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'IMAX Movie of Body' Allows Stanford Geneticist To Stop Diabetes In Its Tracks
sciencehabit writes "Michael Snyder has taken 'know thyself' to the next level. Over a 14-month period, the molecular geneticist analyzed his blood 20 different times to pluck out a wide variety of biochemical data depicting the status of his body's immune system, metabolism, and gene activity. In yesterday's issue of Cell (abstract), Snyder and a team of 40 other researchers present the results of this extraordinarily detailed look at his body, which they call an integrative personal omics profile (iPOP) because it combines cutting-edge scientific fields such as genomics (study of one's DNA), metabolomics (study of metabolism), and proteomics (study of proteins). Instead of seeing a snapshot of the body taken during the typical visit to a doctor's office, iPOP effectively offers an IMAX movie, which in Snyder's case had the added drama of charting his response to two viral infections and the emergence of type 2 diabetes."
Let me know when they can stop, and reverse, Type 1.
...integrative personal omics profile (iPOP) because it combines cutting-edge scientific fields such as genomics (study of one's DNA), metabolomics (study of metabolism), and proteomics (study of proteins)
What's next, an analysis of one's feces--iPOOP?
How about IMAX?
Really neat stuff until the part where the massive testing had nothing to do with his diabetes control. Oh, and I am sure the idea of more testing in a medical-cost-cutting world is going to go over really well.
Slashdot headlines are getting pathetically lame. This kind of twisted deceptive word play is what I expect when I stand in line at the grocery store. Would it have been stooping so low to integrity to post
'IMAX Movie of Body' Allows Stanford Geneticist To See Type 2 Diabetes Progress Like Never Before
?
One man's pink plane is another man's blue plane.
iPOP? IMAX?! iCan't believe that someone iPosted this iCrap! The iAcronym seems a bit iForced for iPOP.
The guy tested his blood and found he was predisposed to diabetes. He changed his diet and hopes he can control diabetes. He did not stop diabetes. Soulskill needs reading classes.
Cell is published by Elsevier which has been in the news recently because of a boycott. A search provides http://www.guardian.co.uk/science/2012/feb/02/academics-boycott-publisher-elsevier I support the boycott.
I posted this for submission yesterday and it was declined. Its already old news by now.
And yes, I know this comment will be subsequently down moderated for saying this. So be it.
Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
So they took 20 blood tests over a 14month period and this is a big deal?
Constant monitoring could be the next big thing in medicine.
We currently diagnose based on discrete measurements compared with cutoffs - "averages" and numbers which are rounded to easily-remembered values. For example, Type-II diabetes is indicated when glucose is over 200mg/dl 2 hours after an oral glucose test. ...that seems like an awfully contrived number, simply because it's so easy to remember.
Instead of single point cutoff measurements, maybe we could get better diagnoses if we could see the change in values over time. Perhaps a more accurate diagnosis of diabetes would come from characterizing the slope of several months worth of glucose measurements.
With the rise of cheap microprocessors, I think there's a lot of opportunity for medical monitoring. Something like a wristwatch which records 10 types of measurements every hour. Of course I don't know how this could be done - perhaps spectroscopic measurements of reflected light through the skin, or terahertz wave reflections.
I've often wondered if it's possible to make a USB peripheral that records to a TI Chronos wristwatch for later display.
I bet there's lots of interesting features there just waiting to be discovered.
Interesting news article, but when I read at the end that he is creating his own startup (and the disclosure of the author), I get funny feelings about the research and read back in the article: no critics. There must be some critical information in the scientific publication, but this article reads like a readers digest. Such articles make people probably pull their wallets quicker I guess... [/rantmodeoff]
Slashdot: stuff for news, nerds that matter, matter for news, stuff that nerd
That's an illness that once cured will be missed.
Help stamp out iliturcy.
'IMAX Movie of Body' Allows Stanford Geneticist To See Type 2 Diabetes Progress Like Never Before
Stop with the IMAX. It's a stupid analogy (I know, not yours) and this is a tech site. Perhaps:
"Comprehensive time-series body data analysis sheds new light on Type 2 Diabetes Progression."
Next thing you know, they'll be changing the Big & Tall Section at the department store to the IMAX Clothing section. I wonder if attendance is down at real IMAX theatres since the brand's destruction.
My God, it's Full of Source!
OUTSIDE_IP=$(dig +short my.ip @outsideip.net)
Slashdot is sliding down the slippery slope of salaciousness that "The Register" regurgitates repeatedly! http://www.theregister.co.uk/
I, personally, like my headlines cut, dry, and factual. Reading "The Register" gives me a headache.
And who was mother to Cain and Able's children? This is what you want to stake your reputation on?
My God, it's Full of Source!
OUTSIDE_IP=$(dig +short my.ip @outsideip.net)
I work in the publishing industry for a small publisher.
I was at a convention several weeks ago and spoke with some people who worked for a subsidiary of Elsevier. As an aside, just like in other industries, the publishing industry conglomerates are GIANT. Beyond the science and medical journals that were involved in starting the boycott, Elsevier owns LexisNexis (synonymous with law databases and also a book publisher), Harcourt (fiction), Butterworth, and many more. They have gobbled up literally dozens of formerly independent publishers, and in general data and knowledge companies in all fields.
Anyway, the employees of this particular subsidiary said Elsevier was SEVERELY hurting because of the boycott. I was shocked... I had assumed the boycott would have minimal impact. These particular employees (again, not of Elsevier directly) were glad as they were fully aware of how expensive Elsevier journals are and how ridiculous Elsevier's links in to government are. One of them said basically that Elsevier had spent millions of dollars over the past 15 years to get exclusive rights to public domain research (link). Once they got it, the situation blew up and Elsevier backed off--waiting no doubt for people to forget.
This also goes to show how many of the individuals in a corporation can believe the "right" thing but that horrible leadership at the top is all that matters.
It's corporations like Elsevier that give ALL companies a bad name. I support the boycott.
FYI:
+ http://diabetes.niddk.nih.gov/dm/pubs/pancreaticislet/
Not problem-free, but some successor or spin-off might be, someday, if not now.
curing diabetics will also eliminate a whole lot of related ailments.
I think a big percentage of hospital visit can be avoided.
Let me short track this by saying it was all Hitler's fault.
Apple patent suite in 3 . 2. 1....
Then chow down on your Mac & Cheese with bacon. That will fix everything.
Help stamp out iliturcy.
The only difference are comments which I will never get to because the subject is so made up.
"Apple tree's fruit allows Cambridge physicist to discover the law of gravity"
I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
And who was mother to Cain and Able's children?
For the first 1650-odd years in the Bible's continuity, there weren't yet enough lethal equivalents in the gene pool for inbreeding to be a problem. After this, there was a great population bottleneck as a side effect of a divine intervention to flood the Nephilim off the face of the planet, and human life span declined sharply.
See also Dr. Fuhrman: http://www.drfuhrman.com/disease/Diabetes.aspx
"The vast majority of my patients, who adopt my nutritional and exercise recommendation for diabetes, become thin and nonâ"diabetic. They are able to gradually discontinue their insulin and eventually other medications. They simply get well. I work with people who have diabetes who want to live a long and healthy life and enjoy the achievement and confidence that they have control this disease. The membership services offered here on this website, and the information in my book, Eat For Health, can get you started on this road to wellness. My hope is that the information below about diabetes will enable you to feel more confident that you or someone you care about can be motivated and work with me to recover their health."
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
"eyelet transplantation" (ie, from a healthy donor, into a Type 1 Diabetes sufferer)
For the sake of helping any searchers not miss a load of references through searching on "eyelets" ....
These are "islets", not "eyelets", i.e. "Islets of Langerhans" (named for the scientist who first described them), they are little islands of special tissue in the pancreas gland, and they contain the beta-cells that normally make insulin, and in Type-1 diabetes they fail after attack by autoimmune processes. Their transplantation has been both promising and problematic, and as the parent post noted, tissue rejection problems have been met by immunosuppression.
-wb-
Interestingly I was reading an article a few months back about obese people undergoing gastric bypass. The report said something like 60 people were followed and 20 had diabetes. Strange thing is, as soon as the operations were over, the diabetes disappeared. Instantly. In all the diabetic patients. No one knows why.
Wuddooeyeno? IITYWYBMAD? Like nuts? eclecticallyincorrect.com
AC because of professional involvement.
No, continuous monitoring will not be the next big thing. The next big thing will be personalized medicine, in which a thorough analysis provides an insightful and predictive diagnosis, rather than broad sweeping categorization. There are probably 20-50 major categories of Type-2 diabetes, diagnosable via "integrated personalized 'omics" (their term), specifically metabolomics, so correctly identifying those categories will provide much more effective treatments.
Without getting into all the details, the field of metabolomics has existed to some degree for the last 30 years, and it is only within the last year that a company (Agilent) has made official forward progress towards certification of a metabolomics analytical tool as a medical device. They now have the first two steps in place: certified manufacturing facility and Class I Medical Device. Combine information like that, with publications like this one, and project like this personalized medicine in Luxembourg), and you can see that we're right on the cusp of being able to tell exactly how you're sick, and coming up with very targeted approaches to address illness.
There's a chance this might actually substantially reduce medical costs, in addition to provide orders of magnitude more information. The problem with current medical tests is that they're based on technology decades old: they're also highly specific in terms of design, and require a lot of sensitive reagents (coupled antibody-based assay). That makes them tough to design, produce, and store. In comparison many of these 'omics procedures are generic: we can extract with one protocol and use the extracted material to assay for 5000 compounds in one test. Cost of extraction in $5-10 in materials, maybe $30 in time, and $100-300 in instrument time. Economy of scale could reduce that, but even as it is currently I believe that's substantially cheaper than a thorough blood panel, and it gives much more useful data.
sure they are experimenting with small implantable devices but they are not real labs. The general purpose discrimination power of a modern medical lab is phenomenal, small implanted device, not so much.
Deleted
But Drug Companies Object ... http://www.youtube.com/watch?v=46_GInjBeQU
"Joel Fuhrman MD has cured hundreds of people of diabetes using diet and lifestyle. The American Diabetic Association wanted him to write about his work -- but then objected because their sponsor, Eli Lilly drug company, might feel threatened by an MD promoting a cure which could destroy the market for their diabetes medications. This is an excerpt from Dr. Furhman's presentation at the Healthy Lifestyle Expo 2007."
This is the cure, and it is free to look at:
http://www.drfuhrman.com/library/foodpyramid.aspx
(Most diabetics need to take vitamin D and some other supplements too, probably.)
You can watch that in action in relation to other diseases, too:
http://www.fatsickandnearlydead.com/
It's sad that the non-profits that claim to be interested in helping people with a disease become invested in perpetuating that disease to perpetuate paying jobs for their staff etc..
We need something like a "basic income" to help move past that conflict-of-interest, where jobs only get done when they need doing.
You can look up multiple other cases where most type 2 is cured, and type 1 is greatly improved. Another example:
http://www.rawfor30days.com/index4.html
Look and you will find plenty more.
Anyway, you can take the red pill or the blue pill, Neo. Or better yet, no pill. :-)
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
http://www.drfuhrman.com/library/PCI_angioplasty_article.aspx
"Interventional cardiology and cardiovascular surgery is basically a scam based on a misunderstanding of the nature of heart disease. Searching for and treating obstructive plaque does not address the areas of the coronary vascular tree most likely to rupture and cause heart attacks. If there was never another CABG or angioplasty performed or stent placed, patients with heart disease would be better off. Doctors would be forced to educate our citizens that their heart disease risk is determined by what they place on their forks. Millions of lives would be dramatically extended. To abandon the theory of stretching and cutting out areas with plaque would shut down interventional cardiology, nearly all cardiovascular surgery, and many suppliers of the biotechnology. In many cases, interventional cardiology is the major income generator to hospitals. The ending of this ill-conceived, out-dated and ineffective technology would dramatically downsize hospitals in the United States and free up over $100 billion annually in medical care costs. Besides being ineffective, interventional cardiology places the responsibility in the hands of the doctor and not the patients. When patients finally realize they must take control of their heart problems with aggressive dietary modifications (and when needed medications for temporary periods) we will essentially solve the health crisis in America.
The sad thing is surgical interventions and medications are the foundation of modern cardiology and both are relatively ineffective compared to nutritional excellence. My patients routinely reverse their heart disease, and no longer have vulnerable plaque or high blood pressure, so they do not need medical care, hospitals or cardiologists anymore. The problem is that in the real world cardiac patients are not even informed that heart disease is predictably reversed with nutritional excellence. They are not given the opportunity to choose and just corralled into these surgical interventions.
Trying to figure out how to pay for ineffective and expensive medicine by politicians will never be a real solution. People need to know they do not have to have heart disease to begin with, and if they get it, aggressive nutrition is the most life-saving intervention. And it is free."
Similar is said elsewhere by others (even Bill Clinton).
"From omnivore to vegan: The dietary education of Bill Clinton"
http://www.cnn.com/2011/HEALTH/08/18/bill.clinton.diet.vegan/index.html
A century of legal intimidation and scamming is slowly coming to an end (not to say non-MDs can't be scammers too, or that 20% of what MDs do is not a miracle):
http://en.wikipedia.org/wiki/Flexner_Report
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
I was having a heart attack, a 100% blockage of the lower anterior decending artery. It was a killer heart attack. Without angioplasty and a stent I was dead. Cardiac intervention is corrective medicine. When you need it, you need it.
they had better sue to keep this off the market.
Dr. Snyder did not analyze his blood twenty times. His lab analyzed his blood twenty times. Presumably, his contribution aside from his blood was obtaining funding for the project.
iSurew iSh iDiots would stop iNsisting, iRritatingly, iN add iTion to iRrationally, on iNitiating iDeas iNth iS fash iOn.
iT's really getting iOld.
Check https://en.wikipedia.org/wiki/Insulin_index to know what NOT to eat, if you're diabetic.
Casteism
The article comments that he's not the typical fat person who you'd expect to get Type 2 diabetes (and my blood sugar is just fine, thank you very much :-) That's what made it surprising when it showed up - but the article also comments on it being an "N=1" kind of result, so it's still just a well-documented anecdote, not up to being a real theory yet. But it's the kind of thing that now they can do more research about.
Bill Stewart
New Fast-Compression-only CPR http://preview.tinyurl.com/dy575ks
"I was having a heart attack, a 100% blockage of the lower anterior decending artery. It was a killer heart attack. Without angioplasty and a stent I was dead. Cardiac intervention is corrective medicine. When you need it, you need it."
AC, I can only plead with you to look into Dr. Fuhrman's approach. It is true the article says "almost" worthless, and maybe you were someone who benefitted from a stent for a time -- although were you really informed of all your options? But if you keep eating the same way that produced the first blockage, your stent and/or arteries will block again leading to another heart attack, possibly in six months to two years time, like happened to my own father and sister. I wish I knew before my loved ones died what I know now. This paper says the median survival time for people with stents in one study was something less than six months:
http://www.ncbi.nlm.nih.gov/pubmed/18766117
"The median survival time in patients treated with metal and plastic stent was 5.9 and 4.4 months (P = 0.074), respectively. "
See also:
http://www.fatsickandnearlydead.com/
You can most likely cure your heart disease by changing your eating patterns today following Dr. Fuhrman's approach or similar, and it will bring you as much joy or more than the way you now eat:
"How to escape The Pleasure Trap !"
http://www.drfuhrman.com/library/article16.aspx
Success stories:
http://www.drfuhrman.com/success/stories.aspx/heartdisease
At least get your vitamin D level checked and try to stay away from refined starches and sugars. Idealy "make the salad the main dish" as Dr. Fuhrman says, and eats lots of fruits, vegetables, and beans.
Good luck if you happen to see this.
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
And who was mother to Cain and Able's children? This is what you want to stake your reputation on?
Abel didn't have any children. Cain's wife came from the people created on the sixth day. Notice the beginning of chapter two, where it describes the garden (and Adam/Eve) having a separate creation timeline? Adam was created before the sixth day, but on the sixth day, humanity was created. We don't know how long it took for Adam to feel lonely and want a mate, but Eve was probably created before the sixth day too.