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Hybrid Robot Uses Rat Brain

CowboyRobot writes "After two recent stories of artificial brains used to control rats and one about MIT doing the reverse, NYTimes now has a piece on similar work done at Georgia Tech From the article: "...the layer of rat neurons is grown over an array of electrodes that pick up the neurons' electrical activity. A computer analyzes the activity of the several thousand brain cells in real time to detect spikes produced by neurons firing near an electrode." But this time you can buy one for $3,000."

19 of 251 comments (clear)

  1. karma whore by Anonymous Coward · · Score: 4, Informative

    Wired to the Brain of a Rat, a Robot Takes On the World
    By ANNE EISENBERG

    The nerve center of a conventional robot is a microprocessor of silicon and metal. But for a robot under development at Georgia Tech, commands are relayed by 2,000 or so cells from a rat's brain.

    A group led by a university researcher has created a part mechanical, part biological robot that operates on the basis of the neural activity of rat brain cells grown in a dish. The neural signals are analyzed by a computer that looks for patterns emitted by the brain cells and then translates those patterns into robotic movement. If the neurons fire a certain way, for example, the robot's right wheel rotates once.

    The leader of the group, Steve M. Potter, a professor in the Laboratory for Neuroengineering at Georgia Tech, calls his creation a Hybrot, short for hybrid robot.

    "It's very much a symbiosis," he said, "a digital computer and a living neural network working together."

    Dr. Potter has been building the system of hardware, software, incubators and rat neurons that constitute the Hybrot since 1993, when he was a postdoctoral student at the California Institute of Technology. He and his group have not only introduced the neurons to the world outside their dish; the team has also closely monitored minute changes that take place in the shape and connections of the neurons as they are stimulated, using techniques like time-lapse photography and laser imaging.

    Dr. Potter hopes that close observation of how brain cells behave as they are exposed to a world of sensation will help researchers understand the way small groups of neurons go about learning. "If the network begins to get better at a job," he said, "we will watch what changed within the network to allow it to do that."

    Dr. Jonathan Wolpaw, laboratory chief and professor of neuroscience at the Wadsworth Center of the New York State Department of Health and the State University of New York at Albany, said that Dr. Potter's research could yield a simple system for exploring the capacity of neurons and circuits to change based on incoming activity.

    "These changes could be analogues of what happens in learning," Dr. Wolpaw said. "You are dealing with neurons, the same tissue as in a brain," although in a different setting and with different circuitry. "Some things presumably are in common, for example, the neuron's capacity for plasticity," he said.

    In Dr. Potter's hybrid system, the layer of rat neurons is grown over an array of electrodes that pick up the neurons' electrical activity. A computer analyzes the activity of the several thousand brain cells in real time to detect spikes produced by neurons firing near an electrode.

    A silver three-wheeled model of the robot is commercially available through the Swiss robotics maker K-Team (www.k-team.com) for about $3,000 and is about the size of a hockey puck. It trundles along at a top speed of one meter per second.

    "We assign a direction of movement, say, a step forward, that is automatically triggered by a pattern of spikes," said Thomas DeMarse, a former member of Dr. Potter's group who is an assistant professor in the department of biomedical engineering at the University of Florida. "Twenty of these patterns, for instance, means 20 rotations of the wheel."

    As the robot moves, it functions as a sensory system, delivering feedback to the neurons through the electrodes. For example, Mr. DeMarse said, the robot has sensors for light and feeds electrical signals proportional to the light back to the electrodes. "We return information to the dish on the intensity of light as the robot gets closer and the light gets brighter."

    The researchers monitor the activity of the neurons for new signals and new connections. Dr. Potter said that the feedback mechanism was crucial to the functioning of the neural network. In traditional, isolated cultured networks, he said, in which neurons are not connected to a body, the activity patterns of the neurons are la

    1. Re:karma whore by joelil · · Score: 5, Funny

      Orkin in Very Intrested..... Just think program 3 rats to invade a house. and then just wait for the phone call to get rid of the rats get paid and have the rats move next door.....

      --
      Never underestimate the power of stupid people in large numbers.
  2. Correction by avalys · · Score: 4, Informative

    You can buy a copy of the robot base they are using, but it doesn't include the cybernetic rat brain.

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    This space intentionally left blank.
    1. Re:Correction by tfoss · · Score: 4, Insightful
      yep. thats the problem with all this research....everyone who does it doesnt share their results.

      Alright, I call bullshit on this. First off, you are reading about aren't you? They *are* sharing results, and better than that, they are talking to wide circulation general press. This means their research is exposed to an audience greater than the same conference crowd that they run in.

      wheres the models for the function reponse of the rat neurons ? the electrical interface to the cells ? the procesedure and problems encountered ?

      Well for a first approximation, at least look at the guy's web page. Notice the section labeled publications & abstracts. Secondly, if you are actually interested on a real level, talk to the guy. I am sure he would love to talk about his research (thats one thing that always tickles scientists, especially academics).

      By the time anyone publishes results its years and progress has already moved on.

      Welcome to manuscript writing, submitting, responding to reviews, re-submitting, publishing. It is slow by its very nature. You can't help it, and actually it's a damn good thing, peer-review is what makes science valid and useful. Without that science becomes nothing but bad journalism (remember cold fusion?).

      the scientific system should be overhauled methinks.

      Ok, what is your suggestion? Until you have an idea how to improve, your bitching is basically meaningless blather.

      this research is critical and interesting enough that lots of people would be ahppy to contribute significantly if it was easy to obtain.

      Ok, first of all while this research is certainly interesting, good basic research, a good foundation for the future, critical i think not. HIV research, cancer research, public safety research, hell, the stuff my lab does are all far, far more critical. As for many people contributing significantly, that can work for open source coding. It's quite different doing science. There is a reason you spend an extra 5 years in grad school after college before you really start contributing to these kinds of topics. They are complex and difficult to understand, they require a great level of scientific understanding and experience. And here's the thing, if it was easy to obtain, then it wouldn't require high-level research to examine it.

      a coupla thousand geeks playing with biological-electronic hybrids could do more than a bunch of researchers at a single university or two.

      Yeah, right. You've no clue how complex, difficult, and expensive this kind of research is. Have you ever grown neuronal cells? It's quite a bit harder than raising a bunch of sea monkeys. Even supposing you could package a Pocket Pal Rat-brain-cell-silicon-interface system, you still have to have the understanding of what the hell is actually going on. This isn't your high-school science fair project.

      High-level research is high-level for a reason. Science is hard.

      -Ted

      --
      -=-=- Quantum physics - the dreams stuff are made of.
  3. Artificial retina by BWJones · · Score: 4, Interesting

    If you could create a multi-laminar structure, this setup might be ideal for an artificial retina. Currently, the bionic retinas being used are nowhere near as sensitive as they need to be to create any useful phototransduction, even if the neural retinal substrate underneath remained intact (which it does not). A multilaminar device could sandwich photosensitive elements combined with neural substrates that would function as the neural interface to the output of the retina, the remaining ganglion cells.

    --
    Visit Jonesblog and say hello.
    1. Re:Artificial retina by .com+b4+.storm · · Score: 4, Funny

      The only word I understood in that whole thing was "sandwich." :) Mmmm Subway...

      --
      "Wow, you're like some kind of superhero able to ward off happiness and success at every turn."
      -- Ryan Stiles
  4. Put the rat in the iron! by showmeshowyoukikoman · · Score: 5, Funny
    I think rats can resist extreme heat. What about using this rat brain to control the blob of iron we are sending to the middle of the earth? That was an interesting headline to be sure. As is this one.

    Who knew they were transplanting rat brains into aibo robot dogs!

    Back in the day, we used to talk about robots. But for us, it was always a frightening thing. Then saturday night live did a commercial about robots stealing our medicine! Believe you me, THAT had me scared for a while! I know it was satire, but it's not hard to imagine robots living off the powerful medicines we old people use!

  5. Revenge of the Lab Rats by Coelacanth · · Score: 5, Funny

    Not that this isn't cool and all, but:

    I don't want to be around when this thing becomes aware enough to take retribution for countless generations of lab rat torture! Someone will stumble into the lab and find a scientist's brain wired into a speak-n-spell, with a rat-bot-shaped hole in the wall and a trail of cheese crumbs...

  6. Obligatory Penny Arcade by Metallic+Matty · · Score: 4, Funny

    "Here's another one: 'More brains, and bring back Hawaiian Fridays'"

    http://www.penny-arcade.com/view.php3?date=2002-05 -03&res=l

  7. Ratbrain enterprise edition! by N2H4 · · Score: 4, Funny

    I will wait until i can purchase a ratbrain pci card before I jump on the bandwagon. Imagine the image recognition possibilites :)

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    Move Zig!
  8. Living tissue by Anonymous Coward · · Score: 5, Interesting

    How do they keep the nerve cells alive? Are they actually fed, oxygenated, and protected from infection?

    1. Re:Living tissue by wolfneuralnet · · Score: 4, Informative

      Yes - the cells live in an incubator and are fed calf-serum enriched media. The incubator has enough O2 in it that the cells get oxygen through the media. The electrodes are on the bottom of the dish. It is also nowhere near anything close to working.

  9. Re:This is odd by BWJones · · Score: 5, Informative

    What the hell do these people target rats that much ? don't mice do the trick too ?

    Rats have much larger brains and visual pathways than do mice, so surgery and implants of bionic and biological devices is spatially easier. The advantage that mice have right now is the genetic resources and databases that currently are not available to the same extent as for rats.

    --
    Visit Jonesblog and say hello.
  10. I hope by Anonymous Coward · · Score: 5, Funny

    They are only using female rats for this experiment. If they use male rats the report would probably look something like

    Monday morning
    Robot tried too shag other robots

    Monday afternoon
    Robot refused to move from candy vending machine

    Monday evening
    Robot tried too shag other robots

    Tuesday morning
    Robot tried too shag other robots ....

  11. Re:I'm going to get flamed, but by Muhammar · · Score: 4, Funny

    As a scientist, I regret that you are not my animal.

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    I doubt that we will ever figure out - and I suspect that even if we did figure out we couldn't do much about it
  12. The implications of this technology by InterruptDescriptorT · · Score: 4, Funny

    At least we'll never run out of politicians now. :-)

    --
    Karma: Excellent Birds (mostly as a result of listening to Laurie Anderson)
  13. Re:This is odd by IamLarryboy · · Score: 5, Funny

    Since when does having a better chance at being selected for a science experiment that will probably kill you count as an "advantage?"

  14. This research is not very far along yet... by wolfneuralnet · · Score: 5, Insightful

    I have seen this guy give a talk every year for 5 years. He always says the same thing "we are close to observing something here." The truth is that no one has a clue whether he will ever see anything in these cultures that is meaningful. These are dissociated cells that are living in a culture dish. The laminar structure that the hippocampus has is destroyed in this process. It would be like throwing a bunch of wires together and hoping to come up with a few logic gates. It is all hype right now. The neurons are not "controlling" the robot at all - the neurons have yet to show any organized activity. Even if they did - would you know what it meant??? I would be very surprised if this ever worked in its current incarnation...

  15. In the words of Captain Picard by Tuxinatorium · · Score: 4, Funny

    They invade our kitchens, and we fall back. They steal entire cheeses, and we fall back. Not again. The line must be drawn here! This far, and no farther. And I will make the mice-borg pay for what they have done!