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UK Scientists to Create Embryo From Two Women

An anonymous reader wrote to mention a BBC story about a UK research group that has been given permission to create a human embryo with genetic material from two women. From the article: "The groundbreaking work aims to prevent mothers from passing certain genetic diseases on to their unborn babies. The researchers are focusing on a group of conditions called mitochondrial myopathy, which include types of muscular dystrophy. These cause muscle weakness and wasting, making it difficult to move normally - some may need to use a wheelchair. At present no treatment for these exists, although things can be done to help with the symptoms. "

20 of 282 comments (clear)

  1. Cool! by Anonymous Coward · · Score: 3, Funny

    I am looking forward to the video. I hope it will be better than cam!

  2. Beginning of a B-Movie? by gbulmash · · Score: 5, Funny
    Seems to me to be the beginning of one of those sci-fi scenarios where women no longer need men to reproduce. Two women want a baby, they just have this procedure done, and voila. No need for sperm to make the baby and there's a 100% guarantee the baby is a girl.

    Gradually, men begin to disappear as old ones die and no new ones are born to replace them, until finally Earth is entirely populated by women.

    Then some major event happens (like a giant meteor strike) that knocks technology back into the stone age. Without men and without labs, no babies can be created. The race is dying out.

    And then, deep in some hidden location, a small cache of men is found in a research facility that was trying to find a way to keep the male half of our species alive. They are the last men on earth, and a planet full of women wants their stud services!

    Commando teams of women try to raid the facility so that the men can be captured, mechanically "milked" for their semen, and it can be distributed. But the facility was created with superior defenses. The men inside are safe. Gradually the women realize that the men are in charge of their own bodies.

    Each day ovulating women line up outside the facility, naked save for a pair of high heels, and bearing gifts of food and assorted lagers. The men choose the ones they find most attractive, then those must face off in an exotic dancing competition to determine who may enter and be serviced.

    I think I've just written the script to a late-night cable movie.

    - Greg

    1. Re:Beginning of a B-Movie? by Rei · · Score: 4, Informative

      This is not anything like "eliminating men". They're not even recombining two women's DNA - they're using using the mitochondrial DNA from one and the combined nuclear DNA from a male and female pair.

      --
      Santa Ana Winds: Like the Dustbowl, but with awards shows.
    2. Re:Beginning of a B-Movie? by Quirk · · Score: 3, Informative

      If you like the idea you've pitched then don't miss A Boy and His Dog.

      --
      "Academicians are more likely to share each other's toothbrush than each other's nomenclature."
      Cohen
    3. Re:Beginning of a B-Movie? by Anonymous Coward · · Score: 3, Interesting

      I think sperm was used to fertilize both eggs.

      That aside, what's wrong with sex not being used for reproduction? Many problems might be avoided if everyone were to be sterilized young and then must make a sane choice (when sober and old enough) in order to become pregnant via these techniques, which still require development in a womb.

      Plus, tons of free lovin' without consequences. That's what I'm talking about.

    4. Re:Beginning of a B-Movie? by Anonymous Coward · · Score: 5, Funny

      Quit with the science, nerd-man. I want to see the movie!

    5. Re:Beginning of a B-Movie? by AEton · · Score: 4, Interesting

      There was an episode of Sliders with a slightly different setup but the same conclusion. ("Love Gods"). It was a whole lot like another episode where LOL WOMEN R THE LEADERZ ("The Weaker Sex").

      --
      We recently had heard in the office over one of the Yellow Machine that's made by Anthology Solutions.
    6. Re:Beginning of a B-Movie? by HangingChad · · Score: 3, Funny
      Each day ovulating women line up outside the facility, naked save for a pair of high heels, and bearing gifts of food and assorted lagers.

      Ah, reminds me of college. ;)

      --
      That's our life, the big wheel of shit. - The Fat Man, Blue Tango Salvage
  3. Muscular dystrophy by lordsilence · · Score: 3, Interesting

    Having had my aunt die due to her muscle dystrophy (heart is also a muscle, remember?) I'm for one glad that research is done in the subject.

    I wonder how long time it'll take until we can get rid of the genetic defects which we otherwise risk pass on.

    1. Re:Muscular dystrophy by Wookie+Monster · · Score: 4, Insightful

      general strategy for not passing off genetic defects is to not have children. duh.

    2. Re:Muscular dystrophy by GuyverDH · · Score: 3, Insightful

      So, the fact that someone's parents chose to create a child, that by chance had a defect (not carried by the parents, but a transcoding flaw during the combination of the 2 components) should never have children of their own?

      Trust me, if that's *truly* how you feel, then by all means, do NOT have children of your own, and leave the world a better place.

      Otherwise allow science to give hope to couples who wish to have children, but do not wish to pass on the health problems they had to deal with during their lifetime.

      I happen to be a parent, who would have dearly loved to have this as an option, to make 100% certain that nothing was passed on to our child.

      I understand, that you may have been making an attempt at humor. In my opinion, you failed miserably.

      If it wasn't an attempt at humor, then I feel sorry for you.

      --
      Who is general failure, and why is he reading my hard drive?
  4. So it's egg from one, DNA from another? by autopr0n · · Score: 3, Insightful

    If they are trying to prevent mitocondrial diseases from being passed on, I take it they are using the egg cell from one mother with the neclious removed, and implanting DNA from another in there? That way, they'll have the mitocondria from one, but the DNA from another. A man's DNA will need to be added to the egg in order to reproduce. So really it's Two woman and one man. Or are they actualy somehow doing meosis with two eggs?

    --
    autopr0n is like, down and stuff.
  5. Human reproduction without men by MisterSquid · · Score: 3, Insightful

    Years ago (1995), I gave a presentation as a graduate student about the increasing representation of men as sex objects much in the same way that women had long been characterized: anxious, vapid, to-be-looked-at as opposed to about-to-do-something, etc.

    In the Q & A, someone asked about gender or some such other, and I remember responding that what I really found fascinating was that though much popular thinking surrounded the creation of artificial wombs, women would soon be able to reproduce without the aid of men. The response I received was tepid to say the least. People, especially straight women, don't want to hear about a society without men.

    Of course, cloning was always a possibility but for complex mammals cloning has less that desirable results (for now). This development means that a woman-only state, municipality, sect, etc. is possible and could conceivably reproduce itself in perpetuity.

    Just a few thoughts.

    --
    blog
  6. Topic = False Impression by Dreoth · · Score: 5, Informative

    This is basically a new surrogate mother approach. Nothing more. The article still mentions the need for sperm. "The result would be an embryo with pronuclei DNA from the parental egg and sperm but mitochondria - and mitochondrial DNA - from the donor egg."

    --
    Fear the turtle farming ninja!
  7. Cytoplasm from one, nucleus from the other by Tau+Zero · · Score: 5, Interesting
    There's DNA in the mitochrondria, which is defective in the nucleus-donor egg but (hopefully) good in the cytoplasm-donor egg. Think of it as trying to replace a chromosome with a defective gene, made easier because this chromosome isn't in the nucleus.

    Curiously, the DNA in the mitochondria use a slightly different genetic code than our nuclear DNA does; genes have moved from the mitochondria to the nucleus over time, but the process is not complete. It's believed that mitochondria come from an ancient endosymbiosis event.

    --
    Time is Nature's way of keeping everything from happening at once... the bitch.
    1. Re:Cytoplasm from one, nucleus from the other by johnnyb · · Score: 3, Insightful

      The problem with mitochondrial myopathies is that it is often unclear whether the problem is nuclear or mitochondrian DNA. Mitochondrion use DNA from both sources, so having faulty mitochondrion doesn't necessarily indicate that using other mitochondrion will solve things.

  8. Excess material ? by Animaether · · Score: 3, Informative

    "UK Scientists to Create Embryo From Two Women"

    There's no way they can fit two women into the tiny package of an embryo - where does the excess material go?

    Joking aside...

    1. They're not making an embryo - they're making a zygote. Which, with any luck, turns into an embryo, foetus, baby, person.

    2. This still involves a man. They're taking one bit of genetic information from one woman - skipping the section where genes are considered out of whack. Then they take -that- section from another woman - where they're considered to be in order. Then they splice those two together and re-insert it into the egg cell. Next up, they get funky with the guy's sperm and do a regular ol' petri-dish fertilization.

  9. Hah! You may jest... by djkitsch · · Score: 3, Insightful

    ...but this was almost exactly the plotline of an episode of Sliders...I kid you not!

    --
    sig:- (wit >= sarcasm)
  10. Just goes to show... by Colitis · · Score: 3, Funny

    ...even God's DRM is hackable.

    And they didn't even need DVD Jon's help!

    What hope do Apple/Microsoft/etc have?

  11. Re:And the brain? by Mostly+a+lurker · · Score: 3, Funny
    I bet if they would develop the embryo, the baby wouldn't have a brain since no male genes are used. ;)

    Careful research by men suggests that the total lack of a brain would occur only if both the women were blondes. In other cases, the mental processes of the fully grown subject would be extremely myserious but nontheless contain elements of apparent intelligence. The ability of the subject to remember random events from long in the past would be particularly evident.