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Cancer Fighting Drug Found in Dirt

firesquirt writes "From an article in LiveScience, the bark of certain yew trees can yield a medicine that fights cancer. Now scientists find the dirt that yew trees grow in can supply the drug as well, suggesting a new way to commercially harvest the medicine."

184 comments

  1. Next headline... by wbren · · Score: 5, Funny

    "Pharmaceutical company patents dirt; Critics claim prior art"

    --
    -William Brendel
    1. Re:Next headline... by delire · · Score: 3, Interesting

      Your joke points to a sad reality however, that it's only through patenting cures (ie having a monopoly over a cure) can pharmaceutical companies (free enterprises) get the investment capital to develop medicines. Cures are IP, traded and guarded.

      Moreso, the last thing any pharmaceutical monopoly can afford is for people to get better very easily. For this reason cures are highly guarded discoveries: there are many cures around we don't have access to, and perhaps never will, either because they threaten an existing sickness market or because the IP pushes the price up beyond our reach. Just because we hear about a cure doesn't mean we'll ever see that cure in the wild. Expand this grim fact 100 fold in places like Africa or India where the cost of IP literally comes between them and surviving an otherwise perfectly cureable disease (if only production and distribution were the only cost).

      In many respects sickness itself is a managed resource and pharaceutical patents - as a monopoly of a cure - are an active ingredient in this logic.

    2. Re:Next headline... by WallaceAndGromit · · Score: 2, Funny

      ... 8 year old sued for telling friend to eat dirt.

      --
      Name: Mr. Anon E Mouse; SSN: 555-55-5555
    3. Re:Next headline... by odourpreventer · · Score: 1

      Yep, they're gonna dig up the dirt on this one. (Sorry, force of habit.)

    4. Re:Next headline... by Anonymous Coward · · Score: 0

      > Moreso, the last thing any pharmaceutical monopoly can afford is for people to get better very easily. For this reason cures are highly guarded discoveries: there are many cures around we don't have access to, and perhaps never will, either because they threaten an existing sickness market or because the IP pushes the price up beyond our reach.

      I'm sure I've seen this situation -- research costs and extreme customer advantages at paying an arm and a leg before -- but where?

      Ah, no time to philosophical talks... I have to close my Firefox browser, turn off my Linux PC and go to work, where several .docs and .xlss await me. Good thing Office can deal with them reasonably well.

      Ah, what the... this is too important. Here's the answer: competition, choice and knowledge available to all (this is confusingly called "free").

    5. Re:Next headline... by CarpetShark · · Score: 1

      Your joke points to a sad reality however, that it's only through patenting cures (ie having a monopoly over a cure) can pharmaceutical companies (free enterprises) get the investment capital to develop medicines. Cures are IP, traded and guarded.


      I dunno, they do a fairly good job of charging a fortune for diagnostic equipment, consumables, etc. For example, diabetics' glucometers take tiny little sticks which seem to be mainly plastic and cotton wool, and are used and disposed of at a rate of four or five per day, per diabetic. These cost £0.50 per stick in the UK. Maybe there's some rare mineral in those sticks, but I doubt it.
    6. Re:Next headline... by bunratty · · Score: 4, Insightful

      For this reason cures are highly guarded discoveries: there are many cures around we don't have access to, and perhaps never will, either because they threaten an existing sickness market or because the IP pushes the price up beyond our reach. Just because we hear about a cure doesn't mean we'll ever see that cure in the wild
      Surely there are researchers involved in finding these hidden cures you refer to. Why don't any of them blow the whistle on this massive conspiracy?
      --
      What a fool believes, he sees, no wise man has the power to reason away.
    7. Re:Next headline... by delire · · Score: 2, Informative

      Why don't any of them blow the whistle on this massive conspiracy?
      Because it's not a consipiracy. It's good common sense capitalism.
    8. Re:Next headline... by timster · · Score: 1

      Ah, once again, it's the favorite conspiracy theory of the modern age. Cures everywhere, locked up by IP. Somebody finds anti-cancer dirt, but nobody sees enough profit to bring it to market, so people still get sick.

      If only it were so simple. So you've discovered some dirt that fights cancer -- so what? We have as many compounds that fight cancer as we have compounds that cause cancer. If you want to really cure people, we're talking scientific medicine, not feel-good natural herbal supplements. That means you need to push your dirt through a huge array of tests to determine what sort of cancer it's really good for, how it compares to the wide array of existing cancer treatments, what the side effects are, etc. It really is 99% perspiration, if by "perspiration" you mean years of expensive research with no guarantee of success. You'll find any number of biotech companies that failed merely because their discovery was just not quite good enough.

      Sure, everybody thinks the discovery should be free, except that the truth is discoveries like this have almost no value in the first place; they are everywhere, and they are not "cures" for anything. In general, these things you say we will "never have access to" wouldn't have done us any good, for a reason that we'd spend millions of dollars to discover.

      --
      I have seen the future, and it is inconvenient.
    9. Re:Next headline... by Anonymous Coward · · Score: 0

      If this actually is a cure, it will never see the light of day. A watered down "treatment" version will likely appear, though.

      Why cure something when you can gouge someone for the rest of their life?

    10. Re:Next headline... by Anonymous Coward · · Score: 0

      Surely you have links to specific researchers studying specific molecules for specific illnesses. Because otherwise you'd be, you know, making shit up.

    11. Re:Next headline... by Anonymous Coward · · Score: 0

      Which is why things like this should be funded by the government. The results should be freely available.

    12. Re:Next headline... by bunratty · · Score: 1

      Surely even multi-billionaires have loved ones who get sick from these diseases? Why don't they pay to have the drugs developed so the cures can be available, even if only to those who are rich enough to afford it? Generally it takes less than a billion dollars to have the drug fully approved by the FDA. It takes much less to fund a small clinical trial to investigate whether a drug is effective. There are plenty of billionaires around with enough money to throw around to develop these cures, if only they existed.

      --
      What a fool believes, he sees, no wise man has the power to reason away.
    13. Re:Next headline... by Bloke+down+the+pub · · Score: 1

      Even if a bunch of bureaucrats had the ability to successfully direct a research programme of such a scale, every dollar you'd save from the "eevil corparashunz" would cost ten in administration.

      --
      It's true I tell you, feller at work's next door neighbour read it in the paper.
    14. Re:Next headline... by Anonymous Coward · · Score: 0

      "threaten an existing sickness market "

      How the individuals that are aware of this reality and operate the corporations that walk this line live with themselves is beyond comprehension.

    15. Re:Next headline... by camperdave · · Score: 1

      Because it's not a consipiracy. It's good common sense capitalism.

      So, what you're saying is that all of the researchers who worked so long, and hard when they developed the cure for muscular distrophy back in the 1980s are being paid hush money, and that's why they have those telethons?

      I'll admit that at a glance it looks like you could make more money treating the symptoms than curing the disease. The problem is that once a cure is developed, you have to suppress the researchers, many of whom are motivated by the desire to cure diseases. One of them is eventually going to talk, or to take their knowledge to a competing firm. Sure, that firm may not legally be able to produce the same drug, but they may be able to tweak it enough to get around any patent issues. Then there are the class action lawsuits that arise when the public finds out you've been holding onto a cure for hayfever so that you can sell more nasal spray. Trust me, I'm cutting myself in on that one.

      --
      When our name is on the back of your car, we're behind you all the way!
    16. Re:Next headline... by GooberToo · · Score: 0, Flamebait

      We have as many compounds that fight cancer as we have compounds that cause cancer. If you want to really cure people, we're talking scientific medicine, not feel-good natural herbal supplements.

      Except there is some historical basis to support the line of logic...which is not to say I believe its one giant conspiracy standing on dozens of cures. Back in the late 80s and early 90s, MD Anderson did a lot of research into alternate treatments. Some of those treatments included mega doses of vitamins and minerals. The results? They were able to obtain cure rates of some cancer, in humans, only several percent less than traditional treatments. At the same time, someone (guess who) wound up the FDA which started raiding shops at gun point, DETAINING CUSTOMERS, and lobbied to get new suppliment legislation passed. Shortly after, MD Anderson's funding for alternate treatments went away. Oddly enough, the number of artificial vitimans (basically, chemically-like, patented, and fully synthesized; which BTW, has a much higher death and illness rate, generally cost 4-8 times of the real thing, and requires a Rx). Oddly enough, this all happened at the same time Kessler was publically campaigning against suppliments of any kind. He made many such anti-suppliment statements such as, "American's have the most expensive urine in the world", and, "Mega-doses of any vitamin is bad or worthless". The second is a paraphase as I don't remember the exact quote. While at the same time, lots of studies directly contradicted him. Studies by crediable organizations. When pushed with these studies he remarked with something like, "Well, they are only effective in non-first world countries as every American receives proper nutrition", which we all know is well documented as factually incorrect.

      Lastly, it was reported that mega-doses of vitamins, when used in conjunction with traditional radiation treatment resulted in yet higher cure rates (some single digit percent), faster recovery, and fewer side effects. The studies were halted before they could determine if continued suppliment treatment, post-cure, would result in a lower recurrence rate.
      So on and so on...

      Long story short, factually speaking, research into cheap cancer treatments using suppliments has been kneecapped by the pharmaceutical industry and razed by the FDA while it was still in a very promising infancy. Its no wonder there are many conspiracy theories bounding about of many hidden cures.

    17. Re:Next headline... by Skraeling2 · · Score: 1
      Look at this cure for cancer http://www.studentprintz.com/home/index.cfm?event= displayArticlePrinterFriendly&uStory_id=c7794f20-d fb1-4494-892d-b529895da103

      Scientists may have cured cancer last week. Yep. So, why haven't the media picked up on it? Here's the deal. Researchers at the University of Alberta in Edmonton, Canada found a cheap and easy to produce drug that kills almost all cancers. The drug is dichloroacetate, and since it is already used to treat metabolic disorders, we know it should be no problem to use it for other purposes. Doesn't this sound like the kind of news you see on the front page of every paper?
      His theory is since its going to earn less money than any other cure, it is unpatented, the media is told not to report it. It makes sense. Capitalism hard at work!
    18. Re:Next headline... by apostrophesemicolon · · Score: 1

      Eat dirt, you sick sick man!

    19. Re:Next headline... by MrNiceguy_KS · · Score: 1
      In your hypothetical example of suppressed researchers, there's one additional factor. If a drug company wants a patent, they have to provide documentation. If there was, to use your example, a cure for Muscular Distrophy developed back in the 80s, either it was patented, with a 10 year life on the patent, or it wasn't, meaning no patents to work around when one of the researchers talks.

      Sure you can make more selling treatments than cures - if you're the only one selling. But what if you're selling a treatment, and your competitor starts selling a cure? Competition can be a beautiful thing.

      --
      Redundancy is good And also good.
    20. Re:Next headline... by LurkerXXX · · Score: 5, Insightful

      Take off the tinfoil hat. I'm a medical researcher. If I discover a cure for a disease, I get famous in my field, guaranteed funding, and get invited to speak at research Universities around the world. Maybe even win a Nobel prize. It's all pluses. What do I get to keep it secret if I'm a researcher? Nada.

      Uninformed conspiracy nuts seem to think Pharm companies do all the medical research. The NIH (National Institutes of Health) will spend more than 28+ Billion on medical research this year (your tax dollars at work). I do research funded by them. My work is all published in journals you are free to subscribe to, or browse for free at your local research university's library.

    21. Re:Next headline... by Gospodin · · Score: 1

      But if it's so cheap and simple, why aren't the uncapitalist socialist-medicine countries developing it?

      --
      ...following the principles of Heisenburger's Uncertain Cat...
    22. Re:Next headline... by Lord+Ender · · Score: 1

      Have you been reading books by that scam artist Kevin Trudeau? You have the message down, man. If only I could find a physician who is not part of the big FDA+Pharma Co. conspiracy! Right now, if I want to cure cancer, the only source to find out how is Kevin's books!

      --
      A slashdotter who didn't build his own computer is like a Jedi who didn't build his own lightsaber.
    23. Re:Next headline... by delire · · Score: 1

      The NIH has done alot of research and publishes much of it in the interest of common good. The NIH (and related organisations in other countries) are not at all the problem however.

      Bear in mind also that a cure can be published in detail while also remaining patented: don't get patentability mixed up with copyright.

      As a medical researcher, you mind find it interesting - perhaps disturbing - to read the following:

      Stagnation in the Drug Development Process: Are Patents the Problem?
      TRIPS and pharmaceutical patents: fact sheet
      Patents, Pharmaceuticals and the Third World

      There is much more out there on this problem. I suggest you look around.

    24. Re:Next headline... by Anonymous Coward · · Score: 0

      Your joke points to a sad reality however, that it's only through patenting cures (ie having a monopoly over a cure) can pharmaceutical companies (free enterprises) get the investment capital to develop medicines. Cures are IP, traded and guarded.

      I have an insane idea. How about we get GOVERNMENTS, whose function it is to protect their citizens, to pay for it? Would I pay a certain amount of tax in order to fund development of drugs that could be made cheaply available to anyone who needed them? I sure as hell would.

      Cue the guy saying "I don't want to fund drugs I won't use." All I can say to that is, you're a selfish dick.

    25. Re:Next headline... by LurkerXXX · · Score: 4, Insightful

      I assure you, being in the field and being involved in the patent process, I am much better versed on the topic than you. Thanks for the offer to look around, but I've already done it. A lot. I do it for a living.

      There is no grand conspiracy as you would have others believe to keep cures hidden. As I said, NIH does most of the basic research for exploring biology and finding new drugs. Pharm companies do some drug exploration, but the bulk of their research dollars are spent on clinical trials which are *extremely* expensive. Many times there are candidate drugs which don't go on to clinical trials. These are not 'hidden'. Anyone is free to look at the literature to see them. And many researchers I know who have published new exciting results, try to get a story in the more general public news. This gets their name out there, and the Institute/University they work at gets some press that they love. Once again, not hidden. No conspiracy.

      Patents are an entirely different issue. Patents are public record. Once again, they aren't hidden from you. Drugs generally have a use patent, so it's easy to see exactly what disease they are for the treatment of. Nothing hidden. Also patents don't last forever. Anyone with a patented drug that works will try to sell it like made for several years, because the patent is going to expire, and then anyone will be able to make a generic version of it, with no patent worries.

      If the company patented a drug and sits on it because they don't think they will recoup as much as it would cost to do the trials/manufacturing, well, the patent is still going to expire, so others will be able to use it then. Nothing hidden again. No conspiracy.

      Now, if the original company didn't want to go through the expense of doing clinical trials for it because they didn't think they would recoup their money, no one else is likely to want to foot the bill entirely either, since when they get it passed, all their competitors are then free to manufacture generic versions as well.

      It all boils down to clinical trials, and who pays for the huge expense of them. No one wants to foot the bill for unpatentable or patent-expired drugs because it's 100+ million down hole for the company doing the trials, and a free ride for all their competitors. It's just terrible business sense. No 'conspiracy' involved at all.

      Put away the tinfoil hats. It comes down to simple business decisions a 12-year old should be able to grasp. Blaming pharm companies and academic researchers for 'conspiring' to keep them off the shelf is simply stupid.

      If you want a better system for orphan drugs, then lobby your congressmen to expand NIH funding to include drug trials for orphan drugs. Public dollars would be well worth spending in that area.

    26. Re:Next headline... by DerangedAlchemist · · Score: 1

      But if it's so cheap and simple, why aren't the uncapitalist socialist-medicine countries developing it?

      They are! It was the University of Alberta. Now there is still much expensive testing and trials to do, and they will not be done by pharmaceutical companies because there is no money in it. Don't worry, anything that promising will be looked into. This is exactly what public funded research should do.

      Why don't we do this with all drug research? Because on average it takes $800 000 000 of investment to develop a drug before any profit is made. No governments or non-profits have been willing pay up nearly the amount that private companies have. To make money off patents, they have to reveal how they did things. This lets places like Brazil decide that it's worth violating patents to create generic drugs to save their citizens. (And drug companies whine about the billions of dollars of lost sales. All the money people never had in the first place, otherwise their country wouldn't risk the repercussions of violating trade agreements.)

      Drug companies will keep making things that pay money (of which there are many). Academic research will continue on anything it can get funding for. Different strategies work better or worse for different products with different markets. This seems to confuse people.

    27. Re:Next headline... by Gospodin · · Score: 1

      Now there is still much expensive testing and trials to do, and they will not be done by pharmaceutical companies because there is no money in it.

      But if it's so expensive to develop this drug, then how does one defend the argument that it's really cheap and simple, and therefore evidence of a conspiracy that Big Pharma isn't doing it already?

      --
      ...following the principles of Heisenburger's Uncertain Cat...
    28. Re:Next headline... by DerangedAlchemist · · Score: 1

      If this actually is a cure, it will never see the light of day. A watered down "treatment" version will likely appear, though.

      Why cure something when you can gouge someone for the rest of their life? Because your competitor just offered them a cure. Which does the consumer pick?
    29. Re:Next headline... by DerangedAlchemist · · Score: 1
      Cheap and simple to make the chemical and non-patentable. That doesn't mean testing is easy or cheap. Why would a company spend hundreds of millions of dollars running animal trials, human trials and the rest when their competitors can just bottle and sell it after at the same cost. Why would a company spend money developing a product that they cannot legally make money on? There are plenty of other products to develop. This product does benefit the public (and the reputation of the University researchers) so it makes sense for public money to develop the drug.

      Most drugs are very cheap to make. They cost a lot because on average a drug company spent $800 million figuring out the treatment. This is before they made a single cent or even started mass producing the drug.

      btw, this article is about a drug that is extremely expensive to make, because Taxol has to be made from laboriously harvested natural products.

    30. Re:Next headline... by hesiod · · Score: 1

      You answered your own question. Because the ones who can afford to purchase/open it are the ones who can afford to pay for the cure. Why pay a billion dollars for a cure when you can pay a few thousand for it? They are greedy and aren't going to spend their money to help others. How do you think they became rich to begin with?

    31. Re:Next headline... by Jorgandar · · Score: 1

      If you want a better system for orphan drugs, then lobby your congressmen to expand NIH funding to include drug trials for orphan drugs. Public dollars would be well worth spending in that area. I agree with everything you said except that. Public money should be spent to promote the greater public good, not the interests of a few. I dont want my tax dollars being used to find drugs for a rare disease that .0000001% of the population has, when it could be used to find a cure for cancer. There is already a system in place for private companies to have incentives to research orphan drugs.
    32. Re:Next headline... by Gospodin · · Score: 1

      Maybe we're reading different articles. The one I read is about a compound called DCA which has already been tested and which is cheap to produce. Maybe Big Pharma is blocking this in the US, but then why hasn't Canada added it to the drinking water along with fluoride?

      Or if you're talking about Taxol, which is what TFA was about, the new twist there was developed in the US in conjunction with a US private company, Weyerhauser. They evidently think it's profitable. So what are you even talking about?

      --
      ...following the principles of Heisenburger's Uncertain Cat...
    33. Re:Next headline... by LurkerXXX · · Score: 1

      If that is your belief, then you are free to lobby your congressman not to fund it, just as the other guy is free to lobby his *to* fund it.

      Yes there are government incentives to develop orphan drugs, but they are relatively small compared to the expense/risk of development. That's one of the reasons you see so few developed.

      Think of the effort we could be putting forth on research to cure cancer if we spent the money on it we are spending on the war in Iraq. There's something to lobby your congressman about. That Trillion dollars could have funded 30+ years worth of total NIH funding (that goes toward many many things other than just cancer research)at it's current rate.

    34. Re:Next headline... by Peter+Hoefsmit · · Score: 1

      Dumbass, it is only HALF a trillion spent on fighting terrorism in Iraq

      --
      Industrial Mathematician
    35. Re:Next headline... by bunratty · · Score: 1

      They are too greedy to help their wives, husbands, children, or parents who are dying from a disease that someone has developed a cure for? Surely there are at least some billionaires who themselves have the diseases that these supposed cures exist for? Why don't they pay for the research on themselves so they can save their own lives? Then scientists could publish the results of the trial. Are the scientists all paid hush money, and the ones who talk are blackmailed, discredited, or "wiped out"? I think you've been watching too many movies.

      --
      What a fool believes, he sees, no wise man has the power to reason away.
    36. Re:Next headline... by DerangedAlchemist · · Score: 1
      DCA (dichloroacetic acid) has not completed testing as a cancer treatment. It was used previously for mitochondrial diseases. Now DCA has shown promise against cancer in the petri-dish but there are still animal and clinical trials to do to find dosages, etc. DCA hasn't been proven as a real treatment in humans but shows lots of promise that it might be. Big Pharma isn't blocking this or researching this either. They cannot make money off DCA or DCA research, so they don't care. The DCA mechanism of fighting cancer by turning on mitochondria respiration might be of interest to Big Pharma if they can come up with a different, patentable drug that does this.

      The point about Taxol was a separate little side note. Unlike most drugs, Taxol is very expensive to make, which is why new methods of gathering the natural product mentioned in TFA are relevant. Since this drug is expensive to make, new production methods are valuable (and patentable) so Big Pharma researches it.

      If this was supposed to be about Big Pharma being good or bad for drug development, sorry. Obviously Big pharma researches drugs that will make the company the most money and not research thing that will loose them money. Big Pharma invests billions into drug research that would not be there otherwise. Not all drugs that help people will be profitable (eg. DCA) so Big Pharma is not the only solution. Different methods for different products.

    37. Re:Next headline... by LurkerXXX · · Score: 1

      Oh well, if it's only half a trillion it's chump change then.

      And you mean fighting in the middle of a civil war, not terrorism. There were no terrorists in Iraq until we took out the old regime.

      Oh, and btw, you must be using Republican accounting numbers. Once you add in all the misc expenses such as projected future bills from caring for the tens of thousands of wounded American soldiers for the next forty years, etc, the total bill goes easily over a full trillion.

    38. Re:Next headline... by Jorgandar · · Score: 1

      Point taken as far as the money spent to fight this war could have been used to make significant progress to cure cancer and probablly even get all the homeless off the street if we wanted to. (or whatever other noteworthy cause you want to use the money for) Its a sad waste of resources indeed.

      As far as orphan drugs, perhaps the best policy is for the feds to create a larger incentive for their development, such as significantly reduced clinical trail requirements, (even moreso than they are now), or longer patent life. (I know, slashdot heresy... :)

    39. Re:Next headline... by Anonymous Coward · · Score: 0

      may be if they have found a real cure for cancer then patening dirt is not a prob

    40. Re:Next headline... by Anonymous Coward · · Score: 0

      thats an individual approach as a researcher but on a greater scale pharmaceutical companies only seems interested in maximizing their profits

      www.Shadow-Point.com Your Personal Proxy for School & Work
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    41. Re:Next headline... by delire · · Score: 1
      No one's talking about a conspiracy. You can safely put that word down and walk away from it.

      The issue is also not about government efforts to fund research for cures using tax payer's money. Of course this happens and of course it is good. The issue at hand surrounds the role patents play in the strategic interests of pharmaceutical corporations, many of which are multi-nationals, to the ends that patents are actively used to restrict the fabrication and consequent distribution of cures known to save lives and/or make existing lives more bearable in the interests of protecting an existing market. It is a question of business ethics. Should we allow legal constructs like patents to support a monopoly over a known cure? Of course it is sometimes more profitable to keep people half as sick - a lifetime of relief prescriptions - than it is to cure them cheaply, but should we allow this?

      As you seem reluctant to actually read real analysis on the matter (even by the W.T.O itself and research parters of your own organisation), I'll give you a case example.

      You are undoubtedly familiar with the recent panic surrounding bird flu, an avian virus transferrable to humans and considered quite deadly. Roche developed an anti-virus pill called Tamiflu, known to be very effective against this H5N1 virus but will not allow anyone else to manufacture the pill on the basis that it breaches their patent.

      Says the Emory University Professor:

      "Something has to be done,'' said Ira Longini, an Emory University professor whose computer model of a potential avian flu pandemic shows that an outbreak could be snuffed out within a month by rushing antiviral drugs to the place where it started. "When you think of the potential damage a pandemic flu could do, and how little drug we have, the situation is quite absurd.
      How about Roche and AIDS? From here:

      Roche, the pharmaceutical giant, recently announced a European price of $20,424 for a year's supply of its anti-HIV drug Fuzeon. This will translate into an AWP (Average Wholesale Price) in the U.S. of close to $25,000. "Roche has priced Fuzeon at almost three times the price of the most expensive AIDS drug," said ACT UP/NY member Mark Milano. "This excessive price will force ADAP programs to cut other cut other life-saving drugs, restrict entry to their programs, or increase already long waiting lists. This will hasten the death of thousands of people with HIV in the U.S."
      How much is a sickness worth?

  2. Re:The official site! by The+Mysterious+X · · Score: 0, Offtopic

    Heh, pity there isn't a +1, original mod really.

  3. In the greater scheme of things... by mudshark · · Score: 4, Funny

    ... it's not all about yew, after all. It's the dirt from whence yew came, and where yew shall ultimately return....

    --
    In other news, astrophysicists have announced that they now know what all that dark matter is: it's stupidity.
    1. Re:In the greater scheme of things... by mrogers · · Score: 3, Funny

      You're barking up the wrong tree.

    2. Re:In the greater scheme of things... by styryx · · Score: 1

      'whence' not 'from whence'

      You will find many, many instances in literature that use 'from whence'. However, the 'from' is redundant.

    3. Re:In the greater scheme of things... by sharkey · · Score: 2, Funny

      Is this Dr. Land Fill?

      "It's not about yew!!! You need to get right, and read my latest book: 'I Made Dirt, My Dirt Don't Hurt'".

      --

      --
      "Outlook not so good." That magic 8-ball knows everything! I'll ask about Exchange Server next.
  4. Time and time again... by Anonymous Coward · · Score: 4, Insightful

    ...we discover these things that the Earth provides us, and yet we learn nothing of protecting it from ourselves.

    Silly monkeys.

    1. Re:Time and time again... by superbrose · · Score: 1

      In fact we ostracise those that insist that there are natural alternatives to fight serious diseases which are conventionally either uncurable or unlikely to be cured even with costly conventional treatments involved.

      \sigh

    2. Re:Time and time again... by Anonymous Coward · · Score: 2, Insightful

      Fuck Earth. Take your tree-loving sacrificial rain-dance bullshit back to whatever liberal leaf-licking college you barely crawled tripping off LSD out of with your "degree". We really don't need this tripe. Do you honestly think us "silly monkeys" would have even made a discovery such as this without technology built by a society powered by the very resources you likely eschew? Sure, we've found yet another cancer fighting drug (which is a pretty insubstantial claim, go hit up Google for "cancer fighting drugs" and you'll find a laughable number of such claims in the past decade) in some dirt. This does little more than provide us with a step in the right direction, perhaps a clue towards something that will, in all likelihood, (and this is making the bold assumption that this discovery will build to anything at all besides some bright-eyed scientist's footnote on slashdot.org) be completely artificial in its synthesis.

      You're an unscientific babbling Slashtard; I'm amazed at how fast you people creep out of the fucking woodworks to preach your gospel and screed to us. You're rated insightful when you deserve a completely off-topic and even flamebait moderation. You're not talking about the study, you're not talking about the nature of the findings that were reported, you're just shitting all over this discussion with your ignorant cut-throat idealistic diatribe about how stupid we are. Fuck.

      Surely your like-minded goons will hop to your aid to hush me, moderating me down and nodding me off as "just a conservative whacko", but I speak for many with "shut the fuck up". If you're such an idealist, go live in a cave and stop promoting the ecosystem-damaging resource consumerism that yes, even your using this computer whose case is likely comprised of many plastics and synthesized oil by-products is promoting. The epic volume of clothes barely covering your gargantuan Slashdotter body? Yep, you guessed it, something you're wearing is likely synthesized as a by-product of crude oil! This preachy shit is getting you nowhere, buddy. Either contribute to the discussion or leave. Don't worry, us silly monkeys will stick around and do the heavy thinking.

      Now, back to your regularly scheduled discussion.

    3. Re:Time and time again... by Skrynesaver · · Score: 4, Informative
      This is not an alternative to anything, this is a chemical which can be found in yew bark. Do you consider Asprin an alternative remedy? it can be harvested from willow bark after all. As yew is a highly toxic plant I don't recommend chewing on it in the hope of a cure, similarly the concentration of salicylic acid in willow bark is variable and chewing on willow bark will give you ulcers as a result.

      Bayer managed to patent not Asprin itself but the process of synthesising it. As I don't believe you can patent discoveries even in the US.

      --
      "Linux is for noobs"-The new MS fud strategy
    4. Re:Time and time again... by Seiruu · · Score: 1

      'Fuck Earth. Take your tree-loving sacrificial rain-dance bullshit back to whatever liberal leaf-licking college you barely crawled tripping off LSD out of with your "degree".'

      Is a very ignorant thing to say. Not to mention bigoted.

      'If you're such an idealist, go live in a cave and stop promoting the ecosystem-damaging resource consumerism that yes, even your using this computer whose case is likely comprised of many plastics and synthesized oil by-products is promoting. The epic volume of clothes barely covering your gargantuan Slashdotter body? Yep, you guessed it, something you're wearing is likely synthesized as a by-product of crude oil!'

      That almost sounds like: "Cuz we can't catch em all, we might as well not start on any of em". Also, being hypocritical doesn't per definition exclude you from being right, and definitely not in this case. It simply means that you're not (entirely) part of a solution. The fact that humans have a pretty significant negative impact on nature is a fact. What's wrong with being reminded of that FACT once in awhile?

      Just because you think science is above this silly old thing known as nature doesn't make it so. Rather, that notion would be the most unscientific thing I've ever heard.

    5. Re:Time and time again... by Goaway · · Score: 1

      They are ostracised because they are nutcases and/or quacks who produce no results, but profit from selling people false hope and placebo effect.

      You seem to imply that it is somehow hypocritical to use one natural remedy but not another, but the difference is that this one works while the other ones don't.

    6. Re:Time and time again... by CmdrGravy · · Score: 1

      The fact that humans have a pretty significant negative impact on nature is a fact. What's wrong with being reminded of that FACT once in awhile?


      Humans have a significant impact on their environment but who's to say its a negative imapact. If we want to play the part of nature for a moment and begin to think in timescales of billions of years then human activity so far is utterly insignificant and since nature has no point of view it's impossible to say whether that insignificant activity was either a positive or a negative one.

      The one key FACT about the nature of the Earth so far is that whole species are killed off in their thousands every few hundred million years or so, thousands of square miles of forest are submerged under the ocean and millions of hectares of grazing land is turned into inhospitable desert every couple of millenia.

      We may well not be doing ourselves any favours by some of our activity around the world at the moment but simply moaning about evil man apes raping the Earth is helping no one ( and simply not true ) and simply diverts attention from the real actions we could be taking to improve our quality of life.
    7. Re:Time and time again... by Anonymous Coward · · Score: 0

      At least monkeys are clever enough to throw dirt at each other

    8. Re:Time and time again... by morgan_greywolf · · Score: 1

      imilarly the concentration of salicylic acid in willow bark is variable and chewing on willow bark will give you ulcers as a result.


      Hence the reason you concentrate the salicylic acid from the willow bark by making a tea out of it.
    9. Re:Time and time again... by Seiruu · · Score: 1

      Humans have a significant impact on their environment but who's to say its a negative imapact. If we want to play the part of nature for a moment and begin to think in timescales of billions of years then human activity so far is utterly insignificant and since nature has no point of view it's impossible to say whether that insignificant activity was either a positive or a negative one.


      I'd like to think that in terms of billions of years, nothing really matters relatively, barring the total destruction of Earth, which is rather unlikely. Even if we nuked the entire Earth, certainly within billions of years, it'll go back to being habitable. Don't want to go "tree hugging" on ya, but relatively, that is compared to any other species, I'd argue that we're hands down the most significant in delivery a negative impact. Parasitic even.

      We may well not be doing ourselves any favours by some of our activity around the world at the moment but simply moaning about evil man apes raping the Earth is helping no one ( and simply not true ) and simply diverts attention from the real actions we could be taking to improve our quality of life.


      That's exactly what's being contrasted right now: nature vs "our" quality of life.
    10. Re:Time and time again... by bkr1_2k · · Score: 1

      Produce no results? How many "cured" cancer patients do you know? I've yet to ever hear any doctor say a patient is "cured". They always say the cancer could reappear. That doesn't sound much like a cure to me.

      I also think you're mistaking the meaning of "results". Results have varying degrees, and while some "modern" medicine does have more effective, long-term results, you'll find plenty of people who use homeopathic options also have results. Most of those people also note a better standard of living during treatment as a result of homeopathic treatments. These are people who use only homeopathic options, and people who use both modern medicine and "natural" medicine. It's a known fact that marijuana lessens the negative side effects of cancer treatment, for example. Is the person smoking a joint after their chemo a nutcase or quack because pot isn't a modern medicine? Will the pot cure the cancer, no. But it definitely has a result for the cancer patient. I think you'll find most of the "nutcases and/or quacks" aren't people who say modern medicine is bad, but that modern medicine should be supplimented by natural remedies, or vice versa, as the case indicates.

      You also seem to be discounting placebo effect. Placebo effect can be very powerful, and I'm sure you can find some cases where a person was "cured" with a placebo. Just because we can't explain it doesn't mean there were no results.

      --
      "Growing old is inevitable; growing up is optional."
    11. Re:Time and time again... by Goaway · · Score: 1

      That doesn't sound much like a cure to me.

      Who's talking about a cure? Other than quacks trying to sell people false hope?

      you'll find plenty of people who use homeopathic options also have results.

      You are familiar with the placebo effect, I would hope.

      You also seem to be discounting placebo effect. Placebo effect can be very powerful, and I'm sure you can find some cases where a person was "cured" with a placebo.

      I guess you are. And you know why I discount it? Because it relies on lying to the patient and having them believe you. This is not a reliable method to cure anyone of anything. It might work, or then again, it might not. You can't control what the patient believes, and thus you can't reliably use the placebo effect.

      And of course it has nothing to do with "natural medicine" in the first place. Giving people salt water injections or sugar pills can work just as well, depending on what the patient believes in.

      It's a known fact that marijuana lessens the negative side effects of cancer treatment, for example.

      Sure, getting high makes anything feel better. That's hardly a secret to anyone, inside or outside the medical profession. I'm sure doctors would be happy to prescribe it in certain cases if they were allowed to do so, but that's a matter of politics and not medical science.

    12. Re:Time and time again... by Skrynesaver · · Score: 1

      Hence the reason you concentrate the salicylic acid from the willow bark by making a tea out of it.
      Sorry to burst your bubble but water doesn't magically increase/decrease the concentration of active ingredients in the bark.

      An infusion made from an unknown quantity of active ingredient is still an unknown quantity, unless you have an extraction/purification method that returns a known concentration of the active ingredient you still don't know how much is there.

      --
      "Linux is for noobs"-The new MS fud strategy
  5. Here we go again by El+Lobo · · Score: 5, Insightful

    I HATE when people and even pseudoscientific articles talk about a medicine against "cancer". Hell, there is NO cancer. There are CANCERS. Lung cancer has a completly different nature than, say, bllod cancer, ot colon cancer, or skin cancer. Yes, all of them are chaotic grow of the cells, but their nature, symptoms, erradication and even cell behaviour is completly different. It's therefore naive to talk about a "cure for cancer". It's like saying: a drug against virus has been found. Hell! WHAT virus? They are all different!

    --
    It's time to realise that Abble's products are the biggest abomination these days. Just say NO to the dumb iAbble way!!
    1. Re:Here we go again by VirusEqualsVeryYes · · Score: 4, Interesting

      But do most people know about these differences? Hell, I'll admit that even I have no idea what you're talking about. All I know is that mutations in cells's DNA can cause them to replicate uncontrollably, hence cancer. There are differences in lung/blod/colon/skin cancer? Sounds plausible! ... but I have no idea what they are. To me, and to most normal people, "cancer" encompasses all cancers.

      I guess it's like saying a certain finding advances "science". But wait, you say, there are a lot of sciences! Yes, there are, and the finding most likely only really advances one of the sciences ... and yet, we all understand what is meant when we say something advances "science".

    2. Re:Here we go again by TheRagingTowel · · Score: 1

      It's like saying: a drug against virus has been found. Hell! WHAT virus? They are all different! Yes, but a drug that targets viruses specifically, when it will be found, will be revolutionary. There is currently no "antibiotic" against viruses.
      Although cancer is another subject, still - these cells should have perform apoptosis and they didn't. Can there be a way to trigger this process in cancer cells?
      --
      4Z5TX
    3. Re:Here we go again by Anonymous Coward · · Score: 0

      But isn't "cure for cancer" and "cure for a cancer" the same?

    4. Re:Here we go again by Scarblac · · Score: 1

      That's exactly why these news articles shouldn't just say "cure for cancer" - because nobody will know that that encompasses a whole range of completely different diseases. Some caused by bacteria, some by viruses, some by mutations, some by inhaling smoke, etc etc etc. The masses will never understand that if nobody tells them.

      --
      I believe posters are recognized by their sig. So I made one.
    5. Re:Here we go again by krotkruton · · Score: 4, Insightful

      I don't think people are really that ignorant about the disease. Ask someone for one of the causes of skin cancer and you'll probably get "too much sun without sunscreen", or ask for one for lung cancer and you'll get "cigarette smoke". I think most people understand that there are many different types of cancer that can all be caused by different things, but I don't know if they understand that a cure for one might not be a cure for all, if that was even the initial point of this thread. On the other hand, someone may very well find a single cure for all forms of cancer, in which case, is it really wrong to call it a cure for cancer?

    6. Re:Here we go again by Anonymous Coward · · Score: 0

      I HATE it when someone talks about medicine for "people". There is NO people. There are INDIVIDUALS. Yes, everyone is similar, but their susceptibilities to diseases, their genetics, and their metabolisms are completely different and many medicines will not work for many people. It is therefore naive to talk about "medicines for people". It's like saying a "medicine for cows" has been found. Hell! WHAT cows? They're all different, too!

    7. Re:Here we go again by pointbeing · · Score: 2, Informative

      But do most people know about these differences? Hell, I'll admit that even I have no idea what you're talking about. All I know is that mutations in cells's DNA can cause them to replicate uncontrollably, hence cancer. There are differences in lung/blod/colon/skin cancer? Sounds plausible! ... but I have no idea what they are. To me, and to most normal people, "cancer" encompasses all cancers.

      A common misconception. Cancer is a catch-all term for more than 100 diseases that display similar characteristics - the ability to mask itself from the host immune system, angiogenesis and some cell replication tricks that normal cells can't pull off.

      The spousal unit has been undergoing treatment for Stage IV breast cancer for almost eight years - it had already metastasized to her lungs by the time she was diagnosed. Breast cancer in your lungs is still breast cancer and at least as far as medical oncology (as opposed to radiation or surgical oncology) is concerned the treatment is the same.

      My father-in-law was treated with a drug called Gemzar for pancreatic cancer a couple of years ago. My wife just finished up Gemzar + Herceptin before we started the current Tykerb + Xeloda regime. Gemzar is first-line chemotherapy for pancreatic cancer but is only indicated in breast cancer after an anthracycline and a taxane have been tried and determined they were ineffective. The Xeloda she's doing now is on the bottom of the breast cancer treatment list but is first line treatment for Stage IV colon cancer.

      Different diseases, different treatment.

      --
      we see things not as as they are, but as we are.
      -- anais nin
    8. Re:Here we go again by AnotherUsername · · Score: 0

      You make a very valid point. However, there is always the possibility that a cure for one type of cancer can trigger relevant research into curing other types of cancer. Once scientists are able to figure out why one type of cancer grows a certain way, and figure out a way to stop it, they can use their research to hopefully figure out ways to stop other sorts of cancer.

      --
      I don't like Linux. This doesn't make me a troll.
    9. Re:Here we go again by Pedrito · · Score: 1

      Yes and no. Roughly half of all cancers are related to a defect in a protein called p53. There are various p53 defects that can cause cancer and very different cancers can result depending on which cells have which defects. But, for example, if a way were found to introduce wild-type (non-mutated) p53 DNA into these cells via gene therapy, then you'd have a single cure for roughly half of all cancers.

      There are similarities in many cancers in how they operate and often, a single drug can be effective against multiple sorts of cancers because of these similarities. I'm actually working on a drug now that appears to be effective in certain types of breast cancer as well as melanoma. melanoma is, in many ways, very different from any kind of breast cancer. But melanoma also has some similarities in how it operates and we may yet discover that it's effective against other types of cancer.

      While it's unlikely that a single drug will be found that's effective against ALL kinds of cancer, I don't think it's entirely incorrect, especially for an article meant for the lay person, to describe a drug as an "effective cancer treatment" vs. listing each individual type of cancer that the drug is useful against. It's not a journal article. If you want to know the specific types of cancers involved, then go look up the journal articles.

    10. Re:Here we go again by tsalaroth · · Score: 1

      Actually, a couple of cancers HAVE been traced to viruses. But yes, I agree, there are multiple cancers, not just one.

    11. Re:Here we go again by TheRaven64 · · Score: 1

      There is currently no "antibiotic" against viruses. Actually, there are a few antivirals and, as with bacteria and antibiotics, different viruses are immune to different antivirals.

      Antibiotics are a lot easier to develop than antivirals, however. A bacterium is basically a cell, and 'all' you need to do is find a poison that will kill it but not hurt the host too much. An antiviral, in contrast, has to attack individual proteins, ideally those that are not found in the host at all and are found in all known strains of the virus. If there were a protein (or, possibly, a combination of proteins, although this makes the problem a lot harder) found in all viruses but not humans, then it would be possible to develop an antiviral that would destroy all viruses. This is something of a holy grail for medicine, and is currently well beyond our current level of technology (and may be completely impossible).

      --
      I am TheRaven on Soylent News
    12. Re:Here we go again by bill_mcgonigle · · Score: 1

      Yes, all of them are chaotic grow of the cells, but their nature, symptoms, erradication and even cell behaviour is completly different.

      Don't they all start with a genetic error, and failure of the DNA repair mechanisms to catch that error? I understood that most broad anti-cancer agents (e.g. whatever it is in tumeric that helps) bolster the DNA repair mechanism.

      --
      My God, it's Full of Source!
      OUTSIDE_IP=$(dig +short my.ip @outsideip.net)
    13. Re:Here we go again by Muad'Dave · · Score: 1
      ...or perhaps they haven't found the thing that unifies them into one disease. Scientific American has an article this month entitled Chromosonal Chaos and Cancer by the controversial Peter Duesberg (he is reported to claim that AIDS is not caused by HIV).

      To make a fascinating story short, he claims that cancer is a result of chromosomal damage and reshuffling, not gene mutations. He provides very compelling chromosome diagrams showing the pieces of chromosomes scattered all over. (Chromosome 2 has pieces of chromosome 8 stuck to it, etc). I was unaware of this property of cancerous cells, even though that knowledge has been around since the 50's. He believes that science took a wrong dogmatic turn by pinning the cause of cancer on gene mutations instead of chromosomal upheaval.

      --
      Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
  6. And you though RMS was just a smelly hippie by Timesprout · · Score: 2, Funny

    When it turns out he is a shower dodger to avoid cancer.

    --
    Do not try to read the dupe, thats impossible. Instead, only try to realize the truth
    What truth?
    There is no dupe
  7. Wow by Tawg · · Score: 4, Funny

    Now this is what i call a cancer Treetment.

  8. Well i never.... by Tawg · · Score: 1

    And just when yew'd thought yew'd heard it all.

  9. It's Soil by Anonymous Coward · · Score: 1, Informative

    I can still hear the words of my college biology instructor from 30 years ago: "It's not dirt, it's soil."

    1. Re:It's Soil by Tawg · · Score: 1

      I think that it's actually dirt in this instance, if it wasn't how would it be linked to the pee-yew?

  10. so close by zsbyd · · Score: 1

    Its right in front of us and underneath us!

  11. Pacific Yew by Tawg · · Score: 3, Interesting

    It's quite interesting to note that one of the species of yew mentioned (i assume the most useful at yielding the drug) has been classified as NT (Near threatened).
    This basically means the species is "considered threatened with extinction in the near future". With such a large area of yew trees producing such a small amount of drug, careful measures are going to have to be taken so as not to kill off our new hope for a cancer cure. It's also quite interesting to note that the yew only grows to about 15metres, and so much smaller than what i would know as a (european) yew tree.

    1. Re:Pacific Yew by NorthWestFLNative · · Score: 1
      The class of drugs that are extracted from the yew tree are the taxanes. Although the Pacific Yew may be scarce, there's also one other type of taxane, Docetaxel that's derived from the European yew tree. Not being an oncologist (just someone who's been treated with Docetaxel) I'm not completely familiar with the differences between the two are, but according to Wikipedia Paclitaxel is more potent than other taxanes.

      Finding that the soil around a yew tree can be a source of taxanes should help prevent the loss of the Pacific Yew though.

    2. Re:Pacific Yew by Flagbrew · · Score: 1

      I witnessed the wanton debarking and destruction of the pacific yew during the early 90s working as wildlife biologist in Southern Oregon. This was driven by Bristol Myers Squibb's insatiable appetite for naturally found taxol, which is cheaper and easier to extract than total synthesis, coupled with a district ranger's personal crusade to avenge his mother's death. While everyone here supports the eradication of breast cancer, we need to temper our worldly destruction of a species with continuing research on cheaper (monetarily and environmentally) ways to acquire taxol. This new dirt theory is an exciting step to saving lives and saving trees.

    3. Re:Pacific Yew by Anonymous Coward · · Score: 0

      It's also quite interesting to note that the yew only grows to about 15metres, and so much smaller than what i would know as a (european) yew tree. How tall do European Redwood trees grow, yew eurofag?
  12. How is this news? by kypper · · Score: 1

    Drug companies do this all the time. It's a hell of a lot faster and cheaper than rational drug design.

    1. Re:How is this news? by Anonymous Coward · · Score: 0

      The yew compound (from TFA) was discovered by the taxpayer-funded screening half a century ago, then handed over to the drug companies as taxol to get rich

  13. Will this make cancer treatment dirt cheap? by Anonymous Coward · · Score: 0

    Keep dreaming.

    1. Re:Will this make cancer treatment dirt cheap? by Anonymous Coward · · Score: 0

      Its free in the UK and other countries.

  14. Re:The official site! by moogs · · Score: 0, Offtopic

    haha... that i didn't mind looking at :P

    --
    I have bad karma. What do I care what you think?
  15. So much for our parents telling us not to eat dirt by Antony-Kyre · · Score: 2, Insightful

    So much for our parents telling us not to eat dirt as kids.

  16. Profit at the lowest levels... by geekmux · · Score: 1

    Pharm. companies are going to be able to process this at the lowest levels (literally), while still being able to charge us $75/pill for the "cure"? Anyone else see the twisted irony of being dirt broke (slaps knee) after you have to pay for 2 years worth of cancer(read soil) treatments?

    1. Re:Profit at the lowest levels... by Architect_sasyr · · Score: 1

      Does that mean you will now be soiling yourself to get well? Coz I grew out of those a few years back...

      --
      Me failed English...
      FreeBSD over Linux. If my comments seem odd, this may explain...
    2. Re:Profit at the lowest levels... by sumdumass · · Score: 1

      Chance are it won't be as cheap[ to mprocess as you think. Transporting dirt on a medical "clean" way will be expensive along with extracting the drug and such. It will be more likely that it would be synthesized if possible and this will give new sources of reference to play with.

      Even of the drug isn't able to be synthesized, planting something that could extract the drug and then processing that might be a better solution. There are certain plants that absorb chemicals/minerals/vitamins and a lot of other things from the ground were they are planted. Onions are probably one of the most flamboyant of these that we come into contact with every day. (think sulfur and vidalia onion)

      Surprisingly, I think one of the medical strains of tobacco might be the best opportunity here. They can produce a synthetic blood plasma form it and it this plasma could carry a drug through the body in it's raw active state, it might be more effective. Can you imagine instead of going for chemotherapy once a week, they just give you an IV of blood plasma for an hour? I would hope something like this could be found but I'm totally guessing at it.

  17. Calm Down by Anonymous Coward · · Score: 0

    I thought the whole point was to find traits common to each of these different types of cancer and target those. For instance, I've read that cancerous tissues tend to have a much higher metabolic rate than other tissues. Is this true of all or most cancers, or only a specific one?

    Amongst all of the crime, political crap slinging, disasters, and crisis that the news brings to us on a daily basis it's nice to find something resembling progress taking place -- even if it is "dumbed down for the masses" who can't or don't study it.

  18. Cancer Fighting Drug Found in Dirt by Rik+Sweeney · · Score: 4, Funny

    *tch*

    The things people throw away these days...

  19. Eat dirt and... live? by gnurfed · · Score: 1

    Damn! This means the phrase "eat dirt and die" will be so outdated, unless said to a tumor.

  20. It isn't a new medicine just a new way to get it by MSRedfox · · Score: 3, Informative

    The headline makes it sound like a new wonder drug was found. According to the article, this drug was found in 1967. So it's been around for quite a while. They've just found that the soil around the trees end up with the drug in it to. Thus when they harvest the drug, they can harvest the soil to get more of it at one time. Nothing new cure wise, just a better way for drug companies to produce a product.

  21. It's a good drug by Anonymous Coward · · Score: 2, Informative

    I was one of the guinea-pigs that tested it. It worked incredibly well, better than the alternative at the time which hadn't worked for me leaving me with a choice of taking part in the experiment or trying a large dose of the other medicine with little chance of success.

    I'd heard at the time that it was becoming viable because they'd found a way of synthesising it using chemicals extracted from the needles of the tree, so reducing the impact on the tree. If they can get hold of it with less impact on the tree then that's great!

    As a point to all those people who think of "natural remedies" as harmless and western medicine as evil: I was treated with yew tree bark and some fungus. These two nearly killed me even in the precisely controlled doses, doses that had been determined through the deaths of some thousand or so rats rather than trial and error on some thousand or so humans. Now many thousands of humans can be saved from what is quite a nasty death thanks to this new treatment.

    Natural remedies are just the same as any other item taken into the body. They can be good, or can cause harm. Unfortunately in this case, animal experiments did work very well and in my opinion have caused net good.

    1. Re:It's a good drug by Rixel · · Score: 1

      psst......you got the placebo.

      All kidding aside, I thought patients weren't supposed to be notified if they were the control or not.

      --
      Never play chicken with a passive aggressive.
    2. Re:It's a good drug by maxume · · Score: 1

      I'm pretty sure it depends a great deal on what they are testing, and whether the test is ongoing(so they might tell you after they have completed their observations, so you could seek other treatment if you were getting the placebo). I also think that when they are testing on terminally ill patients, they don't do so much of the placebo thing, but I'm not sure.

      --
      Nerd rage is the funniest rage.
  22. This is the Wiki on the drug by MSRedfox · · Score: 1

    Paclitaxel is a drug used in the treatment of cancer. It was discovered at Research Triangle Institute (RTI) in 1967 when Monroe E. Wall and Mansukh C. Wani isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors. By 1970, the two scientists had determined the structure of paclitaxel. Paclitaxel has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.[2] It is sold under the tradename Taxol. Together with docetaxel, it forms the drug category of the taxanes. Paclitaxel is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.[3] Paclitaxel drug eluting coated stents are sold under the trade name Taxus by Boston Scientific in the United States. http://en.wikipedia.org/wiki/Paclitaxel

  23. Non-science Slashdot editors at night by methano · · Score: 1

    I wake up and find an articles on finding drugs in dirt and capturing CO2 from the air. A whole lot of drugs were originally isolated from organisms that grow in dirt, most of the antibiotics probably. This is not news. Also, any chemist should know how to capture CO2 from the air. But can you do it efficiently enough to reverse the greenhouse effect. On thermodynamic grounds alone, I'd say it's not possible except by planting a lot of trees to store all the CO2. My point is that the science watch on /. goes a little weak over night.

    1. Re:Non-science Slashdot editors at night by Trent+Hawkins · · Score: 1

      Yeah, I don't become excited about topics with "cure for cancer found" in the title. There seems to be a new one of these each week.

      Truthfully I use to be worried about hem actually finding a cure. That'd be the end of my current job, but thankfully it's always a "treatment" which is a nice way of saying "we're going to keep e'm on this drug for the rest of their lives!".

  24. big pharma's dirty little secret: by Anonymous Coward · · Score: 0

    cheaper generics are already available under millions if American couches.

  25. Hopefully by chanrobi · · Score: 2, Funny

    It'll be dirt cheap for those who need it

    1. Re:Hopefully by sudden.zero · · Score: 1

      If only this were the case, but most likely it will be the most expensive dirt anyone has ever bought!

  26. slash by Anonymous Coward · · Score: 0

    With all the problems in the world like cancer and hunger and war, we sit here getting all flamed up over the most recent version of....

    oh wait...

  27. It's good, clean soil. by Anonymous Coward · · Score: 1, Insightful

    Dirt is what's under your fingernails. Plants grow in earth or soil.

    1. Re:It's good, clean soil. by Anonymous Coward · · Score: 0

      Yep. But soil does get dirty when humans pollute it, for instance with plastics, rusty old nails, broken glass, bits of computer hardware ...

  28. New Product by AikonMGB · · Score: 1

    And they're going to call this new commercial product: Yew Tubes !!

    Thank you and goodnight.

    Aikon-

  29. Moongate =Profit by Rixel · · Score: 1

    Well, I'm off to Sosaria and make me some coin!
    (and maybe kill some guards)

    --
    Never play chicken with a passive aggressive.
  30. Indeed it is not an alternative by superbrose · · Score: 1

    You are right, paclitaxel is not an unconventional alternative at all, but rather a pharmaceutical marketing dream come true, because Bristol-Myers_Squibb, licensed to commercialise paclitaxel, held an exclusive contract in the harvesting of Pacific yew trees from US government lands.

    Also paclitaxel causes cell death both in healthy cells and in cancer cells, and its extraction is quite difficult (costly).

    My comment was rather misleading since I was making a general statement rather than commenting specifically on this chemical.

  31. Kid oath.... by Himring · · Score: 1

    I guess that thing I said as a kid to go ahead and eat my dirty food was true (after dropping on ground):

    "god made dirt, dirt don't hurt...."

    --
    "All great things are simple & expressed in a single word: freedom, justice, honor, duty, mercy, hope." --Churchill
  32. It's not the tree - it's the microbes by csoto · · Score: 4, Interesting

    Most people forget that all higher organisms depend heavily on micribiota for their survival. For example, most of the complex micronutrients (e.g. B-comlplex vitamins) in plants are generated in soil bacteria. For these drugs, look to the rhizobacteria as the source of the genes for these compounds. The commensal relationships these bacteria sustain with particular plant species could be important, but it's possible these things could be grown in vitro and yield a nice industrial solution.

    --
    There exists no way of exchanging information without making judgments. --Bene Gesserit Axiom
  33. Barking mad by ciaran.mchale · · Score: 2, Funny

    So it seems those new age, tree-hugging hippies weren't "barking" mad after all. They "yew" what they were doing all along. And I guess that, as far as pharmaceutical companies are concerned, money does grow on trees after all. Hey, that's "tree" of a kind so far. I'd better stop now and see if I can afford a mortgage on a tree house.

  34. Mount St Helens = Ohio State? by Anonymous Coward · · Score: 0

    The bark of certain yew trees can yield a medicine that fights cancer. Now scientists find the dirt that yew trees grow in can supply the drug as well, suggesting a new way to commercially harvest the medicine.

    Scientists originally isolated the drug paclitaxel--now commonly known as Taxol--in 1967 from the bark of Pacific yew trees (Taxus brevifolia) in a forest near the Mount St. Helens in Washington


    (emphasis mine)

    Well, I guess you could compare Woody Hayes to Mt. St. Helens...
  35. Many a true word spoken in jest... by Joce640k · · Score: 1

    Yew trees normally grow in graveyards (in the UK at least).

    --
    No sig today...
  36. Well, there's a new one... by Khyber · · Score: 3, Funny

    Let the strip-mining operations to cure cancer begin!

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
  37. Bah, it just goes to show by 50000BTU_barbecue · · Score: 2, Funny

    Yews control the medecine market.

    --
    Mostly random stuff.
  38. Ambiguous headline of the week by leoboiko · · Score: 0, Redundant

    So this cancer is fighting a drug they found in dirt?

    Or did they find in dirt some cancer fighting a drug?

    --
    Prescriptive grammar:linguistics :: alchemy:chemistry. Stop being a nazi and learn some science.
  39. Southern Grammar Nazis by Anne_Nonymous · · Score: 1

    "Yew trees" ain't right; it's "y'all y'all's trees", yuh damn Yank!

    1. Re:Southern Grammar Nazis by Anonymous Coward · · Score: 0

      Actually it's 'all y'alls'

  40. the surprise is they didn't check earlier by swschrad · · Score: 1

    it's well-known that black walnut trees make sure they have less competition for water and nutrients by leaching poison out their roots.

    so why didn't anybody think to check the ground around yew trees earlier for taxol?

    moral: everybody fouls their nest. expect it. what, you never heard of an alpha geek who got fired for being the alpha?

    --
    if this is supposed to be a new economy, how come they still want my old fashioned money?
  41. Mystical Sheena dirt cures diseases by muellerr1 · · Score: 1

    Did anyone else think of this movie too? You know, the scene where she buries her boyfriend in the medicinal dirt to save his life?

  42. This is old news by tsalaroth · · Score: 1

    The Celts (probably the Druids before them) used the Yew for medicinal purposes all the time - they also knew to only use small amounts of anything but the berry, as everything about that tree is poisonous in anything but minute amounts.

  43. Cool deal.. by Mockylock · · Score: 1

    Except they forgot to mention that the tools used to extract the molecule cause cancer.

    --
    "Please, shut up. Just when I think you can't say anything more stupid, you speak again." -Archie Bunker.
  44. Ah, good ol' handouts. by Grendel+Drago · · Score: 1

    See some history: 1958, the NCI sends the USDA to test 30,000 plant species for potential anti-cancer activity. 1963, Monroe Wall discovers that the bark of the Pacific yew tree is effective against cancer. 1967, the active ingredient is isolated. 1971, the chemical structure is discovered and published. 1993, Bristol-Myers Squibb starts selling Taxol, at twenty times the cost of manufacturing. The patent still belongs to them today. See more about how this works.

    So, in short: citizens pay for research which is then handed over to corporations who then sell the results back to the aforementioned citizens at a hideous markup. Fabulous work if you can get it.

    --
    Laws do not persuade just because they threaten. --Seneca
  45. It *was* funded by the government. by Grendel+Drago · · Score: 1

    Taxol was originally discovered by a massive National Cancer Institute-funded USDA survey of 30,000 plant species for potential anti-cancer activity. If you want to know why Bristol-Myers Squibb holds a patent on Taxol and can sell it at a 2000% markup (I'm not exaggerating; they sell it for twenty times the manufacturing cost), well, you've got me there. I think Ralph Nader's given a talk about it.

    --
    Laws do not persuade just because they threaten. --Seneca
  46. Wrong. by Grendel+Drago · · Score: 1

    BZZT. Taxol was original discovered and extracted by a government-sponsored program, the kind which you abhor so much. Bristol-Myers Squibb, on the other hand, is selling it at twenty times the cost of manufacture, because of, uh, the magic of the market, or something like that. Blazing efficiency, there. Can't imagine what would have happened if we hadn't handed them the multi-billion dollar patent rights.

    --
    Laws do not persuade just because they threaten. --Seneca
    1. Re:Wrong. by heinousjay · · Score: 1

      Well there you go, you've come up with a single, partial counter example. Obviously the government should be in charge of the whole thing.

      --
      Slashdot - where whining about luck is the new way to make the world you want.
    2. Re:Wrong. by bunratty · · Score: 1

      Bristol-Myers Squibb, on the other hand, is selling it at twenty times the cost of manufacture, because of, uh, the magic of the market, or something like that. Blazing efficiency, there. Can't imagine what would have happened if we hadn't handed them the multi-billion dollar patent rights.
      Drug companies cannot possibly sell drugs for near the cost of manufacture. Most of the cost of getting a drug to market is in the research that went into developing the drug. First, chemists and biologists need to create and find compounds to test. Out of several promising compounds, perhaps one of them makes it past preclinical (animal) trials. Out of several of those compounds, perhaps one of them makes it past clinical (human) trials and gets approved for sale. Out of several of those compounds, perhaps only one makes any significant profit. It's these few blockbuster drugs that fund the research to get the next generation of drugs to market. If pharma companies sold drugs for only a small amount more than the cost of manufacture, that would be the end of private-sector drug research. Perhaps you'd rather pay taxes to fund only government-sponsored research instead? I'm sure that idea will go over well with voters.
      --
      What a fool believes, he sees, no wise man has the power to reason away.
    3. Re:Wrong. by falconwolf · · Score: 1

      Most of the cost of getting a drug to market is in the research that went into developing the drug.... Perhaps you'd rather pay taxes to fund only government-sponsored research instead?

      But it was government sponsored research that led to this drug! The NCI spent $183,000,000 to develop and test Taxol. It then "sold" the rights to all of the data needed to gain FDA approval exclusively to Bristol-Myers Squibb for a measly $43,000,000. The NCI spent $140,000,000 more than it got back.

      Falcon
  47. Interesting. References? by Grendel+Drago · · Score: 1

    Cure rates nearly that of conventional treatments, without the grueling side effects of chemotherapy and radiation? Interesting! Could you point me to where the research was published?

    --
    Laws do not persuade just because they threaten. --Seneca
    1. Re:Interesting. References? by GooberToo · · Score: 1

      Well, at the time my mother was sick with cancer so researching this stuff was her hobby. It's what kept her going. We lived in Houston at the time and the majority of of it was published in the Houston Chronical. My mother said she had some medical journal articles covering what little was published, which she then used to write her representatives about the horrible abuse of government power (FDA, AMA, and lobbiest) which was rising at the time. I quickly tried some Googling but didn't find anything specific to which I referenced. To my surprise though, I did find a lot of vitamin-cancer treatment information is being published against by MD Anderson. I imagine if you contact them directly, you might be able to shake some information loose.

      Needless to say, most sane American's that didn't have their hands in medical related pockets were happy to see Kesslier go. You may even remember the commericals which briefly appeared on TV which simulated vitamin raids into people's homes. Most people thought those were silly because they didn't realize the FDA had already raided several stores and home businesses and held the customers hostage for many, many hours (up to 8 hours IIRC). The logical conclusion is house holds were next because they were actively lobbying to outlaw vitamins. A judge later ruled they did not have the power to do such things and agreed that it amounted to illegal detainment. If you hunt, you can probably find references to these.

      To be absoluetely clear here, I am by no means saying that mega-doses of vitimins are an end-all, cure-all for cancer! I can not stress this enough! What I said was, MD Anderson published some early research which indicates for specific types of cancer, mega-doses of vitamin were a viable alternative with results within spitting distance from conventional treatments of the time. Something else to consider is that traditional treatments have advanced significantly since then; thanks to computer aimed radiation guns, etc. Having said that, considering the research was in its infancy, it certainly showed great promise. The fact that they seemingly have continued vitamin cancer research seems to confirm they believe it still shows promise.

      Just in case you're looking for raid informaiton, a quick Google found: http://findarticles.com/p/articles/mi_m1282/is_n22 _v46/ai_15999889. I'm 100% sure if you want to keep looking into that one, you'll find lots and lots more articles on the subject. The article places it in 1990, so that means the search was probably somewhere between 1988 - 1994 (hey, I've slept since then). If you replied expecting to call my bluff, I believe you failed. If on the other hand, you are sincerely interested, you should have enough information to either find stuff online or to directly contact MD Anderson. I'm assuming we can both agree MD Anderson qualifies as a reputable medical research facility? I'm also assuming it's the research you are wanting to chase and not the FDA raids.

      Do a Google on "MD Anderson vitimin cancer". I show, "765,000" hits.

      A little back story for you:
      At the time, my mother had already received her maximum lifetime dose of radiation which left her skin burned where her breast once was. When her cancer came back, knowing radiation was not an option, she began looking at alternative treatments. Convensional treatment expected her to die within 6-months to a year; two on the outside, if she was very, very lucky. The alternative treatment was a radical change in diet and massive vitamin doses plus a non-FDA approved solution which was injected into the tumors. The injections proved to be somewhat effective but the FDA later came down hard, early 1990's, on the MD that was providing it to her. At which time, she was left strictly with dietary and vitamin treatments. She was in state with cancer from 1986 until she died on Christmas of 2001. That statement is unrivaled with

  48. How is this not flamebait? by mstahl · · Score: 1

    There are many routes to finding this knowledge other than your scientific ones. Natives in North and South America, as well as Africa, have medicine men who work on some completely different level than you or I. They have knowledge of plants and combinations of plants for many therapeutic purposes that we would take hundreds of years to figure out; they've just always known about them. If you asked one of them, they'd tell you that the plants spoke to them and told them about themselves.

    We want to think we're so much more advanced than they are, but it only looks like we're winning because we, living in moderately safer environments (i.e., there aren't really any predators looking to eat any of us here in the city) and having access to hospitals and whatnot tend to live longer.

    And finally, really now, moderators, the "flamebait" mod is there to preserve civility here. Use it.

    1. Re:How is this not flamebait? by heinousjay · · Score: 1

      So we only look more advanced than they are because we are?

      Hell, I could dig up 15 alternative medicine types here in my county who would preach shamanistic bullshit while they rubbed a crystal or an herb or whatever mystical substance on me to cure whatever they could convince me was wrong. It doesn't mean they actually know anything, or are even telling the whole story. Particularly if they can't even began to explain how it was done.

      We don't live in a mysterious world. We just live in one we don't fully understand. The subtle difference is that by striving to make sense of it, we learn more about it and are able to do more with it.

      --
      Slashdot - where whining about luck is the new way to make the world you want.
    2. Re:How is this not flamebait? by mstahl · · Score: 1

      15 alternative medicine types here in my county who would preach shamanistic bullshit while they rubbed a crystal or an herb or whatever mystical substance on me to cure whatever they could convince me was wrong

      Yeah. Totally not the people to whom I was referring. I'm speaking more of people that I've met in the rainforests of Costa Rica that have a sense of the natural world around them so keen and intuitive to them that it's almost as if they were born with it. There's stuff they know that we still don't, or at least stuff that they've known forever that would take concerted effort by us to find out. Apples and oranges, my friend.

      Also, for each of your 15 crystal-waving loons, there's at least a couple, say, accupuncturists that take their work very seriously and study for years to get as good as they are. And unlike waving crystals around, accupuncture is an "alternative medicine" technique that commonly does work for a wide variety of ailments. In fact, my insurance covers it.

      Living in a mysterious world and living in a world we don't understand . . . I don't get what distinction you're trying to make there. Since the world didn't come with a detailed user guide telling us everything about it, and there's stuff we haven't figured out, I'd classify that as being pretty mysterious. Doesn't mean it's a bad thing, though.

  49. get tested for colon cancer! by bobalu · · Score: 1

    Ok kids, here's a Public Service Announcement:

    Do NOT follow the federal guidelines for getting tested for colon cancer. They recommend you start at 50. Well, I'm 47 and apparently I've had it for a couple of years, and in a couple of weeks I'll be having my colon removed and little bag stuck to my side for the rest of my life.

    The good news I'll still have a life.

    And counter-intuitive as it may seem, consider getting a female doctor. Smaller fingers. :-)

    --
    The revolution will NOT be televised.
  50. Oh, more DCA stuff. Whee. by Grendel+Drago · · Score: 1

    Look, the DCA story isn't as simple as we'd like it to be. Clinical trials are going on, and if you're wondering why you shouldn't buy it from a chemistry supply company and try to treat yourself, Orac and Abel Pharmboy have some information which might interest you. "The media is told not to report it"? Look, it's the media not reporting it! Could you even be bothered to do a Google search before throwing out your conspiracy theories?

    In short: (a) The drug has never been actually given to live people for cancer. (b) The drug doesn't kill cancers, it slows their growth. (c) This isn't the first time a drug has shown mighty promise in the lab; this doesn't mean it will work in practice. (d) The drug is not without side effects, and isn't entirely safe, though if it works against cancer, these risks are no doubt acceptable. But until it's shown to be effective, it's not good to give it to people.

    --
    Laws do not persuade just because they threaten. --Seneca
  51. american chestnut by rvr · · Score: 1

    The american chestnut tree once covered 25% of america. (see wikikpedia for a good background, its a story I am fascinated about). There are numerous attempts to overcome the blight that kills them. What does work now, but cannot be supported for large forests is: dirt. For some reason I feel like planting a garden this year.

    1. Re:american chestnut by samwichse · · Score: 1

      At Penn State, we've basically got a blight-resistant line of trees ready, but production in quantity is limited.

      TACF orchards in the Arboretum at Penn State

      They basically cross American chestnut with Chinese repeatedly, then backcross these with wild trees... then the seedlings are innoculated with the fungus and the 2 or 3 out of hundreds that survive are homozygous for the resistant genes.

      The 1 of 64 innoculations were successful, and a few blight resistant trees went out. Cool stuff.

      Sam

  52. Insert next Environmental Crisis by Goblez · · Score: 1

    I can see it now . . .

    Due to harvesting we are now facing a crisis in our Earth's most valuable natural asset, Dirt. We must do something now, or soon we will be floating in space without a Planet!

    --
    - Kal`Goblez
  53. Second best headline ever by DynaSoar · · Score: 1

    I nominate the headline on the parent for second best /. headline ever, right behind "Germs' drummer arrested for carrying soap". Especially when they're taken together.

    --
    "I may be synthetic, but I'm not stupid." -- Bishop 341-B
  54. Time's Cancer Drug of the Year by mkcmkc · · Score: 1

    You guessed it--it's YEW.

    --
    "Not an actor, but he plays one on TV."
  55. I never said that. by Grendel+Drago · · Score: 1

    Of course, in this case, the government was in charge of the whole thing, and it turned out rather well. But I don't quite understand what you're saying--of course there are some things the goverment is good for, and some things that private industry is good for. It's like having a left hand and a right hand. Using that metaphor, here's the story thus far:

    Bloke down the pub: The right hand is the only hand that counts. The left hand is never useful--it would have totally bollocksed up this program.
    Me: But the left hand in fact executed this program, and did so rather well.
    heinousjay: That's only one counterexample! You just want to cut off everyone's right hand!

    --
    Laws do not persuade just because they threaten. --Seneca
  56. Why not cure it? by wakingrufus · · Score: 1

    Didn't they "accidentally" discover two different cures for cancer a couple months ago? Why fight it when you can cure it? They should concentrate on bringing those cures to the marketplace.

  57. You didn't read, did you. by Grendel+Drago · · Score: 1

    Drug companies cannot possibly sell drugs for near the cost of manufacture. Most of the cost of getting a drug to market is in the research that went into developing the drug. First, chemists and biologists need to create and find compounds to test. Out of several promising compounds, perhaps one of them makes it past preclinical (animal) trials. Out of several of those compounds, perhaps one of them makes it past clinical (human) trials and gets approved for sale. Out of several of those compounds, perhaps only one makes any significant profit. It's these few blockbuster drugs that fund the research to get the next generation of drugs to market.
    The create-and-find-compounds bit was performed by the USDA, as well as the initial trials. BMS took over only at the end, and received funding for that from the government. Are you just pasting drug-industry boilerplate, or did you bother to read about the situation we're discussing? I'm well aware that it's expensive to find and test new drugs, but that was already done by the government (which you handwave away as a bad idea below) rather than by the company that's extracted billions of dollars in profits from people with cancer. You've utterly failed to explain how these record profits are justifiable, or why the normal pricing rules on drugs patented by private companies off of publically-funded research were suspended, apart from greed and corruption.

    If pharma companies sold drugs for only a small amount more than the cost of manufacture, that would be the end of private-sector drug research.
    So... how do we get generic drug manufacturers, then? I mean, given that there's no reason for BMS to hold the patent, given that they didn't do the work, they (and you) have no reason to whine about the cost of research, because it's got nothing to do with this drug.

    Perhaps you'd rather pay taxes to fund only government-sponsored research instead? I'm sure that idea will go over well with voters.
    Did you even read the original post? About how the drug was initially discovered through government-sponsored research? I guess it went over rather well with voters, judging by the number of people who've been helped by Taxol. (Though, of course, not as many as would have been if they weren't paying corruption money to BMS.)
    --
    Laws do not persuade just because they threaten. --Seneca
    1. Re:You didn't read, did you. by bunratty · · Score: 1

      The create-and-find-compounds bit was performed by the USDA, as well as the initial trials. BMS took over only at the end, and received funding for that from the government. Are you just pasting drug-industry boilerplate, or did you bother to read about the situation we're discussing? I'm well aware that it's expensive to find and test new drugs, but that was already done by the government (which you handwave away as a bad idea below) rather than by the company that's extracted billions of dollars in profits from people with cancer. You've utterly failed to explain how these record profits are justifiable, or why the normal pricing rules on drugs patented by private companies off of publically-funded research were suspended, apart from greed and corruption.
      If you bothered to read what I wrote, drug companies need profits from blockbuster drugs to fund research for other drugs. The profits are justified by the enormous risks drug companies take -- they pour billions of dollars into developing new drugs, without any guarantee that they will create any revenue. Go read about Risk-Return Tradeoff for more details.
      --
      What a fool believes, he sees, no wise man has the power to reason away.
  58. Steven R. Donaldson declared a saint by rjamestaylor · · Score: 1

    Thomas Covenant the White Gold Wielder declared prophetic of this discovery; loan of the Land declared sacred.

    --
    -- @rjamestaylor on Ello
    1. Re:Steven R. Donaldson declared a saint by Muad'Dave · · Score: 1
      ...loan of the Land declared sacred.

      Wouldn't that me loam?

      BTW, that was a great series of books.

      --
      Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
  59. Hyphens are your friend by Anonymous Coward · · Score: 0

    > So this cancer is fighting a drug they found in dirt?

    > Or did they find in dirt some cancer fighting a drug?

    Yes! So glad that cancer is doing its part in fighting the drug war...

  60. Doesn't matter by Vexor · · Score: 1

    They're just going to cure mice & rats with it, leaving the humans high & dry.

    --
    ~Vexed and loving it!
  61. Yew leave my yew longbow alone. by leftie · · Score: 1

    Maybe... but you can't make a good longbow from yew dirt, now, can ya?

    So there.

  62. You're still missing my point. by Grendel+Drago · · Score: 1

    You're still whining about why drug companies neeeeeed all that money, but you've yet to address my central point, which is that BMS did nothing to deserve the windfall profits they've been drawing from a drug they didn't discover or develop. We might as well just send them an extra fifty billion from the federal budget, by your logic.

    --
    Laws do not persuade just because they threaten. --Seneca
    1. Re:You're still missing my point. by bunratty · · Score: 1

      I'm not whining, just pointing out basic facts about the drug industry, as many people here seem to be ignorant of them. The drug companies do in fact need lots of money to develop drugs. Do you think all the employees work for free? I'm certainly not advocating that the government fund private research. The drug companies are making good profits for the risks they are taking, and thus need no subsidies.

      --
      What a fool believes, he sees, no wise man has the power to reason away.
  63. Re:Next headline...The tinfoil is not all wrong by Anonymous Coward · · Score: 0

    Mostly, I agree with you; but, there are cases where the "tinfoil hat" IS the business decision that the twelve-year-old can grasp:

    "Cure vs treatment". The profit motive (by itself) would far rather sell a treatment than a cure.

    And: "Patentable vs nonpatentable".

    You can see how on *purely* business grounds, cures would not get the clinical research dollars as compared to treatments. (And non-patentable cures versus patentable treatments...well...)

    Lucikly, not all research is purely business (companies can have people in them who genuinely want cures, especially for serious diseases, there is the glory and honor element, and so on...).

    But as an example, consider the minor ailment athlete's foot. It's a huge industry. It's a fungus. It's absolutely not impossible to get rid of. But you will get marketed treatments, not cures (it'll cure the fungus on your foot, but you'll quickly get reinfected from your shoes, socks, shower, and so on; and they don't ever try to sell you anything to fix the problem once and for all. Doing so would be a poor business decision.) People don't have it in Japan, hence, no huge stinky-foot industry either. From a business point of view this is just lost profits!

    "If you want a better system for orphan drugs, then lobby your congressmen to expand NIH funding to include drug trials for orphan drugs. Public dollars would be well worth spending in that area."

    Absolutely.

    (And by the way, it doesn't help our anti-tinfoil-hat position when the government fails to support fair, open and honest research into the various claimed medical effects of cannabis, due to drug-war hysteria, but that's a different roll of foil I guess...)

  64. Tree Farm For Sale by stacey7165 · · Score: 1

    37 acre tree farm covered in Yews and dirt in CT. Note: It was my childhood home and I frequently filled the holes that the yews were in with water to make swimming holes in the summer. I can attest to being cancer free... but not sure if our lack of a proper swimming pool damaged the cancer curing dirt. =)

  65. Goodbye to yew... by rholland356 · · Score: 1

    I reckon they'll be clear-cutting them yew trees to get at that soil...

  66. Re:Next headline...The tinfoil is not all wrong by LurkerXXX · · Score: 2, Insightful

    Ok, I'm going to be silly and feed the anonymous troll...

    Mostly, I agree with you; but, there are cases where the "tinfoil hat" IS the business decision that the twelve-year-old can grasp:

    "Cure vs treatment". The profit motive (by itself) would far rather sell a treatment than a cure.


    So they are hiding the cures because they want to sell a treatment? Who is hiding it? Who discovered it that has that motive? As I said before, NIH dollars fund the most basic research which leads to new biology/drugs. Pharma does a little of that, but most of their dollars go into the clinical trials. So the academic researcher working for NIH funds has *ZERO* motive to hide the cure. *ZERO*.

    So your tin-foil-hat theory rests on the key discovery being made by smaller amount of primary research being done in Pharma companies. Who do you think does the research, runs the bench experiments, crunches the numbers in those Pharma companies? Is it the high-end management who stands to make a killing from corporate profits? No. It's done be Ph.D. scientists and lab techs. A decent sized group of them.

    Do you honestly think someone lab tech with a B.S. biology degree is going to be paid enough money to shut up about some great disease cure that is found by their group?

    How about the Ph.D.'s in the group? Earning a Ph.D. is a long long haul. Most folks doing that are pretty smart and could have made much more money going to business school if making money was their number one priority. Most scientists care about knowledge, care about cures, and yes, like the prestige and recognition for making a major discovery. How likely is it they are going to keep a disease cure secret so the top management can get big bonuses? Not very freaking likely.

    Even if some would do it, all it would take is one in the group to leak it. Keeping secrets in groups just doesn't work very well. Now stop to think what if a friend/family-member/loved-one of a member group has the disease? Not that unlikely with any decent sized lab group. Still think they are going to keep a cure secret? Please.

    But as an example, consider the minor ailment athlete's foot. It's a huge industry. It's a fungus. It's absolutely not impossible to get rid of. But you will get marketed treatments, not cures (it'll cure the fungus on your foot, but you'll quickly get reinfected from your shoes, socks, shower, and so on; and they don't ever try to sell you anything to fix the problem once and for all. Doing so would be a poor business decision.) People don't have it in Japan, hence, no huge stinky-foot industry either. From a business point of view this is just lost profits!

    Umm, Bullshit. Where do you tinfoil hat nutters come up with this stuff. Yes, they get athlete's foot in Japan. Need me to google for you? http://www.japancorp.net/Article.Asp?Art_ID=12391 Now, if you want to claim Japan has a lower incidence, I might believe you because I've never bothered to look up the statistics. However if that is in fact the case, that might be due to a more rigorous cleaning of public pools/showers, (places where it is most likely to be transmitted) in Japan than in the states. Not some secret cure that the American pharm companies are hiding from us.

    Anti-bacterial drugs are relatively easy to make because you can often simply target the cell wall. Fungi are eukaryotes, like humans, and don't have a cell wall. One of the problems that comes along with that is that drugs that damage fungus, also tend to damage humans. Lamisil is a drug you often see marketed on TV. Take enough of it and it is absolutely guaranteed to cure your Athlete's foot. The cure is not hidden from you at all. The problem is it may well also kill your liver before all the athlete's foot is gone. Fungi are hard to kill without killing human cells. Ask any researcher who has had to deal with fungus in their tissue culture.

  67. Iolo would be pleased by Anonymous Coward · · Score: 0

    Get it? Yew trees? Iolo the bard, from Yew? Oh God, it's not that funny, I barely get it myself.

    GOD HELP ME WHY CAN'T I BE FUNNY TOO!?!

  68. Journals by ProfessionalCookie · · Score: 1

    One of the things I'll miss most about being at University is journal access. Journals should be offered for much less. Subscriptions are exorbitant and individual articles run $20 to $80. With publishing going electronic you'd think that electronic versions could be offered for much less. Maybe $10/year per subscriber. Really I already paid for lots of the research so why aren't the articles public domain?

    1. Re:Journals by LurkerXXX · · Score: 1

      Agreed. Much like the recording/movie industries as well as newspapers, etc, scientific journals for the most part haven't adapted to new technology. I think the exception is in physics. Those folks have moved to to a mainly online system much faster than the rest of the scientific community. I expect eventually the rest of us will catch up, but it may take a while.

  69. Uh... Duh!!! by spankey51 · · Score: 1

    Of course that's where they found it!!! I saw some guys from pfizer bury it there after they realized they wouldn't make any money from it...

    --
    -ubuntu others as you would have others ubuntu you.
  70. Taxol by falconwolf · · Score: 1

    Your joke points to a sad reality however, that it's only through patenting cures (ie having a monopoly over a cure) can pharmaceutical companies (free enterprises) get the investment capital to develop medicines. Cures are IP, traded and guarded.

    In this case, Taxol, the company that markets and distributes the drug didn't spend a dime on developing the drug. The National Cancer Institute, NCI, spent $183,000,000 to develop and test Taxol. Then the NCI turned around and "sold", what a joke, the rights to all of the data needed to get approval for the drug by the FDA to Bristol-Myers Squibb for $43,000,000. The NCI spend $140,000,000 more to develop and test Taxol than it got for the rights. In 2000 MBS made almost $1,000,000,000 on Taxol. That's American taxpayers money at work.

    Falcon
  71. medical research spending by falconwolf · · Score: 1

    Uninformed conspiracy nuts seem to think Pharm companies do all the medical research. The NIH (National Institutes of Health) will spend more than 28+ Billion on medical research this year (your tax dollars at work).

    This drug, Taxol, is a good example of government spending on medical research. Taxol was developed and tested by the NCI, it cost $183,000,000. But then the NCI rurned around and pratically gave away the rights to all the test data to Bristol-Myers Squibb for a measly $43,000,000.

    Falcon
  72. hahahaha No "Conspiracy Nuts" Here. Whew. by ImitationEnergy · · Score: 0

    Your contemptuous tone as if anyone saying the Conspiracy word is a nut case. hahahaha The word is still in the dictionaries. Say there buddy ro, how much did you pay for gasoline or diesel or whatever other garbage you pay for so you can breathe it in later? hmm? Maybe your Presidente and Vice Presidente conspired to destroy the faxes I sent them telling them about my engine four years ago . And how much did YOU PAY for last month's electric bill? hmm? $100? $150? $200? I released an engine on November 14 2005 that can make this world's peoples just about total electric, yet isn't that strange. You don't seem to have that one either > http://www.newpath4.com/MillenialDawn1usesFriction forPositiveWork2sharedswitchdefeatsActionReaction3 ForceDualitygeneratorequalsavlowhysteresis4Reverse HysteresisasPowerSource.pdf .

    The word Conspiracy is going to stay in the Funk & Wagnall's a while yet.

    --
    Industrial Age 2 + How-to Stop Malignant Cancers.
  73. Cancer fighting dirt+ C02 extractors... by Velocir · · Score: 1

    What we should do, is get the yew trees to grow in AIR, and then extract the cancer fighting drug from the air :) Much purer that way...

  74. System lords find cure for cancer by Anonymous Coward · · Score: 0

    Lord Yew's underground research facility has finally hit pay dirt.

    Less people dieing of cancer == more slaves

  75. Someone please explain to me... by Anonymous Coward · · Score: 0

    I know that my scientific education isn't good enough to really do much more than sound intelligent when surrounded by a bunch of sales people and bankers, but I was under at least one impression.

    Cancer is a rapid cellular growth caused by a mutation of the DNA.

    So as far as I understand, this means that due to some form of stress, external stimuli, or just 2 wires accidentally getting crossed because with that many cells in a persons body, one will eventually go wrong.

    Now, the world is spending billions of dollars looking for the magical touch that will allow them to clearly identify all sections of DNA as well as develop tailored drugs to specifically target and alter DNA. Also, if I understand some of the other articles I've read, the theory of attacking cancer would be to send out a focused medicine, chemical, radiation, etc... that could some how correct the DNA alteration and allow the damage to heal like a normal wound or cell replacement over time.

    I've watched people... children die from cancer. I most clearly remember seeing an 11 year old girl come to grips with the fact that she can go at any time. The one thing I've got to say is, Chemo-therapy has got to be worse than death itself.

    So my gripe is, who the hell cares about some tree bark, chicken liver, or tribal ju-ju dance that can treat one form of cancer or another when that type of cure seems more like sticking one band-aid on top of another on top of another. Shouldn't the funding and scientists be allocated to the cancer treatment that is more physics and less chemistry? After all, instead of standing in the middle of your field praying for rain, why not get some buckets and bring the water to the crops?

  76. Yes, you *are* whining. by Grendel+Drago · · Score: 1

    I've seldom seen such a failure to get the point. Here, I'll recap the thread for your convenience:

    Bloke down the pub: Government research programs are inherently wasteful, and would never work.
    Me: Actually, a government program discovered the drug we're discussing--but the patent was essentially handed to BMS, and they're gouging patients.
    You: Drug companies have to charge a lot for drugs because of the R&D costs. Government-funded research programs would never work.
    Me: But BMS didn't bear the R&D costs in this case. The government did. Weren't you reading?
    You: I said, drug companies need the high profits because of R&D costs!
    Me: I told you, BMS didn't pay for the R&D costs! You can say that they need the money, but you haven't explained why they actually deserve it in this case, since they didn't do the basic R&D on the drug any more than I did.
    You: But drug companies need to charge high prices because of R&D costs.

    Quoting directly, you said: Do you think all the employees work for free? I'm certainly not advocating that the government fund private research. The drug companies are making good profits for the risks they are taking, and thus need no subsidies.

    If you'd been reading instead of mindlessly repeating yourself, you'd have noticed that (a) the government turned over its research to a private concern for commercialization, (b) the "risk", in this instance, was subsidized, while the profits were privatized. Whether or not BMS "need[s] no subsidies", they certainly got them.

    Also, the government already does fund private research directly; see, for instance, the FDA's OOPD Grant Program, for just one example.

    --
    Laws do not persuade just because they threaten. --Seneca
  77. Bad news for LOTRO fans... by nixkuroi · · Score: 1

    Now in addition to gold farmers picking up all the Yew Wood, you're going to have cancer farmers as well.

    Nice job scientists!