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UK Scientists to Create Embryo From Two Women

An anonymous reader wrote to mention a BBC story about a UK research group that has been given permission to create a human embryo with genetic material from two women. From the article: "The groundbreaking work aims to prevent mothers from passing certain genetic diseases on to their unborn babies. The researchers are focusing on a group of conditions called mitochondrial myopathy, which include types of muscular dystrophy. These cause muscle weakness and wasting, making it difficult to move normally - some may need to use a wheelchair. At present no treatment for these exists, although things can be done to help with the symptoms. "

40 of 282 comments (clear)

  1. Cool! by Anonymous Coward · · Score: 3, Funny

    I am looking forward to the video. I hope it will be better than cam!

  2. Beginning of a B-Movie? by gbulmash · · Score: 5, Funny
    Seems to me to be the beginning of one of those sci-fi scenarios where women no longer need men to reproduce. Two women want a baby, they just have this procedure done, and voila. No need for sperm to make the baby and there's a 100% guarantee the baby is a girl.

    Gradually, men begin to disappear as old ones die and no new ones are born to replace them, until finally Earth is entirely populated by women.

    Then some major event happens (like a giant meteor strike) that knocks technology back into the stone age. Without men and without labs, no babies can be created. The race is dying out.

    And then, deep in some hidden location, a small cache of men is found in a research facility that was trying to find a way to keep the male half of our species alive. They are the last men on earth, and a planet full of women wants their stud services!

    Commando teams of women try to raid the facility so that the men can be captured, mechanically "milked" for their semen, and it can be distributed. But the facility was created with superior defenses. The men inside are safe. Gradually the women realize that the men are in charge of their own bodies.

    Each day ovulating women line up outside the facility, naked save for a pair of high heels, and bearing gifts of food and assorted lagers. The men choose the ones they find most attractive, then those must face off in an exotic dancing competition to determine who may enter and be serviced.

    I think I've just written the script to a late-night cable movie.

    - Greg

    1. Re:Beginning of a B-Movie? by Rei · · Score: 4, Informative

      This is not anything like "eliminating men". They're not even recombining two women's DNA - they're using using the mitochondrial DNA from one and the combined nuclear DNA from a male and female pair.

      --
      Santa Ana Winds: Like the Dustbowl, but with awards shows.
    2. Re:Beginning of a B-Movie? by Sduic · · Score: 2, Informative

      I realise this is a joke, but it should be noted that the first egg is fertilised.

      --
      *this space intentionally left blank
      "One of the four pointers saying 'come and see', and I saw, and beheld a white
    3. Re:Beginning of a B-Movie? by Quirk · · Score: 3, Informative

      If you like the idea you've pitched then don't miss A Boy and His Dog.

      --
      "Academicians are more likely to share each other's toothbrush than each other's nomenclature."
      Cohen
    4. Re:Beginning of a B-Movie? by Anonymous Coward · · Score: 3, Interesting

      I think sperm was used to fertilize both eggs.

      That aside, what's wrong with sex not being used for reproduction? Many problems might be avoided if everyone were to be sterilized young and then must make a sane choice (when sober and old enough) in order to become pregnant via these techniques, which still require development in a womb.

      Plus, tons of free lovin' without consequences. That's what I'm talking about.

    5. Re:Beginning of a B-Movie? by Anonymous Coward · · Score: 5, Funny

      Quit with the science, nerd-man. I want to see the movie!

    6. Re:Beginning of a B-Movie? by AEton · · Score: 4, Interesting

      There was an episode of Sliders with a slightly different setup but the same conclusion. ("Love Gods"). It was a whole lot like another episode where LOL WOMEN R THE LEADERZ ("The Weaker Sex").

      --
      We recently had heard in the office over one of the Yellow Machine that's made by Anthology Solutions.
    7. Re:Beginning of a B-Movie? by LLuthor · · Score: 2, Funny

      I find your ideas intriguing and wish to subscribe to your newsletter.

      --
      LL
    8. Re:Beginning of a B-Movie? by Bent+Mind · · Score: 2, Interesting

      Ah yes, every man's fantasy... I've seen this plot several times and always wondered...

      First there is the question of how many men are there?

      I always loved the stories where it's only a single man. Talk about something being blue; not from under use, but from over use. Lets not even think of the genetic problems.

      So you start with a small cache of men. You still have the problem of too many woman. So you limit who can breed. How?

      Each day ovulating women line up outside the facility, naked save for a pair of high heels, and bearing gifts of food and assorted lagers. The men choose the ones they find most attractive, then those must face off in an exotic dancing competition to determine who may enter and be serviced.

      Not bad. It'll limit the population, but that is probably a good thing. However, you still have multiple problems. I wonder, if you use your criteria, would natural selection give us a race of attractive, over-sexed humans? You could broaden the scope to include intelligence. How long would it take for the intelligent, attractive woman to just take over?

      Of course, you leave out the most important problem. My great, great, great, great uncle through marrage was a polygamist. It was kept a dark family secrat along my Grandfather's line. When my Grandfather married my Grandmother, he shamefully told her about this distant relative. Her responce always amused me, "Any man who can put up with being married to more than one woman at once has my respect." I wonder, what would it be like to have a planet full of woman demanding that you take the garbage out? Worse yet, at that time of the month. Talk about the stuff of nightmares.

      It's a good fantasy, but lets hope it stays that.

      As for two woman having a baby that's geneticly theirs. Fantastic! It's one less road block to same-sex marrage. Yes, couples can adopt. However, almost everyone wants to continue their genetic line. It's how we gain immortality.

      --
      Request a Linux Shockwave player here: http://www.macromedia.com/support/email/wishform/
    9. Re:Beginning of a B-Movie? by HangingChad · · Score: 3, Funny
      Each day ovulating women line up outside the facility, naked save for a pair of high heels, and bearing gifts of food and assorted lagers.

      Ah, reminds me of college. ;)

      --
      That's our life, the big wheel of shit. - The Fat Man, Blue Tango Salvage
    10. Re:Beginning of a B-Movie? by chamenos · · Score: 2, Funny

      Sheesh...

      "I know it's annoying when ppl correct your spelling..."

      That should be "people".

      "but you spelled woman with an e..."

      "Women" is the plural of "woman". Get a clue yourself before you start getting all pedantic man.

  3. Muscular dystrophy by lordsilence · · Score: 3, Interesting

    Having had my aunt die due to her muscle dystrophy (heart is also a muscle, remember?) I'm for one glad that research is done in the subject.

    I wonder how long time it'll take until we can get rid of the genetic defects which we otherwise risk pass on.

    1. Re:Muscular dystrophy by Wookie+Monster · · Score: 4, Insightful

      general strategy for not passing off genetic defects is to not have children. duh.

    2. Re:Muscular dystrophy by lawpoop · · Score: 2, Funny

      Actually, it's hooking up with people from far-away villages.

      --
      Computers are useless. They can only give you answers.
      -- Pablo Picasso
    3. Re:Muscular dystrophy by GuyverDH · · Score: 3, Insightful

      So, the fact that someone's parents chose to create a child, that by chance had a defect (not carried by the parents, but a transcoding flaw during the combination of the 2 components) should never have children of their own?

      Trust me, if that's *truly* how you feel, then by all means, do NOT have children of your own, and leave the world a better place.

      Otherwise allow science to give hope to couples who wish to have children, but do not wish to pass on the health problems they had to deal with during their lifetime.

      I happen to be a parent, who would have dearly loved to have this as an option, to make 100% certain that nothing was passed on to our child.

      I understand, that you may have been making an attempt at humor. In my opinion, you failed miserably.

      If it wasn't an attempt at humor, then I feel sorry for you.

      --
      Who is general failure, and why is he reading my hard drive?
    4. Re:Muscular dystrophy by iibagod · · Score: 2, Funny

      Good news! You've already started Step One: Posting to Slashdot. Congratulations! You're on your way to a lifetime of celibacy!

  4. So it's egg from one, DNA from another? by autopr0n · · Score: 3, Insightful

    If they are trying to prevent mitocondrial diseases from being passed on, I take it they are using the egg cell from one mother with the neclious removed, and implanting DNA from another in there? That way, they'll have the mitocondria from one, but the DNA from another. A man's DNA will need to be added to the egg in order to reproduce. So really it's Two woman and one man. Or are they actualy somehow doing meosis with two eggs?

    --
    autopr0n is like, down and stuff.
  5. Four-Breasted women coming! by Tablizer · · Score: 2, Funny

    Sign me up for one!

    1. Re:Four-Breasted women coming! by Tablizer · · Score: 2, Funny

      I would rather have one-breasted women, one really big breast.

      You could always date a volcano. Just don't piss her off. Then again, that advice applies to *all* women.

  6. Human reproduction without men by MisterSquid · · Score: 3, Insightful

    Years ago (1995), I gave a presentation as a graduate student about the increasing representation of men as sex objects much in the same way that women had long been characterized: anxious, vapid, to-be-looked-at as opposed to about-to-do-something, etc.

    In the Q & A, someone asked about gender or some such other, and I remember responding that what I really found fascinating was that though much popular thinking surrounded the creation of artificial wombs, women would soon be able to reproduce without the aid of men. The response I received was tepid to say the least. People, especially straight women, don't want to hear about a society without men.

    Of course, cloning was always a possibility but for complex mammals cloning has less that desirable results (for now). This development means that a woman-only state, municipality, sect, etc. is possible and could conceivably reproduce itself in perpetuity.

    Just a few thoughts.

    --
    blog
    1. Re:Human reproduction without men by dvdeug · · Score: 2, Interesting

      though much popular thinking surrounded the creation of artificial wombs, women would soon be able to reproduce without the aid of men.

      The artificial wombs are the easy part; the genetic material from the male in mammals is activated in a way that genetic material for the female is not, and a zygote with genetic material from just females will not develop.

    2. Re:Human reproduction without men by Jim_Callahan · · Score: 2, Insightful

      This would be true if the experiment hadn't required the two ova to be fertilized first. You learn a lot of things by, you know, reading the article/supporting documentation.

      --
      ...it's really a sad day for America when we require a goddamn ACT OF CONGRESS to make our DVD players work properly. ~
  7. Topic = False Impression by Dreoth · · Score: 5, Informative

    This is basically a new surrogate mother approach. Nothing more. The article still mentions the need for sperm. "The result would be an embryo with pronuclei DNA from the parental egg and sperm but mitochondria - and mitochondrial DNA - from the donor egg."

    --
    Fear the turtle farming ninja!
  8. Cytoplasm from one, nucleus from the other by Tau+Zero · · Score: 5, Interesting
    There's DNA in the mitochrondria, which is defective in the nucleus-donor egg but (hopefully) good in the cytoplasm-donor egg. Think of it as trying to replace a chromosome with a defective gene, made easier because this chromosome isn't in the nucleus.

    Curiously, the DNA in the mitochondria use a slightly different genetic code than our nuclear DNA does; genes have moved from the mitochondria to the nucleus over time, but the process is not complete. It's believed that mitochondria come from an ancient endosymbiosis event.

    --
    Time is Nature's way of keeping everything from happening at once... the bitch.
    1. Re:Cytoplasm from one, nucleus from the other by johnnyb · · Score: 3, Insightful

      The problem with mitochondrial myopathies is that it is often unclear whether the problem is nuclear or mitochondrian DNA. Mitochondrion use DNA from both sources, so having faulty mitochondrion doesn't necessarily indicate that using other mitochondrion will solve things.

  9. Why only two women? by drgonzo59 · · Score: 2, Interesting
    If they can take from two, take it from 10 and splice in the best genes and 'there you go' - superbaby. In the day and age, where genes come from doesn't really matter as long as they are good genes.

    Up until a while ago people percieved this magic or spiritual connection between child and parents. Today it is all just genes. Manipulate then anyway you can and create custom children, with selected features.

    1. Re:Why only two women? by martinX · · Score: 2, Funny

      Because while you may end up with a superbaby, all the really crappy genes left over will make Danny DeVito.

      Hasn't Hollywood taught you anything!

      --
      When they came for the communists, I said "He's next door. Take him away. Goddam commies."
  10. Way to Go with the Misleading Headline... by eno2001 · · Score: 2

    This isn't about two women having a baby. It's about a male and female couple's embryo being altered with material from another woman. In other words, two women and a man = embryo.

    --
    -"...bad old ideas look confusingly fresh when they are packaged as technology" - Jaron Lanier (Digital Maoism on Edge.o
  11. hrmmmmm by Anonymous Coward · · Score: 2, Insightful

    they're not combining the DNA from 2 women to create 1 child. With a normal child, etc. all the mitochondria come from the mother. Father's sperm doesn't have any play in this. So its 100% inheritance from the mother.

    this disease is passed on within the mitochondria. What they are trying todo, it seems, is replace the defective mitochondria of the mother with the mitochondria from a healthy donor. Thus preventing the transmission of this disease.

  12. Troll? by Anonymous Coward · · Score: 2, Insightful

    Oh come on. Have a sense of humor.

  13. Excess material ? by Animaether · · Score: 3, Informative

    "UK Scientists to Create Embryo From Two Women"

    There's no way they can fit two women into the tiny package of an embryo - where does the excess material go?

    Joking aside...

    1. They're not making an embryo - they're making a zygote. Which, with any luck, turns into an embryo, foetus, baby, person.

    2. This still involves a man. They're taking one bit of genetic information from one woman - skipping the section where genes are considered out of whack. Then they take -that- section from another woman - where they're considered to be in order. Then they splice those two together and re-insert it into the egg cell. Next up, they get funky with the guy's sperm and do a regular ol' petri-dish fertilization.

  14. Hah! You may jest... by djkitsch · · Score: 3, Insightful

    ...but this was almost exactly the plotline of an episode of Sliders...I kid you not!

    --
    sig:- (wit >= sarcasm)
  15. Just goes to show... by Colitis · · Score: 3, Funny

    ...even God's DRM is hackable.

    And they didn't even need DVD Jon's help!

    What hope do Apple/Microsoft/etc have?

  16. Seriously by FST777 · · Score: 2, Informative

    Oh yes, but where will it stop? What are the etical boundaries in the next 20 years?
    This technology -=might=- harm the human race indeed. I'm not kidding! Now they are eliminating genetic diseases, next they are propagating "good" genes (like brain-development and "kindness"), next they are building the supreme human, and before we know it, by forgetting all about the fact that the human genome is far more complex then any human could begin to understand, we have created a new race of homo sapiens that is showing us we did something terribly and irreversably wrong (no, I'm not talking about them taking over the world... watch a sci-fi for that one...).

    Why is it that all the great scientist in the most advanced technological fields (nuclear fusion, AI, biotechnology) are warning from time to time for disastrous side effects while the popular scientist and the politics are propagating the opposite? Will we until our end try to "advance" against the tides?

    --
    Free beer is never free as in speech. Free speech is always free as in beer.
  17. Re:And the brain? by Mostly+a+lurker · · Score: 3, Funny
    I bet if they would develop the embryo, the baby wouldn't have a brain since no male genes are used. ;)

    Careful research by men suggests that the total lack of a brain would occur only if both the women were blondes. In other cases, the mental processes of the fully grown subject would be extremely myserious but nontheless contain elements of apparent intelligence. The ability of the subject to remember random events from long in the past would be particularly evident.

  18. A simpler answer by fluffy99 · · Score: 2, Interesting

    Isn't it simpler to tell these people carrying fatal genetic flaws to not have biological children? Rather than figure out how to pass on defective genes and have a kid living a screwed up life, go adopt a healthy child!

    It's ludicrous that couples frequently put their desire to have a child ahead of common sense when their child stands a significant chance of being abnormal or handicapped. I've heard of people who keep trying to have kids, knowing that there is a %50 chance of passing on serious genetic defect. Also related are Downs kids. It's proven that males siring kids very late in life dramatically increases the chance of Downs to as high as 1-in-20. Don't be selfish about wanting kids when the odds are so high!

  19. It's worse! It's worse! by kahei · · Score: 2, Insightful


    On top of the problems mentioned above, Britain continues to be plagued by leftist panic-mongers who dump truckloads of artificial fear and guilt on anyone or anything that looks too much like it might result in some progress!

    But I guess you knew that.

    --
    Whence? Hence. Whither? Thither.
  20. slippery slope fallacy. by falconwolf · · Score: 2, Interesting

    So, the slippery slope is a fallacy? Well let's see what the a NAZI propagandist had to say:

    Nazi Herman Goering on Military Recruting
    "Why of course the people don't want war. Why should some poor slob on a farm want to risk his life in a war when the best he can get out of it is to come back to his farm in one piece? Naturally the common people don't want war neither in Russia, nor in England, nor for that matter in Germany. That is understood. But, after all, it is the leaders of the country who determine the policy and it is always a simple matter to drag the people along, whether it is a democracy, or a fascist dictatorship, or a parliament, or a communist dictatorship. Voice or no voice, the people can always be brought to the bidding of the leaders. That is easy. All you have to do is tell them they are being attacked, and denounce the peacemakers for lack of patriotism and exposing the country to danger. It works the same in any country."

    It worked for the NAZIs and seems to of had worked for Bush after 911. Now, dispite there being a constitutional ban on imprisoning someone indefinately without being charged, a federal appeals court has ruled that the government holding Padilla is legal.

    Falcon
    1. Re:slippery slope fallacy. by falconwolf · · Score: 2, Interesting

      The fallacy is that not everything goes all the way over the line. The fact that you can provide an example of something that did go over the line does not contradict that.

      The point isn't that it doesn't happen all the tyme but that it only takes once. This was one case of where it did work. And like Benjamin Franklin said, "They that can give up Essential Liberty to obtain a little temporary safety deserve neither Liberty nor Safety." The problem with the slippery slope is that you don't realize you're on it until it's too late. I'd rather prevent it from happening than to fight against it once it's started.

      Faclon