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Scientists Find Brain Cells Linked to Choice

An anonymous reader writes "Scotsman.com is reporting that Harvard Medical researchers may have found the neurons, or brain cells, that play a role in a persons ability to choose between different items. From the article: 'Scientists have known that cells in different parts of the brain react to attributes such as color, taste or quantity. Dr Camillo Padaoa-Schioppa and John Assad, an associate professor of neurobiology, found neurons involved in assigning values that help people to make choices.'"

19 of 279 comments (clear)

  1. Does genetics make our choices? by crazyjeremy · · Score: 3, Interesting
    An interesting article indeed.

    I personally feel that there are so many "disorders" these days, that people often find a crutch for every vice and desire. Instead of working tochange for the better, people say "That's the way I am... I can't change."

    Some of these people may think this article proves that thought. I for one, feel it supports the opposite.

    From the article:

    "The monkey's choice may be based on the activity of these neurons," said Padoa-Schioppa. Earlier research involving the OFC showed that lesions in the area seem to have an association with eating disorders, compulsive gambling and unusual social behaviour. The new findings show an association between the activity of the OFC and the mental valuation process underlying choice behaviour, according to the scientists."

    I think people still have choices regardless of the addiction they suffer from (OCD disorders, Serial Killer, Gambling, etc.) A person doesn't HAVE TO Gamble, but it feels that way. He doesn't HAVE TO wash his hands 5 times, but he thinks he does.

    These abnormalities or "lesions" in our brains may make us feel we do not have a choice. In reality if we are honest with ourselves and we work hard to overcome these urges, we can overcome almost any adversity, vice or compulsion.

    1. Re:Does genetics make our choices? by the_humeister · · Score: 4, Interesting

      I guess it depends on if you believe that reductionism is true. Thus if we reduce all of our actions and decisions to physical phenomena, we're probably going to find that none of our actions are a matter of "choice." Rather, the actions we take are inevitable given the exact state that our brain is in and the exact environment we are in.

    2. Re:Does genetics make our choices? by wideBlueSkies · · Score: 2, Interesting

      I often wonder what compulsive pople would be doing if their vices had not ever been invented?

      For example, the poor fool who claims to have the 'disease' of alocolholism: would the person have the disease if alcohol had never been created?

      The same for the gambler..what if we never got the concept of making a game of of random occurances...what would 'compulsive gamblers' be doing with their lives?

      I suppose that on the other side of this, if we had discovered that you can get high by would we suddenly have a 'disease' for that?

      --
      Huh?
    3. Re:Does genetics make our choices? by onemorechip · · Score: 2, Interesting
      There's more to it than that. Computers are "finite" because their states are digitized. But if you factor in the non-zero probability of error in each operation (due to noise, power surges, crosstalk, setup/hold violations, etc.), computers don't fit that model perfectly, and their behavior cannot be predicted with perfect accuracy.

      Isn't any system whose states can only be described on a continuum also infinite in the sense of the halting theorem?

      --
      But, I wanted socialized health insurance!
  2. Physically change a choice? by the_humeister · · Score: 2, Interesting

    How about putting electrodes in these areas and forcing these macaque monkeys to choose grape over apple juice? That would really prove it.

    1. Re:Physically change a choice? by Joe+the+Lesser · · Score: 2, Interesting

      Except it's probably like 30% of the brain cells have to be stimulated for the monkey to want apple juice, or some other complex system that takes into account the genetic and behavioral training which is constantly being attacked by sensory patterns.

      For example, maybe they get this to work, but then the room temp rises 3 degrees and then the monkey's switch back because their brain has new information so they have to recalibrate etc. If you can control their senses, you might be on to something though, but then, it's likely each monkey is wired differently too...

      --
      "I only speak the truth"
      Karma: null(Mostly affected by an unassigned variable)
  3. Ahh, free will by brian0918 · · Score: 4, Interesting

    It's time for the age-old debate about man's free will. Does it exist, or are we just kidding ourselves? Is the consciousness an intact "entity" within the brain, or is it simply the end result of external stimuli influencing choices? One thing is for sure: neuroscience is making it more difficult for a spirit to hide in our mushy insides. Eventually, we'll know for sure how the brain works. For now, we are stuck with debating the definitions of words like soul, freedom, consciousness, etc...

    1. Re:Ahh, free will by David_Shultz · · Score: 2, Interesting

      Actually, I don't believe any advance in neuroscience makes the debate harder for adherents of free will, because causal determinism in the physical universe has been an accepted truth in the scientific world for some time (disregarding quantum indeterminacy, which is besides the point since no one has been able to coherently describe how quantum indeterminacy could amount to what we call free will.)

      For those people willing to read the right philosophers (ie Dennett) I believe the free will problem has already been adequately solved (not first by Dennett, but he is a good starting point if you are interested in reading into it yourself). The solution amounts to clarifying what we mean by free will, and then demonstrating that this definition of free will is in fact consistent with determinism.

      Memory fails me as to how exactly Dennett chooses to define free will, but personally, I think that the concept of "the ability to choose" fits nicely, where "choosing" means something along the lines of "evaluating different actions, and picking one based on some selection criteria." Note that it is quite easy for this process of choosing (ie free will) to be consistent with a deterministic view of the universe. If anything, this article supports the notion of free will (but then again it doesn't, since we already knew that choosing happens in the brain...)

  4. debate long over for scientific by aepervius · · Score: 2, Interesting

    For neurobiologist the debate is long over. IF they are scientific worth their salt they won't presuppose the existence of a "supplemental entity" like soul to explain our "selves", that is unless somebody bring the data which can't be explained without this so called "soul". hasn't happenned so far. Neurobiologist leave "soul" and other of those to religion and philosophy. As for free will, Since "we" are the sum of all our chemical reaction in the brain (again if you want to bring a 3rd identity in play like soul or conscience bring the data to prove it with), there is no such things as free will, only the illusion that those reaction give to the mass of neuron constituing that "we".

    Bottom line is the debate is over, unless you bring data and evidence to the contrary, not explainable within current frame. Good luck on that...

    --
    C. Sagan : A demon haunted world:
    http://www.amazon.com/gp/product/0345409469/
    visit randi.org
    1. Re:debate long over for scientific by Yokaze · · Score: 2, Interesting

      > As for free will, Since "we" are the sum of all our chemical reaction in the brain [...], there is no such things as free will, [...]

      We may well be the sum of our chemical reactions and still have a free will, in that sense, that our actions are not pre-determined.

      > Bottom line is the debate is over, unless you bring data and evidence to the contrary, not explainable within current frame.

      Quantum Mechanics to the rescue: The Free Will Theorem.

      --
      "Between strong and weak, between rich and poor [...], it is freedom which oppresses and the law which sets free"
  5. I do not understand by thePig · · Score: 3, Interesting

    Shouldnt memory play a role in this?
    I was under the impression that memory (basically hippocampus and amygdala) was the reason we chose items.
    For example -
    Grape - Appropriate synapses of the looks of the grape colour,look etc all get burned up in hippocampus
    Also, when we eat it - the synapses for amygdala set for pleasure also gets set up.
    Also a combination path way neuron for both also gets hardened due to electrons going there - (in hippocampus).
    Now next time I see a grape, this compination path gets a signal when we see a grape - so a signal goes to the other one (for pleasure also), thus the memory of pleasurable experience when a grape is eaten comes to me.
    This is memory.

    Now, for a choice, depending on the amount of pleasure, my synapses fire more and I go for that.
    For example - if there is bittergourd and grape, I will go for grape only.
    I thought the monkeys choice depended on these neurons rather than the one they speak about.

    Or is this the intelligent choice they are talking about - where in I go for bittergourd instead due to the higeher nutrition content ??? .. I thought that also could be expressed in the earlier way mentioned.

    --
    rajmohan_h@yahoo.com
  6. Translation by Anonymous Coward · · Score: 1, Interesting
    If I'm wrong and you actually have some connection aside from what looks to be personal prejudice against people with disabilities, feel free to post it.

    "I don't like what you're saying, so, Shut-Up!"

    You see, the parent probably has one of those "disabilities" that allows him to walk around with an entitlement chip on his shoulder, letting everyone know that they need to treat him special and that they owe him (whatever) because he has a "disability" and if they don't then they're just "prejudiced against people with disabilities."

    When you realize that you don't owe anyone anything and they don't owe you anything, a lot of "prejudice" in this world suddenly evaporates. It funny how it works! It took me 40 years to figure it out and I would have been a lot happier if I figured it out earlier.

    Oh, I'm assuming the worst here that you're in a chair, blind, deaf, or have some other real disability.

    Go ahead, call me an insenitive asshole! And I'll thank-you!

  7. Free will, souls, adn the brain by plunge · · Score: 4, Interesting

    There have been many fascinating finds in this field over just the last couple of years, from the discovery that you can externally trigger feelings of volition to be associated with artificially stimulated actions (i.e. make you feel like you CHOSE to move your arm, when in fact it was the scientists stimulating your nerves), to the discovery that religious ecstasy can be likewise triggered.

    In all of this, I've always been confused by those that suggest that human consciousness is better explained by a soul or free will. As far as I can tell, neither "Free Will" nor "soul" actually explain ANYTHING about conscious volition. Certainly, conscious experience is a philosophical mystery: what is it, and why is it? Nobody knows. But simply referencing some random word like "soul" and noting that it is supernatural doesn't explain anything. It's not that the rules of the natural world are too restrictive to allow "free will" or "conscious experience" to work. It's that we have no idea what they are or how they work at all. So positing some supernatural realm where anything is possible doesn't help, or advance our knowledge even a bit.

    Free will is actually even more bizarre, because although many people claim we have it, no one seems able to actually define what it is or what difference having free will vs. not having it would make. In short, it appears that the concept is completely incoherent and self-contradictory. It's one thing to be free to make choices for yourself, according to your own volition. But that's not what the strong "Free Will" concept is: even computers can make choices for themselves. Strong Free Will posits that people somehow make choices independently of.... well what? Independently of their own natures? That makes no sense! If there isn't some underlying deterministic substrate to my choices, how can they be mine at all? How can I be responsible if you can't causally track my choices back to some "me."

    In short, "Free Will" makes no sense as a concept, and offers no explanatory value for anything. It's SOLE purpose seems to be in theological arguments, a bit of handwaving to avoid having a designer be responsible for the nature of his own designs.

  8. Continuum. by khasim · · Score: 5, Interesting
    Thus if we reduce all of our actions and decisions to physical phenomena, we're probably going to find that none of our actions are a matter of "choice."
    At the far extreme of disfunction, I think that that might be valid. It isn't easy to believe that someone chooses to be schizophrenic.
    Rather, the actions we take are inevitable given the exact state that our brain is in and the exact environment we are in.
    And that's the key.

    If this is valid, then the animals with the same neurological structure would make the same choices, right?

    So far, all that's been shown is that damaging an area of the brain results in failures to react to certain distinguishing features.

    Do monkeys with brain pattern X always choose apple juice? But monkeys with brain pattern Y always choose grape juice? And monkeys with brain pattern Z always choose orange juice?

    The same with choosing to gamble. Why does someone choose ponies over blackjack?
  9. So you think you aren't free? by wytcld · · Score: 4, Interesting

    If you honestly believe you're not free, there are a number of things you might as well stop doing:

    1. Why do you consciously try to deliberate over any choices? If you are not free, that effort you're putting forth - to the extent, you know, that you have decided to try to deliberate, is at best an epiphenomenal waste. So why not save the effort? On the one hand, that epiphenomenal sense of your own agency can't really do anything in the physical world, right? On the other, for the epiphenomenal to exist it must be draining energy from the actually useful parts of the brain, which might be able to run their deterministic algorithm better if you weren't shunting that energy into the appearance of phenomenal consciousness, with its illusion of free agency and all that. So why not just give it up?

    2. The next time you blame your girlfriend or boyfriend or boss for anything, why bother? After all, they have no freedom in what they do. It was all determined from the beginning of time (if not before). So why not just give it up?

    3. When others of us say that we believe - no, we know that we are free agents, in ways that are beyond Newtonian causal physics (although not beyond some interpretations of quantum theory, e.g. Henry Stapp's or Roger Penrose's), it is absolutely determined that we will be saying these things. You could not possibly persuade us to freely change our minds through conscious deliberation on these questions. So why not just give it up?

    What these experiments may show is that the weights of particular desires are represented in particular cells in particular regions. Did you think, for instance, that thirst wouldn't be represented somewhere in the brain? What they don't (and probably can't) show is that it is merely a certain "weight" of thirst, balanced against certain "weights" of other desires, that results in action in some deterministic way. Think of it like a dashboard. There's a certain "weight" of the gas running low, a certain "weight" of the speed you're going, a certain "weight" of the oil light coming on, and even the "weight" of how many miles are on the vehicle. None of these prevent your free operation of the wheel and pedals (until the gas runs out, or a cop stops you, or the engine blows a rod, or the transmission falls on the road). Why should a dashboard in the mind representing how thirsty you are, how horny you are, how clever you think you are with your doubting of the common sense about our freedom ... why should the mere presense of any of these representations in physical instantiation imply any diminishment of your capacity to will? I'd rather say the more representations on the dashboard, the more the driver is freely in control.

    --
    "with their freedom lost all virtue lose" - Milton
    1. Re:So you think you aren't free? by vertinox · · Score: 2, Interesting

      Why should a dashboard in the mind representing how thirsty you are, how horny you are, how clever you think you are with your doubting of the common sense about our freedom ... why should the mere presense of any of these representations in physical instantiation imply any diminishment of your capacity to will? I'd rather say the more representations on the dashboard, the more the driver is freely in control.

      Oh its not that simple.

      1. You are because of 4 billion years of evolutions. You are made of atoms and have to obey the laws of physics. That is a limitation that you have no control over.

      2. You can only think in languages that have had about 10,000 years worth of work far beyond your control. Are there thoughts right now that you cannot comprehend because no human language can express it?

      3. Your child hood and education was mostly done through means beyond your control. Only after your teen age years were you able to seek out material and persons on your own to learn more information rather than just relying on what your parents and school system fed to you... But here is the kicker...

      All that knowledge that you sought on your own... Was created by by someone else.

      Even today... Try to tell me knowledge that you yourself came up with without any assistance whatsoever by another person or predisposed portion of our universe.

      Yet... We claim to have free will as an individual, but everything we see is based on pre-dispotion to knowledge. Our only choices is to take what information that is given to us and pick the one that suits or most logical (or illogical need).

      There is no free in that.

      The only way we are to have free will is to to put our minds in a simulation that lets us live forever, feel no pain, and wipe our minds clean of our memories and let whatever thoughts come on to our own.

      However, that is impossible so true free will may not be possible.

      Free will is just a chemical reaction to make us feel comfortable with the choices as a biological being. Otherwise we cease making decisions and most likley not pass on our genes because we cease to bread.

      Hence... Free will has been evolved into our genetics simply because those who did not have the feeling have died out.

      --
      "I am the king of the Romans, and am superior to rules of grammar!"
      -Sigismund, Holy Roman Emperor (1368-1437)
    2. Re:So you think you aren't free? by plunge · · Score: 2, Interesting

      See this is what I'm talking about. None of your questions make even a tiny bit of sense. Why deliberate over choices? Because that is how one comes to the best choice. Uhduh. Why blame people for what they do? Because they are responsible. Why argue with you? Because a good argument can maybe convince you.

      Were you really under the impression that you were asking stumpers? This is what I mean. You THINK that the concept of "free will" is adding some additional understanding to things, but in fact, it's completely empty.

      "why should the mere presense of any of these representations in physical instantiation imply any diminishment of your capacity to will? I'd rather say the more representations on the dashboard, the more the driver is freely in control."

      Again, see what you did? Now suddenly, there is this "driver" that is an abstraction of what's doing the choosing. But then the question simply becomes: how does the driver's choosing process work? All you've done is postponed the inevitable.

  10. Conciousness, Free Will, etc. by localman · · Score: 2, Interesting

    First I have to plug the Hofstadter books Godel, Escher, Bach, and to a lesser extent, Metamagical Themas. These books are as close to hard science as you're going to get talking about conciousness. Anyone with any interest in these topics really owes it to themselves to read these (sometimes challenging) books.

    Anyways: I am a big fan of digging down and understanding everything we can about how our minds work. But I always had a fear that at some point we'd know that we were powerless machines who could do nothing but react deterministicly. And as a creative emotional person I didn't want that to be true. But after digging as far as I could, in I've come to peace with the idea that reductionism will not reveal the man behind the curtain, so to speak. Maybe I'll be proved wrong someday, but to me, loosely speaking, the combinations of uncertainty, incompleteness, chaos, and feedback effects result in the whole being greater than the sum of it's parts. I'm not saying that there's some magical soul that exists outside our physical selfs, but rather that there is some higher level network effect in complex systems such as our brain where something exists on top of the physical parts, is wholly made from them, but is only loosely determined by them. That is the "I" to me.

    Cheers.

  11. Loading Consciousness 3.30 (c) by Frozen+Void · · Score: 2, Interesting

    Mindware isn't soul IMHO.Soul is probably a bootloader for Mindware OS: skills are applications,data is knowledge,memory is storage,reflexes are drivers,etc.Soul could be in some EM field form attached to one of organs and/or bootup routine replicated in DNA.