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Scientists Produce Fearless Mice

Dotnaught writes "According to New Scientist, a Rutgers University geneticist has found that turning off a specific gene for the protein stathmin makes mice fearless. The story speculates that this research might improve treatment for phobias. It does not mention obvious military applications for the discovery. As noted in this Naval Officer's guide for managing fatigue, the use of amphetamines to stay alert, followed by sedatives to sleep, has a long tradition. Genetic treatments may offer an alternative to pharmaceuticals."

29 of 499 comments (clear)

  1. Good old PCP by ReformedExCon · · Score: 5, Insightful

    Whatever happened to the good old days of pumping soldiers full of angel dust to rid them of fear?

    The non-military uses for such a treatment are pretty far-reaching. Would it be able to cure people that suffer anxiety attacks? Could children with night terrors be cured?

    If the rats don't feel fear, do they also lose understanding of danger? That would be a pretty bad mutation.

    --
    Jesus saved me from my past. He can save you as well.
    1. Re:Good old PCP by general_re · · Score: 5, Insightful
      If the rats don't feel fear, do they also lose understanding of danger? That would be a pretty bad mutation.

      My first thought also. There are some situations where fear is an entirely appropriate response - lose it, and unwarranted risks may start to become a problem.

      --
      ABSURDITY, n.: A statement or belief manifestly inconsistent with one's own opinion.
    2. Re:Good old PCP by Anonymous Coward · · Score: 1, Insightful

      > Would it be able to cure people that suffer anxiety attacks?

      Perhaps. For many people with anxiety attacks, they can be overcome by practicing whatever gives them the most panics. over and over, until it becomes re-learned that it's really a safe behaviour. If a treatment like this could be enabled temporarily, it might help.

      Then again if there's no fear, there may also be no concept of 'safe' either, so when the treatment is eased off everything may fall back to how it was beforehand.

      Much testing to be done.

    3. Re:Good old PCP by blincoln · · Score: 2, Insightful

      Whatever happened to the good old days of pumping soldiers full of angel dust to rid them of fear?

      Um, source?

      From my experience, PCP would be a terrible thing to give soldiers. You'd end up with a Jacob's Ladder scenario where they become afraid of - and attack - friends and enemies at random.

      --
      "...always new atoms but always doing the same dance, remembering what the dance was yesterday." -Richard Feynman
    4. Re:Good old PCP by general_re · · Score: 2, Insightful
      Imagine the evolutionary turn that could create - it would put much more emphasis on critical thinking, and if it weren't for fear, I think we'd end up with a smarter society.

      And/or a much smaller society, as you say ;)

      The other thing that occurs to me is that I think that for many (if not most) people there are certain situations where fear of the consequences is one of the main things that keeps them (us) from behaving badly. Take away that fear, and pretty much the only thing that's left is the relatively straightforward and cold calculus of "can I get away with this?" And unfortunately, there already doesn't seem to be a shortage of people who think that yes, they are clever or careful enough to get away with some bad act - absent fear, they'd have one less restraint on their behavior.

      --
      ABSURDITY, n.: A statement or belief manifestly inconsistent with one's own opinion.
  2. Military applications make me shiver... by stirz · · Score: 5, Insightful

    Giving Methamphetamines to soldies to "stay alert" and to "strengthen confidence" has -sadly enough- a long tradition. As Wikipedia tells us even the Nazis spreaded the drug among their Wehrmacht. What's the point of a government saying "Stay away from drugs!" on the one hand and willingly giving it to soldiers on the other?

    Seems alright, I quit military service a long time ago...

    Regards

    Stirz

    1. Re:Military applications make me shiver... by QuantumG · · Score: 2, Insightful

      What's the point of a government saying "Stay away from drugs!"

      That's all you needed to say. There isn't two hands. Governments should butt the hell out and mind their own business.

      --
      How we know is more important than what we know.
    2. Re:Military applications make me shiver... by skinfitz · · Score: 5, Insightful

      How is this different to a Government saying "Don't kill people!" then putting guns and high explosives into the hands of soldiers?

      The only logic here is 'do what we say and don't question anything.'

    3. Re:Military applications make me shiver... by Mjlner · · Score: 4, Insightful
      "As Wikipedia tells us even the Nazis spreaded the drug among their Wehrmacht."

      What do you mean, "even the Nazis"? A totalitarian government, emphasizing the military and denial of the individual, would be almost expected to do this. What is more scary, is that democracies, which we expect to respect and defend the rights of the individual, even to the point of restricting what the police and military can do, are chemically altering the bodies and minds of their soldiers.

      --
      Lemon curry???
    4. Re:Military applications make me shiver... by GypC · · Score: 2, Insightful

      The purpose of amphetamines is to keep the "push" going; constantly moving forward against the enemy and keeping them off balance, unable to regroup. It's a way to win a battle and keep more of your soldiers alive. It's a standard strategy in all modern armies and would be used regardless of the availability of drugs, the drugs just help them stay awake and stay alive.

  3. i question the ethics of this by caffeinemessiah · · Score: 1, Insightful

    IMHO, there are much better ways of curing phobias than resorting to potential treatments based on genetics. It's much easier to imagine military and other subversive applications to motivate this kind of research. Imagine it billed as a "cure" to shell shock and other combat-related situations. While its definitely interesting that we now understand fear a little better, removing fear, or even tinkering with its inner workings, seems nothing short of asking for disaster. We have fear for a reason, and methink moderating it arbitrarily to within parameters that we specify will be more challenging than it is worth.

    --
    An old-timer with old-timey ideas.
  4. Are these mice really fearless... by Mjlner · · Score: 4, Insightful

    ...or just plain stupid?

    --
    Lemon curry???
  5. Isn't fear important? by Maavin · · Score: 1, Insightful

    I don't think that an army of fearless soldiers would be that effektive.

    Imagine hordes of these running fearless into machinegun fire... Very effective, I presume....

    Fear often prevents us from doing really stupid things. So far this worked good along evolution...

    --


    Crivens! I kicked meself in me own heid!
  6. since when does being alert = fearless? by artifex2004 · · Score: 4, Insightful

    The two certainly do not equate.

  7. fear is a good thing by circletimessquare · · Score: 5, Insightful

    people nowadays like to talk about fear in ideological and propagandistic terms, but fear keeps you alive. it keeps you from wandering into traffic or picking fights with random people. if this were ever applied to humans, you wouldn't have superhuman heroic fighters for the military, you'd have guys shooting themselves with their own guns and jumping off roofs... why not, when you're not afraid of anything, including death

    --
    intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
    1. Re:fear is a good thing by Private+Taco · · Score: 2, Insightful

      Fear (in moderation), like so many things in life, is essential. Deciding which fears to heed is the tricky part.

      --
      If I could, I'd destroy you all.
    2. Re:fear is a good thing by UserGoogol · · Score: 5, Insightful

      I don't think so. Fear is not the source of all human behavior. Without fear, people could still say, "Well... I could jump off the roof, but then I'd probably break a few bones, and that would hurt, and I don't like being hurt." (After all, you are arguing right now that there is something inherently bad about being shot in the head, surely a fearless person might be able to see your argument.)

      Fear is merely a mental shortcut. Instead of rationally arguing that doing something will lead to an unadvantageous situation, our brains merely automatically develop fears of the situation and we avoid it quasi-instinctually.

      That said, if you were to completely remove fear without changing anything else, I do not doubt that shit would happen. Human beings are nowhere near as smart as they could be, and are probably not capable of thinking things out clearly enough. As it stands, we probably need mental crutches like fear until we are able to augment our intelligence.

      But still, we should not imply that fear and desire are the only things capable of driving people. Fear is distinct from pain, desire is distinct from happiness.

      --
      "Never attribute to malice that which can be adequately explained by stupidity." -- Hanlon's Razor
  8. If the fearless-gene was beneficial for the mice by gomel · · Score: 2, Insightful

    this mutation would have dominated the species milions of years ago.

    In a world of cats, fear is the superior evolutionary trait.

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  9. No, fearless mice get eaten. by kale77in · · Score: 2, Insightful

    If you put a fearless mouse in the wild, it will die like anything else that lacks a healthy sense of which dangers are worth avoiding.

  10. Fearless doesn't mean insane by microbox · · Score: 2, Insightful

    Fear is an emotion that rules our lives from moment to moment. Losing fear doesn't mean losing sanity, actually is usually means the opposite.

    --

    Like all pain, suffering is a signal that something isn't right
  11. Re:Military applications ? by varjag · · Score: 4, Insightful

    What you want is soldiers that are more afraid of their commanding officers than the enemy; that way they'll follow orders.

    It is a bit of oversimplification. Soldiers can be motivated by things other than fear: the sense of friendship, pride, the feeling of responsibility and (misguided or not) patriotism. History is full with exapmles of people knowingly and willingly sacrificing their life for good of others, ranging from Spartans to Soviet atheists (neither of those could even hope for a decent afterlife: the void of Hades ain't much better than simple non-existance). I believe that in Iraq fights of today you could find such instances at both sides involved, too.

    That said, your general argument remains valid. Humans for high command are mostly numbers, and are operated from statistical point of view. They would hate to rely solely for underlings' loyalty.

    --
    Lisp is the Tengwar of programming languages.
  12. Re:Military applications ? by killjoe · · Score: 2, Insightful

    Did you see the interview with the tank drivers when they were talking about what kinds of music they were playing while on a "mission"? It was clear that whatever other motivations they had for killing enjoyment was undeniably a factor.

    I think we overlook how much fun it is to kill. It does satisfy a deep urging we have as animals. It's why people hunt, It's why children enjoy ripping legs off of grasshoppers, I knew a guy who used to buy mice and hit them with a golf club. There is a tremendous fun element in killing.

    --
    evil is as evil does
  13. Re:Military applications ? by rstovall · · Score: 2, Insightful

    That's because there is no military applications. You don't want the soldiers to become fearless, because if they do, they might say: "This war is wrong. I used to be too afraid to do anything about it, but now I suddenly feel fearless, and will get the heck away from here !" Basically, fearless soldiers will refuse to obey when given orders that they think are wrong, and cannot be forced to obey by fear of punishment.

    This is so incorrect as to lead me to guess that the original poster either has not served in the armed services or had a bad experience while doing so. In a successful military, soldiers serve because they believe, not because they are forced to. This is exactly why, even in this era of recruiting problems, the US military still strongly prefers to avoid the draft. It is choice, not fear, that makes fighters effective.

    --
    Confined though we are, infinity dwells within.
  14. The appropriate techical term is "berserker" by smchris · · Score: 2, Insightful

    This seems like a profoundly unwise idea. And unless they can reactivate the gene at decommissioning, troops who survive their fearlessness better report to the Soylent Green Division for final debriefing. (And why wouldn't they? They're fearless.)

  15. I doubt it by Joe+Tie. · · Score: 2, Insightful

    "Genetic treatments may offer an alternative to pharmaceuticals." So a company has two options. Either a (theoretically and best case) one time genetic therapy which will raise the wrath of a public who leaned everything they know about science from bad movies. Or slightly less effective pills targeting the same mechanism, but which can be sold again and again to a person throughout their lives. I think the whole customer for life deal has a bit more appeal.

    --
    Everything will be taken away from you.
  16. I'm not so sure by hey! · · Score: 2, Insightful

    We're a big bag of complex chemical equillibria and messy neural wiring. We give names like "love" and "fear" to aspects of the subjective experience of existing this way, but they're seldom precise enough to be something you can switch on and off. You're bound to get either more than you intend or less than you intend, or both.

    Fear would seem to be a good candidate for a neurobiologically switchable emotion, but even fear is more complex than it seems at first glance.

    I saw a photo in some book I read on the psychology of emotions that showed a truck tipping over. The truck was loaded with maybe thirty soccer fans returning from a game, and all that rowdy weight caused the thing to overbalance. The photo was taken just as the truck was approaching 45 degrees, and the people on the top were leaping to safety. What was interesting about the photo was the peoples' faces. The people leaping to safety had no look of fear or emotion at all -- just intense concentration. The driver, however is obviously terrified.

    The point is that there is arousal in response to danger, and there is fear. Arousal in the presence of danger is not fear: fear is specifically an emotional reaction to helplessness in the presence of danger. It's evolution's way of say, "If you're going to do nothing about this situation, then you'd better do it really, really unobtrusively."

    There is already a method for controlling and eliminating fear in a soldier. It's called "training". You ingrain the right response in a danger situation into him so he can act automatically. He may be afraid before hand and traumatized afterward, but you want him aroused and as close to fearless as possible at the moment of truth.

    Because of the imprecision of language, I suspect a pill that turns off "fear" would actually make a soldier's training less effective. The physiological and emotional response to danger which is not fear, or at least not exactly fear, curiously doesn't have a distinct name. Clearly this unnamed state is a kind of emotional state -- one in which reactions are automatic and information is extensively filtered down to that which is paradigmatically most useful for survival. Perhaps "fear" is a reasonable umbrella term for all kinds of arousal reactions to danger, but we have to distinguish between being "frightened" or "scared" on one hand and being "terrified" or "petrified".

    But whatever the word is, I expect the condition of reacting to danger is on the whole more beneficial to the warrior than it is detrimental to a warrior. And, as you say, if the soldier does not react in an emotional way to danger, then the way he does react is probably unpredictable. An ideal pill from a military standpoint would narrowly block the "petrification" reflex, without altering any of the other subjective aspects of fear.

    --
    Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
  17. Re:If the fearless-gene was beneficial for the mic by Wordsmith · · Score: 2, Insightful

    Not necessarily. Darwinian evolution doesn't necessarily dictate that the best mutation wins out. It generally suggests that the mutation best adapted to the species' circumstances will survive, but really, anything that works well enough to allow further breeding will still continue to exist. That's why we have all sorts of absurd animals in nature right alongside the magnificent ones, and why in our own species various forms of genetic disease and handicap continue (although for the latter, our own social evolution and co-dependency has something to do with it too).

  18. Re:My Vision of the Future by justin12345 · · Score: 2, Insightful

    Yeah if you want to see what a fearless soldier would look like, just watch a bunch of little kids play any FPS. They just run around aimlessly and when they find someone, they run straight at them shooting. They die a lot.

    --
    Cool art gallery, if you're into that sort of thing.
  19. Re:Maybe, maybe not, but nothing in it for the Arm by HTH+NE1 · · Score: 2, Insightful

    Because how do you maintain order in an Army if the soldier has totally no fear of the consequences of not obeying ?

    Start a eugenics war? Control them with drugs?

    --
    Oh, say does that Star-Spangled Banner entwine / The myrtle of Venus with Bacchus's vine?