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Reliable Male Contraceptive In the Works

Hugh Pickens writes "The BBC reports that recent tests in China indicate a monthly injection of testosterone, which works by temporarily blocking sperm production, could be as effective at preventing pregnancies as the female pill or condoms. In trials in China only one man in 100 fathered a child while on the injections, and six months after stopping the injections the mens' sperm counts returned to normal. The lead researcher said that if further tests proved successful, the treatment could become widely available in five years' time. Previous attempts to develop an effective and convenient male contraceptive have encountered problems over reliability and side effects, such as mood swings and a lowered sex drive. However, despite the injection having no serious side effects, almost a third of the 1,045 men in the two-and-a-half year study did not complete the trials; no reason was given for this."

19 of 519 comments (clear)

  1. Possibly because it worked? by powerlord · · Score: 5, Funny

    ... almost a third of the 1,045 men in the two-and-a-half year study did not complete the trials; no reason was given for this."

    however their recent child support filings may lend a clue.

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    1. Re:Possibly because it worked? by ByOhTek · · Score: 5, Funny

      Actually, if I remember correctly, excess testosterone gets converted into estrogen doesn't it?

      I suspect those that stopped... Didn't like man boobs.

      --
      Self proclaimed typo king, and inventor of the bear destroying coffee table (patent not pending).
    2. Re:Possibly because it worked? by Anonymous Coward · · Score: 5, Funny

      The real news here is the medical breakthrough hidden by the researchers: the 1/3 of the men that quit the treatment did so because they got pregnant.

    3. Re:Possibly because it worked? by SausageOfDoom · · Score: 5, Insightful

      Irrelevant - any good journalist knows that 33% is statistically insignificant...

      It really frustrates me whenever the media do a science story, especially one regarding medicine. In their desperation to focus on the human angle and "won't anybody think of the children" - and of course, increase number of readers - they completely ignore any basic scientific analysis.

      A classic example was the MMR-gives-you-autism scare - they make a sensational headline from a report without investigating the background of Wakefield (the author who made the public statement that started it - he received money from lawyers trying to build a case), without giving any consideration to the statistical significance of his findings (the paper looked at 12 patients), and completely ignoring the fact that the paper said it couldn't link MMR to autism. Even though it has now been proven that there is no link, the doubt lives on in the public mind.

      Perhaps this is due to scientific journalists having no real understanding of science. Perhaps they do, but have a better understanding of how their job depends on selling a story. Either way, they must take more responsibility for their power over the public.

      Returning to the MMR story, Wakefield has been widely discredited and hauled in front of the GMC and could be struck off. Meanwhile, what has happened to the journalists who built the story into the frenzy that led to measles and mumps outbreaks in the UK? Nothing - they're still writing stories like this.

    4. Re:Possibly because it worked? by Maxo-Texas · · Score: 5, Informative

      1) testosterone shots are painful
      2) testosterone converts to estrogen (http://www.naturodoc.com/library/hormones/masculine.htm) ...The enzyme called aromatase works naturally to convert testosterone into estrogen. ... Fat cells contribute a great amount of aromatase, and many nutrient deficiencies can also produce higher levels.
      3) having more testosterone lowers your natural production (so going off of it can be a bitch)
      4) having excess testosterone can make you more aggressive, angrier (rage), less happy but...
      5) having insufficient testosterone can make you more emotional, angrier(fear), sleep poorly, less happy, anxious (free floating anxiety), loss of lust, loss of happiness, lost of performance when you do have lust.

      I've been on HRT for a few years now. Having a level of about 600 makes me feel like I am 10 years younger plus the andropause symptoms went away within a week of starting supplementation. There are currently two expensive rub on versions (Testim - oil based and Androgel - alchohol based), a ton of compounded rub on versions, and shots.

      Shots produce a much stronger cycle (too high for a few days, then normal for a couple weeks, then too low for a few days before your next shot).
      I've read the shots are painful after you get them (the testosterone hurts inside you). It's not agony and tons of guys do get the shots (much less expensive than the rub-on approach) but the getting shots sucks, and then if it hurts after you get the shot that would suck more.

      I apparently had low testosterone most of my life even before i was in my 40's since I furred out big time once I went on it.
      I play a lot of boardgames and losing them pisses me off more than it used to so that is a downside. I didn't used to care.

      A LOT of males have low testosterone starting at 43-- some earlier. It's an easy test to get. HRT is usually a one-way trip. You go on it and are on it until you show signs of prostate cancer (which estrogen is like gasoline on a fire for).

      --
      She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
    5. Re:Possibly because it worked? by DrLang21 · · Score: 5, Insightful

      Not that I can provide serious input to testosterone injections specifically, but what doesn't increase the risk of cancer? Living in California, I am beginning to think that we have some miasma that turns everything into a carcinogen. I recall hearing about a study that showed repeated injections of saline caused cancer in some laboratory mice. My suggested hypothesis: Too much of anything is bad for you.

      --
      I see the glass as full with a FoS of 2.
  2. quit rate... by Anonymous Coward · · Score: 5, Insightful

    2.5 years of *injections* and 1/3 did not complete the term of the trials. Not surprising. Make it in pill form and you may have a higher completion rate...

    1. Re:quit rate... by Shakrai · · Score: 5, Funny

      2.5 years of *injections* and 1/3 did not complete the term of the trials. Not surprising. Make it in pill form and you may have a higher completion rate...

      But on the bright side we've created a form of contraception that heroin addicts can get behind ;)

      --
      I want peace on earth and goodwill toward man.
      We are the United States Government! We don't do that sort of thing.
  3. 1% ! by Bibz · · Score: 5, Informative

    1% got pregnant, that seems pretty high for contraceptive. It would have to be used with other means

    I stand corrected, the pill is 92-99.7% effective, about 5% of couples will get pregnant. So it seems this way is pretty darn effective.

    --
    I didn't found something funny to put here.
    1. Re:1% ! by Bibz · · Score: 5, Insightful

      Maybe they just wanted to have childs...
      2.5 years is a long time and they probably changed their mind

      --
      I didn't found something funny to put here.
  4. Morning after? by John+Hasler · · Score: 5, Funny

    But where is the male morning after pill?

    --
    Warning: this article may contain humor, sarcasm, parody, and perhaps even irony. Read at your own risk.
    1. Re:Morning after? by Shakrai · · Score: 5, Funny

      But where is the male morning after pill?

      It's called the over-the-counter female morning after pill and breakfast in bed ;) "Here honey, I love you so much that I made you breakfast!"

      Yeah, I'm going straight to hell.....

      --
      I want peace on earth and goodwill toward man.
      We are the United States Government! We don't do that sort of thing.
  5. Hah, they dropped out because by new+death+barbie · · Score: 5, Funny

    "almost a third of the 1,045 men in the two-and-a-half year study did not complete the trials; no reason was given for this"

    Nobody told them WHERE the injection goes.

    --

    It's supposed to be completely automatic, but actually you have to press this button.

    1. Re:Hah, they dropped out because by Inda · · Score: 5, Funny

      Injections (plural). You need to have two. One in each...

      Oh my Lord. Brings tears to my eyes just thinking about it.

      --
      This post contains benzene, nitrosamines, formaldehyde and hydrogen cyanide.
  6. There's one major problem with this..... by benwiggy · · Score: 5, Insightful
    "Have you got any protection?"

    "Don't sweat it, babe, I've had the injection. Honest."

    "Oh, OK, then. On you go."

  7. Re:Huh? by MadKeithV · · Score: 5, Funny

    Because /. is home to a lot of people that use the other reliable Male Contraceptive: Linux.

  8. Re:Citation by Maxo-Texas · · Score: 5, Insightful

    I've always thought that condom success rate depends on intelligence and your actual practices.

    I and a lot of friends used condoms and experienced 0% failure rate (no pregnancies).

    OTH, with birth-control pills, we had a failure-- but it wasn't the pills.

    The lady in question admitted a year or two later that she was lying and had stopped taking the pill because she had decided she wanted to get pregnant. She also later decided she only wanted the money and not the males interference with raising the child.

    As a guy, you know when you are using as condom, but you never really know when you are a using a pill.

    So these shots would be good because you would *know* you were covered from your side.

    --
    She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
  9. This is an interesting development, but... by MoxFulder · · Score: 5, Insightful

    ... I doubt that women will accept it.

    Even if it has no side effects and if men are able to accept the stigma of being temporarily infertile, I expect that women won't trust this treatment.

    Just think about it: who bears most of the risk in case of pregnancy? Women. It might be unjust, but in most societies, men can walk away and abandon women they've gotten pregnant easily without serious social stigma or financial repercussions. Women either have to get an abortion (stigmatized, traumatic, and in many places illegal/expensive/dangerous) or raise a child alone (stigmatized/expensive/time-consuming).

    With the pill or condoms, women are either controlling the birth control themselves, or can verify its use on-the-spot. With male contraceptive injections/pills,

    I foresee a big problem with women not trusting that men are really taking this. Heck, in the pilot study 1/3 of the men just stopped taking it for no apparent reason!!

  10. Re:Huh? by sFurbo · · Score: 5, Funny

    Ha, we foiled your plan by modding you insightful!