Well the big deal is that they 'errors' are not simple transcription errors (at least that's one way to view the data). Something else is mucking with the transcript that, according to the 'Central Dogma' shouldn't be there.
And yes, the old Central Dogma is getting a bit frayed at the edges given all the newfangled RNAs they seem to discover monthly. That's the fun part.
The weird thing (from TFA) is that the imperfections aren't we're they're 'supposed' to be.And there are too many of them.
Robin Egg's analogy is pretty good. Let me try a car analogy: You're in a BMW factory, on the input side, all the instructions and parts are geared towards making BMWs - maybe different colors, different hood ornaments or whatever.
Out pop some BMW's as expected. And a couple of Yugos.
Well, no, that's not right. Go with the baking analogy.
No, the big thing about this (if indeed it holds up) is that the fidelity is much, much lower than expected. It doesn't seem that the mRNAs are miscoding (although it's possible) it seems that the coding is being jiggered with by other factors.
However, this is a statistical analysis of a number of genomes and the original genome coding teams warns that the precision of the decode may not be enough to warrant TFA's (tentative) conclusion.
But it's interesting and exciting. Stay tuned. Beats politics.
Well, no one is planning on grazing off huge chunks of skin to create some blood for a transfusion.... The problem is that these converted cells don't grow well in cell culture. That's not unusual at all - most random non cancerous cells don't grow in tissue culture medium well since a large part of the cell control circuitry is all about having the cell NOT grow randomly (ie, turning into a cancer cell).
As the Nature article mentions, this is just the very beginning of the research into doing anything 'useful'. It's now more interesting to demonstrate that we have the technology to create a specialized cell line (blood forming cells) from another specialized cell line (skin cells) without going through the full blown 'stem cell' routine.
The ability to manipulate cell lineages at will is going to be huge. As long as there are no real gotchas like triggering cancers everywhere (a distinct possibility) it will likely herald the creation of implantable organs, grafts and whatnot.
But it's going to take a while longer. Don't burn your liver or brain out just yet.
One of my biggest complaints against conservatives is that they never really talk about exactly what they want to cut. Assuming that we take recent Sunday morning statements at face value, defense, medicare, and social security are not being considered as targets. What does that leave?
Unfortunately, this liberal approach leaves them a bit unprepared to deal with "uppity" neighbors.
No problem, really. All Costa Rica needs to do is align itself with Google (maybe just drop XP and Office, pick up Google Docs). Snuggle up to Sergey, maybe give the Google Air Force a special hanger or two (Really Sergey, both a 757 and a 767??). One false move and Nicaragua is just offline....
Slashdot Mirror
Whoosh.
Look at this guys: Everybody who wants "simple searches' has at most a 5 digit UID, mostly 3 and 4 digit.
The nurses must be late with the AM meds again.
I really wish Slashdot would create a preview option.
How to say this gently?
It's just to the right of "Quote Parent".
Maybe some new glasses? Coffee?
Wrong date. November 9 is today, not last night.
Hah. You think last night was interesting.
Just you wait...
We know where it came from. Just because you don't isn't a problem.
Signed,
Your Overlords
I'm sorry, my ability to keep reading, without giggling, after seeing this is basically nonexistent...
sez Mr. "Jockeys".
Sounds like you have some issues there buddy.
We have always been at war with the Registry.
That's right. It's funny, most of the posters (who don't appear to be of the biological persuasion) really aren't getting this.
I'm gonna have to work on the car analogy a bit longer.
Well the big deal is that they 'errors' are not simple transcription errors (at least that's one way to view the data). Something else is mucking with the transcript that, according to the 'Central Dogma' shouldn't be there.
And yes, the old Central Dogma is getting a bit frayed at the edges given all the newfangled RNAs they seem to discover monthly. That's the fun part.
NOBODY THOUGHT IT WAS PERFECT
The weird thing (from TFA) is that the imperfections aren't we're they're 'supposed' to be.And there are too many of them.
Robin Egg's analogy is pretty good. Let me try a car analogy: You're in a BMW factory, on the input side, all the instructions and parts are geared towards making BMWs - maybe different colors, different hood ornaments or whatever.
Out pop some BMW's as expected. And a couple of Yugos.
Well, no, that's not right. Go with the baking analogy.
(I so wanted to start the post that way)
No, the big thing about this (if indeed it holds up) is that the fidelity is much, much lower than expected. It doesn't seem that the mRNAs are miscoding (although it's possible) it seems that the coding is being jiggered with by other factors.
However, this is a statistical analysis of a number of genomes and the original genome coding teams warns that the precision of the decode may not be enough to warrant TFA's (tentative) conclusion.
But it's interesting and exciting. Stay tuned. Beats politics.
out of the millions of objects and packages people make and use, printer cartidges are the only ones of the right shape and size to hold explosives.
Nope, there are other dangerous things that are currently prohibited.
According to my notes Time Enough For Love - one of his later / crazier (ie. Batshit insane) books.
Am I dead?
Look around you. See any fjords?
Is time stretching out as we all are hurtling towards the centre of singularity?
No, you're just stoned. Relax, things will settle down in a bit.
Men rarely (if ever) manage to dream up a god superior to themselves. Most gods have the manners and morals of a spoiled child.
R. A. Heinlein
Well, no one is planning on grazing off huge chunks of skin to create some blood for a transfusion.... The problem is that these converted cells don't grow well in cell culture. That's not unusual at all - most random non cancerous cells don't grow in tissue culture medium well since a large part of the cell control circuitry is all about having the cell NOT grow randomly (ie, turning into a cancer cell).
As the Nature article mentions, this is just the very beginning of the research into doing anything 'useful'. It's now more interesting to demonstrate that we have the technology to create a specialized cell line (blood forming cells) from another specialized cell line (skin cells) without going through the full blown 'stem cell' routine.
The ability to manipulate cell lineages at will is going to be huge. As long as there are no real gotchas like triggering cancers everywhere (a distinct possibility) it will likely herald the creation of implantable organs, grafts and whatnot.
But it's going to take a while longer. Don't burn your liver or brain out just yet.
Secret propulsion system.
Rather like this picture?
"I love the smell of napalm in the morning... The smell, you know that gasoline smell... Smells like, victory"
Falafel is for wimps.
Oops, sorry, a real link.
No, no, no. No even wrong. However, the idiot FA is so devoid of information that yours is a reasonable assumption. A better intro.
Useless note to Slashdot editors: Stay away from University PR Blurbs. A bigger waste of electrons than Fox News.
One of my biggest complaints against conservatives is that they never really talk about exactly what they want to cut. Assuming that we take recent Sunday morning statements at face value, defense, medicare, and social security are not being considered as targets. What does that leave?
Your salary, comrade. Hand it over, please.
Didn't that lead to a hospital being targeted and destroyed?
Nope, they went there to rescue some medical students. They picked up some heavier resistance than expected, but didn't blow up a hospital.
Unfortunately, this liberal approach leaves them a bit unprepared to deal with "uppity" neighbors.
No problem, really. All Costa Rica needs to do is align itself with Google (maybe just drop XP and Office, pick up Google Docs). Snuggle up to Sergey, maybe give the Google Air Force a special hanger or two (Really Sergey, both a 757 and a 767??). One false move and Nicaragua is just offline....
This is the 21st Century, folks.
The only way to keep it fair is to keep it symmetrical. They are either acceptable to use in a public space by anyone, or they are not.
What exactly are you saying? That the TSA staff should run around naked? Have you actually been to an airport in the last decade?
I'm not sure I want to continue this conversation....
Not to mention that these products have been on the market for quite some time now. Timer + variable light control = ?profit.
They do seem to work somewhat but nothing to see here, move along.