Stem-Cell-Like-Cells Made Using Only Blood?

Adair writes "Newscientist.com is reporting that a UK biotech firm, TriStem has developed a technique to 'turn ordinary blood into cells capable of regenerating damaged or diseased tissues.' Their method transforms anyone's white blood cells into 'stem-cell-like-cells' which can then be coaxed into one of a myriad of healthy cells such as heart, nerve, or brain. Having made these claims for years, TriStem has recently provided proof to their claims, which some scientists who witnessed called 'stunning."' They have some more proving to do, but if the initial results pan out, the applications could be fantastic -- and without the stigma of traditional stem-cell research."

Comments

Used for cobra bite necrosis?

[Bob Cat - NYMPHS]

There was a guy on Motel William's show yesterday who had been bitten and had a big hole in his abdomen after debriding the killed flesh. He said a frend of his had used white blood cells 'and sumtin' and he healed in 10 days. Anyone know if this is the same process?

Re:Used for cobra bite necrosis?

[Dreadlord]

TriStem claims in the article that the technique can be used to regenerate many kinds of cells, including smooth muscle cells, on the other hand, I wonder if regenerating cells is all what the body needs to recover lost parts, because randomly generating cells isn't going to recreate the same organ after all, so there should be another technique to control how cells are regenerated.

Re:Used for cobra bite necrosis?

[Jesrad]

randomly generating cells isn't going to recreate the same organ after all

IANACellBiologist, but from my knowledge on the subject, replacing randomly the cells of a dying organ DOES replace it efficiently. It'd take a continuous, regular treatment over a few years but it would most probably work. From the article, TriStem managed to cure diabetic and immunodeficient mice with this method, ergo they managed to replace pancreas and bone marrow.

Something sounds suspicious

[Anonymous Coward]

I would check to see if these TriStem people have recently returned from Antarctica or a husky was doing the presentation.

Wow

[tsa]

If this is true these guys can make insane amounts of money. They patented their technique in 1996 in the UK and in 2000 in the US so we are left with a monopoly. Hopefully they won't exploit it too much.

Re:Wow

[Callan]

Only for a bit. Patents don't last forever (just longer than some would like).

Now, if they left it a 'trade secret', then it'd be different ;)

Re:Wow

[Jesrad]

It cannot be kept a trade secret if it is hard to believe technology. There's the same problem with "free energy" devices and antigravity devices, they require repeated reproduced experiments to be taken seriously, which can't happen if they won't tell you how to do it.

Next step in longevity treatments?

[Smidge204]

Since we have some people looking into how sea urchins are practically immortal, I'm curious if there will be some way to mix and cross-reference the two veins of research to come up with a longevity treatment...

=Smidge=

Peer review?

[jdiggans]

Wait until they publish a controlled study in a peer-reviewed journal. Until then, this is all science-by-press-release and not worth the paper on which it's printed.

That said, I hope they're successful and manage to strike a healthy balance between profit and humanity.
-j

Re:Peer review?

[XenonChloride]

Thanks, that was exactly what I missed in the whole thing. So far, their claim to "retrodifferentiate" blood cells to pluripotent stem cells (= similar to embryonal stem cells in the 8-cell-stadium) is questionable. It seems they simply went for profit and propaganda rather than for proof-reading by the scientific community.

One (of many) more serious examples for (embryonal) stem cell research is given by D. Kaufman in PNAS 2001, 98(19), 10716-10721, for an online pdf version see Hematopoietic colony-forming cells derived from human embryonic stem cells.

Although enthusiastic about their results, the authors are honest enough to warn in the last paragraph of the article mentioned above:

The clinical promise of human ES cell-based therapies is great; however, because these therapies will be entirely novel, serious concerns about safety and efficacy will need to be addressed before human clinical trials can be initiated. The malignant transformation of cells that have been cultured for extended periods is a particular concern.

This has indeed been observed by Mathias Hoehn at the Max-Planck-Institute for Neurological Research in Cologne, Germany. As far as I remember, the researchers had caused an apoplectic stroke in rats. One week later, they injected the animals with embryonal stem cells from mice. MRT scans showed that the stem cells travelled through the rat brain right to the damaged region and started to differentiate and form a network. The stem cells, originating from different specimen, had replaced damaged tissue.

However, when the same stem cells (note: embryonal stem cells from mice) were used on mice, everything went out of control! Rather than moving to the damaged region, the stem cells started penetrating surrounding nerve cells and showed uncontrolled growth. In all mice examined, tumors were found!

Keeping that in mind, I prefer to take all "scientific" announcements in non-peer-reviewed journals with a ton of salt.

Re:Luddite opposition

[Daniel Dvorkin]

No, the fanatical Christians' whole point is invalidated; but the grandparent poster's point is right on the money.

Just about major medical advance in history -- dissection of corpses to learn anatomy, sterilization of instruments, immunization, anesthesia, antibiotics, x-rays, blood transfusions -- has met religious opposition when it first came out*. And over time, as the obvious benefits added up, these advances became part of "just the way things are" and almost everyone** stopped complaining about them. But new advances still set off the same alarm bells in the minds of the Luddites, who don't have the grasp of history to see what fools and hypocrites they are.

Plenty of True Believers will happily go to the doctor, take advantage of whatever the latest technology is that's available at that moment to cure what ails them, and then go home and bitch about Those Damn Scientists Interfering With The Will By Meddling With Things Man Was Not Meant To Know. And because of this behavior, unfortunately, there's no selective pressure for that kind of idiocy to die out.

---
* I heartily recommend Jonathan Miller's The Body in Question for an overview of this, as well as other fascinating aspects of medical history.

* With the exception of, e.g., Jehovah's Witnesses and blood transfusions. They may be fanatics, but at least they're consistent fanatics.

Better Yet!

[Lord Kano]

Everybody is Peter North!

Mods, if you understand this joke you're just as twisted as me.

LK