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Detoxing With Magnets for Fun and Profit
Ridgelift writes "Wired has an article on a new way to remove toxins from the bloodstream. The Argonne National Laboratory have designed nanoparticles which 'identify, and then latch onto, target molecules. The nanoparticles are injected into the bloodstream, where they circulate through the body, picking up their target toxins as they go. Once they have made their rounds, all that's needed to remove the particles from the body are a magnet housed in a handheld unit and a small, dual-channel shunt inserted into an arm or leg artery.'"
The article mentions simple, nice uses such as detoxing or removing poisons from the bloodstream, but what prevents a similar method from being designed (all be it you would have to design particles corresponding to these to be in the bloodstream) to remove viral infections from the blood? That seems like where the real interest in this technology would be!
The body would attack those things because they are foreign, and even if they are inert then you have the problem of them getting stuck in strange places, like your brain.
Wouldn't want to get an MRI after either, half your body would probably be torn apart.
Take Chaser 2 shortly after you begin drinking, and drink all night long!
The next morning, just insert the handy-dandy magetized needle, and lookie! Hangover-over!
Karma: Chameleon (mostly due to the fact that you come and go).
Yes, iron has blood (hemoglobin). However, that iron is surrounded by a lipid cell wall, the nanomagnets would have their iron exposed. A weak magnet would only pick up the exposed iron.
At the end of the article was some interesting information:
The research is sponsored by the Defense Advanced Research Projects Agency and the U.S. Department of Energy.
Perhaps this will help DARPA regain some of its cachet after the embarassingly stupid gaffe by Terror Bookie John Poindexter. Got to take the bad with the good, I guess... it's nice to be reminded that the Internet isn't all DARPA ever helped get off the ground.
Stressed? Me? Of course not. Stress is what a rubber band feels before it breaks, silly.
December 9, 2013
Drug Abusers Use Nanotechnology to Duck Routine Screening Tests
It seems that a technology poised to replace dialysis and other blood-purifying procedures has been hijacked to thwart detection of illegal substances in the bloodstream. Using magnetic nanoparticles, drug abusers can pull every last trace of an illegal substance from their system before submitting to the test.
"I first found about this from a friend in L.A.," says black marketeer Hans Gruber. "We are right now mixing cocktails to strip barbituates, THC, amphetamines, you name it. It's going to give a big boost to the illegal drug industry - people don't have to worry about being caught at work anymore".
On the other side of the issue, security analysts believe that surprise screening tests are the solution to this new development. Informing a candidate that they will be required to submit to a test immediately will help catch some of the would-be "nano-cheaters".
"Yeah, you could do surprise tests...or I could just offer a nanostripper with every drug purchase, to be run immediately after the customer comes down off their high." Such a practice still wouldn't let people go to work while intoxicated, but would keep them from getting picked up Monday morning for their Saturday night indescrecions.
It is unknown just how soon these "nanostrippers" will be readily available on the black market, but given the ease with which they can be synthesized, it is expected that production methods similar to the "meth labs" of the '00s could be employed. Even more interesting is the fact that the molecules are only regarded as Class C Nanoproducts under the Nanotechnology Protection Act of 2018, so very little punishment could be currently handed out for their synthesis and/or possession.
And too much causes clotting
There is alot more to oxygen transfer than just the hemo count.
There is also teh S-curve for oxygen to hemo affinity.
Its not that simple.
Auto-reply to ACs: "Truly, you have a dizzying intellect."
Well, that's sort of right.
De-oxygenated hemoglobin isn't magnetic, but oxygenated hemoglobic is paramagnetic. That's why fMRI works. fMRI is a clever technique using the same MRI technology used for imaging, but tuned to see changes in blood oxygen concentration. It's used to estimate brain activity, and also to detect poor circulation in the heart.
According to http://www.rfsafe.com/research/rf_radiation/therma l_hazards/intro.htm:
Magnetite is found in certain bacteria and in the cells of many animals, including human beings.
Does this mean that this treatment would also pull out any bacteria in the body that contains magnetite?
The body would attack those things because they are foreign
Read the article, my friend - they're coated so they don't get recognised as antigens. Nor will they get stuck (they took care over this one, designed wuith reference to pore sizes), and in any case are biodegradable.
I read it too, and I see a couple problems with the claims.
First: While the propylene glycol coating will protect the basic particle (for a while), the active antibodies that cause it to latch onto targets have to stick out. If some of the body's own antibodies latch onto those, it ends up "decorated". This will almost certainly trigger a bunch of attacks on it - which could cause damage to normal tissues nearby even if they don't result in defeating the glycol coat and starting the disassembly or macrophage-consumption of the particle.
The side-effect attack could result in anaphylactic shock if it is large enough, so using it to clean out circulating antibodies may turn out to be probelematic - requiring careful control of dosage and time-before-cleanout.
Even if this scenario is true in practice, however, the technique might still be useful against auto-immune diseases, where the antibodies in question will already be triggering as much collateral-damage as if they were attacking the particles. If it turns out not to be an issue, lots of other severe allergies may be susceptable to treatment by this technique.
Second: The sizing of the particles prevents their being trapped in capilaries or dumped by kidneys. But if the thing they bind to happens to be anchored to the inside of a blood-vessel they still get stuck. This could produce clots blocking the vessel if there's a lot of anchored target in one place. Even if there isn't, the particle gets stuck until the glycol wears off and the biodegradable core breaks down, after which you're left with:
- Antibodies decorating the target. (This may actually be good, but will probably result in blood vessel inflamation which is not.)
- Magnetite particles in the blood stream. (Hard, sharp, reactive, iron oxide particles.) Same cleanup problem as the small number that didn't get cleaned out in the non-anchored case, but much larger. Iron ions are not nice.
Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
I guess it's pretty sci-fi, but it seems like all the pieces need for it to work are already here or will be soon. Will remaining young at some time be much like an oil change for your car? Would you go to the doctors office and have a certain percentage of your cells replaced?
As I understand it, hospitals are reluctant to give some construction workers MRI's as the average worker is sure to have accumulated tiny metal shards in his or her eyes, shards that go unnoticed until someone turns on the juice.
The MRI question for all of this is a good one.
quiquid id est, timeo puellas et oscula dantes.
Has no one else noticed that this approach is:
a) fairly invasive? To treat a lot of blood in a short amount of time you need a pretty good flow rate. Which means you need a big hole in a big artery. I don't like big holes in my major arteries, but that's just me. I suppose if you were fitted with some sort of interface/valve it would be fine, but if you started bleeding through that hole later you'd be in serious trouble.
b) very specific? You have to make an antibody/couple for *every* molebule you want to catch.
I think this is more hype than something practical, at least for the time being. It might be different in a while after they've developed it (and done lots and lots more human trials.)
So instead of passing the blood through an external filter, they send in little buggers to grab the bad molecules and take them out through a similar shunt.
--- Ban humanity.
This is alot of trouble for someone to go through just to pass a piss test. Although as an employer, I think I would have no problems highering someone motivated enough to do this.
A company I worked for a while back had a product that it was testing that could remove all sort of things from the blood. It had been tested in humans a few times removing heprin in people that would have otherwise bled out. The company ditched the product after the higher-ups decided the time and cost to bring it to market was too great. The researcher who championed the technology fought bravely to keep it alive, touting its potential to remove all sorts of toxins, but the short term gains just were not there. Now the technology likely sits in a pile of boxes somewhere instead of saving and improving lives. It makes me wonder how many other stories there are just like this one.
Hadn't heard the outcome there. I doubt he'll do any hard time, probably appeal too. I heard he used some sort of medical defense (fainting spells??). Having traveled in the West where off the main highway traffic signs are rarely obeyed I can see how the accident happened, but it doesn't make it OK. He should have looked.