - that's political, not technical), we just haven't done so. And we don't seem to be making the effort to do so. The nuclear power industry at times is it's own worst enemy. They've been caught trying to cheap it out numerous times. They've been caught pants down in terms of security. They've been caught fudging pretty much everything they can fudge.
The big problem with commercial nuclear power these days is that it's too expensive. Even solar and wind and a shitload of batteries can out compete it.
Ah, you must be new here. Slashdot HTML is based on RFC documents stored in the bottom of a locked filing cabinet stuck in a disused lavatory with a sign on the door saying 'Beware of the Leopard'."
Yes, short term, natural gas is cheap, easy to configure ("just" drag a couple of 30 foot tall turbines to the site), well understood. Unfortunately it's not really clean - TLDR but natural gas extraction and burning may produce just as much CO2 as coal - just think about what happens to nat gas when in oxidizes - it turns into - wait for it- CO2!. And unfortunately our glut of nat gas is likely to be relatively short lived (on the order of a few decades).
Now, nuc plants are not necessarily clean (Fukashima) but could be made to be fairly safe. And nuc plants aren't really long term (each plant lasts a couple of decades) and we still have to figure out what to do with the waste. That's a political, not a technical problem but anybody who doesn''t think that politics can be problematic needs to wake up a bit.\
So neither nucs nor nat gas (nor coal) can get you out of dealing with longer term issues but our current society doesn't seem to want to do any of the hard stuff (planning, conservation, planning) so yep, drag those turbines in....
Well the guy is a known journalist and that means he is a subversive.
So there.
You click on the link.
You're welcome.
"Printing" your own PCBs is about at the level of 3D printers today - eminently practical for a limited number of users. I use a modified laminator and heat sensitive resistive paper and stick the exposed board in some moderately nasty oxidizer. Takes about 4 hours start to finish but about a year of fiddling with the all of the workflow bits.
You can get one or two off PCBs from a number of mail in houses. Just like 3D printers.
I think the 3D printer world will actually look like the low volume PCB manufacturers in a couple of years: The occasional DIYer with their own, the easy accessibility of small shops to send for one off bits. I can''t see 3D printers in my neigbor''s house - they've yet to keep a 2D inkjet alive for more than a couple of months.
You know? That's America's problem. Heroes. You've gotten so used to having heroes do this, do that, that when something bad happens, you stick your head in the sand and wait for a "hero" to take care of it.
Solve your own damned problems instead of blaming others and just watching from the sidelines. It's your country, nobody elses, and unless you don't want that to change, you better act fast.
The problem is that there aren't any more telephone booths and we've cleaned up our radiation pollution to the point where getting bit by contaminated insects isn't very likely. Sort of a dilemma , it is.
I was excited about that product until I looked at the reviews. Not accurate, buggy, proprietary. In other words, typical Wacom. So close, yet so far away.....
Look, people around here would buy ANYTHING with a CPU, memory and screen for pennies on the dollar if they get to take it apart and stare at the innards.
Announcing that a Slashdot user would buy any particular device is the Kiss of Electronic Death to mass markets. Remember the iPod? Lame, eh? Remember the HP tablet? Fantastic?.
Shorting anything that the Slashdot hive mind likes is a good way to make money. You're weird and you know it.
Fatality!
No. Cannot and Will Not go there.
Hollywood and the rest of the graphics industry went to Windows (for individual stuff) and Linux (for heavy lifting) long ago.
Yes, there is a OS X presence, it's just a pale shadow of it's former glory. Apple squandered their lead about a decade ago with their dick waving contest with Adobe (may their soul rot in hell) and the loss of the X server.
I can just see this - a high level presentation to the C level executives:
"Yes, we're planning on using Sparkleshare".
"Sparklewhat?"
"Sparkleshare, it's an open source product that ...."
"Look, we're here to discuss corporate data strategy, not your daughter's favorite website".
As a physician, I constantly tell patients not to do things (or to do other things). Does that help? Not usually.
Why do I persist in doing it? Not sure. There's a quote about that around here somewhere. Something about insanity....
Amateur.
What are we supposed to do with all this tin foil until then?
Last month or so? What happened - did you sober up or something?
Business As Usual. Nothing to see here, comrade. Move along, please.
Remember, doesn't mean 'getting better' or 'improving' - it only means 'dealing with local conditions most effectively'.
Oh. Wait.
If you trust ANY advertising / marketing company, you're in for a world of hurt.
Yep, Nokia got caught on that one but it's just One More Lie. Why it was only yesterday, I believe, that Google was caught hiding the USB power cord on the Chromedealywhopper thing.
And let's not get started about Apple. Or Microsoft. Or Lotus Notes (god, let's NOT get started on Lotus Notes).
No problems parsing the headline. However, my twisted mental faculties imagined things much more entertaining than what eventually played out.....
I basically don't get it. The Navy has developed a new test for Influenza that (apparently) doesn't need the typical surface markers that other tests do. Cool. But TFA just drops that and wanders around the US government's attempt at creating a more unified / functional bio-surveillance program but then complains we don't have the money or expertise to do it.
OK. Fine. Another first world Problem.
I'd like to know more about the test. I'm well aware of the Government's inability to organize anything more complex than an egg coloring contest.