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Scientist Pushing for Early Use of Stem Cells

hzs202 writes "BBC News is reporting that Professor Ian Wilmut is pushing for stem cell treatment to be offered to people with terminal illnesses. Professor Wilmut told journalists that the treatment could save lives or at least speed up the pace of research, however it is yet to be fully tested." From the article: "If we wait until things are totally tested and analyzed in animals, it will deny some people treatment"

34 of 263 comments (clear)

  1. Oblig. Futurama Quote, Serious Thought by TripMaster+Monkey · · Score: 3, Insightful

    Farnsworth: As a man it has become too much of a chore for me to clean out my wrinkles each day. Is it true that stem cells may fight the aging process?

    Geneworks Woman: Well yes, in the same way an infant may fight Muhammed Ali! But -

    Farnsworth: One pound of stem cells please!


    But seriously, it seems to me that the motives of this Professor Wilmut may not be entirely pure. Certainly, it's difficult to argue against offering treatment to victims of neuro-degenerative disorders, and I know for a fact that if I was such a victim, I'd be clamoring for treatment as loud as anyone else, but does that make it right to use humans as guinea pigs to 'speed up the pace of research'?

    It's easy to point out the suffering people and make a play for accelerated protocols based upon sentiment. It's not so easy to adhere to the standards of medical ethics and integrity. If Professor Wilmut was an uninvolved commentator on the issue, his opinion might hold a bit more weight, but the fact that he is one of the central players in the field tends to impune his impartiality in the matter.
    --
    ____

    ~ |rip/\/\aster /\/\onkey

    1. Re:Oblig. Futurama Quote, Serious Thought by crazdgamer · · Score: 5, Insightful

      But seriously, it seems to me that the motives of this Professor Wilmut may not be entirely pure. Certainly, it's difficult to argue against offering treatment to victims of neuro-degenerative disorders, and I know for a fact that if I was such a victim, I'd be clamoring for treatment as loud as anyone else, but does that make it right to use humans as guinea pigs to 'speed up the pace of research'?

      Absolutely. Patients have to sign the form when they get treatment. They know the risks involved. Besides, if there are no other options (usually the case when they're terminal), what do they have to lose? Everything else doesn't work, you might as well better the rest of the human race and be a guinea pig for a drug or treatment that might save the lives of thousands.

    2. Re:Oblig. Futurama Quote, Serious Thought by slavemowgli · · Score: 3, Insightful

      Humans aren't being used as guinea pigs - it's everyone's own choice whether they want to participate in such studies or not, but guinea pigs or other lab animals don't have that choice.

      For that reason alone, I think it's not only OK but in fact the *only* ethically sound opinion that we stop all animal tests immediately and only rely on volunteers for testing. At the risk of sounding cynical, if a disease is bad enough, people will sign up for tests; or, put another way, if noone signs up for tests, then the whole thing can't have been *that* bad, anyway. Humans can volunteer, or choose not to; animal testing is torture, pure and simple, and noone with intact personal ethics should lower themselves to that level.

      (And FWIW, I do say that as someone who has to take medication each day for a chronic disease.)

      --
      quidquid latine dictum sit altum videtur.
    3. Re:Oblig. Futurama Quote, Serious Thought by Elvis+Parsley · · Score: 5, Interesting

      And would starting to treat terminally ill patients right now provide as much scientific value? Or would it divert funding from possibly cheaper or at least more informative on a dollar by dollar basis animal testing, so that in the long run we might save X people but not develop effective stem cell therapies for Y years longer, thereby losing another X+N people who might have been saved had we gone a more orthodox route?

      (Seriously, I'm asking. I have no idea what the answer is.)

    4. Re:Oblig. Futurama Quote, Serious Thought by ceoyoyo · · Score: 3, Interesting

      I need fifty healthy volunteers immediately. You'll have your kidney's chronically instrumented, then will be fed a variety of drugs that will raise or lower your blood pressure. When we're done you will be sacrificed and your kidneys will be inspected.

      There is research that cannot be done on terminally ill volunteers. Not all medical research is simply new-drug-to-treat-terminal-illness testing.

      Research animals are treated better than the grad students who work with them, and are euthanized in much more humane ways than the US uses to execute prisoners. Chances are you, or someone you love is alive today because of animal testing, whether you like or realize it or not.

      They've got a great poster down by the animal resource centre -- it's a bunch of people protesting animal research and the line at the bottom says "Animal research has given these people 20 extra years of life to protest."

    5. Re:Oblig. Futurama Quote, Serious Thought by sfjoe · · Score: 3, Insightful

      And would starting to treat terminally ill patients right now provide as much scientific value?

      It's interesting that this question would never have even come up without the activism of the HIV/AIDS community. Fast-tracking the FDA process was unheard of before then and nowadays many terminal diseases have advocates pushing for approvals, breast cancer is one prominent example.
      Just because you're treating people with an experimental procedure doesn't mean you abandon the scientific method. You can still have control groups and statistical analysis to advance the knowledge gained from treatments. As long as people are fully informed, I see no ethical problems.

      --
      It's simple: I demand prosecution for torture.
  2. Too good to wait? sometimes. by Bananatree3 · · Score: 5, Insightful
    "If we wait until things are totally tested and analyzed in animals, it will deny some people treatment"

    This kind of thinking does actually make sense in some specific cases. If you take a look at the history of Lorenzo's Oil, (or if you have seen the movie), it tells about how the father of a boy found a treatment for a disease (ALD in this case), and he started the treatment right away on his boy. ALD is a degenerative disorder that eventually kills its victims within 2-3 years of diagnosis. This father's treatment worked so well in stopping the disease that the medical community decided to start human trials right away, and it has saved literally thousands of lives already. If they had gone the usual method of rat testing, than maybe humans several years later, many ALD victims would have died by that time.

    From the article: "If you've developed a treatment that might be beneficial in, say, motor neurone disease, then it's reasonable to allow people who are in the last stage of the disease to offer themselves. It sounds like they're being used as guinea pigs but sometimes people with a terminal illness volunteer to be used as guinea pigs if it will advance medical treatment for others," he said.

    Just as with the ALD case, there are people out there with fatal diseases who do not have time to live to wait for some clinical trial ten years away. Assuming the treatment is as effective a Lorenzo's Oil and obvious, I say people should have a choice when it comes to these trials. Obviously there must be some safeguard againt fraud biotech/pharmo companies who make crap treatments. But even with the threat of these charlatans, there are many treatments out there with the advent of Stem cells that are sitting in petri dishes in labs around the world. Many of these treatments have yielded very promising results, and if terminally ill people had a chance to try these promising ones, good treatments that would otherwise have to wait for a decade or two could come to light much more quickly.

  3. Stem cells vs. the aging & the brain by digitaldc · · Score: 3, Funny

    If you are able to replace certain cells in the body with new ones, does the aging process still have an effect on its development and effectiveness?

    Even if you are able to grow a new liver from stem cells for your resident alcoholic, does this mean you will have to grow a new brain in order not to repeat the process?

    --
    He who knows best knows how little he knows. - Thomas Jefferson
  4. Depends greatly by Pedrito · · Score: 4, Insightful

    "If we wait until things are totally tested and analyzed in animals, it will deny some people treatment"

    We generally don't use humans as guinea pigs. Medical treatments need approval before they can be used. This guy clearly thinks the benefits outweigh the risk, but his opinion shouldn't be the one that decides.

    If early testing shows no serious side effects and tremendous benefits, treatments can sometimes be fast-tracked testing phases. But if every time someone believed as this man, a treatment skipped testing, more people would die than be saved.

    Testing and clinical trials exist for a reason. Because in many cases, they save lives. It's an imperfect system, to be sure, but it's better than the alternative.

    1. Re:Depends greatly by mcwop · · Score: 4, Insightful
      This guy clearly thinks the benefits outweigh the risk, but his opinion shouldn't be the one that decides.

      Maybe the patient should decide what treatments they want to pursue (experimental or otherwise), rather than the government.

      --

      "I don't think it's selfish, to eat defenseless shellfish." -NOFX

  5. Good or bad or in between? by Cmdr_earthsnake · · Score: 3, Insightful

    could save lives or at least speed up the pace of research, however it is yet to be fully tested." From the article: "If we wait until things are totally tested and analyzed in animals, it will deny some people treatment"

    There are two arguments for this problem, the first being that people should enjoy life while they are dying and not get tested on and have as long a life as possible. The second argument is that they SHOULD be treated and use whatevers possible that may work to help treat the problem.

    I find myself falling on both sides of the fence, as if it goes horribly wrong, unspeakable things could happen with usage of stem cells. But I also think that if it has the potential to save people's lives, and minimize suffering and help people in general, it should be used.

    --
    #!/bin/bash
    login root
    chmod 775 universe://
  6. So... by StarKruzr · · Score: 5, Insightful

    better to not develop them at all, lest they fall into the hands of wealthy people?

    wtf, man?

    Expensive drugs like AIDS treatments have found their way into the hands of plenty of poor people. What the hell are you talking about?

    What life-saving medical procedures are ONLY available to wealthy people?

    --

    +++ATH0
    1. Re:So... by Elvis+Parsley · · Score: 5, Insightful

      "Expensive drugs like AIDS treatments have found their way into the hands of plenty of poor people."

      Major pharmecutical companies have been fighting attempts by African governments to essentially pirate the design of AIDS drugs. Poor African countries, which are suffering from AIDS epidemics, might be able to buy significant quantities of drugs at cost, but certainly can't pay prices which include the drug companies getting their royalties. Which means that lots of poor Africans are dying so that multinational drug companies can show a profit.

      Of course, if they did give away those drug designs (and, by extention, other massively useful and necessary drug designs) so that the poor could live, there's every chance that the companies would fold and there wouldn't be any new drugs to stop the next plague.

      To sum up: life sucks.

    2. Re:So... by timster · · Score: 4, Insightful

      You make me sick. Really.

      I have a chronic condition that may always require treatment (though it's not AIDS). It's a near miracle, though, that treatment is available at all. Coming up with that required dedication by scientists around the world, and you spit on their efforts just because they haven't come up with a "cure". I'm just happy to be alive, and that's only possible in this day and age (and yes, with the help of "evil" drug companies.)

      News flash, brother -- we aren't gods, and we don't have magic. Sometimes treatment is all we can do.

      --
      I have seen the future, and it is inconvenient.
    3. Re:So... by sfjoe · · Score: 3, Informative

      Expensive drugs like AIDS treatments have found their way into the hands of plenty of poor people.

      You have a definition for the word "plenty" that I'm not familiar with.
      17 million people in Africa have died of AIDS and less than 1/10 of 1% of HIV+ people are receiving treatment. Doesn't sound like "plenty" to me.

      --
      It's simple: I demand prosecution for torture.
    4. Re:So... by jnaujok · · Score: 3, Insightful

      In Uganda (I believe it was Uganda, I read the article some time ago) where the government started a policy of AIDS prevention education the rate of AIDS infection dropped by over 90%. Uganda now has one of the lowest infection rates in Africa. The cost of this education was less than 5% of what they would have spent on the drugs to treat the new infections had the previous infection rate continued.

      You, on the other hand, advocate allowing the infection rate to continue, and demand that drug makers must pay for creation and shipment of drugs to people who are unwilling to simply not engage in dangerous practices. This is the equivalent of telling the people of London in the 1600's suffering from the Black Plague, that the problem is there's not enough penecillian (not to mention that it hadn't been invented yet), not that we need to clean the rats and human feces out of the streets. In your world, you'd make Alexander Fleming pay to distribute it through the rat infested warrens of the city and damn the sanitation department as prejudiced jerks if they want to do anything about the slovenly conditions.

      In typical emotion-led fashion, you take the point of advocating that they continue to live in filthy ignorance and that you'll preserve that lifestyle no matter how much it costs to those who've gotten themselves out of that same self-destructive lifestyle.

      And I bet you consider yourself compassionate too.

      --
      Life, the Universe, and Everything... in my image.
    5. Re:So... by Razor+Sex · · Score: 3, Insightful

      You're the only one who is making medication and education seem mutally exclusive. Why not do BOTH?

    6. Re:So... by susano_otter · · Score: 3, Insightful

      Given how fragile the AIDS virus is, and how difficult it is to transmit, I'd have thought that the easiest and cheapest way to prevent the spread of AIDS in Africa would be for African governments to convince their citizens to stop behaving like asshats.

      But hey, why bother trying to educate and empower your people, when you can simply blame it all on big pharma while you sit back and wait for^H^H^Hdemand handouts from the world government?

      --

      Any sufficiently well-organized community is indistinguishable from Government.

    7. Re:So... by BorgCopyeditor · · Score: 3, Insightful
      Are you saying that the people of Africa lack the insight to see the wisdom of such a course, and the self-control to adopt it?

      Self-control or self-mutilation? Staying indoors is a guaranteed prophylactic against roadway accidents. Do you have the insight to see the lack of wisdom in inferring from that that one should just stay indoors?

      I'm against horrible diseases and unwanted pregnancies, but I don't have to be celibate to uphold those values. Why should anyone else be? The only reason can be that one is surreptitiously advocating a life in which people have little to no sexual intercourse, or only under highly restricted circumstances (e.g., marriage as a "sex license"). This is not wisdom. People who have no sexual contact in their lives are unhappier and unhealthier than those who do. It's something we're made for, and it's not something that false threats (of death, pregnancy, or worse :) can or ought to change.

      Are you aware of studies that show no discernible change in the number of unwanted pregnancies in U.S. school districts where "abstinence-only" education is mandated by school boards? Teaching teens about safer sexual practices, by contrast, has been shown to have the good effects on which you claim to base your appeal to abstinence. If those results were proved to your satisfaction, would that change your mind?

      --
      Shop as usual. And avoid panic buying.
    8. Re:So... by susano_otter · · Score: 3, Insightful

      It might, in fact, change my mind.

      On the other hand, it may not. I suspect there are other factors involved.

      For one thing, not all people are made happier and healthier by increasing their sexual activity or their number of sexual partners. It's my contention that the healthy and fulfilling role of sexual intercourse is not well understood, nor well communicated, and that the failure of the abstinence-only program may be due in large part to its being presented in a vacuum.

      Also, I'm not sure that the adolescent bias in favor of the more permissive, sexually promiscuous teaching, and the adolescent tendency to reject the more restrictive, contrary-to-passing-hormonal-urges teaching, is in itself indicative.

      Mind you, I'm not advocating the repression of human sexuality, but rather a more thoughtful and self-controlled approach to it.

      Animals act without thinking on their various urges. Humans do not, or should not, anyway.

      Human sexual intimacy isn't just "animal sex with condoms", and pitching it that way won't solve all our problems.

      I mean, how much of our current problems with sexual intercourse in both America and Africa can be attributed directly to a culture of sexual promiscuity? And how much of those problems can really be solved by moving to "sexual promiscuity with a condom on top"?

      Millions of people, in all times and places, have lived happy, healthy, satisfying, and fulfilling lives, all the while practicing the disciplines of chastity and monogamy.

      Now you pooh-pooh those disciplines, and offer a rubber sheath as a superior solution. It'll be interesting to see how the Condom Generation turns out, and if their understanding of human sexuality ends up building a better tomorrow than our parents' did.

      --

      Any sufficiently well-organized community is indistinguishable from Government.

  7. Stem cells from newborns by AnonymousJackass · · Score: 5, Informative

    I learned something interesting last week from friends of my wife and I. When their daughters were born (now 4 and 6yrs old, respectively), they had stem cells taken from their umbilical cords and sent off to a facility in (I think) Texas, where they're safely stored and frozen. Apparently the thinking is that (hopefully never, but...) maybe one day one of the girls will have some kind of ailment that requires the re-growth of an organ (for example), or similar. So they will pull the stem cells out of storage and use the 'current' medical advances to hopefully cure them.
    I was amazed to find out that it is possible to do this and that people are doing it already! I think that is so cool! I meant to ask them if it cost anything, but I forgot. Anyone know?
    Just thought I'd share, since we're on the subject...

  8. The Fable of the Dragon-Tyrant by LionKimbro · · Score: 4, Interesting

    Here's a stronger argument, the Fable of the Dragon Tyrant.

    It argues that it is immoral and lethal for us to delay our work into longevity reasearch.

  9. Re:And feed them with our babies ... by SengirV · · Score: 4, Funny
    Hell, what do you think happens when a woman has her period? MENSTRUATION IS MURDER!

    An unfertilized egg is lost, as well as the newly formed lining of the awaiting uterus. Do I have to explain the birds and bees to you to help you differentiate between an unfertilized egg and a fertilized one?

    --

    Prof. Farnsworth - "Oh a lesson in not changing history from Mr I'm-My-Own-Grandpa!"

  10. Been here, done this by PMuse · · Score: 3, Insightful

    In what way is the argument for untested deployment of stem cell therapies different from the argument for untested deployment of any other new drug or treatment?

    There is always a balance to be struck between safety and delay. The procedures exist for exactly this reason: to guide us in balancing risk and potential reward.

    --
    "We reject as false the choice between our safety and our ideals." --The American President (20.1.2009)
  11. Re:And feed them with our babies ... by scheming+daemons · · Score: 3, Insightful
    ....that gives you the right to murder(as seen by the other side) a baby for better looking skin?

    This straw man of yours.. "for better looking skin" is bit ridiculous. Find any reference in the article... or in any of the words by serious proponents of fetal stem cell research... that is referring to something as superficial as "better looking skin".

    It's a false argument, and you know it. Nobody's talking about stem cell research for non-life-saving purposes.

    It's a common tactic of "your side"... and it stinks.

    and you also said this: So because you believe life begins when a baby leaves the mother's womb with absolutely nothing from me to indicate that. Fetal stem cell research is done with cells from unimplanted embryos... not from full-term babies. And you know it. Unimplanted embryos that were the result of IVFs and designated for the trash ANYWAY. You knew that too. We're not talking about "babies in their mother's wombs".. we're talking about embryos that have never been implanted IN a womb ... AND NEVER WILL BE. And you knew that too.

    But keep setting up your straw men to knock down. It's a lot easier to win an argument when you invent the other side of it.

    --
    "I have as much authority as the pope, I just
    don't have as many people who believe it" - George Carlin

  12. would I? by hostingreviews · · Score: 5, Insightful

    My mom died and dad died of illnesses that could have been prevented, assuming this stem cell hype is true. Would I sign the waver allowing it to be done for them without knowing if they wanted it? Absofreakinglootly.

    Why wouldn't I? Whos stalling here? People are dying, at least try it ONCE for crying out loud. Some patients can't get worse.

    1. Re:would I? by lonesome+phreak · · Score: 3, Informative

      President Bush, in 2001, halted all federal funding on stem cells outside of the already-established 78 lines. Many of those cells have been corrupted and can't be used in human trials.

      However, he did a partial reveral just recently and signed a law creating a national stem-cell bank based on umbilical cord cells. This is really good news, and hopefully will allow the US to catch up to other countries.

      --
      Maybe we DID take the blue pill. You wouldn't remember anyway.
  13. Re:Something to ponder by vertinox · · Score: 4, Informative

    Certainly lots of people have heard of snake-oil. Heck, asperin was also a cure-all.

    The difference between stem cells and asperin is that all of your cells were created via stem cells (indirectly or directly) and not asperin.

    In theory, you could regenerate most (if not all) of your dead and dying body cells with stem cells because stems cells are basic building blocks of original cell generation. The reason we get sick, old, and die is because cells self replicate until they are beoyond damaged and damaged cells can only replicate damaged cells.

    Go back to the starting point and create healthy original cells via stem cell therapy and you've got young and non-damaged cells again.

    Calling stems cells a cure all is akin to calling atoms the cure all for reality. It is what we are made out of.

    --
    "I am the king of the Romans, and am superior to rules of grammar!"
    -Sigismund, Holy Roman Emperor (1368-1437)
  14. Snake Oil by argStyopa · · Score: 3, Insightful

    While I understand the good faith efforts of people to implement working cures faster, I think this is incredibly thin ice to tread on.

    Let's all keep in mind Barnum's Maxim when we hasten to implement all those "great" cures out there, that the (pokey, old fashioned, heartless gov/corps) don't immediately start distributing. There are LOTS of examples where the "perfect cure" ended up having heartbreakingly bad collateral consequences. Thalidomide, anyone?

    If you, as a terminally ill patient, are willing to make yourself into a medical experiment that's cool - you will good or bad end up advancing medical knowledge to the benefit of all of us. (In fact, my father is still alive and thriving today due to a then-experimental bone marrow replacement technique.) But when you sign up for this stuff, you MUST then accept the consequences of being a lab rat, ie. you may die.

    But make these decisions for YOURSELF, not for others. For the bulk of the population, the nice, long duration exhaustive testing works just fine. I personally think it's irresponsible for a scientist or a doctor to advocate this for anyone else.

    --
    -Styopa
  15. Re:So, this would imply that... by scheming+daemons · · Score: 4, Insightful
    what is not mentioned enough is that there are three type of stem cells. 1. Adult, in use currently have had the most success with these. 2. umbilical cord stem cells, work great also, everyone should donate their child's cord. (my wife and i will around july 20th.) 3. stem cells from fetus's. they have only been found to cause cancer, they are testing with the ample set they have, and have not been able to have ANY success. 1,2 work great, 3 DOES NOT WORK at all yet.

    This is patently false, which is why I suppose you posted as AC. Stem cells from fetuses have NOT been found to cause cancer - that is misinformation put out by religious right groups. And there is NOT an "ample set" of fetal stem cells to test with... Bush lied about that. There are only 12 lines available for legal research in this country, not the "over 60" that Bush told of.

    Thank goodness that the current U.S. administration doesn't have control over research being done elsewhere in the world... so this important work is still being done - just without the U.S.'s help.

    You can all cut through the bullshit by learning for yourselves what stem cell research is all about:

    Stem Cell FAQ by Stem Cell Research Foundation

    --
    "I have as much authority as the pope, I just
    don't have as many people who believe it" - George Carlin

  16. Re:Well... good.... by jnaujok · · Score: 3, Insightful

    Come again?

    Stem Cell research is thriving in the United States. In fact, most of the applications have come from U.S. labs.

    Even Embryonic stem cell research is going on right now in the United States, including labs funded with Federal Research Grants.

    The *only* thing not allowed in the U.S. is the creation of new embryonic stem cell lines (through the destruction of a fertilized embryo) using Federal funds.

    And given the fact that currently adult stem cell research is approaching 40 different applications and embryonic stem cell research has currently found, uhm, zero , I'm okay with that.

    --
    Life, the Universe, and Everything... in my image.
  17. From the medical professions standpoint... by QuaintRealist · · Score: 3, Insightful

    Most people don't realise it, but you can get non-FDA approved therapies, including drug therapies, in this country unless they have been banned for some reason (like heroin, for example, or Laetril). Non approved drugs can be imported for personal use on order of a physician.

    We in the medical fields do, however, have a responsibility to protect the public from fraud. It is hard to make an informed decision even if you are trained, and have the facts at your disposal. And to say "well, I'm dying anyway, what can it hurt" doesn't take into consideration the many harms done by bad therapy - delay in proper treatment (if any), co-morbidities, and even economic ills. I mean, you're dying - do you want to impoverish your soon-to-be widow by spending everything on worthless treatments? How about your kids?

    I'm not saying stem cell research is worthless - it's almost undoubtably not. Healthcare decisions are hard, though. TFA(uthor) does not give enough credit to the thought and work which should be done before giving these therapies to anyone, dying or not.

    --
    Using plain ol' text since 1968
  18. Response from someone with a terminal disease... by jamescarl · · Score: 5, Insightful

    When you are faced with a terminal disease, there are a number of issues that most people don't understand. First off, you want to extend your life as long as possible. There comes a time, however, when regular treatments don't work and the only options available are experiemental treatments. As someone about to reach that point, I feel that if I can donate my body to medical science before I die so that others can be saved, it's the least I can do. Also, from a selfish standpoint, there is the possibility that experimental science can extent my life. Now, I'm not in favor of experimenting myself for studies that are too dangerous but that's my decision, not others. In a free country, the right to control how and what I do with my life and my body are not the decisions of the government or any of you. Obviously, these studies need to be controlled so that they don't get written up in the National Journal of Evil under studies on growing arms out of backs, but they are currently done every day at hospitals and research centers around the world.

  19. Cost to Harvest Umbilical Cord Blood Stem Cells by GeorgeTheGiraffe · · Score: 3, Interesting

    My wife and I had considered this--if it wasn't for the $2000 down payment and the $100/year fee beyond that, we probably would have signed up yesterday. It actually involves harvesting stem cells from the umbilical cord blood.

    http://www.cordpartners.com/

    http://www.cordblood.com/

    http://www.corcell.com/