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Protein Gel Quickly Stops Bleeding

Stefan vd Linden writes, "An international team of scientists has discovered a substance to heal bleeding wounds within seconds. They're using a solution of protein molecules that self-organizes into a biodegradable gel. Until now they've only tested it on animals, but the tests were highly successful. From the article: 'Some surgeons are already excited about the material. "I see great potential in the eye field, the gastro-intestinal field, and in neurosurgery," says Dimitri Azar, head of ophthalmology at the University of Illinois at Chicago, US. "In the eye, even a drop of blood will blur your vision for a long time," Azar adds. "A material that would stop the bleeding could lead to a paradigm shift in how we practice surgery in the eye."'"

44 of 167 comments (clear)

  1. I already have a protein gel that stops bleeding by csoto · · Score: 5, Insightful

    It's called platelets. It was invented long ago. Thank goodness, or I would have died the first time my nose bled...

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  2. protein gel by Anonymous Coward · · Score: 3, Funny

    I make my own protein gel.

    1. Re:protein gel by Anonymous Coward · · Score: 3, Funny

      Given the number of comments along these lines, and the fact that you were first, don't you think it was a bit premature?

  3. Finally... by ackthpt · · Score: 4, Funny

    An alternative to ingesting krazy glue!

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  4. as a hemophiliac by Rooked_One · · Score: 5, Insightful

    this would be great... if I cut myself shaving its a real pain in the ass... I have to doctor myself for a good hour to get some litle nicks to stop. My shots to stop bleeding cost around 1,000 bucks a pop, so its not like I can just give myself a shot for a minor nick - granted this won't help with joint bleeds, but hey, as long as they don't charge an arm and a leg for the stuff, i'll be happy.

    Now if I could just rub it on the skin to stop joint and muscle bleeds... wow... a gift from heaven?

    1. Re:as a hemophiliac by Frosty+Piss · · Score: 4, Insightful
      if I cut myself shaving its a real pain in the ass... I have to doctor myself for a good hour to get some litle nicks to stop. My shots to stop bleeding cost around 1,000 bucks a pop...

      Consider an electric razor...

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    2. Re:as a hemophiliac by tacokill · · Score: 2, Interesting

      Since you are a hemophiliac, I'd like to know if you can use a styptic pencil in this situation?

      I am not quite sure how it works but I was curious because I used one successfully on a fairly major leg wound -- and it worked like a charm. It hurt like hell but it DID stop the bleeding, eventually.

      (sidenote: I was in a pinch and didn't have other options at my disposal)

    3. Re:as a hemophiliac by Rooked_One · · Score: 3, Interesting

      yah, i try to use styptic pencils but they just mostly sting more than do anything helpful. Yet another downer. The really sad thing is that the pharmco's are making so much cash off the few of us (i think the ratio is 1:10,000) but do you ever see any charity jars in your local stop and shop for hemophiliacs?

      I'm not going for a sob story, i've long ago made peace with my situation and the lovely hep C that was given to me by Bayer when they were so kind as to make 'the newest, latest and greatest' product back in '88 or so that eliminated long stays in the hospital while bags of plasma were injected. Instead, you just mixed up a batch of freeze dried factor IIX that came from *dubious* sources.

      Sorry to get off topic there... I havn't made peace with Bayer for that.

    4. Re:as a hemophiliac by Anonymous Coward · · Score: 5, Funny

      if I cut myself shaving its a real pain in the ass

      Most people use the razor on their faces.

    5. Re:as a hemophiliac by Anonymous Coward · · Score: 2, Funny

      My heart bleeds for you...

      C'mon, you were all thinking it, somebody had to say it!

    6. Re:as a hemophiliac by StikyPad · · Score: 2, Funny

      Perhaps he misread the "A" in faces as an "E".

    7. Re:as a hemophiliac by Rooked_One · · Score: 2, Interesting

      there were no tests, but they could have NOT taken blood from prisoners with the same needles, then concentrated it down.... I'm just thanking whatever god is out there that I didn't get HIV... My doctor when I was very young suggested a treatment that would have given me AIDS 100% chance. Luckily my mother had done her research enough to know it wasn't safe enough yet. I think I got the medicine that infected me (monoclate-p) after they developed the HVC test, but i'm really not quite sure. Frankly, after six months of interferon + ribovirin treatment, then having atrial fib from the side effects, then trying it again, and 8 months in having the same thing happen, but continuing the last 3 months, and then having the treatment not work, i'm sick of caring.

      I did hear that overseas they have developed a treatment that affects the RNA of the virus directly istead of tricking around with your body, but i'll just have to wait for the FDA to take their slow time with the process of approving it... anyone care to start a fund so ill be able to afford it? :)

  5. Re:I already have a protein gel that stops bleedin by ackthpt · · Score: 3, Interesting

    It's called platelets. It was invented long ago. Thank goodness, or I would have died the first time my nose bled...

    Platelets are fine for small wounds, but they don't do much for larger than a small cut. For external cuts I usually stick it together with a little superglue. I don't expect this will be over the counter though..

    in case of massive fragging mix contents with one cup of tea and drink really fast!

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  6. Re:I already have a protein gel that stops bleedin by gomiam · · Score: 2, Informative

    Well, unless my Google search fails me (no, I'm not a native English speaker, and I didn't know what platelets are), platelets are cells. As such, calling them "protein gel" is quite a stretch, since there happens to be more than proteins inside them. Besides, the idea is to stop bleeding quickly, and platelets aren't that fast.

  7. Re:I already have a protein gel that stops bleedin by russ1337 · · Score: 3, Interesting

    This reminds me of when I was watching the cannon run on the Edinburgh tattoo a few years ago. One of the soldiers got hit on his head (#1 haircut), and cut quite badly. A medic ran out with a thing that looked like a staple gun, sprayed it with 'numbing spray', stapled the wound closed with about three staples, then wiped some kind of gel/wax on it. The guy looked a little sore, but he wasn't bleeding and his wound was closed enough that he could carry on. - all in about 10 seconds.

  8. Re:I already have a protein gel that stops bleedin by lockholm · · Score: 2, Interesting

    But they do have them. The real problem in hemophilia is with clotting factors, associated proteins that bind the platelets together and stick them in place, rather than a lack of platelets.

  9. But... by steveo777 · · Score: 2, Interesting
    I read TFA. Doesn't say much about what happens besides that it stops bleeding.


    Does this mean it will make a way for blood to flow in an artery? Or does it just get in the way?
    Does it make room for healing cells? TFA says it doesn't interfere, but does it get out of the way when the body starts to heal?
    Could something be added to 'nourish' the or promote more healing cells?


    Does it promote healing or just act like a mega-bandage?

    Don't get me wrong, I think it'd be great to throw this stuff in a first aid kit so you could just glop it on if you get a gash while out hiking or hunting. They could be the first real 'med-packs' like in them 'video games'.

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    1. Re:But... by reverseengineer · · Score: 4, Informative
      The journal article doesn't seem to be up on the site for Nanomedicine yet, but the same group's prior research on protein scaffolds (also referenced in the news article) may provide some answers.

      The proteins they use are structurally very similar to natural silk, which is composed of proteins arranged primarily in a beta-sheet conformation. This conformation lines up strands of amino acids in a rough plane and cross-links them, usually with hydrogen bonds, but sometimes with ionic attractions or hydrophobic interactions.

      The use of spider silk for clotting wounds has been known since ancient times; coagulation basically requires the onsite formation of a sticky, fibrous protein mess, and spider silk is almost completely sticky, fibrous protein (and unlike many similar foreign substances, doesn't provoke a dangerous immune reaction). This protein gel is basically the same sort of thing, but with the neat added trick that the cross-links are the result of ionic interactions, so that you could have an anhydrous powder of this stuff that you sprinkle onto a wound, and when it contacts electrolyte-rich bodily fluid (their paper on peptide nanofiber nerve scaffold notes it only requires normal physiological concentrations of salt, like those in saline or spinal fluid- from the news article, that's not especially clear), it turns to a fibrous gel.

      As far as whether it promotes healing, interestingly enough, clotting itself promotes healing- the clot itself stimulates the cells in charge of repair- really, the sooner a stable clot is formed, the sooner your own cells can start fixing the damage. In the neural scaffold paper, the group also points out that, being composed of just the same amino acids ubiquitous in the body, the scaffold can be safely broken down to amino acids and then metabolized or excreted; I would imagine the same would be possible for the clotting gel when it is no longer needed.

      --
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  10. Sounds like the HemCon bandage by count0 · · Score: 4, Insightful

    There's a company called HemCon that makes a chitosan bandage - it's a protein gel bandage made from chitosan extracted from shrimp shells. The US Army currently uses it in Iraq & Afghanistan.

    1. Re:Sounds like the HemCon bandage by Perx · · Score: 2, Informative

      Chitosan is a polysaccharide, not a protein.

  11. Battlefield use even more exciting by Marxist+Hacker+42 · · Score: 4, Informative

    A large percentage (which I don't have the time to look up right now) of battlefield deaths are really bleeding to death, not instantaneous. To this end, soldiers carry "Quckclot", a powder that is similar to this product- similar but not the same. This seems to work faster- and would save lives on the battlefield.

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  12. Re:I already have a protein gel that stops bleedin by gomiam · · Score: 2, Informative

    There's several different kinds of hemophilia. Besides the genetic caused ones (usually platelets will be scarce, nonfunctional or both), lack of certain elements in food intake (see vitamin K) will affect bleeding.

  13. Re:I already have a protein gel that stops bleedin by Yold · · Score: 3, Informative
  14. Re:Gaping wounds by Chris+Burke · · Score: 4, Funny

    Geeze, you sure do have a cynical view of scientists. They love animals just as much as you do!

    In the study, they only used animals with emotional problems who would cut themselves. They would watch the animals, and after the animal would cut themselves, they'd apply the protein gel. While they were studying the healing of the wound, another team of scientists who are conducting experimental depression therapy would treat the animals to stop them from cutting themselves any more. Both humans and animals benefit!

    Also, I have it on good authority that rabbits actually enjoy having mascara smearing into their eyes, and were quite upset when they discovered certain humans were trying to stop the practice.

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  15. Re:I already have a protein gel that stops bleedin by ToreTS · · Score: 2, Informative

    Hemophilia can be caused by a lack of several proteins that take part in the clotting cascade, but the substance usually responsible is factor VIII.

  16. Re:I already have a protein gel that stops bleedin by pilgrim23 · · Score: 4, Interesting

    Sometime in pre-history, it was noticed that many things like; dried marigold petals and spider web staunches blood. It was common practice to bleed patients at one time, and when the leech was removed, spider web was used as a poltice. I have personally used spider web on cuts, and it stops the flow in seconds. I should have applied for a research grant dang it!

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  17. coat bullets with it by 10100111001 · · Score: 5, Funny

    As a potential solution to rising gun fatalities, maybe we could use it to coat bullets.

  18. Why is the protein gel bleeding? by Ichijo · · Score: 4, Funny

    According to the title the gel quickly stops bleeding, but I think it would be better if it didn't bleed in the first place.

    So I think I'll wait for version 2.

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    1. Re:Why is the protein gel bleeding? by Fordiman · · Score: 2, Funny

      Do they sell a protein gel that *never* stops bleeding?

      If so, I'll make a house out of it and sell it to Glen Danzig.

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  19. Re:I already have a protein gel that stops bleedin by symes · · Score: 4, Insightful

    Indeed - superglue was invented to close wounds http://en.wikipedia.org/wiki/Superglue#Medicine and is still used in hospitals around the world

  20. Will your protein gel stop bleeding? by Anonymous Coward · · Score: 2, Funny

    I make my own protein gel.

    Yes, but have you ever squirted it into any gaping holes to see if the bleeding would stop?

    1. Re:Will your protein gel stop bleeding? by Thrakamazog · · Score: 5, Funny

      My protein gel stops the bleeding for about nine months, then needs to be reapplied.

    2. Re:Will your protein gel stop bleeding? by darkuni · · Score: 2, Funny

      Damn, I just spit soda everywhere....

  21. My wife could use this by ArcherB · · Score: 2, Funny

    She bleeds all the time! Maybe this will help with that "not so fresh feeling".

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  22. The poor use of corporate buzz words. by rvw14 · · Score: 2, Funny
    "A material that would stop the bleeding could lead to a paradigm shift in how we practice surgery in the eye."'"

    Quick, leverage the synergy!

  23. It's all become true... by The-Bus · · Score: 2, Interesting

    A few weeks ago, I was talking about Trauma Center for the Nintendo DS with a friend of mine. In the game, you play a doctor who operates on patients, removing tumors with your stylus, sewing them back up, etc. My friend's girlfriend is in med school currently and says that all the basic procedures are accurate enough, with the exception of one: a gel you apply to stop bleeding. I guess that's not true anymore.

    --

    Small potatoes make the steak look bigger.

  24. As they teach in medical school by Anonymous Coward · · Score: 2, Funny

    All bleeding stops one way or another no matter how bad it is....

  25. Re:I already have a protein gel that stops bleedin by nizo · · Score: 4, Insightful

    How about packing helmets/vests/etc with a layer of this stuff for things that get through? I for one would prefer that the padding in a helmet be filled with this rather than plain ol' squishy gel.

  26. Oh noes!! by IlliniECE · · Score: 2, Insightful

    I was really enjoying the article blurb going 'oh right! Awesome!' to myself until I read "paradigm shift"... Not even the best technology can overcome the power of a cliche.

  27. Some interesting nuggets of info by Hahnsoo · · Score: 4, Informative

    Here is the original press release:

    http://web.mit.edu/newsoffice/2006/hemostasis.html
    Not much new information here, but it's nice to read things that come "straight from the horse's mouth", so to speak.
     
    Of real consequence is the main researcher's lab website:

    http://web.mit.edu/lms/www/
    It is chock full of interesting research on self-assembling peptides, including what substances they've been trying, and the eternally-asked question, Can I run my laptop off of spinach?(They isolated the chloroplast/photosystem of spinach, and hope to use it for photovoltaic purposes).
     
    As far as discussion, most of the application has been suggested in the field of delicate microsurgery. Why not band-aids for the masses? Most likely due to the cost. Aside from the financial barriers in bringing an idea to mass-market, especially in the medical field, imagine trying to keep the candidate liquid substance stable for storage, to be used at a moment's notice; if it self-assembles easily, then it can "gel up" just as easily, too. This is combined with the fact that there are already several fairly effective ways to stop the typical cuts-and-scrapes of a household, from regular band-aids and gauze to liquid bandages (which quickly seals off a wound and prevents bleeding, in about the same amount of time). The real application would be in situations where regular hemostasis measures cannot be used or are undesirable. Again, this goes back to microsurgery. In most surgery, hemostasis is achieved by either tying off the bleeding vessel with suture, cauterizing the end of the vessel with a Bovey (an electrical tool used for cutting and cauterizing) or a laser, or simply clamping the vessel with a hemostat. There are other methods, but those are the most common ones in routine surgery. Clamping the vessel is not practical in confined spaces (the hemostat takes up space), cautery can't be used in all situations, and you can't always tie off the bleeder. The self-assembling gel described would be a boon in those surgical situations, another "arrow in the quiver", so to speak. The aforementioned application in patients with hemophilia is also plausible, if less certain.
     
    Sadly, the journal that they are publishing in, Nanomedicine, is fairly brand new and not stocked by my local library yet. There have only been three issues of it so far (June 2006, August 2006, and October 2006) and the latest is not on their website yet. I would really like to read that article in full.

  28. Healing by cHALiTO · · Score: 3, Funny

    Yay! gotta get some of that stuff, re-bottle it and sell it to thinkgeek as "Potion of Healing Serious Wounds" =P

    --
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  29. Re:I already have a protein gel that stops bleedin by Nulagrithom · · Score: 2, Insightful
    Guaranteed this will be weaponized - and then only the government and terrorists will have it.
    Except for not. Why would this be "weapon" be any better than a fine dose of arsenic, or even just pipe cleaner or something nasty? Or just a bullet, those are cheap. I don't really see weapon potential here that surpasses anything already created...
  30. Re:I already have a protein gel that stops bleedin by sandwiches · · Score: 2, Interesting

    That idea kinda reminds me of what they used to line the fuel tanks of some of the larger bombers in WW2. A rubber that when it came into contact with the fuel would swell and harden. So, if a bullet hit it, it would self seal.

  31. Re:I already have a protein gel that stops bleedin by TractorBarry · · Score: 3, Interesting

    Not only that but spider webs are covered with antiseptic agents too.

    There's a small summary and a nice picture at http://www.microscopyu.com/galleries/smz1500/spide rsmall.html

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