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Detoxing With Magnets for Fun and Profit

Ridgelift writes "Wired has an article on a new way to remove toxins from the bloodstream. The Argonne National Laboratory have designed nanoparticles which 'identify, and then latch onto, target molecules. The nanoparticles are injected into the bloodstream, where they circulate through the body, picking up their target toxins as they go. Once they have made their rounds, all that's needed to remove the particles from the body are a magnet housed in a handheld unit and a small, dual-channel shunt inserted into an arm or leg artery.'"

11 of 287 comments (clear)

  1. What about... by mgcsinc · · Score: 4, Interesting

    The article mentions simple, nice uses such as detoxing or removing poisons from the bloodstream, but what prevents a similar method from being designed (all be it you would have to design particles corresponding to these to be in the bloodstream) to remove viral infections from the blood? That seems like where the real interest in this technology would be!

    1. Re:What about... by KrispyKringle · · Score: 3, Interesting

      But there are a few comments about treating auto-immune diseases and anthrax. So maybe it's useful as an intermediary treatment for some easily-targeted particles, but doesn't completely remove an infection?

    2. Re:What about... by hollo32 · · Score: 4, Interesting

      I'm no doctor, but I'd make a couple of guesses:

      Well I am a doctor, but it's not really my field and I've had a few drinks. I'll have a go anyway.

      There are two problems with this technique for dealing with viruses like HIV. One is that viruses can only reproduce inside human cells and spend most of their time there. None of these nanoparticles are going to be able to get inside the cells so they are not going to get to where the virus is. Instead there is the much trickier task of detecting cells which have the virus inside.

      The other problem is that the HIV virus in particular appears to mutate very rapidly. There is one part of the outside of the virus capsule which has to stay the same as it binds strongly to a particular protein on the outside of the cells it is going to infect in order to attach to them. This region which stays the same is flanked by areas that change rapidly from generation to generation to make it difficult for the body to recognise the virus.

  2. Introducing Chaser 2! by numbski · · Score: 4, Interesting

    Take Chaser 2 shortly after you begin drinking, and drink all night long!

    The next morning, just insert the handy-dandy magetized needle, and lookie! Hangover-over!

    --

    Karma: Chameleon (mostly due to the fact that you come and go).

  3. DARPA redeemed by RobertB-DC · · Score: 3, Interesting

    At the end of the article was some interesting information:
    The research is sponsored by the Defense Advanced Research Projects Agency and the U.S. Department of Energy.

    Perhaps this will help DARPA regain some of its cachet after the embarassingly stupid gaffe by Terror Bookie John Poindexter. Got to take the bad with the good, I guess... it's nice to be reminded that the Internet isn't all DARPA ever helped get off the ground.

    --
    Stressed? Me? Of course not. Stress is what a rubber band feels before it breaks, silly.
  4. Fast-Forward 10 Years by johnthorensen · · Score: 5, Interesting

    December 9, 2013

    Drug Abusers Use Nanotechnology to Duck Routine Screening Tests
    It seems that a technology poised to replace dialysis and other blood-purifying procedures has been hijacked to thwart detection of illegal substances in the bloodstream. Using magnetic nanoparticles, drug abusers can pull every last trace of an illegal substance from their system before submitting to the test.

    "I first found about this from a friend in L.A.," says black marketeer Hans Gruber. "We are right now mixing cocktails to strip barbituates, THC, amphetamines, you name it. It's going to give a big boost to the illegal drug industry - people don't have to worry about being caught at work anymore".

    On the other side of the issue, security analysts believe that surprise screening tests are the solution to this new development. Informing a candidate that they will be required to submit to a test immediately will help catch some of the would-be "nano-cheaters".

    "Yeah, you could do surprise tests...or I could just offer a nanostripper with every drug purchase, to be run immediately after the customer comes down off their high." Such a practice still wouldn't let people go to work while intoxicated, but would keep them from getting picked up Monday morning for their Saturday night indescrecions.

    It is unknown just how soon these "nanostrippers" will be readily available on the black market, but given the ease with which they can be synthesized, it is expected that production methods similar to the "meth labs" of the '00s could be employed. Even more interesting is the fact that the molecules are only regarded as Class C Nanoproducts under the Nanotechnology Protection Act of 2018, so very little punishment could be currently handed out for their synthesis and/or possession.

  5. Re:X2 a Reality by Roger_Wilco · · Score: 5, Interesting

    Well, that's sort of right.

    De-oxygenated hemoglobin isn't magnetic, but oxygenated hemoglobic is paramagnetic. That's why fMRI works. fMRI is a clever technique using the same MRI technology used for imaging, but tuned to see changes in blood oxygen concentration. It's used to estimate brain activity, and also to detect poor circulation in the heart.

  6. Magnetite occurs naturally in the body, so ... by Ranazar · · Score: 5, Interesting

    According to http://www.rfsafe.com/research/rf_radiation/therma l_hazards/intro.htm:

    Magnetite is found in certain bacteria and in the cells of many animals, including human beings.

    Does this mean that this treatment would also pull out any bacteria in the body that contains magnetite?

  7. Life Extension by Michael+Crutcher · · Score: 3, Interesting
    It would seem to me that another use of this technology would be dramatic life extension. I envision scientists creating replacement cells and attaching them to the nanoparticles. Then the particles go through the blood stream attaching to damaged cells. The attachment to a damaged cell causes a replacement cell attached to the nanoparticle to be released. Then the nanoparticles and the damaged cells they are attached to are removed from the blood stream.

    I guess it's pretty sci-fi, but it seems like all the pieces need for it to work are already here or will be soon. Will remaining young at some time be much like an oil change for your car? Would you go to the doctors office and have a certain percentage of your cells replaced?

  8. Re:MRI by mariox19 · · Score: 5, Interesting

    As I understand it, hospitals are reluctant to give some construction workers MRI's as the average worker is sure to have accumulated tiny metal shards in his or her eyes, shards that go unnoticed until someone turns on the juice.

    The MRI question for all of this is a good one.

    --

    quiquid id est, timeo puellas et oscula dantes.

  9. "picking up target toxins..." by ramk13 · · Score: 4, Interesting

    Has no one else noticed that this approach is:
    a) fairly invasive? To treat a lot of blood in a short amount of time you need a pretty good flow rate. Which means you need a big hole in a big artery. I don't like big holes in my major arteries, but that's just me. I suppose if you were fitted with some sort of interface/valve it would be fine, but if you started bleeding through that hole later you'd be in serious trouble.

    b) very specific? You have to make an antibody/couple for *every* molebule you want to catch.

    I think this is more hype than something practical, at least for the time being. It might be different in a while after they've developed it (and done lots and lots more human trials.)