Slashdot Mirror
Stem Cells to Treat Brain Injury in Children
BigDukeSix writes "The first stem cell trial with widespread public health implications is set to begin in Houston. From the article: "Trauma is far and away the main cause of death and disability among children, and the main reason children die from trauma is brain injury...The clinical trial is the first to apply stem cells to treat traumatic brain injury. It does not involve embryonic stem cells.""
Some more information on using stem cells from bone marrow to grow neurons can be found here.
As you can see from the date of the above referenced article, the idea of using stem cells derived from bone marrow to treat brain injury has been around for a while, but now that we've finally progressed to human trials, this field is going to get very exciting very fast. This has the potential to completely rewrite the textbooks on brain & nerve trauma...it's a real pity that Christopher Reeve had to leave us before we made these advances.
____
~ |rip/\/\aster /\/\onkey
Well, that's good news. No ethical dilemma.
It would have been nice if the media stressed the promise of non-embrionic stem cells to the public more (there has been some stories), but it is nice to see it now.
Except for ending slavery, the Nazis, communism, & securing American independence, war has never solved anything.
A couple of days ago people were freaking because experimental drugs were being used on India's poor. http://science.slashdot.org/article.pl?sid=05/12/1 9/1838223&tid=191&tid=219
So how come nobody's up in arms about this experimental procedure being used on children in Texas? Presumably the Indian subjects were in need of treatment too.
at the pearly gates. St. Peter is at gates, interviewing each person as they get to the front of the queue. Suddenly, a man appears in surgical scrubs walks up to the front of the line, nods to St. Peter, and enters the kingdom of heaven. Outraged, the man at the back of the line chrages up to St. Peter and demands to know why the doctor does not have to stand in line with the rest of the people. St. Peter replies, "Oh, that was God...he just thinks he's a doctor."
Is it just my observation, or are there way too many stupid people in the world?
Stem cells might be a neat buzzword to get funding, but as a parent of a child with serious brain damage, I can tell you that this is more likely a politically motivated stunt to grease the slippery slope of stem cell research, than something that will generate measurable results. After all, nobody wants to hurt brain damaged children.
The reason I'm so cynical is that babies are very resilient, and for the most part they are like stem cell factories on their own. As they grow, they produce new brain and nerve material, which adults cannot do. It is adult disease and injury (and greed) that fuels the stem cell craze, since our adult bodies cannot heal like young children can.
My daughter had a stroke two months before she was born. This stroke wiped out 85% of the left hemisphere of her brain, replacing it with a fluid filled cyst. When she was three months old, she had an operation to add a drainage passage to this cyst, as it was filling with cerebral spinal fluid and had expanded to fill the entire left half of her cranium cavity. This operation cut through parts of her brain, leaving her completely blind.
At nine months of age, the drainage passage had collapsed, and the cyst had enlarged to block all drainage of cerebral spinal fluid from her brain. Her head swelled with a condition know as hydrocephalus, and she almost died. That night, the CAT scans showed that 75% of the volume that should have been occupied by her brain was filled with fluid. She had an emergency operation to install an artificial drainage valve (a shunt). This event was catastrophic, and was like having her "reset" switch activated, she had to re-learn everything.
Now, the good news. She is eighteen months old now, and has recovered remarkably. Her last CAT scan showed that the original cyst had been reduced to only 25% of the left half of her brain, and the right half is completely restored. The original passage that was cut, that caused her blindness, has healed shut. Her vision is steadily improving and she shows signs that she may be functional without the use of a cane someday. Sure, she's a little behind developmentally, but she is showing lots of promise. All of her healing was without the use of any stem cell treatment, because babies are stem cell factories. Her same injuries would have killed an adult, several times over.
-- Len
On behalf of the Slashdot anti-religion crowd, please stop turning every topic into an unprovoked attack on religion and Bush. It's making us look bad. Especially when the attack is as stupid as this.
But they do want access to embryonic stem cells, which suggests to me that embryonic stem cells have some useful property that adult stems cells don't.
They have a higher potential benefit in that they may be more able to develop into a larger numbers of types of tissue. Basically, it was initially thought that stem cells from marrow could only be used to generate red blood cells whereas it seemed perfectly evident that infant stem cells could turn into all kinds of tissue given they're what the body starts from. Since then, we've found that adult stem cells can transform into a number of different kinds of tissues. *wry grin* Not that most of these experiments try to actually transdifferentiate the stem cells. If you read into the details of these experiments, most come down to "we inject a bunch of stem cells into part of the body and see if anything happens."
Basically, the whole thing is over potential. The proponents of infant stem cells say that those stem cells may work better and the adult stem cell people are finding ways to use stem cell therapy without the requiring the sacrifice of another human life for a potential benefit.
This sig has absolutely no significance and serves only to take up screen space and waste the time of the reader.
Hate to argue against Segan, but those "wasteful wars" are part of what got us to where we are today. Without the V2 would we have space exploration? Without the typhus and cholera of world war I would there have been as much pressure for antibiotics and insecticides? Without constant warfare would we have had any reason to move from copper to bronze to iron to steel? Without britain stripping her forests for the navy would she have needed to move to coal power? Ok, so wars destroy, and for that I condemn them, but you can't say "if we held hands and sang ku-bah-yah for 20 centuries we would have flying cars now". War is part of the history which brought us here, and part of what drove our progress.
Boys from the City. Not yet caught by the Whirlwind of Progress. Feed soda pop to the thirsty pigs.
Well, still, using embryonic cells is pretty sick, unethical
I guess you're not an organ donor, either, huh? And, if you were dying of, say, liver cancer, you'd turn down a chance to live our your life with a donated organ? Why? Because it's "sick" to use something that's beyond the use of a dead body?
We sure wouldn't want people living longer, healthier, more productive lives if it means burying someone with a pound less of their internal tissue, now would we?
Now, normally I'd stop right there, presumingi that no one could be so obtuse as to not see how this is exactly the same situation as the stem cells from an about-to-be-discarded surplus IVF blastocyst, or the recovered cells from a failed fetus, or the recovered cells from a pregnancy that was aborted, and was going to be aborted anyway. People like you, that would rather use that tissue for fertalizer in a landfill than save some poor brain-injured kid's life are (well, to use your words) "sick" and "unethical" to a nauseating degree.
Don't disappoint your bird dog. Go to the range.
> just so they can see Christopher Reeve ride a polo pony again.
i sincerely hope that you realize the magnitude of a spinal cord injury. let's see how fun life is when you can't control your own bodily functions.