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Fantastic Voyage Into the Heart
Roland Piquepaille writes "According to the Journal of Clinical Investigation (JCI), researchers from the Harvard Medical School have written a sequel to 'Fantastic voyage,' the 1966 sci-fi movie. By injecting self-assembling peptide nanofibers loaded with pro-survival factors into rats, they've showed that the animals could be protected from heart failures. So far, the researchers have not extended their experiments to humans."
</hoping the RIAA wont sue him for posting lyrics>
For those of us without PhD's in medical sciences?
The title of the article is rather confusing... but here's my take -
First of all, I doubt that this is going to be approved for human use any time soon, even IF they can prove a good success rate.
Speaking of which, what IS their success rate? As promising as this seems, I don't know if I want this if it's a save-you-or-kill-you sort of treatment. However, their study results show that, in mice, it seems to work just fine.
From TFA:
"A blinded and randomized study in 96 rats showed that injecting nanofibers with PDGF-BB, but not nanofibers or PDGF-BB alone, decreased cardiomyocyte death and preserved systolic function after myocardial infarction. A separate blinded and randomized study in 52 rats showed that PDGF-BB delivered with nanofibers decreased infarct size after ischemia/reperfusion."
"[Note: PDGF stands for "Platelet-derived growth factor" and is is one of the numerous proteins that regulate cell growth and division according to Wikipedia.]"
I'm not a doctor/biologist/etc, but is this something we want to be messing with? I mean, sounds like encouraging excessive cell growth in the heart wouldn't be a good idea at all. It's one thing if the patient is dying, but quite another if people are taking this so they're at a lowered risk of a heart attack later. TFA doesn't seem to mention side effects at all, much less potential side effects in humans.
I'm also not a statistician, but their sample size doesn't seem to be all that large, either.
I may be overanalyzing this, but I'll definitely want to see a LOT more research before I'll write this off as anything other than another group of scientists claiming a magic bullet.
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Fantastic Voyage is originally a book by Asimov, who already wrote a sequel (Fantastic Voyage II: Destination Brain). The link between TFA and Asimov's novel is faint, if not null. People with interest in Medical research shouldn't be getting their feeds from ZD Net. And while we're at it, the past participle of show is shown.
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... the better SF reference is not to "Fantastic Voyage", for that movie used mAcrotech made tiny, without any changes allowing for different effects of nano-scale. The atomic-powered minisub was a normal atomic-powered minisub, the two-handed surgical laser was a normal two-handed surgical laser, and the madatory busty female was a normal mandatory busty female. They were simply rendered smaller, that's all.
In contrast, Borg nano-technology takes full advantage of the unique properties of objects in small scale, just as does the self-assembling peptide nanofibers referenced in the announcement.
We wouldn't want our SF references to be unrealistic, would we?
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So far they've only used rats for the trials. I say they should take the next step and use politicians for the next round of tests. Medical science has shown that politicians and rats share 99.99% of their genes in common, so the risks should be minimal. Besides, with the current state of political affairs in the U.S. I doubt that many of the voting public would complain if a few wayward politicians made a valiant sacrifice in the name of science.
---
First step: Politicans with a heart.
Second step: Politicians with a soul.
Third step: .
Fourth step: Utopia.
Stop fixing the rats dammit!, they gonna kill us all!
Does it star Coolio?
I spend most of my time in bed, darling.
Hmm, my marketing filter is flashing again..
Panten Pro-V conditioning shampoo with "self-assembling peptide nanofibers loaded with pro-survival factors" for extra shine and longevity..
I'm not calling BS, but cant a crack team of Hardard scientists be a little bit more specific with a short quote!
The sample size isnt too bad, if you have a good correlation. Cutting open that many mice and giving them heart attacks can take some work. Then you need to let them recover, then you need to "harvest" the mice and examine their hearts.
Storm
Scientists, the leading cause of cancer in lab rats.
I'm too lazy to read the actual study results, and TFA doesn't say, but "self-assembling peptide nanofibers" sound an awful lot like prions to me. Given all the work that's been done on using viruses for genetic engineering, I suppose prion-based therapy was bound to come along eventually.
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