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The Thalamus - The Kernel in Your Mind

corbettw writes "This article on Yahoo Science News describes a new finding that explains how the thalamus is used by your brain to essentially boot your brain, and provide for central processing and control of all impulses going to and from the cortex. The article describes its function as an operating system, but from the description it actually seems closer to the functions of a kernel." From the article: "The finding, published last week in the journal Neuroscience, changes the way scientists understand nitric oxide's role in the brain, and it also has them rethinking the function of the thalamus, where it is released. The thalamus was thought to be a fairly primitive structure, sort of a gate that could either open and allow sensory information to stream into the cortex, the higher functioning part of the brain, or cut off the flow entirely. Godwin says the new research shows it's more accurate to think of the thalamus not as a gate but as a club bouncer, who doesn't simply allow a huge rush of people to go in or no one at all, but picks and chooses whom to let in and out. "

49 of 217 comments (clear)

  1. I can think it now. by suso · · Score: 5, Funny

    it's more accurate to think of the thalamus not as a gate but as a club bouncer, who doesn't simply allow a huge rush of people to go in or no one at all, but picks and chooses whom to let in and out. "

    Thalamus: Whoa buddy, you can't go in.
    Neuron: But, I'm with her!
    Thalamus: Her? Yeah right!
    Neuron: Cortica! Cortica! Come back! We can be together!

    [meanwhile in the real world]

    John: Hey Bobby, catch... whoa, heads up!
    Bobby: Owwww!

  2. Drugs... by posterlogo · · Score: 3, Funny

    KERNAL PANIC!!!

    1. Re:Drugs... by Tackhead · · Score: 2, Funny
      > Drugs...
      >
      > KERNAL PANIC!!!

      Knew I shouldn't have read the Nam-Shub of Enki out loud. Bloody buffer ovrflows. At least I got this nifty Sumerian-to-English plug-in from L. Bob Rife.

    2. Re:Drugs... by Rude+Turnip · · Score: 2, Funny

      Depends upon the drugs:

      coke/crack/meth: KERNEL PANIC!!!!!!OMG!!!!Eleventy!!!!11!!
      alcohol: Kernel is really fucking pissed off and wants to fight!!!
      nicotine: Kernel laid
      THC: Kernel mellow
      LSD: Kernel trails, whoa purple sounds awesome and crunchy.....

  3. The "yeah, but does it run Linux" department by krell · · Score: 4, Funny

    "the thalamus is used by your brain to essentially boot your brain"

    Which now raises hope for those of us who want dual-boot flexibility.

    --
    Where were you when the voynix came?
    1. Re:The "yeah, but does it run Linux" department by MattS423 · · Score: 2, Funny

      We might have to wait for Book Camp for that one...
       
      ...and I hear theres no linux dirver support for the sense of smelll. (yet)

    2. Re:The "yeah, but does it run Linux" department by Jerf · · Score: 4, Funny

      Which now raises hope for those of us who want dual-boot flexibility.

      So are you saying you're bi-curious?

    3. Re:The "yeah, but does it run Linux" department by megaditto · · Score: 2, Funny

      No, but it runs Linus, who happens to run Linux.

      --
      Obama likes poor people so much, he wants to make more of them.
    4. Re:The "yeah, but does it run Linux" department by wyip · · Score: 2, Funny

      Well version 1.1 was recently released which added support for eye sight, among other things.

  4. Like the Internet? by MECC · · Score: 4, Funny

    FTP:"Your Brain Works Like the Internet"

    A collection of pipes moving pr0n around?

    --
    "We are all geniuses when we dream"
    - E.M. Cioran
    1. Re:Like the Internet? by just_another_sean · · Score: 2, Funny

      A collection of pipes moving pr0n around?

      It's tubes man, tubes.

      --
      Creationist Textbook Stickers Declared Unconstitutional by CowboyNeal
  5. What some people need... by AltGrendel · · Score: 3, Funny

    ...is a brain that will boot in the first place.

    --
    The simple truth is that interstellar distances will not fit into the human imagination

    - Douglas Adams

    1. Re:What some people need... by another_fanboy · · Score: 2, Funny

      They boot fine. It's the BSOD that causes trouble.

    2. Re:What some people need... by uglydog · · Score: 2, Funny

      It says Keyboard not found. Press F1 to continue. What do I do?!

    3. Re:What some people need... by zephc · · Score: 2, Insightful

      I think its all the garbage that gets installed after it boots for the very first time.

      --
      "I would say that 99 per cent of what my father has written about his own life is false." - L. Ron Hubbard Jr.
  6. Godwin? by computational+super · · Score: 5, Funny
    Godwin says the new research shows it's more accurate...

    But then they drifted off topic and started arguing about Nazis and Hitler and the discussion had to be ended.

    --
    Proud neuron in the Slashdot hivemind since 2002.
  7. From: Andy T. by ettlz · · Score: 4, Funny

    From: Andy T.
    To: The Almighty

    I still maintain the point that designing a monolithic kernel in -3000 BC is a fundamental error.
    Be thankful you are not my student. You would not get a high grade for such a design :-)

    1. Re:From: Andy T. by daveed · · Score: 5, Funny

      -3000 BC. That's like 1000 years in the future man!

  8. Netcraft confirms it! by Anonymous Coward · · Score: 2, Funny

    BThalamusD is dying. I'd give it 80-90 years. 100 years tops.

  9. Re:Disturbing by Anonymous Coward · · Score: 2, Insightful
    Godwin says the new research shows it's more accurate to think of the thalamus not as a gate but as a club bouncer, who doesn't simply allow a huge rush of people to go in or no one at all, but picks and chooses whom to let in and out. "

    Sounds like the Thalamus is more like IPtables, rather than a kernel.

  10. My brain kernel's just fine... by Flashpot · · Score: 4, Funny

    but i'm paging out to my liver!

    --
    That which does not kill her only prolongs my agony.
  11. Brain vs. computer comparisons only go so far by andrewman327 · · Score: 3, Informative
    description it actually seems closer to the functions of a kernel.
    A reason to be even more afraid of Sony's rootkit!


    Anyway, this is an interesting article. This research has a lot of promise in coming years and decades as better understanding brain chemistry advances pharmaceuticals and medical treatments. From TFA: "This study shows a unique role for nitric oxide. It may help us to someday understand what goes wrong in diseases that affect cognitive processing, such as attention deficit disorder or schizophrenia, and it adds to our fundamental understanding of how we perceive the world around us."


    People have been comparing brains to computers almost as long as they have been comparing computers to brains. The Computational Theory of Mind looks at the mind (the brain's software as some have described it) in pretty a logical way, not too far away from computational reasoning. These comparisons are useful for understanding larger concepts but they generally fall apart when you get to the nuts and bolts of it. For example, the brain processes many shades of grey instead of a computer's binary perception. Neural networks and, to a lessor extent, quantum computing seek to emulate some of the processes of the brain.


    On an aside, if you are interested in learning more about machine intelegence, I highly recomend reading Ray Kurzweil's books.

    --
    Information wants a fueled airplane waiting at the hangar and no one gets hurt.
    1. Re:Brain vs. computer comparisons only go so far by Kouroth · · Score: 2, Interesting

      The software and hardware are interchangeable. The brain makes hardware and software changes to itself during operation.
      *Tangent*
      Some day we may make DNA to build cells for computational biomasses. Such cells DNA would not need to be nearly as complex as real living creatures. Even single celled creatures need much more DNA based information than any artificial cells. Artificial computational biomass cells would only need enough information for replicating on command, following operation instructions and continuation (aka living). Some day we may have enough knowledge to build such systems (creatures). A biomass computer is only the first step to harnessing a very powerful technology. We may even be able to make cells that can build new cells with new DNA that we program. That way we could experiment with out having to build such cells and DNA by hand.

      --
      Thermal depolymerization - Lazy recycling.
  12. Obligatory Homer Simpson Quote.... by Himring · · Score: 2, Funny

    Homer: Okay, brain. You don't like me, and I don't like you, but let's get through this thing and then I can continue killing you with beer.

    Homer's Brain: It's a deal!

    --
    "All great things are simple & expressed in a single word: freedom, justice, honor, duty, mercy, hope." --Churchill
    1. Re:Obligatory Homer Simpson Quote.... by Apocalypse111 · · Score: 2, Funny

      Homer: Shut up brain, or I'll stab you with a Q-Tip!

      --
      There is no mod option "-1: Disagree" for a reason. "Overrated" is not an acceptable substitute. Post something instead.
    2. Re:Obligatory Homer Simpson Quote.... by Himring · · Score: 3, Funny

      Homer's brain: Use reverse psychology.
      Homer: Oh, that sounds too complicated.
      Homer's brain: Okay, don't use reverse psychology.
      Homer: Okay, I will!

      --
      "All great things are simple & expressed in a single word: freedom, justice, honor, duty, mercy, hope." --Churchill
  13. embracing the overblown analogy for a moment... by pb · · Score: 2, Insightful

    Are you sure that it doesn't sound more like a bootloader, or a DHCP server, or a firewall/router, at the edge of the network, protecting the main Beowulf cluster, etc., etc....

    Ok, enough of that.

    --
    pb Reply or e-mail; don't vaguely moderate.
  14. nitric oxide by Mr.+Slippery · · Score: 2, Interesting

    One interesting thing about this is that nitric oxide is produced in the sinuses. Does "proper" nasal breathing result in altering the concentration of this molecule in the blood and therefore have an effect on consciousness?

    --
    Tom Swiss | the infamous tms | my blog
    You cannot wash away blood with blood
  15. Metaphor City by exp(pi*sqrt(163)) · · Score: 3, Insightful
    The thalamus is a gate, a bouncer, a kernel, a bootloader, a chamber, a relay, a telephone exchange.

    I personally think that the thalamus is like a coathook. You can hang whatever metaphor you feel like on it.

    --
    Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
  16. The better question is, what do we call it? by s20451 · · Score: 5, Funny

    From the summary:

    The article describes its function as an operating system, but from the description it actually seems closer to the functions of a kernel.

    Does this mean we should call the brain the Brain/Thalamus? It's unfair to give the entire package precedence over the kernel, as one is useless without the other.

    --
    Toronto-area transit rider? Rate your ride.
    1. Re:The better question is, what do we call it? by MillionthMonkey · · Score: 5, Interesting

      Does this mean we should call the brain the Brain/Thalamus? It's unfair to give the entire package precedence over the kernel, as one is useless without the other.

      I used to study neuroscience. The thalamus is a HUGE bank of relay switches in the brain- all these trunk cables go into it from all over. Basically anything you're paying attention to involves some circuit going through the thalamus, and the way the thalamus works is what limits your ability to focus on multiple things at once. Once something becomes rote- like QWERTY typing or good guitar playing- the thalamus is no longer involved.

      I have epilepsy- really bad seizures- and my brain gets really messed up on restarts because it regains function piece by piece. Occasionally I'll be totally conscious (forming some long term memories again), and watching stuff come back online- I can hear, then I can see, then I can recognize things I see, etc. There are intermediate states where I can see but not recognize things. The seizures start in the right temporal lobe, so the right hemisphere is completely screwed up, but if my left brain works I can compensate with higher functions. Usually I'm looking for water fountains because my head is really hot and sweaty after a seizure. I'll find a water fountain and think, is this a water fountain? Well it has a stream of stuff that looks drinkable... it has a thing coming out the side that you can turn... it MUST be a water fountain! I almost pissed on my wife's chair once after somehow figuring it was a toilet. But without thalamic activity I'd never be able to patch right brain functions and send sensory information to the forebrain from the left side. If I'm able to pay attention to something at all, then there is some thalamic function. Recognizing it is a different task.

      The ability to form long term memories comes later and is a more distributed gradual process as areas of the cortex recover. I was in this cubicle working once... doing simple stuff like cleaning up someone's crappy code... then I started doing more mentally intense work, and I turned around after an hour or two and noticed my cubicle was a mess. Everyone said, "you had a seizure a few hours ago, don't you remember?"

      Recently my brain has been passing through a metastable fugue state after really nasty seizures where I have partial function, but it's not me yet- it's like someone else. I answer yes/no questions completely differently, I don't recognize my wife, I fight with people if they get in my way, and I don't know where I'm going but I'm going somewhere, sometimes out the door. Usually no new memories are being formed; I have to go by what people tell me afterward. Apparently I'm getting better at fooling people in the fugue state because my speech in the fugue is starting to almost sound normal even though I have only partial brain function. One of these days I'm going to regain consciousness in jail.

    2. Re:The better question is, what do we call it? by iluvcapra · · Score: 2, Funny
      all these trunk cables go into it from all over

      So, what you're saying is that the brain isn't like a truck, but it's actually a bunch of tubes? You can't just pull your brain up and load it and drive it away, 'cause it's tubes.

      --
      Don't blame me, I voted for Baltar.
    3. Re:The better question is, what do we call it? by Anonymous Coward · · Score: 2, Interesting

      This sounds somewhat similar to some recreational experiences I've had with dissociative drugs, primarily Dextromethorphan, although much less pleasant! The brain is a complex web of interconnected systems, the world becomes radically different when elements of that system operate out of spec. Have you ever had "strobing"? That was always one of the more interesting qualities of DXM at certain dosages - it's almost like being in a dark room with a strobe light except there is almost a kind of buffering, it's really quite amazing the first time it happens. At higher doses the part of your brain that handles facial recognition goes completely out of synch, what's interesting is that everything else can still be recognized properly, but identifying faces becomes like the water fountain in your story ("I know she has blue eyes and blond hair, this MUST be Susan!").

    4. Re:The better question is, what do we call it? by talljuan · · Score: 2, Interesting

      While I do not have seizures, I can relate a little. Two years ago I had neurosurgery to remove a brain tumour. The first couple days in the ICU were difficult, not from any sensation of pain, but beacuse my perceptions of the world were so distorted by the trauma of the procedure. Whenever I opened my eyes, everything was like an offset double-image. Very confusing. By the third day, my brain had fully remembered how to properly integrate the inputs from each eye. Now, I am pretty much back to normal. The main thing that remains is that I lost about half of the peripheral vision on my right side (the tumour was on the left side of my brain), and a difficulty in maintaining concentration (a frequent result of having brain tumour/surgery, but have meds that help that).

      Anyways, best wishes for you in getting effective treatment!

      -j

  17. Norton Ghost by krell · · Score: 2, Insightful

    This also brings us closer to the day when we can re-program our brains to a desired previous state. This is something you might want to do after (for example) learning Esperanto or how to speak very fluent Klingon, when you start to think that Jon Katz news items make perfect sense, having gone to see "Gigli" or "Star Trek 10", having seen the Goatse image one too many times (once is too much!) or getting infected with an embarassing Olivia Newton-John earworm: things you'd really not have in your wetware. Perhaps Symantec should roll out a new version of Norton Ghost. One that uses real ghosts, this time.

    --
    Where were you when the voynix came?
    1. Re:Norton Ghost by zlogic · · Score: 2, Interesting

      How about watching one (good) movie, playing one (good) game, reading one (good) book all over again?
      After forgetting the plot and characters you'll get the same experience as reading/watching/playing for the first time.

  18. Research abstract by FleaPlus · · Score: 4, Informative

    I really wish submitters would include a link to the research paper, so we could actually judge the research for ourselves instead of relying on some journalist's interpretation. Here's the abstract for this paper, from Neuroscience:

    Diurnal gene expression patterns of T-type calcium channels and their modulation by ethanol

    The transient (T-type) calcium channel participates in the generation of normal brain rhythms as well as abnormal rhythms associated with a range of neurological disorders. There are three different isoforms of T-type channels and all are particularly enriched in the thalamus, which is involved in generating many of these rhythms. We report a novel means of T-type channel regulation in the thalamus that involves diurnal regulation of gene expression. Using real time polymerase chain reaction we detected a diurnal pattern of gene expression for all T-type channel transcripts. The peak of gene expression for the CaV3.1 transcript occurred close to the transition from active to inactive (sleep) states, while expression for both CaV3.2 and CaV3.3 peaked near the transition of inactive to active phase. We assessed the effect of chronic consumption of ethanol on these gene expression patterns by examining thalamic tissues of ethanol-consuming cohorts that were housed with the controls, but which received ethanol in the form of a liquid diet. Ethanol consumption resulted in a significant shift of peak gene expression of approximately 5 h for CaV3.2 toward the normally active phase of the mice, as well as increasing the overall gene expression levels by approximately 1.7-fold. Peak gene expression was significantly increased for both CaV3.2 and CaV3.3. Measurements of CaV3.3 protein expression reflected increases in gene expression due to ethanol. Our results illustrate a novel regulatory mechanism for T-type calcium channels that is consistent with their important role in generating thalamocortical sleep rhythms, and suggests that alterations in the pattern of gene expression of these channels could contribute to the disruption of normal sleep by ethanol.


    Curiously, I get the impression that the emphasis of the research is somewhat different from what was emphasized in the popular-press article.

    1. Re:Research abstract by mspohr · · Score: 4, Interesting
      Thanks for posting this abstract and link. Most articles in the popular press are written by idiots so it's good to go to the source.

      From the abstract, it appears that the thalamus does act as a kind of "pacemaker" (or "motivator" as in R2D2).

      The really important finding of the study is that this may be the path that alcohol uses to disrupt sleep.

      --
      I don't read your sig. Why are you reading mine?
    2. Re:Research abstract by phystor · · Score: 5, Informative
      As a neuroscientist I completely agree that it would be useful to present at least some simplified version of the actual findings instead of some nifty computer analogy to make it sound cool. The actual findings are in stark contrast what is being claimed by the news piece.

      The paper you link is a different one. This is the actual paper:

      Alexander GM, Kurukulasuriya NC, Mu J, Godwin DW. Cortical feedback to the thalamus is selectively enhanced by nitric oxide. Neuroscience. 2006 Jul 28 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=p ubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=168 76956&query_hl=12&itool=pubmed_docsum

      Indeed the area they study is somewhat mysterious: The thalamus provides separate communication channels for essentially all sensory information from the sensory organs (e.g. eyes) to the cerebral cortex. However, unlike most brain areas it appears that there is no transformation going on in the thalamus. So if there is no computation, it must be a relay! As much as much most neuroscientist find the idea of pure "relay" unsatisfactory we simply have no evidence for anything beyond it. Hence all the speculation. Unfortunately, the present paper sheds no light onto the thalamus mystery. The authos cut a slice out of a brain and study in isolation. Clearly you won't get much functional information about what's actually going on in this way. Then the authors dump a drug onto the slice to show that it differentially turns up the gain of one input and turns down the gain of another one. Nice, but we don't know if this is actually going on in the brain or how this chemical would get there. If --as the journalists claim-- this finding were to transform our ideas about the thalamus then it probably wouldn't be published in a third tier journal like 'Neuroscience'.

      So much for science journalisms.

      -phystor-

  19. Linus is it you? by steincastle · · Score: 2, Funny

    brain ... it actually seems closer to the functions of a kernel

    so... God and Linus invented the same thing?
    #@$&!!@# I always thought Linus is God =)

  20. Book camp by krell · · Score: 2, Funny

    "We might have to wait for Book Camp for that one..

    Dilbert: "Why has Wally been barking, chewing the managers, and peeing on the flowcharts all day?"
    Dogbert: "He rebooted his brain with Cujo using that new 'Book Camp' software."

    --
    Where were you when the voynix came?
  21. Researcher by Anonymous Coward · · Score: 2, Funny
    Godwin says the new research shows it's more accurate to think of the thalamus not as a gate but as a club bouncer, who doesn't simply allow a huge rush of people to go in or no one at all, but picks and chooses whom to let in and out.

    Godwin also says that the thalamus is like Nazi Germany; it declares some people are full citizens and others are untermensch.

  22. Let's not forget the order by suv4x4 · · Score: 2, Interesting

    It's not the brain that works like an OS, apparently it's the OS that has a similar structure to a brain (already).

    I guess we're on the right way to seeing higher intelligence emerge from machines in the next few decades.

  23. login? by rolyatknarf · · Score: 2, Funny

    What happens when someone boots their brain and can't remember the password at the login screen?

  24. Scary even to think about this by roman_mir · · Score: 4, Funny

    I don't know if I can trust any kernel to be compared to the brain, after all Windows gets the Blue Scream of Death and the Linux gets Panic Attacks, DOS has to be rebooted often to modify memory management, Unix gets segmentation falls and bus errors. This is terrible news, I think I am just going to walk around in circles until I stop thinking about this... Damn! It's a deadlock forced by a race condition! I just want to go to sleep.

  25. Relic Reference by Anonymous Coward · · Score: 2, Funny

    That is why the creature only ate the thalamus of the humans it killed .

    A mind is a terrible thing to waste... Especially if you're really hungry

  26. Re:Wrong wrong wrong by Anon-Admin · · Score: 2, Informative

    Thought is merely a series of chemical reactions.

    Which is why I think Ps. Cubensis and Ps. Mexicana mushrooms are so much fun. :)

  27. Re:Yeesh by Anonymous Coward · · Score: 3, Interesting
    How hard could it be to add some tracer isotopes to lithium salts, then use fMRI to see exactly what happens from start to finish?
    Dead easy but not terribly useful. Watching the blinking lights on all the network cards tells you precious little about why the LAN just melted down. To be able to analyze problems, we need detailed information about how individual neurons work, how they interact with the glial cells and blood vessels, and the structure of the larger networks of neurons. Unfortunately the individual cells are fearsomely complicated, and the connection networks are even worse and change constantly. Another difficulty is that human brains have significant differences from even other mammals, so rapid progress would require a great deal of vivisection work on healthy subjects. (For some reason most potential subjects run away when you go after their skull with power tools.) This work will take a long time and cost a lot, but will eventually give solid answers about how the brain malfunctions.

    As a stopgap, large genetic studies will be more fruitful. What we need is for gene sequencing to come down to the $1000/person range--and it's getting there. Then we take detailed medical histories and sequences from a hundred each of normals, bipolars, epileptics, and migraineurs. Comparing their genes will tell us which ion channels, transporters, receptors, and so forth are "hot spots". Once we know that, it's straightforward to find drugs that target just those proteins. Right now we're stuck with "dirty" drugs that madly stomp on all sorts of stuff at the same time, which means bizarre and evil side effects. (The antipsychotics and antiepileptics are notoriously dirty. The tricyclic antidepressants, which I take for chronic migraine, are only a little better.)

    We're far more technologically advanced, but in all of my visits to neurologists or pdocs, I have never seen any meaningful technology in use.
    Indeed. Right now the best diagnoses come from a conversation and a basic neurological exam. fMRI scans might be helpful, but the cost is very high, and it's hard to catch an intermittent event that happens the day before a migraine attack or manic episode.

    Incidentally, I seem to remember that lithium acts as a sodium or potassium analog all over the body. It competes for the same transporters and ion channels, but acts just a little different. I think it also builds up in cells and changes their osmotic conditions (concentration of water versus everything else). The upshot is that it pushes many things a little out of equilibrium, putting them at new operating points where, for unclear reasons, they are less likely to oscillate.

  28. Monolithic kernel or interrupt controller? by skeldoy · · Score: 2, Interesting

    Well.. I think the kernel analogy is far from precise. The kernel (at least the monolithic one) is a far too complex and massive system to be paralelled to the thalamus. I think interrupt-controller is a more suitable analogy. Shit comes in and shit goes out and control is being enforced (to some extent).

    Drivers in a kernel would in the brain be something like "control of muscular movement" (cerebellum, parts of cortex, somatic part of the peripheral nervous system, etc...), interfaces would be something like "riding a bike" (using all the "drivers" for muscular movement, balance, memorysystems for planning route, motivational systems for motivation, sensory systems for navigation and real-time collision avoidance, etc...).

    The Thalamus is (at least as I see it) an interruptcontroller issuing "interrupt service routines" on a regular basis, telling our brain that we are about to loose our balance or crash into the tree in front of us.

    The (brain) kernel is the abstract "mind"/"soul" "thing" that is a mental superorganism made up of all our brains organs.

    well... thats just my 2 eurocents.