Sound Waves Kill Skin and Prostate Cancer Cells
Anonymous Coward writes "A recent Study
in the
British Journal of Cancer shows that the use of
Quercitin
and 20KHz ultrasound for 60 seconds killed skin and prostate cancer cells. 90% of the
abnormal cells were dead within 48hrs.
Since low frequency ultrasound was previously shown to enhance the skin penetration of
topical substances up to 1000 times, it would seem that a topical Quercetin cream with a low
frequency ultrasound wand might be just the ticket for those annoying little skin cancers that
tend to occur in older geeks who have spent a bit of time in the sun."
Sounds great!
PayPal $$ if you sign up for free offers (eBay, cred cards, e
They exist?
"might be just the ticket for those annoying little skin cancers that tend to occur in older geeks who have spent a bit of time in the sun."
Interesting. Is this some kind of career benefit one accrues with experience or time spent at the company?
Libertarianism is rich wolves and poor sheep playing gambler's ruin for dinner.
Therapeutic selectivity plays a crucial role in determining the success of chemotherapy. Some of the current targeted therapies attempt to localise drugs to cancer cells based on overexpression of epidermal growth factor receptors (EGFR) (Mendelsohn and Baselga, 2000) or angiogenesis (Carter, 2001). Antibodies, inhibitors, antisense therapy and gene therapy are also among a few strategies that have gained momentum (Guillemard and Saragovi, 2004). Many of these strategies have now reached clinical trials; however, these methods are still limited by issues including low potency, delivery complications, multi-drug resistance, side effects, collateral damage (Tattersall and Clarke, 2003) or incomplete success (Lynch et al, 2004). In an attempt to develop a targeted chemotherapeutic strategy, we propose the use of bioflavonoids, which are common dietary supplements, in conjunction with low-frequency ultrasound. Quercetin, a major bioflavonoid in human diet, has been identified as a chemotherapeutic agent for the treatment of breast cancer (Singhal et al, 1995; Choi et al, 2001), colon cancer (Salucci et al, 2002), ovarian cancer (Chan et al, 2003) and prostate cancer (Knowles et al, 2000; Nakanoma et al, 2001; Kobayashi et al, 2002). Antiproliferative action of quercetin is hypothesised to be mediated by attenuating phosphorylation of activated hsp transcription factor (hsf), shortly after its trimerisation (Nagai et al, 1995; Lee et al, 1998), thereby resulting in increased susceptibility of hsf to proteolytic degradation and as a consequence inhibiting all downstream events, including hsp expression (Li et al, 1999). Since hsps are constitutively overexpressed in many tumours (Jaattela, 1999), inhibition of hsps is an attractive chemotherapeutic strategy. hsps form a complex with mutant p53 protein (mp53), thereby prolonging the half-life of malignant mp53 and allowing tumour cells to bypass the normal mechanism of cell cycle arrest (Selkirk et al, 1996). In spite of its therapeutic benefits, utilisation of quercetin in clinical applications has been limited by low potency and poor specificity. Additionally, it is difficult to sustain therapeutic quercetin concentrations in blood by oral ingestion (Lamson and Bringall, 2000). Here, through in vitro studies, we demonstrate for the first time, using two pairs of normal and cancer cells (human skin fibroblast and human prostate epithelial cells), that ultrasound selectively sensitises cancer cells against quercetin. LC50 of quercetin for skin cancer cells is selectively decreased by almost 80-fold by a short pretreatment with ultrasound. MATERIALS AND METHODS Cell culture Normal and cancer cells derived from prostrate and skin tissues were investigated in this study. DU145 prostate cancer cells were provided by Dr L Wilson at UC Santa Barbara, CA, USA. Nonmalignant prostrate normal cells (Catalog No. CRL-11609), nonmalignant skin cells (Catalog No. CRL-7761) and skin cancer cells (Catalog No. CRL-7762) were obtained from the American Type Culture Collection (ATCC, Rockville, MD, USA). All cells were grown as monolayers and were kept in a 5% CO2 environment at 371C. Cell cultures were maintained in Dulbecco's modified Eagle's medium (DMEM) with glucose (1 g l1), NaHCO3 (3.7 g l1), L-glutamine (2mM), nonessential amino acids (0.0815 g l1) and 10% FBS. Antibiotic-antimycotic cocktail (Catalog No. 15240-062, Gibco, Invitrogen Corporation, Carlsbad, CA, USA), at a final concentration of 100Uml1 of penicillin, 100 mgml1 of streptomycin and 0.25 mgml1 of amphotericin B, was added to all cultures. Cells were harvested at a concentration of about 3105 cells ml1, by washing with versene (NaCl - 8 g l1, KCl - 0.2 g l1, NaH2PO4 - 1.15 g l1, K2HPO4 - 0.2 g l1, Na2- EDTA - 0.2 g l1 in distilled water with pH adjusted to 7.2) followed by 2-3-min digestion with trypsin/EDTA (0.25%/0.02%). Revised 1 November 2004; accepted 18 November 2004; published online 1 February 2005 *Correspondence: Dr S Mitragotri; E-mail: samir@engineering.ucsb.edu Ultrasound application and quercetin treatment Aliquo
Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound (god that's a mouthful)
I just downloaded that to my iPod and I'm using it to remove my tattoos.
insert this speaker...
Oh where is John Katz when you need him?
Too bad the 20 Kelvin*Hertz waves kill skin.
Is that "skin cancer" and "prostate cancer" cells or "skin" and "prostate cancer" cells? (fp?)
13. Any legal action is absolutly excluded. (Pi World Ranking List rules)
Sun? Only serious geeks program those... This is one of the few times I'm glad I program a Windows box.
Maybe protiens and waves have something in common.
Now I have to choose between keeping my skin or avoiding prostate cancer....
Blog via SMS text messaging
I didn't fart, that was my prostate cancer prophylaxis!
I didn't even RTFA, but it seems from the summary that the sound itself doesn't kill the cancer cells -- it helps the drug penetrate into the tissue.
Escher was the first MC and Giger invented the HR department.
I haven't read TFA, but if this process only kills 90% of the cancer cells, won't the regrowth eventually become resistant?
D
I love how slashdot goes from Bill Gates' taxes, to Chuck Norris, to cures for cancer.
"I assumed blithely that there were no elves out there in the darkness"
Hard choice there. The title actually talks about killing skin cancer cells as well as prostrate cancer cells...
You can have only two of the following three qualities when developing a product: cheap, fast or good.
What is that fiery orb in the sky? I'm pretty sure the incidence of skin cancer in geeks is way way below that of the rest of the population. Now if we're talking carpel tunnel syndrome then we're into geek territory. But the sun? Geeks live indoors.
Enjoy your Karma, after all you earned it. Feel your Karma Joe, feel it burn.
What was that?
Pretreatment of cells with ultrasound (20 kHz, 2 W cm(-2), 60 s) selectively induced cytotoxicity in skin and prostate cancer cells, while having minimal effect on corresponding normal cell lines.
Selective toxicity is what cancer treatment is all about, so while the sound man not "kill" cancer, it's a promising treatment.
It would be nice to see the actual studies. I'd like to see the statistics, and see if any other methods were tried and the researcher's reasoning. It may be that dysplastic cells are susceptible to sonic damage and this might work with other therapy methods, such as xray or heat. I'd also like to know how they treated prostate cancer, which is the number two cancer killer of men in the US.
Friends don't help friends install M$ junk.
1. Make CD full of songs with proper frequencies
2. Kill cancer
3. ?????
4. PROFIT!!!
Ron Paul 2012
I mean, this is absolutely terrible to think about, but wouldn't it be hilarious to see some guy holding a speaker to his nuts blasting Barry White just to get rid of cancer?
just the ticket for those annoying little skin cancers that tend to occur in older geeks who have spent a bit of time in the sun.
:)
Oh yeah, and we all know that's a billion-dollar market just waiting be tapped!
Hey guys, not all geeks adhere to the strict cathode ray glow suntan. I for one sport a genuine tan, although it's not hard to get in an Australian summer. This is sometimes the thing that irritates me about the nerd cliche. Although many people live the cliche, there are probably many more "nerds" out there that are playing sport and out in the sun all the time. my 2c
well this calls for a new iPod accessory: the 20KHz ultrasound stick. and it should come complete with topical Quercetin cream. but for the 60 secs of 20KHz Ultrasound, you will have to buy it 99cents on the iTMS. ant
But you have to put the special cream on, too, eh?
In Soviet Britain, you kill cancer!
At first, I thought the title was saying that the sound waves kill both prostate cancer cells and skin.
...Prostate kills YOU!
...Prostate kills YOUR Sound waves!
...Sound Waves kill YOUR Prostate!
...Sound Waves kill YOUR Prostate CANCER!
No, hang on...
Nope, that's not it either...
Wait wait, that sounds nasty....
Yeah, that's it.
"Women are just like ninjas; They lie even when it is more convenient to tell the truth." ~ Unknown
You must not be too handy at Googling.
kelvin-hertz relationship (physics.nist.gov)
Maybe you'd prefer a Pittsburgh (PA)-based acid jazz DJ Kelvin Hertz
My Human Gets Me Blues.
Sun??? Sun???
Nah, they just mis-spelled "CRT Monitor"
I saw that.
The link you reference shows the relationship between the two and NOT
that the term "Kelvin Hertz" is used as a unit. Since kelvin
is a temperature unit, presumably the relationship has
something to do with molecular vibration -- but it is not
possible to tell from the provided link.
I for one... am not entirely sure I welcome our new sound/vibration emitting anal probe developing overlords. :-/
Beware: In C++, your friends can see your privates!
...I knew there had to be a use for all those boy bands!
Time is an illusion. Lunchtime doubly so. - Douglas Adams
Wait untils he releases his Casetticons - More than meets the eye.
Life is just nature's way of keeping meat fresh.
I knew decepticons were just misunderstood.
There's lots of scientist geeks out there who interact with the sun. (and by 'interact with', I mean, sit in basements and look at pictures of it)
But I've actually seen some of them go into the big blue room while the glowy thing is still out.
Build it, and they will come^Hplain.
Prostate...
Must ... not ... visualize ...
I was under the impression that most humans could hear 20Hz to 20kHz, which would mean that 20kHz can't be ultrasound.
In other news, 90 seconds of Britney Spears has been shown to kill brain cells.
And Bose will be adapting their acoustic waveguide technology to produce a suppository-based speaker that gives you booty-shaking bass while killing colon cancer.
GCHQ Quantum Insert installed. If only our tongues were made of glass, how much more careful we would be when we speak
Well his story is a facisnating read anyways.
http://www.rife.org/
I think the conspiracy theories surrounding Rife are as numerous as those on the Kennedy assassination and engines that run on water.
Rife's basic theory was everything had a frequency - including diseases. If you could find the frequency of the specific disease the person had and then bombard them with high energy RF you could disrupt the disease enough to wipe it out.
The implementations today range from quack devices to actual medical testing (outside of the U.S.) Lots to be learned still. Great to see people still talking about it and working on it.
Use a multi-beam or acoustic holography technique to deliver destructive ultrasound to specific tissues. That may provide sufficiently selective toxicity. Surgery causes its own tissue damage, and I've even heard the needle biopsy described as creating a stream of metastases along the path the needle is withdrawn.
This is why I was initially apprehensive about diagnostic ultrasound with my kids, but the diagnostic ultrasound process delivers orders of magnitude less energy.
Assembly is the reverse of disassembly.
You probably don't truly qualify as a geek. Somewhere you got this stupid idea that, these days, it is cool to be a geek, so you call yourself one. It never was cool and never will be cool. Yes, I use a computer, too. I'm not a geek because of it. Geeks don't call themselves geeks, other people brand them geeks.
geeks...sun...geeks...sun
it does not compute
Depending on the source you refer to, the human audible range is quoted as being as large as 16-22,000 Hz, meaning this falls short of ultrasonic.
What the article ultimately seems to say, is that listening to Mariah Carey can improve the effectiveness of topical cancer treatments. I say it's not worth it.
Why do people say 'sound waves' in contexts such as these? "Sound waves" and "sound" are interchangeable. If sound waves kill cancer cell, sound kills cancer cells. In ordinary conversation we say "sound". We don't say "the sound waves from my stereo are great". So why do we say "sound waves" in this context?
"The White House is not an intelligence-gathering agency," -- Scott McClellan, Whitehouse spokesman.
*dances*
Now google "quercetin" and you'll find the sort of market this substance has.
Sound waves have long been used by quacks to swindle cancer patients out of their money when they're vulnerable.
The experiment is done in vitro. It involves growing a thin layer of cells in a petri dish (well test tubes in this case). It's not too surprising that sound waves can affect such a small layer of cells. In real life, we are exposed to 20kHz sound all the time! It can destroy the cells in your ears, that's called industrial deafness, but is otherwise harmless.
The reason they're using skin cells, is that it's easy to grow in culture. It forms a nice thin layer, and will keep growing.
Cancerous cells also keep growing, so they are often easier to culture than normal cells.
The treatment apparently harms malignant cells more than normal ones. But due to the nature of the research, I really cannot trust their findings just yet. It's semi-interesting, but really pretty meaningless.
In terms of harming skin.. it would probably harm other cells too. If it only harmed skin, it wouldn't matter, we'd need a probe to get the soundwaves close to the prostate, sound wouldn't transmit far through a beer gut.