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Birth Control For Men Edges Closer

ananyo writes "Developing oral contraceptives for men has not gone as swiftly as researchers imagined in the early 1970s; they suggested at the time that a 'male pill' was not far off. But researchers now report a new way to make male mice temporarily infertile. Although the treatment is not ready for human use, the method avoids some of the pitfalls of earlier attempts. The technique appears to have a much more specific action than previous methods: it impairs sperm production by blocking a protein called BRDT. This protein was singled out as a potential therapeutic target five years ago because it only occurs in the testes, where it is required for the division of sperm cells. If the approach proves safe in humans, it would be an improvement over hormone-based methods of male contraception, which are not completely effective and cause side effects such as mood swings, acne and a loss of libido (abstract). On the downside, however, the compound 'shrank the mice's testes.'"

16 of 407 comments (clear)

  1. Nice tagline... by jez9999 · · Score: 5, Funny

    "No major side effects; it'll only shrink your testicles!"

    1. Re:Nice tagline... by Cryacin · · Score: 5, Insightful

      I have yet to meet a woman that finds big balls a turn on. As a man, you need big balls in the metaphorical rather than literal sense. The *real* question is, does it make you infertile over time.

      --
      Science advances one funeral at a time- Max Planck
    2. Re:Nice tagline... by Anonymous Coward · · Score: 5, Insightful

      Are you qualified to comment, with your username?

    3. Re:Nice tagline... by Forty+Two+Tenfold · · Score: 5, Funny

      it's usually the dangly thing ABOVE the balls that matters

      This?

      --
      Upward mobility is a slippery slope - the higher you climb the more you show your ass.
    4. Re:Nice tagline... by Anonymous Coward · · Score: 5, Informative

      The page 5 of the original article PDF has a size comparison of disected specimens. The treated mice testes weight is roughly halved but the size is 2^(1/3) ~ >0.70 of the untreated ones.

      There is a meassurement device called Prader orchidometer that works by comparison with standarized orbs. It's very difficult to get an accurate size/volume in vivo without using ultrasounds and if even the orchidometer method is not precise much less expect that anybody could notice a significant difference just looking at them.

      Certainly after some time not even yourself will notice at all. Definitely noticeable if meassured or compared side by side, but most probably irrelevant for a partner. The major issue may be the own psychological selfesteem burden that some insecure people could have of knowing that their testes shrank a bit, but far worse and by large would be that you got instead a vasectomy and later couldn't reverse it.

      Always could do nothing and let all the responsability to your girlfriend/wife behaving like a macho(TM) or just ask for her opinion about it and decide together since also are "her nuts".

    5. Re:Nice tagline... by outsider007 · · Score: 5, Funny

      Exit polls are notoriously unreliable.

      --
      If you mod me down the terrorists will have won
    6. Re:Nice tagline... by cffrost · · Score: 5, Funny

      it's usually the dangly thing ABOVE the balls that matters

      This?

      I hadn't realized that the need for male contraceptive was to prevent male pregnancy.

      --
      Thank you, Edward Snowden.

      "Arguments from authority are worthless." —Carl Sagan
  2. Re: by TheInsani7y · · Score: 5, Funny

    Meh. Smaller potatoes make the steak look bigger.

  3. I have the perfect drug for male contraception by Tastecicles · · Score: 5, Funny

    it's called try being married for twelve years.

    --
    Operation Guillotine is in effect.
  4. Re:Beats paying child support! by Anonymous Coward · · Score: 5, Interesting

    You see, that's why male contraceptives are a big deal. Currently, the only way for a man to have sex and have any say in whether the woman gets pregnant is either irreversible with some significant probability or ineffective with some significant probability: You can get snipped or use a condom. That's it. Woman can use the pill, and since that's a relatively reliable contraceptive that also doesn't prevent the woman from getting pregnant later when she wants to, it's the most widely used method of birth control. It's however 100% in the control of the woman, who can therefore basically unilaterally decide to get pregnant. So yes, it does take two, but the realities are such that women can and do get pregnant to get a commitment out of men, even if it ends up being just financial commitment.

  5. Re:This will change everything. by Anonymous Coward · · Score: 5, Interesting

    modern society demands they are 50% liable for children

    FWIW, here in Ontario family law judges are bound to award child support by applying a chart called the Child Support Guidelines. It takes into account the number of children and the parent's individual income. Equality never enters the picture. If the parents have joint custody and one makes $10,000 / year while the other makes $60,000 and they have two children, the first parent owes a grand total of $0 / month while the second must pay over $900 / month (according to 2010 numbers).

    The only time equalization can possibly occur is in the case of joint custody and, say, their incomes just happen to be equal. They therefore need to issue a payment to the other every month for the exact same amount, and so the two payments just happen to cancel each other out.

    While double income families are becoming more and more common, there is a LOT of incentive for one partner to become a stay-at-home-parent if they have no moral or ethical qualms about turning their partner into a potential slave. Rather than look at it as: the parent who worked made their own sacrifice by working harder (in some cases two or more jobs) in order to give the stay-at-home parent the opportunity to be with their children all day, "society" tends to take the view that having kids is a major sacrifice (how nice for the kids, huh?) and if someone stays home to "raise your kids" then you owe them (the parent, not the children) individual financial (spousal) support ON TOP OF child support.

    Two friends of mine lived together for some years as common-law spouses, never legally married, but they had children when they broke up. The female sought legal counsel and later explained to me that her lawyer was baffled that she would actually want to seek work and earn her keep. The lawyer took it as her job to achieve a state where my friend would not have to work thanks to the spousal support (in addition to child support) that she could expect to collect from her ex on top of various government programs.

    We hear a lot about misogyny, but I'm starting to witness more and more misandry over the years. The misogyny card almost seems like an excuse or a red herring these days. Women may have been treated unfairly in marriage and that needed to be remedied, but I don't see any equality to be found anywhere. Instead I see giving women more and more advantages by taking them away from men.

  6. Re:But, why? by rossdee · · Score: 5, Funny

    "Have you ever seen mice balls?!"

    Yes, back in the day before optical mice we had to clean them (and the rollers) regularly if you want a smooth moving pointer.

    Of course this was before most people on this forum were born
    now get off my lawn

  7. Does anyone realize the consequences? by Sqreater · · Score: 5, Insightful

    Women, who now have essentially the ability to get pregnant when they want to, will have to ask a man for permission to become pregnant, maybe even beg for permission to be a mother. Do they actually understand the shift in reproductive power that unthinking feminists have been pushing for for so long? Do they realize they lose control of their own pregancies? No more Tom Brady and Giselle kinda thing. No more babies by philandering pretty-boy candidates. No more rock star accidents. No more (oops) having that second child because you want one and hubby maybe isn't so keen. And can a silly woman who depends on a man to take his pill trust him to do so? No. Think of pregnancy as revenge etc., an act of aggression. Male contraception empowers men in a way that women may not find so "fair." Nobody really knew the society-wide changes female contraception would bring starting in the 1960s. Perhaps we are not really projecting the changes easy male contraception in pill form will bring in the future as its benefits to men become widely perceived by them.

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    E Proelio Veritas.
  8. Re:Wishful thinking by Daniel+Dvorkin · · Score: 5, Insightful

    So what's your standard for manhood, then? Mine involves concepts like "keeping your word," "standing up for what's right," and "taking care of your family," and it's hard to see how a minivan or a vasectomy interferes with any of those things. But maybe you're using some different set of criteria.

    --
    The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
  9. Re:Wishful thinking by Daniel+Dvorkin · · Score: 5, Insightful

    Try being a man in a job interview and having to rely solely on merit and get back to me. Try being a man and getting out of a traffic ticket and get back to me. Try being a man and actually having to take some risk and do some work just to have a relationship, let alone a good one.

    Despite presumably being a biologically adult male human being, you've clearly never actually been a man yourself. Why don't you try it and get back to us before you start telling others what it's like.

    --
    The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
  10. How long till we can get this added to all alcohol by drhank1980 · · Score: 5, Funny

    I think it might make the world a better place.