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New Drug Rapidly Repairs Age-Related Memory Loss, Improves Mood (newatlas.com)
A team of Canadian scientists has developed a fascinating new experimental drug that is purported to result in rapid improvements to both mood and memory following extensive animal testing. It's hoped the drug will move to human trials within the next two years. New Atlas reports: Gamma-aminobutyric acid (GABA) is a key neurotransmitter, and when altered it can play a role in the development of everything from psychiatric conditions to cognitive degeneration. Benzodiazepines, such as Xanax or Valium, are a class of drugs well known to function by modulating the brain's GABA systems. This new research describes the development of several new molecules that are structurally based on benzodiazepines, but with small tweaks to enhance their ability to specifically target certain brain areas. The goal was to create a new therapeutic agent that can effectively combat age-related mood and memory alterations caused by disruptions in the GABA systems.
In animal tests the drug has been found to be remarkably effective, with old mice displaying rapid improvements in memory tests within an hour of administration, resulting in performance similar to that of young mice. Daily administration of the drug over two months was also seen to result in an actual structural regrowth of brain cells, returning their brains to a state that resembles a young animal. The new study was published in the journal Molecular Neuropsychiatry.
In animal tests the drug has been found to be remarkably effective, with old mice displaying rapid improvements in memory tests within an hour of administration, resulting in performance similar to that of young mice. Daily administration of the drug over two months was also seen to result in an actual structural regrowth of brain cells, returning their brains to a state that resembles a young animal. The new study was published in the journal Molecular Neuropsychiatry.
They've invented cocaine1
Weed? Doesn't weed do this?
Like, how long does it last, and, oh by the way, how much will they charge for a dose?
"Get it off my lawn"
how much will they charge for a dose?
How much do you have?
What were we talking about?
They say that memory is the second thing to go when you get older. I can't remember the first thing.
Getting old sux.
Here's the paper abstract:
Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric disorders, normal aging, and neurodegenerative disorders and reduced function of GABA interneurons is associated with both mood and cognitive symptoms. Benzodiazepines (BZ) have broad anxiolytic, but also sedative, anticonvulsant and amnesic effects, due to nonspecific GABA-A receptor (GABAA-R) targeting. Varying the profile of activity of BZs at GABAA-Rs is predicted to uncover additional therapeutic potential. We synthesized four novel imidazobenzodiazepine (IBZD) amide ligands and tested them for positive allosteric modulation at multiple α-GABAA-R (α-positive allosteric modulators), pharmacokinetic properties, as well as anxiolytic and antidepressant activities in adult mice. Efficacy at reversing stress-induced or age-related working memory deficits was assessed using a spontaneous alternation task. Diazepam (DZP) was used as a control. Three ligands (GL-II-73, GL-II-74, and GL-II-75) demonstrated adequate brain penetration and showed predictive anxiolytic and antidepressant efficacies. GL-II-73 and GL-II-75 significantly reversed stress-induced and age-related working memory deficits. In contrast, DZP displayed anxiolytic but no antidepressant effects or effects on working memory. We demonstrate distinct profiles of anxiolytic, antidepressant, and/or pro-cognitive activities of newly designed IBZD amide ligands, suggesting novel therapeutic potential for IBZD derivatives in depression and aging.
Bruce Perens.
If this new drug helped to reverse the effects of long-term alcohol abuse, millions of people would benefit.
So they patented a GHB analogue ? Ho hum.
They only banned GHB at the behest of the liquor industry and the narco warrior zealots. They called it a date rape drug when it was rohypnol, a prescription drug that was actually the substance being used. Cops used to take GHB as an alternative to drinking alcohol because it wouldn't interfere with their steroids or lower their testosterone levels. Both of which were legal for personal use in Canada.
This article is by a subset of the authors and seems to be about the same molecules.
Bruce Perens.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219542/ = you don't know what you're talking about.
So I actually looked at the paper and they're still mucking about with benzodiazepines that have a stronger action on GABA. Its like forcing a square peg into a round hole. I suppose it's necessary for patentability reasons, but GHB analogues/homologues and derivatives are better suited for the job, even if there's no money in them for big pharma.
Use some viagra or cialis and you will remember what is the first thing.
Canadians, they'll practically give it away and a US company will swoop in with a similar patent and gouge everyone while burying anyone who tries to make the low cost version.
Big Science just keeps on finding ways to make their lifespans longer and better!
and then you never hear about it again, i bet the government and the financial elite buy it and then make it disappear so nobody can use it except them, leaving the wider world to just do without
Politics is Treachery, Religion is Brainwashing
Can we pick which young animal we will resemble?
Quick, send some of this to every internet user, stat!
"There is more worth loving than we have strength to love." - Brian Jay Stanley
is it multiple choice?
GLeeMONEX?
And preferably hold his head under till the bubbles stop.
Once again, our esteemed senior /. editor BeauHD posts another dubious brain altering article. He seems to have a fixation on this topic, perhaps he feels mentally inadequate in some way?
The CIA tried LSD. The Hell's Angels tried Meth. Others have tried speed. All have failed miserably. There is no such thing as the "perfect drug." I highly doubt this latest drug won't have terrible side effects just like all the others in the past.
BeauHD - get some help dude. It's okay to be less than average. Trying to "fix" things often makes things worse. Just be happy with who God created you to be.
Is that you?
https://med.stanford.edu/sbfnl...
Y Maze Spontaneous Alternation Test
Y Maze Spontaneous Alternation is a behavioral test for measuring the willingness of rodents to explore new environments. Rodents typically prefer to investigate a new arm of the maze rather than returning to one that was previously visited. Many parts of the brain--including the hippocampus, septum, basal forebrain, and prefrontal cortex--are involved in this task.
Testing occurs in a Y-shaped maze with three white, opaque plastic arms at a 120Â angle from each other. After introduction to the center of the maze, the animal is allowed to freely explore the three arms. Over the course of multiple arm entries, the subject should show a tendency to enter a less recently visited arm. The number of arm entries and the number of triads are recorded in order to calculate the percentage of alternation. An entry occurs when all four limbs are within the arm. This test is used to quantify cognitive deficits in transgenic strains of mice and evaluate novel chemical entities for their effects on cognition.
Mit der Dummheit kämpfen Götter selbst vergebens
When the rodents replace us, they'll look back on the age when Homo sapiens invested massive effort to make them immortal with some perplexity. Why did we do it?
Which reminds me; would someone put some flowers on Algernon's grave for me?
Don't worry, if you're in the USA you can't afford this drug. It's for the rest of the world only, because we have the greatest system in the world that nobody can afford.
Even fucking Rand Paul goes to Canada for health care.
You are welcome on my lawn.
that a volunteer, identified only as "Charlie", has been recruited to be the first human trial subject. https://en.wikipedia.org/wiki/...
I've been on my own GABA influencer journey and wanted to mention an already easy to get substance, at least outside of Russia where it is a prescription only substance, that I'm 99% sure many people take already with great effect. And that it also focuses on the same GABA alpha receptors like they mention targeting in the paper, though the paper's substance is attempting to be selective about where they trigger things. Most GABA alpha items are used for anxiety, at least when given out by prescription. GABA itself is a relaxing/calming neurotransmitter.
Phenibut is pretty cheap, seemingly safe at high doses (yes people take WAY more than the typical prescription dose used in Russia for fun), and the way people talk about it I think it can have some of the same effects as the goal of this new substance when used in moderation. Phenibut doesn't only affect GABA, but seems to release a bit of Dopamine too...the reward chemical.
For a more global GABA increaser for the brain...Inositol. Taking GABA won't get into your brain because it doesn't pass through the blood brain barrier easily. Inositol definitely calms me initially, and makes me more ready for sleep. It was originally misclassified as a B vitamin, and is generally safe up to really huge doses. I've read 6-12g/day is a typical dose for anxiety. I can't seem to stomach more than a gram a day, and I'm getting lots of nausea and other side effects. So not my "magic bullet" solution. But it's another cheap, safe option for GABA manipulation/influence.
I'm not advocating anything here. Please research anything you put in your body. And yes, you can hurt yourself if you take too much phenibut. Or if you take too much for too long, your body will start to downregulate those receptors and you won't get the same effects. And stopping suddenly will be VERY uncomfortable from what I read.
But many people already use GABA beta substances daily (alcohol). The alpha vs. beta refer to a fast vs. slow change substance, as I've understood it. The alpha receptor is designed to react quickly to changing levels of triggers (agonists). The beta, much more slowly. Hence how large a dose of alcohol we need before we can feel it (comparatively), compared to a pill like typical benzodiazepines.
And one of the reasons healthy eating helps calm us is the probiotic organisms we'd be encouraging create GABA in our guts for us. Those eat fiber and other things, are killed off by alcohol, and generate GABA and many other helpful substances we cannot. This is one of the reasons that changes in gut flora is so scary/bad for many people.
For those curious to read more...Google it, :D. There are tons of articles and reddit posts on experiences, and safe places to order from. Below is a wikipedia article on the two GABA receptor types as I'm sure I'm not explaining it all well.
https://en.wikipedia.org/wiki/...
Could you please, next time, put the really important info into the title? "New Drug Rapidly Repairs Age-Related Memory Loss, Improves Mood *in Mice*. Thank you.
You can have something similar right now, it is called phenibut. It is not very expensive.
"It's such a fine line between stupid and clever" -- David St. Hubbins, Spinal Tap
> Taking GABA won't get into your brain because it doesn't pass through the blood brain barrier easily.
> And one of the reasons healthy eating helps calm us is the probiotic organisms we'd be encouraging create GABA in our guts for us. Those eat fiber and other things, are killed off by alcohol, and generate GABA and many other helpful substances we cannot.
Those two sentences are mutually exclusive.
Excellent find, bravo!
I've a real problem with grumpy mice. The only thing saving us is that when they go out they forget where they live.
Phenibut can cause some nasty withdrawl.
GABA can kill you. It works as a roofie afaik. A bit too much and you can die.
Benzodiazepines are already the next and worse epidemic. Will the withdrawal include seizures like benzos when patients can't get anymore?
You can't remember the first thing? I'll give you a hint: It's the thing that hurts now but didn't hurt when you were 30.
Velociraptor = Distiraptor / Timeraptor
55yo male here. a few years ago i started having 'senior moments' where i could not remember/voice things that i knew i knew. this went on for months and i was seriously freaked about my time in the SW industry having gone past some kind of biological expiration date.
I wound up changing my diet so as to get ~50% of my calories from saturated fats and as a result, an unexpected benefit appeared within a few days of transitioning to a better fuel: the memory retrieval fails disappeared. within a year the initially disgusting fatty diet became my new normal. i have 2+ addtl hours of energy every day, need to sleep less and am lean and never hungry, never any low blood-sugar or concentration or fatigue issues.
after 2 years of slapping butter on everything, dropping all carbs except greens and the occasional drink, i've remembered and let go of personal history stories and things that clogged my brain and can literally tell you everything i ate and did for the last month, in reverse order, day by day. i have continuation on people i meet at work to the point that i can tell what they were wearing .. and overall need far fewer bookmarks than i did in the past.
i have some excellent work-habits and ymmv, but if you clicked this post to see if the meds mentioned were something for you and found that you could not get them, perhaps you'll do some research into the experiences of people who've transitioned away from sugar into the land of saturated fats for fuel. perhaps just dropping all sugars will do it for you; for me, i enjoy the no strain/pain/tiredness aspects of the anti-inflammatory effects this provides me with.
know that your gall-bladder is likely not working optimally when you start taking in more fats -- which will lead to you having 2..3 days of non-fever fog-head/flu-like symptoms as you start eating better. its not a big deal and it will pass quickly if you just suffer through it.
a steady marker for being in the 'proper fat' zone is that you will (as i and some friends have found) suddenly develop a taste for water ~20mins after eating. i find that's the only regulator i need. if i messed up by eating socially that thirst won't be there and i'll need to snack on some unsalted butter to get it back. calories are not a concern for me at all. looking down i can see my pubes unambiguously. that wasn't the case before.
in any case, if you too have discovered what a 'senior moment' is and if you don't enjoy them either, get smart, learn a bit about fat and oils, and feed your body-mind with fuels like butter that are good for many many hours while not moving the needle on your blood-sugar at all.
within some weeks you too might realize that you have zero cravings or desire for sweets. none. which is weird and will startle some people socially. just tell them you prefer honey. i use that along with a good cm of 40% cream in my coffee for a no jitter coffee experience. perhaps start with a few days of that while you research the rest.
phew, that got long. may it profit you too!
(this stream of consciousness after a 12hr workday at the end of a 6 day week. now i'm off to go dancing!)
Won't do any good. I'll never remember to take it.
The opioid crisis has caused politicians, and hence doctors, to become extremely skiddish about anything that produces euphoria, regardless of how helpful it might be for patients. People love easy answers to complicated problems, so prohibition and paternalism are the watchwords here.
If you aren't already, try taking inositol with a meal.
Contribute to civilization: ari.aynrand.org/donate
Thanks. Nope, I actually have a pretty strong stomach normally (take tons of pills daily, empty stomach or not) so hadn't thought about taking it with food before.
I think simultaneous glutamine powder (just before bed) wasn't helping either (I've read muscles and our intestines can repair better with enough glutamine). Apparently we turn glutamine into glutamate, which is a stimulant in our brains...kept me awake a couple times much later than planned. Guessing it made me a little nauseous too.