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A Mouse With Two Mothers
jabberjaw writes "Both the BBC and Nature are reporting that scientists at Tokyo University of Agriculture have used two sets of chromosomes belonging to a female mouse to create what are essentially fatherless mice. The process by which this was accomplished (parthenogenesis) does not naturally occur in mammals. The mouse used lacked a gene known as H19 which in turn activated the Igf2 which allowed this process to occur."
So does this mean we men have no use anymore?
Parthenogenesis (straight from the Wikipedia Link): Parthenogenesis (Greek , "virgin", + , "birth") means the growth and development of an embryo or seed without fertilization by a male. In other words, an embryo/seed develops without receiving a second set of chromosomes from a 'father'. It doesn't matter if that second set came from a female or a male. When NPR covered this story, one of the scientists interviewed actually SAID this was different from parthenogensis, which had been demonstrated previously in many species.
The Y chromosome is a mutation of the X chromosome and contains much less information
True but misleading.
Yes, the Y chromosomes contains less genetic data but it's information not found in the X chromosome. So because data is repeated, two X chromosomes contain less information than an X and a Y.
Yes, it's likely that the Y chromosome is a mutation of an X chromosome, but it differentiated so long ago that 95% of the Y chromosome is male specific.
BTW: I'm not suggesting that this is a deliberate attempt to mislead.
The Y chromosome is a mutation of the X chromosome and contains much less information.
but you forget that males have both X and Y chromosomes. so, while 2 females (only X's) can only create female offspring, males can create both male (XY), female (XX).
I AM a scientist, and I read the research paper in Nature rather than the popular-press rehashings of the article. Of the 371 embryos that were transferred to recipients there were 8 born live and 2 who survived the perinatal period. That should stop the handwaving about the likelihood of producing humans infants using ths approach on the grounds of cost alone.
An extensive amount of genetic engineering was done in order to produce parthenotes that were capable of surviving past 10d of gestation, which is when naturally-occuring parthenotes usually die. One of the two survivors was raised by a foster mother to adulthood and has herself produced a litter of apparently normal pups. The other survivor was sacrificed for gene expression profile studies.
Some whack job might indeed try this on humans, but it is unlikely. It is easy to obtain enough mice recipients for 371 embryos. It will be significantly more challenging to do that for humans. We also do not know what regulatory differences there may be between mice and humans that would prevent the reported protocol from producing viable embryos in vitro.