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Domain: millipore.com

Stories and comments across the archive that link to millipore.com.

Comments · 7

  1. Re:I wonder how many people will just try it/ by YttriumOxide · · Score: 1 · on New Drug Mimics the Beneficial Effects of Exercise

    Like anything else, you can just buy it over the internet:

    http://www.millipore.com/catalogue/item/554726-25MG?cid=bios-C-epdf-1032-1302-RC

    Rather expensive for a useful dose though... To quote from that page (emphasis mine):

    A 7-day administration of SR9009 ( 100 mg/kg , i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern.

    So, 100mg/kg at $149 per 25mg, comes to $596 per kg; or around $350000 for a typical person taking a one week course...

    Obviously, after the research is done, if it's a marketable product, they'll sell it significantly cheaper than this; but at these prices, there's no realistic way for any normal person to buy it in quantities that will have a useful/noticeable effect on them (which is also probably deliberate since they make quite a point of stating it's not intended for use in people).

  2. Re:This can't end well by reverseengineer · · Score: 4, Informative · on New Drug Mimics the Beneficial Effects of Exercise

    SR9009 is available for research purposes, $150 for 25 mg. From the structure, I would say it's likely to be only slightly soluble in water; also, the only solubility data given is in DMSO. It requires storage by refrigeration or freezing, and comes packaged under inert gas, so I would say its environmental persistence would be rather low. I don't know if a molecule like this would be stable enough for oral administration, actually. In their mouse study, injections were made.

  3. I wonder how many people will just try it/ by ezrec · · Score: 1 · on New Drug Mimics the Beneficial Effects of Exercise

    Like anything else, you can just buy it over the internet:

    http://www.millipore.com/catalogue/item/554726-25MG?cid=bios-C-epdf-1032-1302-RC

  4. 20 nm Virus Filtration is a Tough Problem by mkcheme · · Score: 2 · on "Lifesaver Bottle" Filters Viruses Out of Water
    Being a bit of a nerd in the area of virus filtration, I thought I'd pipe up.

    This is a very bold claim. Commercial virus filters that are in the ~20 nm pore size rating tend to have capacities measured in the hundreds of liters per square meter (1 m^2 = 10 ft^2)--even with very clean feed streams seen in the biotech industry--and cost anywhere from $3000 to $6000 for the same amount of area. They are also difficult to clean and difficult to protect with pre-filters because the crap that plugs them can be much smaller than the pore size of the filters (material can deposit on the inside of the pore walls).

    Throughput can be improved by operating in a tangential flow mode (flow sweeping past the membrane surface to avoid junk build-up), but this isn't a straightforward way to operate a filter bottle.

    I have significant doubts about these claims. The more so because this page is completely blank. They don't even give reduction values for the particles they claim to remove. 90% would be very poor performance...99.99% is wher eit ought to be. How do they validate the pore size of the membrane (integrity test)? Many questions, 0 answers.

  5. Re:Not right! by SilverspurG · · Score: 1 · on Violating A Patent As Moral Choice
    I suppose you think that your little avian quip has wings?
    GS4071 (the active metabolite of oseltamivir) inhibited viral replication in MDCK cells
    MDCK cells are canine kidney cells.
    7.5-12 microM) and neuraminidase activity
    If you search protein databanks there are dozens of different neuraminidases. You've shown nothing to support that a mouse neuraminidase has an active site even close to that of the overly hyped mutated bird flu neuraminidase. It's likely that bird neuraminidases and human neuraminidases differ significantly. As an example, even the human strain of Hepatitis C has 6 different NS5b RNAases distributed across the world's population.
    GS4104 prevented death of mice infected with A/Hong Kong/156/97 (H5N1), mouse-adapted A/Quail/Hong Kong/G1/97 (H9N2), or human A/Hong Kong/1074/99 (H9N2) viruses
    Funny. No mention of a bird strain anywhere.
    and prevented the spread of virus to the brain of mice infected with A/Hong Kong/156/97 (H5N1) and mouse-adapted A/Quail/Hong Kong/G1/97 (H9N2) viruses
    Mouse adapted, huh? Can we get some human adapted bird strains so that this is actually relevent?
    in combination with rimantadine (1 mg/kg per day) reduced the number of deaths of mice
    The current hype is about the possibility of a bird strain adapting to humans. I'm not sure that inhibiting the deaths of mice using a product proven to inhibit a mouse neuraminidase makes any difference.
    Thus, GS4104 is efficacious in treating infections caused by H5N1 and H9N2 influenza viruses in mice.
    Oh look. It says MICE.

    Sit down already. You obviously can't fly. You don't even have a leg to stand on.
  6. Only 0.02 um? by mkcheme · · Score: 2, Interesting · on Would You Drink This Water?

    As a biopharm engineer, I don't trust anything more open than a 200-300 kDa filter (about 10-15 nm) to clear all viruses by size excplusion. [/shameless plug] ;-)

  7. Re:Where's biotech? -- it's all about the ChemE! by Anonymous Coward · · Score: 0 · on IT (And Other) Salaries On The Rise In The U.S.

    A lot of the well-paid biotech people are Chemical Engineers. Since they get their own category, it drops the net biotech average. For something-bio-whatever people to make "good money," they are more likely to need an advanced degree than ChemE majors like me, otherwise they end up starting off as lab techs.

    My company pays its biotech-oriented ChemEs pretty well, though not as much as Genzyme/Genentech/Biogen/Amgen/Lonza/etc.