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Steps Toward a Universal Flu Vaccine
Plasmoid writes "The NYTimes is reporting that scientists have starting developing what could turn out to be a 'universal' flu vaccine. They created antibody proteins that can neutralize different strains of the influenza virus, including the deadly H5N1 bird flu, the virus behind the 1918 epidemic, and common seasonal strains. These new antibodies target part of the virus that is shared between different strains and thus appear to be broadly effective. However, some experts question whether a universal vaccine of this kind is even possible, since the human body has been unable to come up with an antibody solution. An article on nature.com describes the work further."
Influenza
In humans, common symptoms of the disease are chills, fever, pharyngitis, muscle pains, severe headache, coughing, weakness, and general discomfort.[1] In more serious cases, influenza causes pneumonia, which can be fatal, particularly in young children and the elderly. Although it is often confused with the common cold, influenza is a much more severe disease and is caused by a different type of virus.[2] Influenza can produce nausea and vomiting, especially in children,[1] but these symptoms are more characteristic of the unrelated gastroenteritis, which is sometimes called "stomach flu" or "24-hour flu".[3]
We geeks often neglect our health, especially during the cold and flu season (Which is a prime time to stay inside, Frag noobs, write badass scripts, Watch Babylon 5, etc). Make sure you take all the necessary precautions to keep your wetware virus-free!
some experts question whether a universal vaccine of this kind is even possible, since the human body has been unable to come up with an antibody solution.
Experts in what? Theology?
So either evolution is perfect and has already done it or it can't be done?
Riiiight. Evolution != god.
There was a talk about this at TED. Turns out the same ideas of shared virus parts can be used to identify and diagnose, or even as this article suggests, cure various diseases very quickly.
"However, some experts question whether a universal vaccine of this kind is even possible, since the human body has been unable to come up with an antibody solution. "
Using this logic we shouldn't have come up with vaccines for smallpox, polio or rabies either.
love is just extroverted narcissism
I found this quote rather comical.
"If you have one or two that cover the vast majority of isolates, I wouldn't be ashamed to call that a universal vaccine."
So, universal now means "vast majority." So I guess, to really refer to universal, we'll have to say "actually universal." Hm.
However, some experts question whether a universal vaccine of this kind is even possible, since the human body has been unable to come up with an antibody solution.
No offence, I love the human body and all, but there are LOTS of things it has 'been unable to come up with', including the much needed ability to render stupid people unconscious by concentrating hard.
Being part of a system of evolution is not a panacea for disease; quite the opposite. Almost every positive thing you can say about our resistance to disease comes directly or indirectly off the back of people who didn't have a particular type of resistance 'taking one for the team', so to speak. There's nothing wrong with hunting for cures that DON'T involve the mass extinctions of the genetically unfortunate. There'll be plenty of time for it to all work itself out.
> some experts question whether a universal
> vaccine of this kind is even possible, since
> the human body has been unable to come up with
> an antibody solution
First, the researchers don't claim a universal anti-virus, simply a broad spectrum one.
Those nay-saying, have no lab data, those doing the research do. Its effective in animal studies and human studies will soon begin.
The human body does not search for the best antibody, or the most universal one. It simply throws stuff out there and sees what sticks (figuratively and literally).
This approach goes after an area on the virus that is hard to reach because of its structure.
Quoting TFA:
" The flu virus uses the lollipop-shaped hemagglutinin spike to invade nose and lung cells. There are 16 known types of spikes, H1 through H16.
The spikeâ(TM)s tip mutates constantly, which is why flu shots have to be reformulated each year. But the team found a way to expose the spikeâ(TM)s neck, which apparently does not mutate, and picked antibodies that clamped onto it. "
Sig Battery depleted. Reverting to safe mode.
However, some experts question whether a universal vaccine of this kind is even possible, since the human body has been unable to come up with an antibody solution.
Firstly adding to your point (and according to the theory,) evolution is only "perfect" over an infinite time frame. The fact that there is no universal antibody could mean one of two things: the time frame was too short or there's a reason why the human body doesn't want a universal solution, and I can think of at least one big one.
The human body has thousands of known symbiotic relationships and potentially thousands or millions of unknown ones. Most of these are bacterium (or more rarely viruses) that do something to help the human body. The digestive tract has literally trillions of non-human cells within it. There is even an organ who's use (which was previously unknown) is to store 'good' bacteria when the body is fighting other harmful invaders. I'm speaking of course of the appendix - the one organ which literally oozes symbiosis. The human body might not 'want' a universal solution as those which are adapted to allow the potential for additional symbiotic relationships before ejecting them have a better chance at thriving as every tiny advantage helps.
I'm not saying this is a step in the wrong direction and I'm not saying this is necessarily a bad thing because the vast majority if not all viruses of this strain are harmful to humans at this point, but to say that evolution couldn't come up with a solution therefore there isn't one makes a ton of huge assumptions which probably aren't all valid.
Well, back to rejecting software patent applications.
Playing gods again, are we?
We kind of have been ever since we mastered fire. Humans have never gone with the natural flow. Where have you been for the last million years?
Have you seen a movie called "Terminator?" Better stop using your computer.
Don't screw with bears... at least not this one!
http://community.atom.com/Post/An-Ode-to-Voytek-The-Most-Badass-Soldier-in-WWII/03EFBFFFF0182C7B8000800A747EC
You're right...that silly Jules Verne, actually thought we'd be up to the moon someday. HAHAHA
Next all those weirdo reading books about artificial intelligence would actually expect us to do research and developing neural nets.
And cloning, you can't possibly ever make a genetic duplicate. I mean come on, someone else walking around with your same genes that wasn't born at the same time as you? The odds must be astronomical.
The point is, imagination and wondering and writing about what could be, can lead people to try to figure out if it's possible or if we even should.
There are groups in the government that write papers on worse case scenarios and plan for disasters. Of course this was also a bunch of books and movies...so...couldn't possibly happen can it?
I'm going to simply respond to your rambling, seemingly paranoid post with a single [Citation Needed].
Paranoid conspiracy theories require some verifiable proof, especially when they directly contradict peer-reviewed and verified science so conspicuously.
Explain Smallpox, Polio, Hepatitis B, HPV, Chicken Pox, Measles, Mumps, and Rubella. It is not futile. You do it, or you risk dying from easily communicable diseases.
You're an idiot parroting "Vaccines are poison!" crap, who told you this, Jenny McCarthy?
Predjudice? No, that requires knowing nothing about you and making a rash judgment. You've plainly proved you're ignorant and little better than a wishful-thinking conspiracy theorist and deserve every flame fired against your dangerous spreading of mis-information.
I was fortunate enough to be working with general practitioners during the bird flu scare, and between high school biology and the catch-up courses being run for the doctors about bird flu at the time I have a decent working knowledge of the subject.
In brief: please provide links for your paranoid delusions, I'd enjoy the read.
The flu variant believed to be responsible for the 1918 pandemic killed by causing a cytokine storm (wiki it yourself) - the host immune system overreacts and kills the host. Of course this is most effective against otherwise healthy people with a strong immune system that can really kick some ass... against their own body.
Yes it is. It's widely studied. All flu viruses are of avian origin and most of them can't even infect pigs and humans, the secondary carriers. The ones that can can be very deadly against humans because while human-specific diseases can't be deadly enough to kill their hosts often or the virus won't have anywhere to live, avian flu can persist as a minor annoyance in bird populations then leap out to massacre some humans from time to time.
You suggest that the pharmaceutical industry has duped the entire medical profession into believing in a disease that doesn't even exist, and will inject the entire population with a potentially lethal disease causing agent, causing massive global economic collapse simply because they can get paid for every unit they produce? No comment.
.evom ton seod gis eht
What do you mean playing? I AM a God.
;)
I'm going to simply respond to your rambling, seemingly paranoid post with a single [Citation Needed].
I for one believe the GP of this when they say that they cannot afford the housing they live in. No citation needed.
Moved to http://soylentnews.org/. You are invited to join us too!
The only reason her kids are healthy an unvaccinated are because everyone else IS vaccinated. She is an idiot, as is everyone working with her. Especially since she claims vaccines are "toxic". They haven't been since 2001 or so when they phased out mercury in all vaccines. Evolution and nature are not magic. They don't make "perfect" things. They make "good enough" things. If evolution were perfect, we would be able to see in the dark as well as cats, and wouldn't get sunburned or cancer.
My blog. Good stuff (when I remember to update it). Read it.
If you had actually read the article, you might have noticed that the antibodies discovered are in fact naturally produced in the human body and not the result of "playing God". Unfortunately the body doesn't seem to produce enough of these antibodies to result in immunity; probably because the influenza virus has distracting structures that are rapidly mutating. The researchers are proposing stimulating the immune system to produce more antibodies for the non-mutating parts of the virus by making a vaccine out of the non-mutating part.
Apocalypse Cancelled, Sorry, No Ticket Refunds
... or not attack the beneficial ones for long enough to cause serious long term effects. Kind of like the viral equivalent of antibiotics, right?
Can you say "superbug?"
Let's check back in 50 years.....
I don't therefore I'm not.
No, I am Spart- err, God.
Scientists point out problems, engineers fix them
altslashdot.org: The future of slashdot.
The key word in that wall of text is "chiropractic". Chiropractors are not doctors. By and large they are quacks trying to cure things by supposedly realigning the vertebrae (which they don't in fact).
I've heard the arguments pro and con, but have a personal anecdote. For about 6 months of my life, I had excruciating back pain. It got much worse when laying down, so my nightly routine was to eat four Advil or a couple of Alleve and maybe some sleeping pills and try to get a couple of hours of sleep before the little gremlin shoved the rusty knife into my spine. I went to several well-respected doctors who gave me painkillers and muscle relaxants and told me that it would go away on its own - but it didn't. Although I never became suicidal, I now understand why people would start considering that as an option.
I eventually agreed to go to a chiropractor that my dad recommended. He ran that goofy, debunked "alignment meter" up my spine a few times, then cracked my back. When my eyes uncrossed and I stopped yelling, he gave me a bill for $40 and told me I didn't need to come back. From that moment on, from the instant he cracked my back, it stopped hurting. Permanently. I was fixed.
Now, I understand why people write off chiropractors, and as the husband of a surgeon, I'm extremely pro traditional medicine. In this one specific case, though, a chiropractor flat-out cured my problem in a single visit after other doctors had failed for half a year. Maybe he (or I) was just extremely lucky, but I can't dismiss the whole category of doctors.
Now, "natural health care" is at least as good an indicator of potential quackery.
Dewey, what part of this looks like authorities should be involved?
They have never been toxic, ever.
The mercury was about 3-5 Nano Grams with a half life of 4 days. Completely undetectable in 30 days.
Just an FYI
The Kruger Dunning explains most post on