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Nature's Timepiece Identified

Makarand writes "Nature's timepiece, a two-sided cylindrical protein that tells cells when to grow and when to rest, has been identified according to these reports on MSNBC and on Purdue News. The protein directs 12-minute growth and rest cycles in living cells. Scientists at Purdue were able to confirm its function by first identifying the gene that produces this protein and then altering the protein to produce cycles of between 22 and 42 minutes. This discovery promises new insight into cellular activity such as cholesterol synthesis, respiration, heart rhythms, response to drugs, sleep and alertness. We may be able to improve our of methods of minimzing jet-lag and correcting sleep disorders."

24 of 51 comments (clear)

  1. Prediction: by sporktoast · · Score: 2, Funny

    There will follow lots of posts with jokes about overclocking.

    Some may actually be funny.

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  2. so if i stop the protein by Unknown+Poltroon · · Score: 2

    do i live forever or die instantly? And what if i have some kind of mutation that affects production of this protein? DOes that explain Lazarus Long? ;)

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    1. Re:so if i stop the protein by Simon+Field · · Score: 3, Interesting


      Of course it isn't that simple. Stopping it would probably be similar to stopping another clock in you, such as your heart or your breathing.

      What interested me was the comment about crystallizing it (to get X-ray crystallography). This might be one of those cases where the crystal form is not as useful as something like attosecond laser freeze-frames. We want to see this thing in action. I suppose one could crystallize it in each of its forms, and then guess which one did what.

  3. Caffeine is now obsolete by Anonymous Coward · · Score: 3, Insightful
    We may be able to improve our of methods of minimzing jet-lag and correcting sleep disorders.
    Why not correct this disorder known as "sleep"?


    Sleep is for the weak. And the genetically un-modified.

  4. Re:Timer by pauldy · · Score: 3, Interesting

    If I remember right these proteins are released in intervals and build up when they hit a level a reset condition occurs were the proteins are re-assimilated. In theory one could create conditions were these proteins are released faster or slower to regain clock sync.

    I'm confused and maybe someone can clarify why this particular article seems to be so behind in this new technology as they already have shows on the discovery channel that explain this to the point a ten year old can understand the goings on? Or is it simply the fact they understand how to control the timekeeping piece of it?

  5. Where are mad scientists when you need them... by Orne · · Score: 4, Insightful

    "The light that burns twice as bright burns half as long... ...and you have burned so very, very brightly, Roy." -- Dr. Tyrell, Blade Runner

    1. Re:Where are mad scientists when you need them... by iggymanz · · Score: 2

      There's actually more to that......."The light that burns twice as bright burns half as long....and you have burned so very, very brightly, Roy.......aaaaAAAAAAAAAAAAH" *crunch* *slop* (brains slopping out ears and eye sockets as Roy crushes Tyrell's skull)

      Yay Blade Runner, the greatest sci-fi movie EVER made!!!!

  6. Re:12 hours in a day? by Bonker · · Score: 2

    It's cause Greeks and Romans did some numbers in base 12. Also the reason we have 360 degrees in a circle despite the fact that radians make much more sense is because greek

    365 days a year is just a lucky coincidence.

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  7. I'm missing something by aztektum · · Score: 4, Interesting

    I don't want to sound like I'm trying to pick o a fight, but who cares about fixing jet lag? Isn't this a more about helping sick people get better? I didn't realize jet lag was such a detriment to society.

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    1. Re:I'm missing something by Fyz · · Score: 3, Funny

      To hell with the sick! I want to know if this can make me immortal!

    2. Re:I'm missing something by mph · · Score: 2
      I didn't realize jet lag was such a detriment to society.
      Then you need to travel more, or work a rotating schedule.
  8. Unavailable for comment at the time by Hubert_Shrump · · Score: 4, Funny

    were Nature's wallet, suspenders, and sock garters.

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  9. Help me stay awake... by c0d34w4y · · Score: 2, Funny

    Could this help me (one day, maybe?) stay away for much longer each day? Presently, I max out at 18 hours a day without sleep. This much time is enough to churn out only so much of code.. but think of the implications if I and numerous others who find joy in churning out free code could code for a bit longer within a span of 24 hours?

    And all this with little side-effect to other bodily functions... ;-)

  10. Re:12 hours in a day? by BCoates · · Score: 4, Funny

    Also the reason we have 360 degrees in a circle despite the fact that radians make much more sense is because greek

    "Drive 3 blocks north, then take the one-quarter pi radian turn right, and go another block."

    Yeah, that's a real useful unit.

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  11. Re:12 hours in a day? by red5 · · Score: 4, Interesting

    Well there are closer to 13 28 day months(moons) in a year. 13 x 24 = 364.

    But then 13 is an unlucky number.

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  12. Go! go! go! (pills) go! go! by notany · · Score: 2, Informative

    Indeed, the U.S. Department of Defense has offered research funding for the goal of sustaining a fully wake, fully functional 24/7 soldier, sailor, or airman. -- Professor J. Christian Gillin,

    I guess next time I operate my F-16 I can't get so
    high anymore.

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  13. Re:12 hours in a day? by Alsee · · Score: 2

    the one-quarter pi radian turn right

    Ahh, you must live in one of those neighborhoods with funky corners. Most of the corners around here are one-half pi radians.

    -

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  14. Reference to the paper by mlush · · Score: 5, Informative

    The links given don't actually supply the reference to the paper. Its in Biochemistry

    Biochemical Basis for the Biological Clock Morre, D. J.; Chueh, P.-J.; Pletcher, J.; Tang, X.; Wu, L.-Y.; Morre, D. M.; Biochemistry ; (Accelerated Article); 2002; 41(40); 11941-11945.

  15. something isn't adding up... by G.+W.+Bush+Junior · · Score: 2, Informative

    ok, so this is really groundbreaking news...
    I mean, Explaining the circadian rythm has been a priority for decades.
    It has an enormous impact on the pharmaceutical industry, it's extremely important for biochemists, chemists, theoretical chemist and non-linear dynamics people...
    And the importance is REALLY obvious.

    my question is this: Why do they publish it in Biochemistry?!?!

    This is Nature or Science material... if it's true.

    Something is obviously wrong with their argumentation, but I haven't figured out what's wrong yet... anybody?

    They DEFINITELY need more sampling points... but I guess there's more to it than that.

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  16. But I thought.... by watzinaneihm · · Score: 2, Funny

    From the article Heavy water - water made of two atoms of deuterium, the isotope of hydrogen with an extra neutron in its nucleus - could alter the clock to run on a 27-hour day.

    Heavy drinking causes sleepiness.... So

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  17. Of course... by Wireless+Joe · · Score: 2, Funny

    "Nature's timepiece, a two-sided cylindrical protein...

    I thought about how a cylinder could have two sides for a second, and realized that of course it's two sided...it has an inside and an outside.

    Ba-dum-bum.

  18. Re:12 hours in a day? by jguevin · · Score: 2, Interesting

    Actually, isn't 360 more useful than 400? Not that I know anything about the origin of "360 degrees", but:

    360/2 = 180
    360/3 = 120
    360/4 = 90
    360/5 = 72
    360/6 = 60
    360/8 = 45
    360/9 = 40

    whereas

    400/3 = 133.3...
    400/6 = 66.6...
    400/9 = 44.4...

    Of course, it may be the case that you have a sense of humor and I don't.

    I also can't help thinking that using 360 has greatly improved the math skills of skater & snowboarder dudes the world over.

  19. New Medicine by Strange+Ranger · · Score: 2


    So now can I get a pill that will keep me from being late all the time?

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  20. Re:two sided cylindrical? by Trick · · Score: 2

    All cylinders are 2-sided. Get a piece of paper and make one; you'll see.