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Should DNA be Patentable?

nexex writes: "This story seems brings the patent debate home; specifically, should a company or person be able to 'own' your DNA? Obviously researchers want to profit from their discoveries, thus funding new research. But critics counter they are profitting at the expense of our health, citing restrive screening licenses for things such as breast cancer and Alzheimer's. Citing a figure from a UK activist group, 500,000 gene or gene sequence patents have been applied for worldwide. Another excellent article on this issue from Salon.com was from a couple years ago."

21 of 257 comments (clear)

  1. too late by dal3 · · Score: 3, Insightful

    If someone tries to patent my DNA, shouldn't I be able to provide them with lock of hair as an example of prior art?

  2. Patent AIDS, Herpes, Malaria... by Calle+Ballz · · Score: 4, Funny

    Put a patent and a copyright on the strands that make up diseases like AIDS, Herpes, Malaria & the common cold. I'm tired of catching a cold, and I sure as hell don't want to get any terminal diseases in the near future. If you think about it, DNA is really a kind of software, it is intellectual property that's been unclaimed. Well dammit someone should claim that IP and protect it's right to not be copied unless specifically authorized by the rightful owner and in compliance with the DMCA!

  3. Patenting therapies, not the gene by HEbGb · · Score: 5, Informative

    Two requirements of a patent are the existance of an 'inventive step' and another is 'novelty'.

    Patenting a gene itself (if that's what's done) is nothing more than patenting a transcription of an already-existing structure. It won't hold up - there is no novelty, and no invention - you're just writing down what already exists.

    However, an inventive, novel step could be the application of the knowledge contained in the gene for specific therapies which were developed. These can and are patented, and I don't see anything wrong with this.

    I think there's a common misconception that these companies are patenting genes themselves-I think that with few exception, this isn't the case - they're patenting applications of the knowledge to new therapies, much like someone who has studied the physiology of the body can patent a drug to treat an illness. You're not patenting the mechanism of the body, you're patenting a tool based on that knowledge.

    1. Re:Patenting therapies, not the gene by WillWare · · Score: 4, Insightful
      an inventive, novel step could be the application of the knowledge contained in the gene for specific therapies which were developed. These can and are patented, and I don't see anything wrong with this

      Patenting genes that occur in nature would be an obviously questionable practice, and it worries me that this issue has been kicking around unresolved for at least two years. But the thing you are describing here also worries me: it sounds like you're saying that the genetic information is properly unpatentable, but having sequenced it, I could apply for a patent controlling ANY useful application of that information. I would prefer to see patents limited to controlling a specific application of the information.

      But the obviously worst-case scenario would be where any fool could operate a sequencer for a couple weeks, and patent whatever he gets, regardless of whether an application is apparent at the time of filing.

      --
      WWJD for a Klondike Bar?
    2. Re:Patenting therapies, not the gene by the+gnat · · Score: 3, Interesting

      The highly indignant researcher from Penn was using a patented research tool which was very expensive to invent and perfect.

      See, this is what bugs me so much about scientific discussions on Slashdot- for every expert in the field, there's always one idiot who makes a forceful argument based on a complete lack of understanding.

      Anyway, you need to read up on DNA testing, PCR, gene expression, genome analysis, and gene finding. I'm guessing the genetic test the Penn researcher was doing was for a defective form of a certain gene- could be just a single polymorphism. This could be done from a simple tissue sample, probably, and wouldn't require use of Myriad's "invention" or "perfection". Anyone can get the proper homologous sequences for detection made up with the right amount of money- my university has it's own center for this.

      Secondly, gene finding is more a matter of hard work than of genius or innovation- hardly meeting the "non-obvious" requirement. There are many methods, but right now it could be as simple as this:

      - run a gene-finding program against the raw sequence
      - find matches to suspected genes in protein databases

      and in some cases you can have an almost certain functional identification of the given gene this way- and you can do it all by computer. This isn't like some super-drug that took teams of researchers years to synthesize, it's a natural product that's relatively easy to find and characterize, with a huge probability of multiple independent discovery.

      The real problem is that these genes aren't inventions at all- they are no more than discoveries, however much the biotech corps try to twist definitions. An invention might be something like a human-modified gene that when expressed yields a desireable product. But in this case the protein product would be the better target for a patent.

      This is the real indignity- biotechs aren't coming up with useful products, they're just patenting genes like mad in the hope of coming up with a product later. In the case that someone else independently makes a product, they're besieged by lawyers. Myriad couldn't come up with a use for their patented gene, but they're willing to sue a publically-funded researcher to prevent her from performing a valuable medical service that doesn't even require their data. They're parasites, pure and simple, and the single largest reason why we need projects like the HGP. I think the public research centers should begin patenting every new gene and licensing it free of charge, just to keep companies like Myriad from screwing real scientists.

  4. analogy? by cowscows · · Score: 3, Interesting

    If I discover a new comet, should any astronomer that wants to look at it through a telescope have to pay me royalties?

    It's rediculous. And that's an example of something that doesn't effect human health (Unless the comet is going to smash into earth I guess).

    I cannot see how this could be construed as anything other than choosing money over humanity. It's repulsive.

    --

    One time I threw a brick at a duck.

  5. Please understand.. by mindstrm · · Score: 4, Insightful

    They do not Patent DNA. They did not invent DNA.

    THey can patent specific genes for a specific purpose.

    So if they discover a gene that permits them to do something interesitng, like grow you a third arm... they can patent that.
    If they discover a gene that will make you smarter... they can patent that.

    They cannot patent genes until they have a use for them.

    1. Re:Please understand.. by sam_handelman · · Score: 5, Informative

      All of what you say is, or ought to be, true.

      However, Biotech companies are interpreting these patents in a very broad way, as you can see from the article.

      The more sophisticated the biotech you're trying to develop is, the more burdensome these low level, frankly not-very-clever patents become.

      By analogy in software, imagine how difficult it would have been to write Kazaa if quick sort, merge sort and the binary search were all patented. Supposing you needed all of them (and that bubble sort wouldn't do, but stay with me), you'd need to enter into negotations with each of three different parties who hold the patents, and get permission from each of them, before you could finish Kazaa. Now, Kazaa, even though it maps to the set of integers, is a legitimate achievement; the people who wrote it deserve protection of their coding investment. Merge Sort, while a cute idea, is NOT. There is a qualitative difference between the two.

      The biotech patents that are being issued are, likewise, so basic, and generated on such an industrial scale - companies just churn them out as fast as they can - that they are begining to hamper innovation.

      These biotech companies often won't enter into negotations about selling their intellectual property. They're flush with cash, by and large, and if they don't know what their property is worth, why would they sell it?

      When you're trying to develop something really new and sophisticated (the biotech equivalent of a complete piece of software) you may need literally dozens of tiny processes which someone has patented. Even if none of these patents will hold up in court, the risk that not one but several parties could sue you to defend their interests - usually in different jurisdictions! - makes the legal risks of implementing such a procedure prohibitive, even if none of these patents would really stand up in court.

      I have to add that Columbia university, where I am a graduate student, makes more money from patents (in particular one, rather basic, biotechnology patent) than any other University in the world, including the combined patent income of the Universities of California (my BS & BA are from UCSC). That money is what pays my stipend.

      --
      The good and new comes from no quarter where it is looked for, and is always something different from what is expected.
  6. Properties of Nature by Baldrson · · Score: 3, Insightful
    Properties of nature are not patentable. Specific applications of properties of nature are patentable.

    Patents that attempt to cover general applicability of properties of nature are invalid and the courts that uphold such patents in error.

  7. For shame by Digitalia · · Score: 3, Insightful

    I always assumed that a patent was intended to cover a new or uniquely contrived object. Were these geneticists to be patenting recombinant DNA, I would be alright. When they begin to patent DNA that they discover, it becomes a travesty of science. Not only do they have no rights to that DNA, but it impedes scientific progress. Of course, most modern geneticists aren't working for the benefit of man. Some work for their own good first and last, Monsanto, while others work for their own good first but hope to benefit civilization in the process. Even academic research is beginning to fall under the latter category. In both examples, progress is stifled by greed and gluttony.

    --
    Pax Digitalia
  8. My position by MarkusQ · · Score: 3, Insightful
    Digital information should not be patentable, period.

    The space of all-possible-digital-information maps directly onto the space of integers. Asking for a patent on a chunk of digital information (DNA, object code, what have you) is the same as asking for a patent on an integer. The claim that "oh, but it's a very large integer" is specious. Patents are for inventions not facts-of-math.

    Copyright is only slightly more reasonable.

    -- MarkusQ

  9. Open Source by DeadBugs · · Score: 4, Funny

    I am releasing my DNA under the GPL license.

    --
    http://www.kubuntu.org/
    1. Re:Open Source by pyramid+termite · · Score: 3, Funny

      I am releasing my DNA under the GPL license.

      My wife's patented mine with a marriage license.

    2. Re:Open Source by Bios_Hakr · · Score: 3, Funny

      More of a license to your copyrighted material. I'm guessing that exposure of said copyrighted material to a third party is grounds for termination of beforementioned license.

      --
      I'd rather you do it wrong, than for me to have to do it at all.
  10. Legal argument for why genes are patentable by TekkonKinkreet · · Score: 5, Informative

    Caveats:
    a) I know nothing about genetics or law myself. I learned all this from the genetics law expert I sat next to on a plane last week.
    b)The duration of the explanation was part of a flight from Salt Lake to Seattle
    c) I had a first class upgrade and took full advantage of the free Heinekens. That is to say, I hope I'm remembering this right.

    Goes like this. It's illegal to patent an object, right? But a sequence of DNA in addition to containing the gene you're interested in, is always full of random and irrelevant pairs. So what they want to patent is not the gene as it naturally occurs, with all the junk DNA in it, but a cleaned-up version containing only those bits which are relevant to the patent. This is not a naturally occuring sequence, and so is patentable. So to answer the fellow who says "wait, I have that gene, every cell of me is prior art," no, you don't have that exact gene, yours contains different randomness. Yes, this sounds like a legalistic dodge to me too, and the expert acknowleged the point, but there it is.

    A further wrinkle is that they patent the transcriptase necessary to make the cleaned-up gene, not the gene itself, though I had a sufficient buzz by that point in the conversation that I was ready to talk about football. :)

  11. Things that belong to "MANKIND" by erroneus · · Score: 3, Interesting

    I think at some point, an international summit for "Things that belong to mankind" should be held and agreed upon.

    Profit at the expense of public health has always been considered "wrong." But this is generally when it's a company unwilling to keep the air, water or land clean and safe for human habitation. But in cases such as patented AIDS drugs being suppressed when a far greater good could be served?

    When mankind cannot 'afford' to be healthy or to survive, there is something very BROKEN in the way we are thinking. I'm not a communist, but get real... should one person DIE simply because he can't afford to live? It's all around us and no one is willing to say I'm wrong about that. But who is willing to actually step up to the plate and actually give to mankind rather than profit from its needs?

  12. patentable only if by Alien54 · · Score: 4, Insightful
    DNA should be patentable only if

    they can document the functionality down to the level that computer code is now

    The functionality is one that is not previously existing or discovered in nature.

    a unique combination of features where the majority of the code is new work. The thought here is that Ford company probably could not patent a new engine unless they owned the patents on the component parts and technologies. But there are an indefinite number of ways to build car engines.

    Thus one probably could not patent a fire breathing dragon, but could patent the various implementations of the various subsystems.

    patenting huge random chunks of DNA, hoping that something practical will come out of it is not the way to go.

    --
    "It is a greater offense to steal men's labor, than their clothes"
  13. Comment removed by account_deleted · · Score: 3, Insightful

    Comment removed based on user account deletion

  14. For a more detailed explanation... by Alik · · Score: 3, Informative

    There's a primer on gene patents (PDF file) that I wrote about a year ago. It explains the generally-accepted patent criteria and how genetic material has been interpreted to meet those criteria. The arguments for and against patentability of genes are presented, although the bias is against strict patentability; my personal viewpoint is that applications of genetic information are fair game, but the raw sequence itself should be off-limits.

  15. Patented Genes in Agriculture by gotan · · Score: 3, Interesting

    Patenting genes seems to be common business practice in agriculture. Patented rice and grain seeds with special properties (like resistance to a specific herbicide) are sold all over the world already to Farmers more or less licensing the stuff. There are some problems with this aproach:

    How can we be sure that the patented genes really came out of some laboratory, and were not found in some countries where people already knew about the specific properties of the stuff (maybe because they cultivated it over thousands of years). Some corporations are accused of doing just that with rice varieteys in 3rd world countries (where the farmers probably couldn't even pay the flight to USA, when dragged before a court there). We haven't even begun to catalog all species on earth, let alone their genetic diversifications, but maybe there should be a puplicly accessible database of genetic material from particularly successful or common crop sorts all over the world that are not yet patented, to be able to prove prior art.

    Another problem is, that unlike music, films, books, software and whatnot life has it's own builtin copy-mechanism, in fact, once it's out it's sometimes hard to stop it from replicating or crossing borders. I remember a case, where a Farmer had to pay license fees, because grain from seeds his neighbour (who had planted patented stuff) blew on his fields and grew there. How could that man have prevented that, short of burning down his own corn? We already know to what ends the rights holders struggle for getting each and every use of IP paid led us in the case of copyrights. What will we see now? Genes with builtin DRM schemes (like if you don't spray your crop with a specific shortlived virus it won't survive the next month)?
    --

    --
    "By the way if anyone here is in advertising or marketing... kill yourself." -- Bill Hicks
  16. The dangers of terminology. by caduguid · · Score: 3, Insightful

    Notwithstanding the fact that your point was funny, you give a great example of why it's dangerous and unfortunate that we apply the vocabulary of physical property to the concept of "intellectual property".

    it is intellectual property that's been unclaimed

    ...as if intellectual property is part of a landscape you want to stake your claim to, instead of being part of the creative process. Sigh. If only we could discuss it differently, as a means instead of an end, or a journey more than a destination.