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Sequencing the Weed Genome
GNUman writes "Maybe soon we'll be able to genetically modify humans so that a specific action (e.g., tapping your nose, pinching your ear) triggers the release of THC directly from your own cells. From the Nature blog post: 'At last, the field of genomics has something to offer Cheech and Chong. DNA sequencing hit a new high last night with the midnight release of the Cannabis sativa genome. The raw sequence was posted on Amazon's EC2 public cloud computing service by a young company called Medicinal Genomics, which aims to explore the genomes of therapeutic plants.'"
I fucking hate potheads. Somebody needs to make a version of weed that causes cancer.
i know i wish i could get natural cbd's to treat arthritis without messing up my mind.
Don't complain about syntax, grammar, or spelling. There is no.hell like input on android.
with the Opera gestures.
Hold your arm and move to the right for the next high.
Boss coming? Minimize: down and then left.
I'm not a lawyer, but I play one on the Internet. Blog
DNA sequencing hit a new high last night ...
I don't like it.
signature is pants
Now all we need is for someone to take an existing food plant that is legal to grow (and that couldn't be banned) like corn and add some weed genes so that when its consumed, it gives the effects of weed (i.e. make the corn contain the THC and things that the weed contains)
No way for the cops to detect it short of chemical analysis and there is far too much corn grown in the US to make that possible.
Right, because what humanity really needs right now is the ability for the next generation to get high, whenever they want, from birth. It'd be like masturbation, but only this time it would actually affect brain development and social ability. In any case, I didn't see anything in the primary article relating to a connection between some sort of kinesthetic macro-action and THC release, so I don't see why it's included in the summary. Yay for decriminalization, but at least with smoking it there's some sort of limitation relating to resource production and regularity of use.
I'm not reading "high times", I'd rather not see this sort of junk.
PS: I don't reply to ACs.
Is Dave there?
what I can and cannot put in my body.
It's not your fucking business, or anybody else's.
Take the goddamn safety labels off of everything, for fucks sake.
Add it to yeast. Houblon or Sugar + Yeats = Mari jeanne. And you don't need a field.
C. Sagan : A demon haunted world:
http://www.amazon.com/gp/product/0345409469/
visit randi.org
Unfortunately, I foresee a new kind of prohibition. How long before the US Congress legislates to make a gene illegal?
once cannabis can be re-engineered for maximum potency, it can become the new self-perpetuating crack
Does this mean Kona Gold and Maui Wowee is bk? Cool Bro, sign me up!
"Computers are a lot like Air Conditioners" "They both work great until you start opening Windows"
It's not true, of course - but even if it were, they'd just ban all oranges, like they did to hemp cloth.
Quidquid latine dictum sit, altum videtur
1.) They are certain that heredity is solely controlled by genes.
2.) They are certain that DNA is the sole mechanism for passing on genes.
3.) That looking at DNA sequences is a productive method of finding causes of things.
Personally I believe that they are uncertain in (1), uncertain in (2) and that (3) is not true. DNA is a waste of time with regards to 99.99999% of human behaviour.
John_Chalisque
I just can't help myself.
Ontopic (sort of), and funny, IMHO.
Real, or not, still funny.
Down With Slashdot BETA!!! I've been around the corner and seen the oliphant; you can only abuse me from your perspecti
4:20 was four and a half hours ago, man. it's almost 8:21...roll another one!
French fries would be better.
sysadmins and parents of newborns get the same amount of sleep.
Pretty damn anonymous too...
http://bitcoinpyramid.com/r/472
Then he can Bogart the weed with out actually bogarting the weed.
General Relativity: Space-time tells matter where to go; Matter tells space-time what shape to be.
I want to inform you that all the real smokers already know that Nate Dogg was passing nuthin but dope indeed.
could this be a "gateway" to the falsely promised "science over ideology?"
That's what you take to prevent malaria! Nothing to do with cannabis.
CLC work was performed on a 64Gb RAM MacPro with 6.5Tb of Disk and 12 hyperthreaded Cores (24 threads total).
I looked at the README and cringed. These are really top-notch scientists, though they can't even get their (b)its and (B)ytes correct.
Going by what they said, the setup had 8GB RAM with 812.5GB of disk.
I hope that they don't mix up other measurements like this!
I think this argument that something is worth taking because it is 'natural' is a weak position, not well though out. There are a lot of things out there that occur naturally but are downright poisonous and will kill you. There are many synthetic products that are really helpful. I'd like to see a more rigorous discussion of the difference between 'natural' and 'unnatural/synthetic'. I have this suspicion that there are many borderline products and preferring 'natural' is just a psychological position that comforts people rather has medical benefits. Interested to hear further evidence....
Glanding?
Watch this Heartland Institute video
...And what about legal drugs?
Did you ever consider that there are legal drugs (meds) that are far worse for you -- amphetamines, strong narcotics (morphine) and other things -- than illegal things like cannabis?
Did you ever consider the fact that your own body produces cannabinoids? Those are called endogenous cannabinoids. Inhibiting their metabolism or their absorption/psychoactivity would mess up a lot of your bodily functions.
The world isn't as one-sided and simple as some self-centered assholes (ahem...) like to think.
http://www.youtube.com/watch?v=30ruBtLIvJM
for the next 5 years. j/k
but you realize, there are a huge number of unemployed biotech people who have started up their own 'DIY biotech' movement? they have 'hack spaces' but instead of soldering irons they have PCR machines.
Would this allow them to find a way to counteract the THC reaction? Two options off the top of my head:
1. The ability to turn off and stop the "high" affect
2. The ability to create a resistance to this affect.
What someone does in their own home is their own business as long as all present are willing and consenting. (apologies, trying to get this into a readable form, it is still early for me.) Plausible scenario, an individual is getting high and receives a call that their friend or family member was in an accident or some other tragedy. They are in a need to get to that friend/family member. If they could do something to suppress the high affect, they would have less "problems" getting to their friend. Full mental state to drive and make decisions. If pulled over for speeding, outside of smell, they would not give the officer reason to go through a drug check (other profiling withstanding). Arrival at location and the ability to hide the fact they were high from either authorities at the scene or family members who do not know of their hobby.
The ability for a government or group to create a way for THC to no longer be affective and the high affect will no longer be achievable. Therefore possibly eliminating a hobby that many groups see as evil/wrong/sinful. Possibly even breeding people to be immune to THC (yes, last sentence a longer shot, but who knows)
Any discussion on these questions?
...or hate them. Depends right?
Seriously, haven't you ever had a bad week? I have. Haven't you ever gathered with friends, looking for a evening of social antics? I have.
One of the basic, simple pleasures in this world is a nice buzz, and there are many different kinds, some good eats, entertainment, and friends. Have a nice long chat, tickle the senses, and just wash away lots of painful things for a while, happy to just be, love, do, share.
Anything good can be abused. That goes with simple food.
I like a nice high once in a while. Lots of ways to get it too. Write some brilliant code, skydive, pot, opiates (poppy tea is particularly nice), booze (hate it generally), etc...
Before you expound on "those illegal drugs", maybe you should consider more fully why some are illegal and some are not, plug that into your AM radio morals, and get back to me.
Blogging because I can...
The really interesting question is what the community will do with the data. First there's the problem of getting the data assembled. They should have the entire genome, they sequence 300x what they should have needed. Now that's all going to be random and in pieces though, so they've had trouble with a couple assemblers. This is the kind of thing that's done often though for other species, and should be doable with freely available tools.
Then, once you have the assembled contigs, you have to figure out what they mean. That means searching for open reading frames and then testing those for homology against known genes. THC acid synthase is already known, so that helps. But I don't think all the genes in the pathway are sequenced yet, so hopefully this helps nail that down.
Then what? Either extraction of that biosynthetic pathway into another system, or transgenic manipulation of the plant for better yields.
Give me Classic Slashdot or give me death!
Maybe soon we'll be able to genetically modify humans so that a specific action (e.g., tapping your nose, pinching your ear) triggers the release of THC directly from your own cells.
I will pick up a gun and fight in the streets to put a stop to that. Just letting you know.
Well It is legal here in COLORADO!
But yes, we are not hippie Calif. or Ohio Gangster that do not want legalization and cannot function without a nanny state..
God Bless america!
Name THC% CBD% CBN%
HYBRIDS
red island octopus 127.4 0.58 0.46
GreeninYellowzonker 138.8 0.29 0.21
Crampdown Racers 98.7 0.26 0.52
The internal synthesization of the cannabis chemicals would be a disaster for our country. Consider the revenue the government makes from tobacco. That in itself ensures that tobacco products will never be banned, and they are more destructive, more addictive than marijuana. It is only a matter of time before marijuana gets legalized and establishes another money cow for our government. Why, legalization of maryjane might even resolve our national debt issues and weaken organized crime. Don't any of our legislators have the balls to recognize this and propound legalization accordingly?
Urban legend. The scion of a grafted plant does not rewrite its DNA to match the rootstock. Hops grafted onto Cannabis rootstock is still hops and lacks the genes for Cannabinoid production.
But then again, science doesn't stand a chance against anecdotal evidence. /botanist