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Scientists Use Quake 2 To Study the Brains of Mice

An anonymous reader writes "In this week's issue of Nature, scientists from Princeton University trained mice to navigate around a virtual environment using a setup that resembles a combination of a giant trackball and a mini-iMax theater displaying a virtual world rendered using a modified version of the Quake 2 open source game engine. (Here's the academic paper, subscription required.) They hold the mouse's head still atop a giant trackball, which the mouse turns by running. The scientists use the rotations to move the mouse around in the virtual environment, and when he reaches certain places, he gets a reward. Because they are able to hold the head still, they can stick microscopic glass electrodes into individual neurons in the hippocampus of this mouse as it 'navigates.' They find the neural activity that resembles activity during real life navigation, and learned new things about the inputs and computations that are going on inside these neurons, which weren't known before. No word as of yet whether the scientists plan on giving the mice control of the gun. Wonder whether John Carmack ever envisioned this when he opened up the Quake code?"

185 comments

  1. FP by CrazyJim1 · · Score: 5, Funny

    Yo dawg, I heard you liked mice, so I put a mouse on your mouse.

    1. Re:FP by hitnrunrambler · · Score: 2, Insightful

      Yo Dawg, I heard you liked idiot replies, so here's an idiot reply for your idiot reply!

    2. Re:FP by Anonymous Coward · · Score: 0

      Now Mac users can right click with their right mouse and left click with their left mouse.
      Macintosh: Efficient.

    3. Re:FP by Anonymous Coward · · Score: 0

      Blarg! Scar red black fart bunnies!

    4. Re:FP by Chris+Mattern · · Score: 0, Troll

      So now you can Quake while you Quake!

    5. Re:FP by Anonymous Coward · · Score: 0
    6. Re:FP by Anonymous Coward · · Score: 0

      Are those the self-balancing fart bunnies?

    7. Re:FP by Anonymous Coward · · Score: 0

      It looks like someone has a problem with mouse on mouse action.

    8. Re:FP by bbx · · Score: 1

      Ha , really great. As a Quake Player i look forward playing the MICE Clan :) only bad thing in this video : theres not a single frag :(

    9. Re:FP by Anonymous Coward · · Score: 0

      Yo dawg, I heard you like trolling so I put a troll in your troll so you can troll while you troll!

    10. Re:FP by Hurricane78 · · Score: 1

      Yo dawg, we heard yo like herd dawg herding Yo Yo yo yoing with yo Wii so we hid yo Wii and Yo Yo yo yoing in yo Wee dawg herd so you can herd yo wee herd with yo wee dawg and Yo Yo yo yoing while yo dawgs Wii hides in yo wee herd with Yo Yo, Yo Yo's yo yo, and yo wee dawg, yo.

      N00b!

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
  2. Quake Fit? by natehoy · · Score: 4, Funny

    If only we could do this with gamers who need exercise. They get a better immersive experience AND get fit at the same time.

    OK, so the open-brain surgery thing is going to be controversial, but...

    --
    "This post contains words, known to the State of California to cause thought. Wash brain thoroughly after reading."
    1. Re:Quake Fit? by Interoperable · · Score: 4, Funny

      Combine it with Google street view and you'll have a completely virtual mundane experience!

      --
      So if this is the future...where's my jet pack?
    2. Re:Quake Fit? by FlyingBishop · · Score: 1

      Given a throttle to adjust how fast the view moved as you walked, it would be anything but mundane.

      Not that much more impressive than seeing streetview on a large screen, but still not mundane.

    3. Re:Quake Fit? by clone53421 · · Score: 3, Funny

      You mean just like going outside and taking a walk in real life? But why would I want to do that?

      --
      Alexander Peter Kristopeit bought his basement from his mommy for one dollar.
    4. Re:Quake Fit? by Anonymous Coward · · Score: 0

      If only we could do this with gamers who need exercise. They get a better immersive experience AND get fit at the same time.

      It's called "paintball."

    5. Re:Quake Fit? by dandart · · Score: 0

      Why streetview when you can have a camera on a blimp?

    6. Re:Quake Fit? by hoggoth · · Score: 2, Informative

      You can.

      See here: http://www.virtusphere.com/

      DO WANT.

      --
      - For the complete works of Shakespeare: cat /dev/random (may take some time)
    7. Re:Quake Fit? by Anonymous Coward · · Score: 0

      You mean just like going outside and taking a walk in real life? But why would I want to do that?

      I find myself outside in this "real life" you talk of occasionally, and sometimes I wake up from my day dreaming, see something pretty and go "Whoa, great graphics!"

    8. Re:Quake Fit? by carlmenezes · · Score: 1

      Well, add in the gun, a city with lots of 3D buildings and some physics and you have an experience that's anything but mundane. Heck, take out the person, add in a car which allows you to race through the city. Now put guns back on the car and make it multi player for a "Death Race" kind of experience. Even wilder, allow a player to roam a real city using their exported World of Warcraft character and mount for a crazy glimpse of what it would look like if you merged our modern cities with a magic world. Not unlike the whole Harry Potter thing, but there is something to be said about a wizard on a mount getting a Whopper at a Burger King ride thru ;)

      --
      Find a job you like and you will never work a day in your life.
    9. Re:Quake Fit? by Anonymous Coward · · Score: 0

      2D treadmill:
      http://www.youtube.com/watch?v=moq1Dclza90

    10. Re:Quake Fit? by Anonymous Coward · · Score: 0

      I want to see the world from my own home, the sun scares me...

    11. Re:Quake Fit? by ZarathustraDK · · Score: 1

      When in doubt assume you're playing Diablo II on hardcore hell difficulty (aka. don't fuck up).

      --
      If you quote this signature there'll be 72 copies of Windows ME waiting for you in Heaven.
    12. Re:Quake Fit? by BobMcD · · Score: 4, Funny

      I can see numerous advantages to a virtual walk:

      1) Not impacted by weather
      2) Not possible to get run over by a virtual truck
      3) Few financially losses from being virtually mugged
      4) Fewer possibilities for disease when you virtually hook up with that virtually hottie you met on your virtual walk

    13. Re:Quake Fit? by cjb658 · · Score: 1

      You mean just like going outside and taking a walk in real life? But why would I want to do that?

      Maybe you live in a bad neighborhood and don't want to get shot. Or perhaps if you go outside and are exposed to sunlight, your body will melt.

    14. Re:Quake Fit? by cjb658 · · Score: 1

      I just saw them get pwn3d on Sharktank yesterday.

      What a shame...

    15. Re:Quake Fit? by X0563511 · · Score: 1

      But, you (normally) cannot walk down the street doing horrible things to other people with weapons of your choice...

      Also - imagine the Portal Gun! Come on!

      Walks suck!

      --
      For large sets, this will be our guide even unto death, for the LORD will work for each type of data it is applied to...
    16. Re:Quake Fit? by lennier · · Score: 1

      That sounds actually like a fun idea. I wonder how big the ball would need to be for a person to stand on it?

      A couple metres maybe? Hmm. That'd probably fall into 'amusement ride' level of safety needed.

      --
      You are not a brain: http://books.google.com/books?id=2oV61CeDx-YC
    17. Re:Quake Fit? by lennier · · Score: 1

      Oh man! That's it! Want indeed.

      (checks brochure)

      Exciting Offer For First Time Buyers!
      $10,000.00 Discount Off Retail Price.
      Minus $10,000.00 Discount, Net Price: $25,000.00 ... okay I won't be plugging this into my Wii anytime soon.

      --
      You are not a brain: http://books.google.com/books?id=2oV61CeDx-YC
    18. Re:Quake Fit? by natehoy · · Score: 1

      A series of smaller balls that make up basically a "slippery surface" with the player suspended in some form of harness to prevent falling?

      --
      "This post contains words, known to the State of California to cause thought. Wash brain thoroughly after reading."
    19. Re:Quake Fit? by maratumba · · Score: 1

      "Unfortunately, no mice can be told what the 'Quake' is. You have to see it for yourself."

    20. Re:Quake Fit? by Anonymous Coward · · Score: 2, Funny

      Just one downside about that virtual hottie... his name's Stan and he's a 50-year-old welder. That would never happen in real life. No sir, not to me :-|

    21. Re:Quake Fit? by vegiVamp · · Score: 1

      4) will still provide you with interesting viruses if you're running on windows :-)

      --
      What a depressingly stupid machine.
    22. Re:Quake Fit? by holmstar · · Score: 1

      I was trying to figure out how you would do something like that. Makes sense now that I see it. Looks like they still have a bit of a problem with the amount of rotating mass. It isn't able to react quite as fast as would be optimal.

    23. Re:Quake Fit? by bigngamer92 · · Score: 1
      5)Can visit the Spiral Minaret, without needing to get a passport or plane ticket.

      6)Guy who sets this up for profit, Profits.

      No need for a ??? here folks.

    24. Re:Quake Fit? by Anonymous Coward · · Score: 0

      Pretty sure he was joking there, slick

    25. Re:Quake Fit? by Hurricane78 · · Score: 1

      Wait another version, and we will add those things for "immersion".

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
  3. Online play by Xebikr · · Score: 5, Funny

    If I ever get fragged by a mouse, I hope no one ever tells me.

    1. Re:Online play by vertinox · · Score: 3, Funny

      If I ever get fragged by a mouse, I hope no one ever tells me.

      PRO TIP: Don't use cheese yellow colors for your model skins!

      --
      "I am the king of the Romans, and am superior to rules of grammar!"
      -Sigismund, Holy Roman Emperor (1368-1437)
    2. Re:Online play by jason.sweet · · Score: 1

      I pwn humanz.
      B3N

    3. Re:Online play by Anonymous Coward · · Score: 0

      On the Internet, no one knows you're a mouse.

    4. Re:Online play by bigngamer92 · · Score: 1

      Yeah it would almost be as embarrassing as getting fragged by a Frenchie.

    5. Re:Online play by Xebikr · · Score: 1

      Hey! I am French, you insensibles motte!

  4. Damn! by mcgrew · · Score: 2, Funny

    Fragged by a rodent! Damned thing was camping, too, the bastard.

    1. Re:Damn! by moogied · · Score: 3, Interesting

      I'd be interested to see what would happen if they provided some kind of negative feedback to the mouse when a player shot it, and then just let them run rampant in there. I'd imagine mice would have a far better reaction rate then people in it.

      --
      So basically, -1 troll/offtopic is really slashdots way of saying "I hate that you thought of something before me."
    2. Re:Damn! by Hadlock · · Score: 1

      I was thinking something along the same sort of lines; there's no force feedback (tactile feeback/negative feedback) for when he runs into stuff. I would like to see how the neuro-map for a mouse just being placed into the simulator looks compared to a mouse who spent his whole life "on the ball". I bet my brain's neuro-map looks a lot different when I'm playing TF2 compared to when I'm mountain biking or paintballing.

      --
      moox. for a new generation.
    3. Re:Damn! by Miffe · · Score: 5, Funny

      They need to hook it up to the device that gave mice orgasms at the push of a button, so that one frag is one orgasm. And then let them loose in quakelive.

    4. Re:Damn! by clone53421 · · Score: 3, Interesting

      Hmm, yeah, and they should train the mouse to fire the gun by rewarding it – first, make it find a target and operate the "gun firing" switch (whatever that is). Then train it to find a person and target them and "fire". Finally, put it up against armed opponents, give negative feedback if the mouse gets shot, and see what happens. Will the mouse go for positive feedback (by shooting opponents), will it hide/flee from the opponents (to escape the negative feedback it learns to associate with being shot by them), or will it be intelligent enough to create a new self-defense mechanism whereby it learns that by shooting the opponents before they can shoot it, it can both avoid the negative feedback and at the same time get positive feedback?

      --
      Alexander Peter Kristopeit bought his basement from his mommy for one dollar.
    5. Re:Damn! by Compuser · · Score: 2, Interesting

      Once you have these smarter mice identified, give them two guns and see if they learn to choose the right one for the situation.

    6. Re:Damn! by clone53421 · · Score: 4, Interesting

      I suspect learning to use the in-game offense/defense mechanisms would tax the mouse's brain far beyond its capacity already without adding the complexity of choosing between different weapons.

      Although that does make me think of another interesting thing. Mice are more of a foraging creature... they look for food and hide from predators, fighting back only when cornered. A FPS, on the other hand, lends itself to predatory tactics... seeking your prey and killing them without being killed by their defensive tactics. Is it even possible for a mouse to learn to exhibit predatory behavior using a reward system, if their prey tendencies to flee or hide are being simultaneously triggered as their target fights back? If a bunch of mice were put into such a simulation, would they all hide from each other? Would they actively seek and kill each other? Or would there be some of both, where some mice tended to behave in a predatory manner (aggressive personalities?) while others hid (passive/survival)?

      --
      Alexander Peter Kristopeit bought his basement from his mommy for one dollar.
    7. Re:Damn! by popeye44 · · Score: 1

      Nah, he was trying to find out Who Moved His Cheese.

      --
      Inane Comments are Generously Disregarded
    8. Re:Damn! by xyph0r · · Score: 0

      If a bunch of mice were put into such a simulation, would they all hide from each other? Would they actively seek and kill each other?

      This is beginning to sound like Battle Royale! What'd be interesting is to hook a more predatory creature up to this system. Give them the same reward system as the mice, and see how much the outcome in the game mimics nature.

      --
      SQL programmer goes to a bar. Walks up to two tables and says 'Excuse me, may I join you?'.
    9. Re:Damn! by clone53421 · · Score: 1

      Yup, that would be the next logical step.

      P.S. the sig made me LOL. :)

      --
      Alexander Peter Kristopeit bought his basement from his mommy for one dollar.
    10. Re:Damn! by Chris+Burke · · Score: 4, Funny

      Um... Squeak?

      --

      The enemies of Democracy are
    11. Re:Damn! by X0563511 · · Score: 1

      These are some truly interesting conjectures...

      I hope someone with the grant money (or BS abilities to get some) and the expertise sees this.

      --
      For large sets, this will be our guide even unto death, for the LORD will work for each type of data it is applied to...
    12. Re:Damn! by izomiac · · Score: 4, Funny

      There's no way this would fly with animal rights. So it'd probably have to be done in China... prompting the question, which rodent is most efficient at gold farming? My bet would be on squirrels.

    13. Re:Damn! by montibbalt · · Score: 1

      This sort of sounds like the text file explanation of some of the characters from the first Quake, who had a similar device embedded in their brains.

    14. Re:Damn! by flyingsquid · · Score: 2, Interesting
      Mice are more of a foraging creature... they look for food and hide from predators, fighting back only when cornered. A FPS, on the other hand, lends itself to predatory tactics...

      The implication is that cats would be better FPS players than mice. The problem of course is that cats are sit-and-wait predators, sitting quietly and waiting for their prey to move before suddenly striking. In other words, campers. So playing on a server against a bunch of cats would probably suck. Dogs, which are pursuit predators, would be probably be better opponents. Probably better at playing cooperatively as well, given the pack mentality.

    15. Re:Damn! by Anonymous Coward · · Score: 0

      Well, if you can figure out how to connect a shrew to this thing... Good luck with that!

    16. Re:Damn! by Anonymous Coward · · Score: 0

      Better hope they aren't fighting ermines.

    17. Re:Damn! by Anonymous Coward · · Score: 0

      Don't underestimate mice, as far as i know they only let us believe that they are stupid. It is the most intelligent species on earth, followed by dolphins and than we, the humans.

    18. Re:Damn! by Follier · · Score: 1

      A FPS, on the other hand, lends itself to predatory tactics... seeking your prey and killing them without being killed by their defensive tactics.

      The only reason we see it as a hunt and kill experience is because we're pretending it is. For us, the toons are people, and we are "shooting" them with "guns".

      For a mouse, the toons are just colorful moving things. This would be no different than the "find the lever, hit the lever, get the cheese" exercise, for which they evidently have no aversion. Although, I haven't seen one of those experiments with a moving lever, so maybe I'm wrong.

    19. Re:Damn! by clone53421 · · Score: 2, Interesting

      That's the key, though... what you described is exactly a "foraging" tactic. Find the lever, hit the lever, get the cheese.

      When the toon is able to interact with the mouse in a negative way (unpleasant) in addition to a positive way (pleasant), it's no longer just a maze or puzzle to solve. That's what would be so fascinating: would the mouse have the intelligence to plan and attempt to get the positive stimuli (reward) while avoiding the negative stimuli. (What you mentioned – the "target" is moving – is another point of interest, to be sure, but I'm more fascinated by the fact that it has both positive and negative associations to the mouse.)

      It's sort of like the whole clever mouse vs. mousetrap thing. Is the clever mouse actually able to figure out how to get the bait without springing the trap? It's probably more sheer luck... the mouse is either lucky or it's dead, which doesn't lend itself to learning from mistakes. An immediate-feedback, non-lethal yet still unpleasant stimulus is much more interesting, because then we can see how the mouse learns and, in particular, how it reacts to a "lever" which is directly associated with both reward and discomfort.

      A mouse that ends up either happy or unhappy is a whole lot more interesting to do follow-up research on than a mouse that is either happy or dead. Did it learn anything, and how will it react next time? Will it react so as to try to get the ideal outcome, or merely in the interest of avoiding the negative one?

      --
      Alexander Peter Kristopeit bought his basement from his mommy for one dollar.
  5. Quad Damage by uncleroot · · Score: 1

    In this week's issue of Nature, scientists from Princeton University confirm pleasure centers of mouse brain lights up after grabbing the Quad Damage jumping off the platform, spin 180 degrees and rockets his opponent who explodes in a mass of flying bloody chunks. Film at 11.

    1. Re:Quad Damage by DaedylusSL · · Score: 1

      I don't know about mice, but I can easily picture my cats learning to do that. Scary, psychotic animals...

  6. 270 FOV by jgtg32a · · Score: 1

    Damn that would be awesome to have when playing Quake

    1. Re:270 FOV by foxx1337 · · Score: 1

      I believe that's technically impossible with BSP (which is being used in quakes, at least in those before Quake 4).

  7. How many roads must a man walk down? by domatic · · Score: 2, Funny

    Great. Now I have to worry about getting pwned by Frankie and Benjy.

    1. Re:How many roads must a man walk down? by Anonymous+Monkey · · Score: 2, Funny

      Our whole planet has already been pwned by Frankie and Benjy.

      --
      We are the Borg...
    2. Re:How many roads must a man walk down? by mcgrew · · Score: 1

      I don't know, I'd rather be fragged by a couple of hyperintelligent pan galactic beings than some snotnosed 12 year old human.

    3. Re:How many roads must a man walk down? by MistrX · · Score: 1

      If they can have Quake in their brain, I want to have mice in my Quake!

      I rooting for the mice launcher and the BMG10k!

  8. mice or men by ZenDragon · · Score: 5, Insightful

    I invision an army of mice farming gold in World of Warcraft, we could do it even cheaper than the Chinese!

    1. Re:mice or men by Yvan256 · · Score: 1

      "Hey look, CHEESE DEPOSITS!" - Mouse farmer #5482390.

    2. Re:mice or men by Clandestine_Blaze · · Score: 2, Funny

      Naw, they'll be too busy raiding the cheese shop in Stormwind.

    3. Re:mice or men by Geirzinho · · Score: 1

      I thought the mouse army was Chinese...

    4. Re:mice or men by BobMcD · · Score: 3, Funny

      If it was virtual cheese they were after, they'd need look no farther than these jokes, I think.

    5. Re:mice or men by Lotana · · Score: 1

      A shame that no one got the reference.

      Diamond Age if my memory serves me right.

    6. Re:mice or men by sixsixtysix · · Score: 1

      led by mouse zedong?

      --
      ...
  9. Oh great by davidbrit2 · · Score: 5, Funny

    Catching mice that get in my house is enough of a pain, but now I have to snag the bastards while they're rocket jumping? Thanks, jerks.

    1. Re:Oh great by Darth_brooks · · Score: 1

      Just fix your cursor on the apex, time their jump, and rail them. That's what I do. I'll grant you its a bit of a mess to clean up, but it's better than my experiments with rockets.

      Splash damage takes on a whole new meaning when you start spending the majority of your income on aluminum-based solid rocket fuel, semtex, and lots and lots of paper towels.

      --
      There are some people that if they don't know, you can't tell 'em.
    2. Re:Oh great by mcgrew · · Score: 4, Funny

      Catching mice that get in my house is enough of a pain

      Christ, now even my cat is posting on slashdot.

    3. Re:Oh great by Chees0rz · · Score: 1

      just make sure they didn't throw down a grenade for extra height, or they could be camping for a lonnnng time.

    4. Re:Oh great by Anonymous Coward · · Score: 0

      On the internet, nobody knows if you're a cat.

    5. Re:Oh great by Hurricane78 · · Score: 1

      Well, that's what you get for not letting him have "cheezburger"!

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
  10. Open Source Helping Humanity by Satanboy · · Score: 5, Interesting

    This is a great example of open source really helping humanity learn new and interesting things.

    It's great to see that the tools provided by open software can really help speed up research.

    I wonder what would happen if old versions of adobe photoshop, 3ds max, or cubase were left to open source for research purposes. What kind of discoveries would scientists make with programs like these?

    1. Re:Open Source Helping Humanity by Korin43 · · Score: 2, Insightful

      They'd discover that the total size of all bittorrent swarms has suddenly decreased ;)

    2. Re:Open Source Helping Humanity by Brian+Gordon · · Score: 1

      I wonder what would happen if old versions of adobe photoshop, 3ds max, or cubase were left to open source

      Probably not much.. Id released an engine to build on while those are just products. Old products that have better free alternatives, at that.

    3. Re:Open Source Helping Humanity by interkin3tic · · Score: 1

      I wonder what would happen if old versions of adobe photoshop, 3ds max, or cubase were left to open source for research purposes. What kind of discoveries would scientists make with programs like these?

      The photoshop alone would lead to a wave of discoveries. Some of the discoveries might even turn out to be real!

      (like as in not just photoshopped "that cell should be red to support my hypothesis so I'll just use a little filter action...")

    4. Re:Open Source Helping Humanity by 4D6963 · · Score: 1

      Given how little Photoshop has actually evolved in the last decade, and the excitement generated by Photoshop, it would undermine GIMP, create a project dedicated to improving the old Photoshop and ultimately it would give Adobe a free competitor to Photoshop that's nowhere near as bloated and probably better.

      People keep telling me that I should have an open source scheme for my program (see Homepage link) but yeah, all it would do would help people make a free competitor. See it's fine to do it with a game because to Carmack what sold Quake 2 was the content (which is still not free), not the engine. Open sourcing an entire program isn't the same thing, as you give it all away.

      --
      You just got troll'd!
    5. Re:Open Source Helping Humanity by earthbound+kid · · Score: 1, Insightful

      Helping humanity, needlessly torturing mice.

      Seriously, what did they really learn from this? The benefit to humanity here is disproportionately less than the cruelty involved. It just seems like an excuse to play around with Quake because "dude, wouldn't it be cool if we could train our mice to play?" I wouldn't let anyone involved in this kind of experiment date my sister.

    6. Re:Open Source Helping Humanity by Chris+Burke · · Score: 3, Funny

      Seriously, what did they really learn from this?

      They learned about brain structure and relationships between cognition and motor control.

      You may not think that's worth it, but we've done a lot worse to mice than non-lethal brain surgery in order to learn a lot less.

      I wouldn't let anyone involved in this kind of experiment date my sister.

      *puts down bouquet of flowers, scalpel, and bundle of electrodes*

      Man, you're no fun.

      --

      The enemies of Democracy are
    7. Re:Open Source Helping Humanity by icepick72 · · Score: 1

      Um... I haven't made up my mind yet. Can you post a picture first?

    8. Re:Open Source Helping Humanity by Larryish · · Score: 1

      Yeah, I wouldn't let him date my sister either.

      No telling what the sick bastard would do if he had a cardboard tube.

  11. Free information by Dripdry · · Score: 5, Insightful

    Someone is likely to say it, so I will:

    This is what happens when you have a free flow of information. Carmack got well paid for Quake 2 then opened the source up (eventually). If more people/institutions/corps did this it seems there would not only be more hearts and flowers (for all the open source hippies) but there would be MORE technology we could patent! The ability to make MORE money!

    If I have 2 innovative products and I decide to open them up to general use, and at least 1 new idea comes from that, someone out there will create something with it and hopefully create a net gain for the system as a whole in the long run.

    I know people are selfish, but for Science's sake, open up your information already! The economy is dying a slow, painful death (though the market might refute that this week), wouldn't the SOLUTION in The States be to repeal some copyright laws and let information flow freely so as to foster innovation like this? Even if it's a mouse on a ball in a hall at the mall, I have to believe only good could come from opening things up a bit more.

    --
    -
    1. Re:Free information by Anonymous Coward · · Score: 0

      The economy is dying a slow, painful death (though the market might refute that this week),

      I'd hate to break it to you, since you're trying really hard to sound all doom and gloom, but the market has been recovering for quite some time now. It bottomed out at 6 or 7k (Dow jones) and it's hit 10k recently. That's from it's ultimate peak of 14k before the implosion.

      It didn't jump 3-4k in 1 week.

      That's all I'm saying. Though, I do have some speculation to believe this is yet, another bubble. A mini-bubble, but a bubble.

    2. Re:Free information by CannonballHead · · Score: 1

      The economy is dying a slow, painful death (though the market might refute that this week), wouldn't the SOLUTION in The States be to repeal some copyright laws and let information flow freely so as to foster innovation like this?

      That kinda depends on what you mean, doesn't it? I'm not sure most software companies will be making too much money selling free software, which in turn won't help the market too much, I wouldn't think. Or maybe you meant to let "old" information flow freely, like Quake 2. That'd be different...

    3. Re:Free information by Anonymous Coward · · Score: 0

      I think if there was no open-source engine available, they would just have hired someone to develop a primitive engine ;).

    4. Re:Free information by lgw · · Score: 1

      Market != economy. It's not certain the economy has yet found bottom - there are some encouraging signs, but of course the goernment can destroy anything (and they seem keen to).

      --
      Socialism: a lie told by totalitarians and believed by fools.
    5. Re:Free information by PrimaryConsult · · Score: 1

      If this is true, then this is what will happen: -China disregards patents
      -China creates better technology than the US (and the rest of the world)
      -out of necessity to remain relevant, US (and other) Patent Systems are redesigned.

      I read somewhere [citation needed] that Japanese companies are preparing for this eventuality by focusing brand recognition/loyalty tactics on children, as when they become adults the companies will no longer have the quality advantage.

  12. What are we going to do today, Brain? by Jeremi · · Score: 3, Informative
    1. Train mice on Quake 2 until they are really good at it
    2. Outfit mice with miniature rocket launchers and rail guns
    3. Turn the armed mice loose
    4. Rule the world!
    --


    I don't care if it's 90,000 hectares. That lake was not my doing.
    1. Re:What are we going to do today, Brain? by Dripdry · · Score: 1

      You forgot the "5. Profit" motive. This is a capitalist sector you're in, don't forget.

      --
      -
    2. Re:What are we going to do today, Brain? by El+Torico · · Score: 2, Funny

      I was thinking something different -

      4. Pay per view!

      or maybe -

      4. UMFC (Ultimate Mouse Fighting Championship)

      --
      In the land of the blind, the one-eyed man is usually crucified.
    3. Re:What are we going to do today, Brain? by SnarfQuest · · Score: 1

      In the next version they are going to use sharks, with lasers.

      --
      Who would win this election: Andrew Weiner vs Andrew Weiner's weiner.
    4. Re:What are we going to do today, Brain? by EkriirkE · · Score: 3, Funny

      Pinky! Are you thinking what I'm thinking?

      --
      from 09 F9 11 02 9D 74 E3 5B D8 41 56 C5 63 56 88 C0
      to 45 2F 6E 40 3C DF 10 71 4E 41 DF AA 25 7D 31 3F
    5. Re:What are we going to do today, Brain? by Anonymous Coward · · Score: 1, Informative

      Are you pondering what I'm pondering?

    6. Re:What are we going to do today, Brain? by BobMcD · · Score: 1

      I heard Michael Vick already has one of those set up in his new home in Philly.

    7. Re:What are we going to do today, Brain? by EkriirkE · · Score: 1

      D'oh! :(

      --
      from 09 F9 11 02 9D 74 E3 5B D8 41 56 C5 63 56 88 C0
      to 45 2F 6E 40 3C DF 10 71 4E 41 DF AA 25 7D 31 3F
    8. Re:What are we going to do today, Brain? by rikkitikki · · Score: 2, Funny

      Umm, I think so Brain. But why do we need polka dotted pants at a lan party? Narf!

    9. Re:What are we going to do today, Brain? by Anonymous Coward · · Score: 0

      Um... I think so, Brain, but what if the chicken won't wear the nylons?

    10. Re:What are we going to do today, Brain? by Anonymous Coward · · Score: 0

      Now imagine robots 8 feet tall with a neutron laser operated by mice inside them. We'll make billions on the intergalactic arms market!

  13. Scientists Scan the Brains of Mice Playing Quake by abbynormal+brain · · Score: 0

    ... and find they are equivalent to the brains of humans who play Quake.

    --
    L'esperienza de questa dolce vita (The experience of this sweet life) - Dante Alighieri, The Divine Comedy
  14. Further evidence FPS are best played with a mouse by Saishuuheiki · · Score: 5, Funny

    Beats a console controller any day, even lab scientists agree

  15. Hmm.... by Anonymous Coward · · Score: 1, Interesting

    Human controlling fighter jet in fighter jet.
    Human controlling fighter jet in console type game system.
    Mice controlling console type game system.

    Is no-one else seeing the dangerous possibilities?!

    1. Re:Hmm.... by kalirion · · Score: 1

      Yeah, these mice will put our CHAirForce pilots out of work!

  16. Frame rate? by 192939495969798999 · · Score: 2, Interesting

    So what was the frame rate on the mouse's brain? Could it run crysis/linux?

    --
    stuff |
    1. Re:Frame rate? by ZERO1ZERO · · Score: 1
      Could it run crysis/linux?

      Yes, but it could not manage Vista.

  17. Mice playing Quake, huh? by Anonymous Coward · · Score: 0

    The sad part is that their scores are higher than mine

  18. Don't kid yourselves... by fahrbot-bot · · Score: 1

    No word as of yet whether the scientists plan on giving the mice control of the gun.

    ...they'll be training, I mean, "testing" sharks next.

    --
    It must have been something you assimilated. . . .
  19. Are you pondering what I'm pondering? by ehaggis · · Score: 1

    Gee, Brain, what do you want to do tonight?

    The same thing we do every night, Pinky—try to take over the world!

    --
    One ring to bind them - should probably have more fiber and less rings in their diet.
  20. Mice vs. Managers by DieselPup · · Score: 4, Funny

    They initially tried this study using managers, but there was no evidence that the managers were learning anthing or that they even perceived their environment

    1. Re:Mice vs. Managers by Follier · · Score: 1

      Having actually played my manager in Quake, I can confirm this.

    2. Re:Mice vs. Managers by DieselPup · · Score: 1

      Having actually played my manager in Quake, I can confirm this.

      Funny, that's what my staff said too.

  21. A few years into the future... by TheSpoom · · Score: 1

    The world was shocked today when the World Cyber Games championship was taken from fragu4life, champion for the last several years, by a newcomer, sirsqueaksalot. Information is sketchy as to the newcomer's origins, but it has been stated that he greatly enjoys cheese.

    News at eleven.

    --
    It's better to vote for what you want and not get it than to vote for what you don't want and get it.
    - E. Debs
  22. ZORT! NARF! ZOWIEE! by wowbagger · · Score: 4, Funny

    "Are you pondering what I am pondering, Pinky?"
    "I think so Brain, but how can I bunny-hop over the lava when I'm a mouse?"

  23. Cat and mouse quake version 2.0 by Anonymous Coward · · Score: 0

    Imagine if they gave it buttons to press, to fire a gun, plus some virtual cats to frag...

  24. Ideas by lymond01 · · Score: 2, Informative

    No word as of yet whether the scientists plan on giving the mice control of the gun.

    Just whisper this when you say it. Rodents have unnaturally good hearing.

  25. Nothing New by Anonymous Coward · · Score: 0

    Quake has had a mouse interface since it first came out. This is nothing new. And don't tell me to rtfa - I'm sure it won't tell me anything I need to know.

  26. Wonder whether John Carmack ever envisioned this by Anonymous Coward · · Score: 0

    "Wonder whether John Carmack ever envisioned this"

    Obviously he did:
    http://www.youtube.com/watch?v=5wh3g0NJWUE

  27. 270 FOV - tried & tossed by dazedNconfuzed · · Score: 1

    Early versions of Doom included the ability to link 3 PCs and use their monitors for left/front/right displays. Pity it was dropped.

    --
    Can we get a "-1 Wrong" moderation option?
    1. Re:270 FOV - tried & tossed by EdtheFox · · Score: 0

      What? So you could have really shitty graphics on three monitors instead of just one? I'm glad they dropped it!

  28. They're waiting for you. In the TEST CHAMBER. by reverseengineer · · Score: 5, Funny

    The researchers originally wanted to use Half-Life instead of Quake 2, but they could never get the mice to do anything in the game other than murdering the scientists.

    --
    "FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
    1. Re:They're waiting for you. In the TEST CHAMBER. by BOFslime · · Score: 1

      Half-Life did use the Q2 engine.

    2. Re:They're waiting for you. In the TEST CHAMBER. by megamerican · · Score: 2, Informative

      Half-Life did use the Q2 engine.

      It actually used the Quake engine which was modified with some parts of the Quake2 codebase. The modified Quake engine was known as Quakeworld.

      http://developer.valvesoftware.com/wiki/Quake_Engine_Hierarchy

      --
      If you have something that you dont want anyone to know, maybe you shouldnt be doing it in the first place -Eric Schmidt
    3. Re:They're waiting for you. In the TEST CHAMBER. by Anonymous Coward · · Score: 0

      No, VALVe's version was known as goldsrc.

  29. Rats by hoggoth · · Score: 5, Funny

    Just thought I'd point out that
    despite all my rage, I am still just a rat in a cage.

    --
    - For the complete works of Shakespeare: cat /dev/random (may take some time)
    1. Re:Rats by Anonymous Coward · · Score: 0

      Well played, sir. Well played indeed.

    2. Re:Rats by Anonymous Coward · · Score: 0

      the article was about mice.

      not funny

  30. When Sips Of Water Are A Reward by Anonymous Coward · · Score: 0

    It's too bad that the whole God/Satan/Heaven/Hell thing isn't true, 'cause I'd get some small amount of satisfaction at seeing what is done to people behind experiments that involve depriving critters of fucking water. Science is cool and all, but we're all sentient creatures and no species has a monopoly on feeling thirst and hunger and fear and warmth and happiness.

    1. Re:When Sips Of Water Are A Reward by 4D6963 · · Score: 1

      Oh noes, thirsty insects, teh horror! Unrelatedly today I've squished 4 insects before breakfast.

      --
      You just got troll'd!
    2. Re:When Sips Of Water Are A Reward by Anonymous Coward · · Score: 0

      Oh noes, thirsty insects, teh horror! Unrelatedly today I've squished 4 insects before breakfast.

      Squished any rats? How about cats? Ever made dehydrated doggies do tricks to earn water? Squished any monkeys? Inserted any needle probes into primate brains? Have you ever withheld water from a person? Ever squished a person? What's the "highest level" of creature that you can make fun of feeling empathy toward before it starts feeling uncomfortable? Oh noes! :D

    3. Re:When Sips Of Water Are A Reward by 4D6963 · · Score: 1

      Insects. That's the line.

      --
      You just got troll'd!
    4. Re:When Sips Of Water Are A Reward by Fantastic+Lad · · Score: 1

      Nicely put.

      Tom Brown Jr. told a story about how his grandfather sent him off to hunt and kill a deer, but told him he wasn't allowed to take a bow & arrow, which he explained was too impersonal. He had to use a knife. So off into the woods he ventured, carrying no food. Only a knife.

      He found a group of deer, stalked them and learned their patterns. The deer were very aware of him because they are deer, and after a week or so, they had accepted them into their environment. He picked out his target; a baby deer with a gimpy leg which would not survive well on its own. When the time came, (he was beginning to starve at this point), he walked up to it and it didn't run away because it had accepted him as part of the herd, --which wasn't far from the truth both physically and emotionally. He looked into its eyes and killed it with his knife. He reported that it felt like killing his brother.

      Because Tom Brown Jr. is not a psychopath or a coward, he was wracked with tears and confusion and shame while he carried the animal back home. His grandfather met him and said,

      "Very good. Now, when you can connect that way with the smallest blade of grass, you will have learned."

      We have to kill in order to live here in this reality. There's simply no getting around that. It's the awareness and intent we kill with that matters in the end. Many try to hide their souls away from this question because it can hurt. But until these basic lessons are learned, we remain in kindergarten, lying to ourselves. There are a lot of souls which will be returning to this world for more fire and pain until they figure this stuff out.

      Just my opinion.

      -FL

    5. Re:When Sips Of Water Are A Reward by Anonymous Coward · · Score: 0

      Insects. That's the line.

      Observe them for awhile, and you will see that they feel thirst and hunger and react to danger too. Then see if you can figure out why insects is your line.

    6. Re:When Sips Of Water Are A Reward by 4D6963 · · Score: 1

      Oh shut up, you spider hugger lol.

      --
      You just got troll'd!
  31. Acknowledgements by interkin3tic · · Score: 2, Interesting

    If anyone is wondering, the authors did thank Carmack and id software:

    Acknowledgements We thank E. Chaffin for help with mouse behaviour,
    J. Carmack and id Software for providing the Quake2 code

  32. I wonder if they've realized... by space_jake · · Score: 1

    They can get there faster by bunny hopping.

  33. Teach them to play CTF! by Anonymous Coward · · Score: 0

    It would be cool to play against a mouse. I wonder if they could navigate q2ctf1 (my favorite map).

  34. New definition by SnarfQuest · · Score: 2, Interesting

    Gives you a new definition for a head mounted display.

    --
    Who would win this election: Andrew Weiner vs Andrew Weiner's weiner.
  35. Explains a lot by Darth_brooks · · Score: 3, Funny

    I wondered why the last arena I logged in to had the quad damage replaced by a wheel of cheese, and why the rocket pickups were shaped like little smudges of peanut butter.

    --
    There are some people that if they don't know, you can't tell 'em.
  36. I for one... by Q-Hack! · · Score: 0, Redundant

    I for one, welcome our new virtual mice overlords.

    --
    Some days I get the sinking feeling Orwell was an optimist.
    1. Re:I for one... by Anonymous Coward · · Score: 0

      Pinky: Gee, Brain, what do you want to do tonight?

      Brain: The same thing we do every night, Pinky - try to take over the world!

  37. Not used to it by Anonymous Coward · · Score: 0

    I'll never will get used to "YOU HAVE LOST THE LEAD" phrase in Quake. Now to be beaten by a mouse... I... I... *sniffs*

  38. Now thats a by harris+s+newman · · Score: 1

    real gaming mouse

  39. Mice? try hyperintelligent pandimensional beings by kipling · · Score: 2, Funny

    Mice already know how to interface with computers, having built the greatest computer in all space and time. The mice are running this quake experiment just so that they have a bit of fun "decommissioning" the hardware later.

    --
    -- open source? sounds like the real book --
  40. Re:Mice? try hyperintelligent pandimensional being by aicrules · · Score: 2, Funny

    I'll take a computer than runs Quake 2 at a reasonable 60 fps over a computer that takes millions of years to say "42".

  41. And what do the mice use to study hoomans? by sgt_doom · · Score: 1
    Late breaking news: Mice researchers use Internet Porn to study brains of humans.

    Squeeked one Mice professor, "This humans have seem pretty drecky thoughts tumbling around in their little minds."

  42. Re:Mice? try hyperintelligent pandimensional being by meringuoid · · Score: 1
    Mice already know how to interface with computers, having built the greatest computer in all space and time.

    Nonsense. The mice just paid for it and operated it. The second greatest computer in all time and space designed it, and the Magratheans built it.

    --
    Real Daleks don't climb stairs - they level the building.
  43. So they've taught a mouse to play Quake... by deadhammer · · Score: 1

    But can they teach a robot to love?

    --
    I'll be honest, we're throwing science against the wall to see what sticks. -Cave Johnson
  44. forget Virtual Reality... by Cycon · · Score: 2, Interesting
    ...they need to hook up the screen to a camera feed from the flying beetles earlier this month.

    Let the mice steer the beetles!

    --
    Your Brain + EEG + LEGO Robots = Brainstorms
  45. VIDEO??!?? by teh_commodore · · Score: 0

    Dear God there MUST be video of this.

    --
    --"insert clever quote here"
  46. That just seems sick. by tjstork · · Score: 1, Troll

    I'm no PETA person, by any stretch of the imagination, but, I think some of these experiments they perform on animals are barbaric.

    --
    This is my sig.
    1. Re:That just seems sick. by Anci3nt+of+Days · · Score: 3, Interesting

      Care to volunteer for open brain surgery instead?

    2. Re:That just seems sick. by Fantastic+Lad · · Score: 1

      Care to volunteer for open brain surgery instead?

      It's all about intent. Researchers who study living systems by killing and mutilating other creatures without awareness and compassion do so at their own expense. I've met researchers who kill animals without having adequately made peace with themselves or the creatures involved. Instead, what often occurs is that they shut parts of themselves off and try to believe that "it's all for the greater good", (usually a lie). Some are better at convincing themselves of this than others. The ones who break down after ten minutes of discussing the problem have souls which are either budding or which have not yet been killed off. Those who do not are very often living in a self-delusion which carries a price.

      All costs are tallied and will be paid back regardless of what people believe in the present moment. What comes around goes around.

      Behaving with stupidity and barbarism is like buying on credit.

      -FL

  47. When do we set them to work for the Air Force? by Anonymous Coward · · Score: 0

    These mice would make excellent drone pilots. Heck, you could even not have to worry about remote piloting, just wire them into the drones themselves and we can have our first cyber-rodent assault force.

    We'll seperate the REAL mice from the men!

  48. Rise of the triad (ROTT) by Anonymous Coward · · Score: 0

    Someone needs to dig up the old "Dog Mode" in the old 3d shooter Rise of the Triad.

    Ho hum. Its been done.

  49. Upcoming arcade game... by Samah · · Score: 2, Funny

    Konami presents: "Quake Quake Revolution", coming to a mouse-accessible game arcade near you!

    --
    Homonyms are fun!
    You're driving your car, but they're riding their bikes there.
  50. what i'd like to know is... by yanyan · · Score: 1

    How do i disable that fucking live twitter feed on the right? I clicked on the link to read a Wired article, not listen to random dumbasses whining!

  51. Another dangerous, dumb ape with a uni-perspective by Fantastic+Lad · · Score: 1

    How do i disable that fucking live twitter feed on the right? I clicked on the link to read a Wired article, not listen to random dumbasses whining!

    Actually, on any given screen other than your own, you appear as a random dumb-ass. And gee, you are also whining. --About a non-issue as it happens. If you want to insulate your precious self from the outside world, then it's entirely possible to do this by configuring your browser accordingly.

    Just a few thoughts for you to consider. --If indeed you have the brain tissue required for such a feat. Which is very doubtful.

    -FL

  52. To quote a Q2 Space Marine... by EricTheO · · Score: 1

    "It hurts make it stop!"

    --
    -Eric
  53. BFG by Anonymous Coward · · Score: 1, Funny

    I know this map.

    The mouse is running straight for the BFG (Big F**** Gouda)

  54. I didn't think mice could see in 2D ... by Anonymous Coward · · Score: 0

    Remember in Turner and Hooch when Turner wants Hooch to ID the perp with a photo and the trainer is like .. "Dogs don't see in two dimensions".. All the science I know I learned from Tom Hanks movies, therefore this article is completely false.

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  56. Doesn't anybody realize.... by pinkushun · · Score: 1

    .. that this is how Skynet is born?

  57. Anonymous Coward by Anonymous Coward · · Score: 0

    Well, I think the controller is quite ingenious. A styrofoam ball suspended by air to create a multi-directional treadmill. Give a person something to hold on to and a VR helmet, and you have a pretty cool gaming experience.

  58. You know, by King+Coopa · · Score: 1

    I find it amazing that not only has id's game engines been played on more platforms than any other, but is now being played by different species!

  59. I wonder what Summer will do to Eliza? by Impy+the+Impiuos+Imp · · Score: 1

    John Carmack immediately altered the map to put in knee-high obstacles. The mouse protested, saying, WTF why can't I jump over that low thing?!? Carmack was quoted as saying, "We need to put in things to overcome as part of the fun."

    --
    (-1: Post disagrees with my already-settled worldview) is not a valid mod option.
  60. obligatory overlords comment by Anonymous Coward · · Score: 0

    Seeing as no one has done it yet...

    I for one welcome our virtual mouse overlords.

  61. That's a might makes right argument by tjstork · · Score: 1

    Care to volunteer for open brain surgery instead?

    Your argument is might makes right. Because you are stronger than someone else, and need something exploitation would provide, that exploitation is ok.

    --
    This is my sig.