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A team of Canadian scientists has developed a fascinating new experimental drug that is purported to result in rapid improvements to both mood and memory following extensive animal testing. It's hoped the drug will move to human trials within the next two years. New Atlas reports: Gamma-aminobutyric acid (GABA) is a key neurotransmitter, and when altered it can play a role in the development of everything from psychiatric conditions to cognitive degeneration. Benzodiazepines, such as Xanax or Valium, are a class of drugs well known to function by modulating the brain's GABA systems. This new research describes the development of several new molecules that are structurally based on benzodiazepines, but with small tweaks to enhance their ability to specifically target certain brain areas. The goal was to create a new therapeutic agent that can effectively combat age-related mood and memory alterations caused by disruptions in the GABA systems.

In animal tests the drug has been found to be remarkably effective, with old mice displaying rapid improvements in memory tests within an hour of administration, resulting in performance similar to that of young mice. Daily administration of the drug over two months was also seen to result in an actual structural regrowth of brain cells, returning their brains to a state that resembles a young animal. The new study was published in the journal Molecular Neuropsychiatry.

A Portland man appears to have a pill-sized camera stuck in his gut. That man is me... Let me explain.

For the average Joe, the following statement might sound a bit peculiar: I have swallowed a pill-sized camera a number of times. You see, I have Crohn's Disease (CD) in the small intestine -- a 20 foot-long portion of the gastrointestinal tract that runs between the stomach and the large intestine (colon). A "PillCam" is the most non-invasive, detailed method to survey this area as it doesn't require a scope up the rectum or down the esophagus, nor does it require any tissue slicing. It's also one of the safest procedures available -- the retention rate is as low as 1%. Unfortunately, this most recent capsule endoscopy resulted in my admission to the 1% club.

On March 27th, 2018, I swallowed the PillCam that is currently lodged in my small intestine. If you do the math, that's more than 82 days ago (over 12 weeks). After hiking Smith Rock and summiting Black Butte a couple weeks later, I thought for sure the pill would have exited. It didn't, as evident by the follow-up X-ray. It can be difficult to find research on such a what-if scenario that happens to so few, but I did manage to find a Motherboard article telling the story of Scott Willis, a CD patient that had a PillCam lodged in his gut for eight weeks. One of the key differences between him and me is that he had a partial block and endured more symptoms, prompting him to schedule a procedure to get it out quicker. I'm relatively symptom free.

We have tried upping the dose of corticosteroids to reduce inflammation and help the pill pass through the strictured areas, but that didn't seem to work. Most recently, I had two double-balloon enteroscopy procedures done within a week apart. They were able to locate the PillCam during the second procedure, but weren't able to retrieve it without risking the scope itself becoming stuck. The next step is to try again via the esophagus. The potential issue/complication here is the location. As my doctors warned, the PillCam is stuck 15 feet down and the scope is only 20 feet in length. There's little wiggle room if the pill is slightly further down the GI tract than estimated.

I am sharing this story with the Slashdot community for two reasons. First, those entrenched in the world of cyborgs and/or modern-day medical procedures may find this experience particularly interesting. Second, the more people who know about the procedures and complications of Crohn's Disease the better. For those interested, I'll update this post after the next procedure. Have you or someone you know experienced a capsule endoscopy? Please share what you feel comfortable with.

UPDATE 7/11/18: Yesterday, I had the procedure to remove the PillCam via the esophagus and it wasn't successful. The doctor said he tried everything he could to retrieve it but the scope wasn't quite long enough to reach the pill. I'll be talking with a surgeon next week and will update this post when a surgery date is confirmed.

Artem Tashkinov shares a report from Medical Xpress: Antidepressant medications, most commonly prescribed to reduce depression and anxiety, increase the risk of death, according to new findings by a McMaster-led team of researchers. It's widely known that brain serotonin affects mood, and that most commonly used antidepressant treatment for depression blocks the absorption of serotonin by neurons. It is less widely known, though, that all the major organs of the body -- the heart, kidneys, lungs, liver -- use serotonin from the bloodstream. Antidepressants block the absorption of serotonin in these organs as well, and the researchers warn that antidepressants could increase the risk of death by preventing multiple organs from functioning properly.

Interestingly, the news about antidepressants is not all bad. The researchers found that antidepressants are not harmful for people with cardiovascular diseases such as heart disease and diabetes. This makes sense since these antidepressants have blood-thinning effects that are useful in treating such disorders. Unfortunately, this also means that for most people who are in otherwise good cardiovascular health, antidepressants tend to be harmful. The study has been published in the journal Psychotherapy and Psychosomatics.