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Would You Like Drugs in Your Rice?

Digitus1337 writes "Wired has the scoop on a new type of rice that was just approved for production by a narrow vote. 'Ventria believes growing drugs that produce proteins like lactoferrin and lysozyme in rice could be a cheaper way to develop drugs than building and maintaining expensive manufacturing plants... Opponents say growing the crops in open fields endangers organic and conventional crops, as well as human health...'" Update: 03/30 23:15 GMT by T : That should probably read "growing rice that produces proteins like lactoferrin and lysozyme."

36 of 310 comments (clear)

  1. Pharmin Phool by panxerox · · Score: 5, Funny

    Before you know it we will have sarin producing dandelions and botulism producing crabgrass. Once the gate is open who know what comes thru.

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    1. Re:Pharmin Phool by AvitarX · · Score: 5, Funny

      Or THC producing Cannibus and Opiate producing Poppys.

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  2. Hey dude... by Smitedogg · · Score: 5, Funny

    Have you ever posted to Slashdot......on rice?

    1. Re:Hey dude... by Anonymous Coward · · Score: 5, Insightful

      The story sounds humorous, but it also raises serious issues. Is it really a good idea to start growing lactoferrin-enriched rice in the open?

      Anyone who has bought bulk rice is familiar with the fact that harvested rice is contaminated with bits of debris and wild rice. Speaking in a practical sense, it is clearly inevitable that this GM rice will get mixed in with the food supply.

      Even eating organic rice will not save you, since small amounts of rice seeds will surely drift on the winds and contaminate all crops. Do we really want to risk our young daughters eating abnormal quantities of lactoferrin and risking a higher rate of gigantomastia and breast cancer?

    2. Re:Hey dude... by macshune · · Score: 4, Informative

      Do we really want to risk our young daughters eating abnormal quantities of lactoferrin and risking a higher rate of gigantomastia and breast cancer?

      I think you mean gynecomastia. Women don't get it, so I'd be more concerned about our young sons looking like young daughters, more than anything else. But your point is taken. Messing with the natural way of things hasn't always worked in ways we have intended. Putting iodine in salt worked pretty well, but the creation of a rice-based pharmacy when a substantial number of people depend on rice as their sole staple does merit some cause for concern, IMHO.

  3. Well by Neil+Blender · · Score: 4, Funny

    You had me at 'drugs'.

  4. the risk... by tsunamifirestorm · · Score: 5, Insightful

    of cross pollenization should be important in determining what plants and drugs should be used. While protein enhancements spreading to other plants or fields could be beneficial, other drugs such as the human growth hormone would have a definite risk.

    1. Re:the risk... by rjstanford · · Score: 5, Insightful

      It would be far more easier to accept it, embrace new technologies and let technology and nature sort it out. In the end, we will find a way out. Its inevitable, because we have reached that stage as a species.

      That's the real danger - that we haven't, quite, reached that point. We're on the cusp, evolutionarily speaking, but right now we have a lot of the power with almost no safety. We're still in a very vulnerable time, where one large catastrophe could effectively wipe us out. We've been in that situation for a long time now, but only recently have we actually gained the ability to cause such a situation as a species.

      That's the real value of space flight - controlled risk reduction. Once we're off the planet in sustainable numbers, we're much less vulnerable. Once we're out of the system - continued success is almost guaranteed.

      For the species, that is. Each individual can still be royally fscked up, no matter what, until and unless we come up with backups of some sort. But that's another subject entirely.

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  5. Naive? by lazuli42 · · Score: 5, Interesting

    Maybe I'm really naive, but why can't they grow this sort of crop indoors?

    I know that it would probably cost a lot more, but by growing it indoors you cut down on the possibility of cross contamination quite a bit. Also, if you're growing a crop to use it for pharmaceuticals wouldn't you want it to be grown in a bit more of a controlled environment?

    --

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    1. Re:Naive? by tanguyr · · Score: 4, Funny

      Van Leuwin: Thank you, Officer Ripley, that will be all.
      Ripley: God damn it, that's not all! 'Cause if one of those things get down here then that will be all! And all this bullshit that you think is so important, you can kiss all that goodbye!

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    2. Re:Naive? by rjstanford · · Score: 5, Insightful

      First, you ask: Maybe I'm really naive, but why can't they grow this sort of crop indoors?

      Then you say: I know that it would probably cost a lot more

      Ding! That's it in one. After all, if one company is growing it the expensive way, and another one (in another country if necessary) is doing it the cheap one... guess who wins? Especially in the current environment of trying to get drug prices as low as possible... Yup, its the cheap one. Go figure. So as long as growing it the cheap way is possible, that's the way that commercial entities will do it.

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  6. Monsanto by Saeed+al-Sahaf · · Score: 5, Interesting

    This is really an interesting question. For example Monsanto has sued farmers that are growing "their" soybeans, yet these farmers are actually growing from stocks of their own crop that has been contaminated by virtue of cross pollenization. Sort of the Genie out of the bottle thing.

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    1. Re:Monsanto by rokzy · · Score: 4, Insightful

      yep, Monsanto are the SCO of the pharmaceutical industry, and manage to be even more evil.

      SCO "only" demand massive payments for something they don't own. Monsanto destroy what you already have, then demand massive payments.

  7. hmm.. by SinaSa · · Score: 5, Funny

    Does anyone else see this as just another thing thinkgeek can sell, caffienated?

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  8. Rice: Its whats for dinner by TJ_Phazerhacki · · Score: 5, Funny

    Really, must these liberal whiners continue to degrade the march of science based solely on their opinion? I eat genetically engineered food, and there's nothing wrong with me! And besides, the third hand really helps to type! Seriously, though, It really comes down to what is necessary for survival. Glo-Fish? Faddish, but really laying the groundwork for the next generation of bio-reactors. And franken food? There's already a huge industry out there for "Organic" food, why can't both co-exist? I'll take my golden rice steamed, and my Kobe Beef fresh from the secluded, beer fed haven it grew up in.

    --
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  9. Rice is ever evolving... by cmeans · · Score: 5, Funny
    First I see this /. article, then I see this one...Rice to Testify Publicly Before 9/11 Commission.

    Scary...

  10. Re:Naive! by FreeLinux · · Score: 4, Insightful

    Ever tried to put 50 acres under a roof? How about 1,000 acres? Then ther are all those other minor details that are required for sustaining life under a roof, sun light, temperature and humidity control, water, minerals and ferilizers.

    There's a fair bit more to large-scale hot-house or hydroponic farming than you have had to deal with when you grew a little pot in your closet.

  11. Re:Drug resistance? by fireduck · · Score: 4, Informative

    these aren't antibiotics. these are naturally occuring proteins that are present in breast milk that help fight infection. once a baby is weaned off breast milk, s/he no longer receives these proteins. so the idea is to give the non-breast feeding babies a supplement made from this rice so that the infant has a constant supply of the protein.

    given that these are naturally occuring proteins that everyone was exposed to as a child, i think the liklihood of bacteria developing a new resistance to them is low (otherwise, it would have happened sometime within the past several thousand years)

  12. Dude, rice IS a drug by Anonymous Coward · · Score: 5, Funny

    Speaking as an extended member of the asian community, I propose the idea that rice IS a drug. It's damn addictive -- just ask most asians! Gotta have rice on a daily basis, if not at least twice a day. Otherwise you start getting the shakes. Potatoes don't cut it, bread certainly isn't it, and pasta just can't compare to the asian grain of choice.

    Low carb diet? Might as well call it detox!

    Worse yet, its multi-cultural nature can lead to cultural degradation through Ricism. Asian rice tend to be smaller and stick together, texas long-grain tend to be big and separate, and brown rice is "out there" as far as culinary acceptance goes.

    So rice with drugs is harmful. Rice IS already comparable to drugs without the additional drugs. :)

  13. Drug rice... by highwaytohell · · Score: 4, Insightful

    With all this genetically modified food being pushed forward for the betterment of mankind, has anyone ever questioned what would happen to the immune system if we are so hellbent on preventing disease from food sources. Everyone is so cleanliness obsessed that they disinfect everything, but as a child, your immune system has to be built up to defend itself against diseases, with these GM foods being created to basically prevent disease, does that not weaken our immune system, and wouldnt this make us more susceptible to diseases such as the common cold? Fair enough these chemicals are good at for us, and are needed in prevention of certain diseases, but to actually battle the disease and win, our immune system must be up to the task.

    1. Re:Drug rice... by fireduck · · Score: 4, Informative

      most genetically modified foods aren't made for the direct betterment of mankind. rather they are modified for the betterment of the plant. So, rather than make a tomato that is free of salmonella, they are making tomatos that are yucky to tomato worms (for the most part).

      The species that are being made for the betterment of mankind typically are done to rectify dietary defficiencies in a given population. For example, vitamin A rice for developing countries which often have large populations of people who don't get enough vitamin A (lack of causes blindness). The rice in this particular story isn't meant to be used to better all people, but (as i read it) to be a supplement for babies who are not breast-feeding (as it was engineered to have proteins naturally occuring in breast milk).

      The problem with genetically engineering crops isn't that we are "babying" our immune system (that's a separate issue mostly involving the overuse of antibiotics). Rather, the problem is the overreliance on single species (such as the vitamin A rice) and the lack of natural diversity. Eventually an opportunistic pest is going to come along and decimate your rice field; a condition that would be limited if multiple strains of rice were to be grown.

  14. Don't forget after harvest by PIPBoy3000 · · Score: 4, Informative

    There have been documented problems that can occur after harvest as well.

    I personally don't have anything against generically engineered organisms, only that you have to be very careful managing them. While they shouldn't be able to compete as well as "natural" varieties, all it takes are a few big screw-ups to destroy the industry.

    Indoor growing helps, as do a number of other controls that can be put in place. Moderate regulation is a good thing, in my opinion.

  15. Although it seems like a novel idea... by Seoulstriker · · Score: 5, Interesting

    I don't know about the specifics of what kinds of proteins they want to produce with rice, but I do know that it is much more efficient and safe to produce proteins with E. Coli.

    Although they're going for 'out of the lab production' with rice, the potential for problems is just too great. Unlike crops which are genetically modified to produce more of their own proteins or molecules that will be in their environment anyways (like Round-Up), the rice would be producing proteins/molecules/drugs which are completely foreign to the crop environment. What really irks me is that they are producing drugs which will possibly be leaked into the ground after degradation or harvesting. If there happen to be bacteria in the ground with some sort of drug resistance that can be transmitted to other bacteria by plasmids/recombination through contamination of the crops, there will be big problems.

    The use of E. Coli in the production of pharmaceuticals is much more efficient and can be grown in larger quantities using huge vats in research labs.

    On a much more practical note: how exactly are they going to extract the drugs from the rice? Would the rice be sold with the drugs inside and then cooked prior to ingestion? Or would they be steamed and the resulting water ingested?

    Bottom line: using ANY crop for pharmaceutical production is inefficient and dangerous and impractical. E. Coli can do what crops do but with much higher efficiency and practicality.

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  16. ideal solution by KombuchaGuy · · Score: 4, Funny

    Breast-feeding right through to adulthood. I'll sign up.

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  17. Excuse me? by spellraiser · · Score: 5, Funny

    From the article:

    "Even food-processing corporations are very upset about this as well, because they know all you need is one shipment of corn flakes that has a contraceptive in it and there's a real problem, obviously," [Paul] Achitoff said.

    Yes, well obviously ... errr ... yes, a condom in a shipment of corn flakes would cause a problem... not sure what that has to do with genetically engineered rice, but, well, errr ... yes.

    Someone give the man a cigar!

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  18. Genetic material travels well by EmbeddedJanitor · · Score: 4, Insightful

    The biggest concern I have with GE/GM is that too many people think that genetic material can be contained and controlled. Pollen carries genetic material and can easily be blown around the world (let alone over the road into the neighbours crops). Furthermore, viable pollen has been found that is hundreds of years old. So folks, do we really want to let these kinds of things out of the lab?

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    Engineering is the art of compromise.
  19. Re:GM products by adug · · Score: 5, Insightful

    Nobody could adequately test the consequences for genetically modified crops in a time frame that would suit the corporate farming interests like Monsanto that push this stuff.

    The consequences of growing these types of crops and the impact on their surroundings may not be measureable or manifest themselves for years.

    This is why genetically modified crops are such a gamble. Scientists just *don't* know what will really happen, they are hoping for the best based on a shallow dataset of information.

    The thing is, there really is no reason to modify foods genetically in this manner. It's one thing to cross one tomato with another tomato strain to get a redder, juicier tomato, it's quite another to put drugs in them, or make them glow in the dark, or somesuch nonsense.

    If one needs drugs, they should take a pill. Leave the drugs out of the food supply for those of us who don't want it them in our food.

    I hate to bring up the "slippery slope" but given the current state of environmental policy in this country (and worldwide) I choose to *always* default to caution. Destroying, modifying, genetic diversity should be undertaken with *extreme* caution.

    The problem is that it is large corporations with no regard for the environment, or even the best interests of other people, who are railroading this stuff through in the court of public opinion and in government hearings. Anyone who dissents is "against science" or a "luddite" according to them.

    These corporations will tell you that they are doing it to feed poor people in starving nations. This is crap. There is *no* food shortage. There are food distribution problems caused by political or economical concerns.

    If these companies were really concerned about creating nutritious and helpful foods they would learn soil conservation techniques. By and large the vegetables that you eat today are not nearly as good for you as the ones that your grandparents ate because soil depletion and crappy farming techniques have robbed them of their minerals and nutrients.

    I am not a luddite, I am an environmentalist. There is lots of room for scientists to come up with clever plans to increase crop yields and preserve soil *without* putting manmade chemicals and drugs in them.

    Using technology to simply coverup and put a bandaid over mismanaged farming policies is a bad use of said technology and a cheap grab for a buck by people that have no concern what happens to your children.

  20. I'd like rice without carbs first, please by cpu_fusion · · Score: 5, Funny

    Let's apply genetic manipulation to produce carbohydrate-free rice please. This Atkins diet is killin' me!

  21. An equal risk... by qtp · · Score: 4, Insightful

    There is an equal risk that the patent holders will attempt to extort payments from the farmers who's seed stocks have become contaminated with thier "intellectual property".

    Monsanto has already done this. I'm sure that this will not be the last lawsuit of this type, and I'm also sure that the biotech companies are calculating this type of enforcement as an essential part of their income.

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  22. Re:Hey dude... a couple basic questions by waterbear · · Score: 5, Insightful

    Even eating organic rice will not save you, since small amounts of rice seeds will surely drift on the winds and contaminate all crops. Do we really want to risk our young daughters eating abnormal quantities of lactoferrin and risking a higher rate of gigantomastia and breast cancer?

    Just a couple of questions of the kind that often get overlooked ..

    Since when was rice eaten raw?
    Since when did cooked (i.e., denatured) proteins retain the hormonal/enzyme activities of the native protein?

    There's a whole lot of wild imagination going into the stories of these so-called risks.

    -wb-

  23. Why food crops? by tgibbs · · Score: 4, Insightful

    I don't have any problem at all with genetically modified foods. We've been genetically modifying food crops for thousands of years; we've just gotten better at it lately.

    But these aren't genetically modified foods--they are food crops modified to produce drugs. Granted, they seem like fairly benign substances, but I don't understand why they need to use food crops. Surely there are plants that could be used for drug manufacture that are not normally cultivated for human consumption, obviating concerns that pharmaceutical crop seeds will get mistakenly mixed in with food crop seeds, or that pharmaceutical crops with cross-pollinate food crops.

  24. Re:come on guys, lets not be that stupid! by jratcliffe · · Score: 4, Interesting

    "Also consider this, once the naturally genetic code is gone... there is no getting it back."

    The "organic" canola plants used to produce food products are the result of serious human genetic intervention. The first rapeseed plants capable of producing edible oils (previously, it had just been an industrial lubricant) were introduced in Canada in 1968 , and dubbed canola, a contraction of "Canada Oil."

  25. Re:Drug resistance? by Ironica · · Score: 4, Insightful

    it makes far more sense to simply make sure babies get real, complete breast milk, and anything that might be seen to undermine that (hello, Nestle) is going to garner negative press.

    There are cases where breast milk is not an option:

    - Some mothers cannot produce milk at all or cannot produce sufficient milk to feed their baby.

    - A mother who has to take certain drugs for her own health and well-being may not be able to breastfeed because of the risks those drugs present to the baby.

    - Sometimes mom isn't available to breastfeed at all. Women still do occasionally die in childbirth, or more commonly, give their baby up for adoption at birth.

    - Newborns can have several different disorders that make all milk products, including those from mom, anywhere from very uncomfortable to severely damaging to them. Phenylketonuria, severe lactose intolerance, etc.

    So, for several reasons, it's a good idea to improve infant formula as much as possible. We'll probably never be able to get it as good as breast milk (since mom's body can adapt the formulation to environmental factors, such as passing on antibodies to whatever cold is going around), but it's not necessarily a bad idea.

    Interesting that these can also serve as food preservatives, though. You may very well be right about the "true" motivations for this product.

    --
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  26. A Potential Problem by windside · · Score: 4, Insightful

    One of the things that we've seen happening in Canada is that a huge corporation (ie: Monsanto) will sell its genetically modified seed to farmers and charge them an annual licensing fee. The problem arises when some of the seed blows onto neighbouring farmers' fields and starts to merge with their crops. In turn, Monsanto takes legal action against the farmers.

    Here's a link to a good, comprehensive story.

    Basically, the issue at hand is that even before considering the ethical implications of lacing crops with drugs, we should be thinking about the leverage such enhancements will give to corporate heavyweights like Monsanto in their ongoing struggle to preserve "their" intellectual property.
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  27. True accounting... by Genda · · Score: 4, Insightful

    I see this problem at two levels, the specific issue, and a larger systemic problem...

    The first and obvious one, being that the production of crops which have been bioengineered to produce biologically active chemicals and drugs needs to be strickly managed. They must be kept away from other plants, and for that matter, need to be kept away from bateria which can take genetic material and communicate it to wild species (cross species genetic communication is not commonly considered and is a real issue when dealing with novel or unprecedented genetic application.)

    Thalidamide looked like a great idea until deformed babies began to happen. Having a genetically altered crop, speading a gene into wild plant species that might have a significant impact on human health and reproduction, or simply further threaten the viability of endangered environments, is a potential disaster just waiting to happen. We need to place care, and responsiblity ahead of the bottom line, or we might just greedy ourselves to death.

    The second, is an administration that has ramrodded through the various dept. of government, the agenda "Rubberstamp Anything Big Business Wants". Just today, the EPA was forced to push through new business practices which may cause a 700% increase in mercury in the fish we eat over the next 10 years. This is in an environment where the mercury levels are already high enough to warm pregnant women "That eating top tier ocean caught fish more than once a week poses a significant risk for birth defect".

    I'm a firm believer in capitalism, I believe we need to support business, and create a strong and sustainable economy. However, that strength must not come at the cost of social disaster. Our government has become a machine designed to force all resistance including sanity, aside to promote the wishes of large multinational powers. Time and time again the track record is clear. The public is at risk, every single time our welfare come to a head against some D.C. connected industry's profit margin. It's vital that we not try to reduce this to a Republican/Democratic, Conservative/Liberal issue. These are issues involving the fact that our elected officials are too easily bought and sold for the price of funding future election campaigns. We need to change the system, and waiting for the people who benefit from that system, to change it, is clearly pointless. The people need to stand up and mandate a change from the ground up. The quality and longevity of our lives demands it.

    Genda

  28. Re:Hey dude... a couple basic questions by mosb1000 · · Score: 4, Informative

    Yeah, but you'd never produce prions in this manner, or at all for that matter. Prions do a very poor job of catalyzing reactions and are completely useless for anything other than giving people vCJD. And I can't think of any other proteins that work when denatured. The shape of a protein is what gives its unique catalytic capability, denature it and that shape is gone, along with its functionality.

    As for prions, not a lot is understood about them. It seems like they work by denaturing proteins, thus shutting down cell functions and generating more prions. They only seem to be a problem for nerve tissue, perhaps because of its low rate of division, but no one really knows. Also, while they do seem to be a large problem for herbivores (mad cow, chronic wasting disease, and a few other variants) they don't seem to have much of an effect on the carnivores that eat those herbivores. This seems to be true of people as well. Despite the fact that many millions of people (in Britain and elsewhere) have been exposed to BSE contaminated beef, there have only been a few thousand reported cases of vCJD.

    Some researchers believe that natural herds of animals rely on carnivores to remove the animals with chronic wasting. While human hunters usually select the largest, healthiest animals, carnivores typically target the smallest, or weakest animals. This is a theory that will be soon put to the test as the elk herds in Yellowstone become infected with the chronic wasting epidemic that is sweeping northward through the Rocky Mountains. Researchers have noted chronic wasting starting to appear in the elk herds in Teton National Park, which borders Yellowstone on the south.

    Also, CJD (the original kind of CJD which hits people in the later years of their life) seems to be tied to prions, but doesn't seem to be a problem for young people. CJD hasn't been tied to exposure to BSE, it seems that some people just get it later in life.