Slashdot Mirror


Genetically Modified Mouthwashing Bacteria

Moxen writes: "The BBC is running an article about a genetically modified bacterium that is intended to replace the existing lactic-acid-producing variety currently residing in your mouth. Once the new bacteria have replaced the old, you can apparently expect the elimination of 'most tooth decay.' Rather clever, if you don't mind playing host to a colony of GMOs."

11 of 47 comments (clear)

  1. Kissing is a patent infringement. by andaru · · Score: 5, Interesting
    How do they prevent this from indiscriminately spreading between people who kiss each other?

    If it did spread through kissing, how would they make their money back?

    Police Officer: I'm sorry, son, you're going to have to come with me. Seems like you've got an illegal copy of DNA sequence 9422136A residing in the bacteria in your mouth.

    --

    Why is Grand Theft Auto a much more serious crime than Reckless Driving?

  2. Darwin. by WasterDave · · Score: 3, Insightful

    It appears to me that we've evolved to have the organisms in our mouth that we do have for a reason. Whatever that reason may be. Maybe sometimes we should just *not* fuck with nature?

    Dave

    --
    I write a blog now, you should be afraid.
    1. Re:Darwin. by Cuthalion · · Score: 3, Insightful

      Just like we're evolved to have lice.

      --
      Trees can't go dancing
      So do them a big favor
      Pretend dancing stinks!
  3. This will never work :( by eggstasy · · Score: 3, Interesting

    Because of the Almighty Buck's all-mighty interests.
    If we could be free of cavities forever with just one whiff of a spray, then half the dentists out there would be out of business, and so would toothpaste/brush industries.
    I would sure like a bit of that spray though.
    I have a genetic condition that weakens my teeth somehow. My grandmother had mostly false teeth when she turned 20 and my mother has the same problem. I brush my teeth like 5 times a day and I keep getting cavities. Most of my teeth have already been drilled at least once and I'm only 22 years old :|

  4. Re:What do you get instead of lactic acid? by linuxator · · Score: 3, Funny

    Alcohol ;) :P

    --
    * Origin: XBase BBS (2:490/4100) Well the good old days may not return and rocks might melt and sea may burn.
  5. Mouthwash by PoiBoy · · Score: 3, Interesting
    Listerine and other breath fresheners work in part by killing bacteria in the mouth. Are these bacteria immune?

    More importantly, it seems implausible that this treatment is a once-in-a-lifetime affair. I might believe it would last a week, but no more than that. What if someone brushes his teeth? Even if one need no longer worry about cavities, brushing is still required to remove plaque and prevent gum disease.

    --
    Sig (appended to the end of comments you post, 120 chars)
  6. just wait... by doooras · · Score: 3, Funny

    until it mutates from mouthwashing bacteria to brainwashing bacteria. (which will then be patented by AOL Time Warner, of course)

  7. View from a Biochemist by Anonymous Coward · · Score: 5, Informative
    Unfortunately, the linked article is a little lacking on details. They mention that Streptococcus mutans has been engineered to not produce lactic acid. This has *probably* been done by knocking out a gene in the lactic acid production pathway. -- Nothing more complex than what probably happens via normal mutation. (You don't think bacteria are sitting around all "perfect" clones of each other waiting for some scientist to mess them up, do you?)

    Of course, there is the question of why this strain would outcompete the resident S. mutans. After a rather infuriating search of the U.FL website I found http://www.dental.ufl.edu/Offices/Oral_bio/Faculty _pages/JHillman.html which includes a list of peer reviewed journal references.(Note: there isn't much more there.)

    A quick read of Infection and Immunity, February 2000, p. 543-549, Vol. 68, No. 2 indicates that they created the GM bacteria by deleting almost the entire gene responsible for lactic acid production (lactic dehydrogenase) and make up for the loss by inserting another alcohol dehydrogenase (from Zymomonas mobilis) in the gap. (Which means the other poster was correct - it produces alcohol instead of lactic acid .) The paper also indicates that the bacteria are able to compete with resident mouth bacteria by producing a "Lantibiotic" antibiotic (mutacin 1140). This antibiotic was not introducd by the researchers, but instead is naturally occuring in the (naturally occuring) strain of S. mutans which they selected (because of the antibiotic).

    1. Re:View from a Biochemist by phazei · · Score: 3, Interesting

      But what type of alchol does it produce? AFAIK most alchol is poisonous to us. Even at the minute levels it would be producing I would think its effects over time wouldn't be a good thing.

  8. Is Listerene once-in-a-lifetime? by andaru · · Score: 3, Interesting
    These bacteria would survive in the same way the current ones do. Either the Listerene doesn't kill them all, and they just repopulate from what survives, or the population gets replaced from outside (like from putting your fingers in your mouth).

    Either way, if the new bacteria outcompete the old bacteria (which is the requirment for ensuring that they will take over your mouth), then the new bacteria will probably be better able to survive a Listerene attack than the old one.

    --

    Why is Grand Theft Auto a much more serious crime than Reckless Driving?

  9. Good, now can they make this? by PD · · Score: 3, Funny

    How about a variety of bacteria that doesn't produce scatane when it digests food? That would be wonderful. I would suggest that it could make some nice ketones instead, so our farts could smell like bananas or something.