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Adding Capsaicin Improves Anesthetic Treatment

Posted by samzenpus on from the so-hot-it's-numb dept.

eldavojohn writes "It's no secret what capsaicin, the fiery molecule of peppers, does to cell walls. In fact, it's now being used to open cells up to local anesthetics. Combine it with a new drug that works only from the insides of cells and you have a great system for relieving pain. From the article, 'QX-314 is known to reduce the activity of pain-sensing neurons in the nervous system and theoretically heighten pain thresholds. But there's a catch: Researchers found that "it wouldn't work from outside a nerve cell but it would work if you could get it inside," says Bruce Bean, a professor of neurobiology at Harvard Medical School and co-author of the new study."

17 of 151 comments (clear)

  1. Just a thought... by thatskinnyguy · · Score: 4, Funny

    ...but wouldn't that burn like hell?

    --
    The game.
    1. Re:Just a thought... by wamerocity · · Score: 5, Interesting
      I actually was reading an article about capsaicin (which is also the active ingredient in pepper spray, hence the name). One doctor once recommended that oxycontin and other opiates should have capsaicin put into the pills. People who swallowed it wouldn't taste anything different, but people who take the drugs and chop them up into a powder and then snort it have a really special surprise in store for them, similar to what this guy did with wasabi.

      I'd guess people would only make that mistake once though.

      --
      "Thank you for using Stop-n-Drop, America's favorite suicide booth since 2008"
    2. Re:Just a thought... by wamerocity · · Score: 4, Informative

      Not to be a dick or anything, but it IS the active ingredient in peppers. From http://en.wikipedia.org/wiki/Capsaicin, I quote "Capsaicin /kæpse.sn/ (8-methyl-N-vanillyl-6-nonenamide) is the active component of chilli,(sic) peppers, which are plants belonging to the genus Capsicum. It is an irritant for mammals, including humans, and produces a sensation of burning in any tissue with which it comes into contact"

      --
      "Thank you for using Stop-n-Drop, America's favorite suicide booth since 2008"
    3. Re:Just a thought... by martinX · · Score: 4, Informative

      Could be a difference in common names here...

      In Australia, these things are called Capsicums (no, no-one calls them Capsica :-) ) We reserve the word "pepper" exclusively for that stuff made from peppercorns. Chillis are chillis, not chilli peppers.

      Capsicums in the US are called, I believe, bell peppers.

      --
      When they came for the communists, I said "He's next door. Take him away. Goddam commies."
    4. Re:Just a thought... by ozmanjusri · · Score: 4, Informative
      Not to be a dick or anything, but it IS the active ingredient in peppers.

      It's a language problem.

      Outside the US, capsicums and chillies aren't called "peppers". Interestingly though, the piperine which makes real pepper (the spice) taste hot works on the TRPV ion channel in the same way as capsaicum, so it might have a similar effect.

      --
      "I've got more toys than Teruhisa Kitahara."
    5. Re:Just a thought... by DMUTPeregrine · · Score: 4, Informative

      Bell Peppers are actually the only chilli peppers that do NOT contain capsaicin.

      --
      Not a sentence!
    6. Re:Just a thought... by justin12345 · · Score: 4, Insightful

      Sounds like a plan... except for one thing. Capsaicin come out just as hot as it goes in. Add to that the constipation that opiates cause and you are talking about an excruciating bowel movement.

      --
      Cool art gallery, if you're into that sort of thing.
    7. Re:Just a thought... by ChameleonDave · · Score: 4, Informative

      Outside the US, capsicums and chillies aren't called "peppers".

      Nonsense. Don't confuse Australia with "outside the US". Australia is strange in reserving the word "pepper" for actual Piper nigrum. The UK, for example, is just like the US in that "pepper" is used to refer to the fruit of the Capsicum genus native to Mexico. The hot varieties are called "chillis" or "chilli peppers", and the mild varieties are known as "green peppers", "yellow peppers" or "red peppers" according to their colour; the generic term is "sweet peppers". Piper nigrum is known as "black pepper" or "white pepper" according to its colour.

      There is never any ambiguity even when a colour is not mentioned, as the word is used as a mass noun to refer to Piper nigrum and a count noun to refer to Capsicum, i.e. "I like pepper" means one thing and "I like peppers" means another.

      The recycling of the word "pepper" is not even peculiar to English: the word for Capsicum is many languages is just a minor variation on the word for Piper nigrum. Here are the respective words for pepper, sweet peppers, and chilli in some languages. French: poivre, poivron, piment/chili. Spanish: pimienta, pimiento, chile/ají. Italian: pepe, peperone, peperoncino.

      Strangely, Australians will use the word "peppers" to refer to Capsicum if they are roasted. I believe this is under foreign influence. They do, however, stubbornly make sure that pepper spray (containing capsaicin) is always referred to as "capsicum spray".

      Aussies tend to think that their usage is more exact than UK/US usage, in that they do not extend the old-world term "pepper" to cover the new-world fruit, but what they usually don't realise is that to botanists "Capsicum" includes the fiery fruits which Aussies always call "chillis", and never "capsicum".

      One final bit of trivia: Australians virtually always mispronounce it "capsicun", although they are rarely aware of it.

      — A Brit in Oz

    8. Re:Just a thought... by adatepej · · Score: 4, Insightful

      Yeah, those "addicts" out there will do a bit for their drug of choice, but they're not going to snort some sadistically formulated pill, if that's what you're thinking.

      They're just going to take whatever other prescription opiate is most available at the time. And others will just find a way around capsaicin and any other measure devised by those who'd waste their talents devising ways of preventing other people from taking pills of their own volition.

      It's a war that can't be won, nor does it deserve to be. It's wrong-headed and truly hateful towards freedom.

  2. Cell walls? by Atmchicago · · Score: 5, Informative

    Mammalian cells have no cell walls. Do they mean plasma membrane? This is basic biology, guys, please get your facts straight.

    --

    You can lead a horse to water, but you can't make it dissolve.

    1. Re:Cell walls? by ragingmime · · Score: 5, Interesting

      It's no secret what capsaicin, the fiery molecule of peppers, does to cell walls.

      Actually, I've studied cell biology and I have no idea what capscaicin does to cell walls (or even plasma membranes.) Come to think of it, chili pepper cells have walls, and capsaicin doesn't seem do anything to them. So maybe it is a secret after all.

      --
      I produce electronic music and write little games. Have a look.
    2. Re:Cell walls? by wizardforce · · Score: 4, Informative

      correct, the plasma membrane is studded with a number of receptors, ion channels and signalling compounds- this in particular seems to use capsacian as a "key" to allow the second compound through so that it can work. the plasma membrane being semipermeable as it is, does act somewhat like a wall- a barrier that maintains a chemical gradient/controlled intracellular environment. an all too common mistake on their part.

      --
      Sigs are too short to say anything truly profound so read the above post instead.
    3. Re:Cell walls? by csubi · · Score: 5, Informative

      Not a secret - capsaicin opens the Vanilloid Receptor 1, also known as TRPV1, when binding. So it does "open up" the cell membrane but these openings are quite specific and small, the open VR1 will mostly let through hydrated Ca2+ ions.
      And not all cells express the VR1 - it is mostly nerve cells responsible for transmitting signals for inflammatory and neuropathic pain and epithelial cells like the skin lining our mouths.
      Unlucky for those who like to feel their mouth burn when eating a good chili con carne(like me), the receptor is also expressed in the cells of the anal region - hence the burning feeling in the butt, when going to crap 1-2 days after eating the hot dish...:)
      Wiki link: http://en.wikipedia.org/wiki/TRPV1

  3. Terrible Write Up by headhot · · Score: 5, Informative

    Well the Write Up didn't make any sense so I read the link. Here is the deal.
    1. QX-314 block pain neurons. It doesnt block other neurons for heat, pressure, ect.
    2. QX-314 only works if you can get it inside the neuron cell itself.
    3. Capsaicin opens a channel on only pain neurons that will let QX-314 through.

    So, using Capsaicin and QX-314 together, you can block pain but no other senses.

    1. Re:Terrible Write Up by FlatCatInASlatVat · · Score: 4, Insightful
      Close, but not quite:

      1. QX-314 blocks all neurons.
      2. QX-314 only works if you can get it inside the neuron cell itself.
      3. Capsaicin opens a channel on only pain neurons that will let QX-314 through.

  4. More than just that... by RobertM1968 · · Score: 4, Interesting

    It helps metabolize fat, helps with prostrate issues and a bunch of other things as well...

    It can be taken in pill form (for those who dont like eating red hot chili peppers) which is good considering some of its benefits require moderate to large doses.

    When combined with other spices such as garlic and cinnamon, the results in numerous areas are quite good, and quite nice... (adding to the list above better sugar absorption, insulin creation, appetite suppression, thermogenic fat burning without lean muscle mass loss, pain relief, sinusitus relief and a LOT more)

    Interestingly none of this is news... it's ALL ancient news - that the pharmaceutical companie$ dont want people to know... a nice spicy/sweet bowl of chili (made with just a tiny pinch of cinnamon, a bunch of chili powder, and some garlic) each day (or substitute with a different food that those ingredients can be put in from a steak sauce to you name it) and you've eliminated billions of dollars in income for related chemically created products from the pharm companies - and you have also eliminated the side effects.

    --
    StarTrekPhase2 - The Five Year Mission Continues!
  5. Ok by xx01dk · · Score: 5, Funny

    I promise I'll RTFA, but the first thought that came to mind was "Oh boy! Modern medicine can ease my pain... with FLAMING HOT NUCLEAR CODE RED WING SAUCE" followed by "GOOD LORD I'M NEVER SHITTING AGAIN."

    --
    There is simply too much glass..