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Birth Control For Men Edges Closer

ananyo writes "Developing oral contraceptives for men has not gone as swiftly as researchers imagined in the early 1970s; they suggested at the time that a 'male pill' was not far off. But researchers now report a new way to make male mice temporarily infertile. Although the treatment is not ready for human use, the method avoids some of the pitfalls of earlier attempts. The technique appears to have a much more specific action than previous methods: it impairs sperm production by blocking a protein called BRDT. This protein was singled out as a potential therapeutic target five years ago because it only occurs in the testes, where it is required for the division of sperm cells. If the approach proves safe in humans, it would be an improvement over hormone-based methods of male contraception, which are not completely effective and cause side effects such as mood swings, acne and a loss of libido (abstract). On the downside, however, the compound 'shrank the mice's testes.'"

29 of 407 comments (clear)

  1. Nice tagline... by jez9999 · · Score: 5, Funny

    "No major side effects; it'll only shrink your testicles!"

    1. Re:Nice tagline... by Cryacin · · Score: 5, Insightful

      I have yet to meet a woman that finds big balls a turn on. As a man, you need big balls in the metaphorical rather than literal sense. The *real* question is, does it make you infertile over time.

      --
      Science advances one funeral at a time- Max Planck
    2. Re:Nice tagline... by Anonymous Coward · · Score: 5, Insightful

      Are you qualified to comment, with your username?

    3. Re:Nice tagline... by Forty+Two+Tenfold · · Score: 5, Funny

      it's usually the dangly thing ABOVE the balls that matters

      This?

      --
      Upward mobility is a slippery slope - the higher you climb the more you show your ass.
    4. Re:Nice tagline... by Anonymous Coward · · Score: 5, Informative

      The page 5 of the original article PDF has a size comparison of disected specimens. The treated mice testes weight is roughly halved but the size is 2^(1/3) ~ >0.70 of the untreated ones.

      There is a meassurement device called Prader orchidometer that works by comparison with standarized orbs. It's very difficult to get an accurate size/volume in vivo without using ultrasounds and if even the orchidometer method is not precise much less expect that anybody could notice a significant difference just looking at them.

      Certainly after some time not even yourself will notice at all. Definitely noticeable if meassured or compared side by side, but most probably irrelevant for a partner. The major issue may be the own psychological selfesteem burden that some insecure people could have of knowing that their testes shrank a bit, but far worse and by large would be that you got instead a vasectomy and later couldn't reverse it.

      Always could do nothing and let all the responsability to your girlfriend/wife behaving like a macho(TM) or just ask for her opinion about it and decide together since also are "her nuts".

    5. Re:Nice tagline... by outsider007 · · Score: 5, Funny

      Exit polls are notoriously unreliable.

      --
      If you mod me down the terrorists will have won
    6. Re:Nice tagline... by cffrost · · Score: 5, Funny

      it's usually the dangly thing ABOVE the balls that matters

      This?

      I hadn't realized that the need for male contraceptive was to prevent male pregnancy.

      --
      Thank you, Edward Snowden.

      "Arguments from authority are worthless." —Carl Sagan
    7. Re:Nice tagline... by Belial6 · · Score: 4, Insightful

      Men are legally financially responsible for any child they generate if the woman chooses to press the point. In many states, women can dump their kids off at any number of places and be 100% clear of any responsibility for them. Women can choose to get an abortion and avoid further responsibility as well. Men do not have that option.

      You must have missed the last 3 decades. Our culture has already changed.

    8. Re:Nice tagline... by mug+funky · · Score: 4, Funny

      it's well known that men (even sort-of men) give the best head.

      takes one to know one, that sort of thing.

      what are you afraid of? it's not gay unless balls are touching, and according to TFA the odds have significantly improved.

  2. Mod this story as Redundant by Zubinix · · Score: 4, Funny

    Its not like most slashdotters are getting any.

  3. Re:Beats paying child support! by Cazekiel · · Score: 4, Insightful

    What is this, this putting his wallet in involuntarily? Are you talking about the woman getting pregnant and the man having to pay child support? Well... um, if the man in this hypothetical situation was raped for that there sperm, then sure--he shouldn't pay a red cent. If he wasn't, then he needs to re-enroll in his sixth grade health class to learn that when you stick your junk in a vagina, it may produce a pregnancy.

    Seriously. This argument is so old and so tiresome. If you get a woman pregnant, that's your kid. You need to take care of your kid. Is that too hard a concept to grasp?

    --
    You want to know how to help your kids? LEAVE THEM THE F*&K ALONE. --George Carlin
  4. Re: by TheInsani7y · · Score: 5, Funny

    Meh. Smaller potatoes make the steak look bigger.

  5. This will change everything. by diakka · · Score: 4, Insightful

    It's estimated that 1/2 of all pregnancies in the US are unplanned. Really, every child should be wanted by both parents. Willing parents are the best parents. If this world only had children that were wanted, the quality of child rearing that each child gets is going to be far better. Population explosion could possibly come under control as well.

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    -- Knowledge shared is power lost. -- Aleister Crowley
    1. Re:This will change everything. by markdavis · · Score: 4, Insightful

      +1 on your post. It is just as important for men to have control over reproduction- modern society demands they are 50% liable for children (with which I do agree).

      I would only add that there should also be no financial rewards to women having children, making sure it is the CHILDREN that are wanted, not the money from the government (yes, this is a big problem with certain socioeconomic populations).

    2. Re:This will change everything. by Anonymous Coward · · Score: 5, Interesting

      modern society demands they are 50% liable for children

      FWIW, here in Ontario family law judges are bound to award child support by applying a chart called the Child Support Guidelines. It takes into account the number of children and the parent's individual income. Equality never enters the picture. If the parents have joint custody and one makes $10,000 / year while the other makes $60,000 and they have two children, the first parent owes a grand total of $0 / month while the second must pay over $900 / month (according to 2010 numbers).

      The only time equalization can possibly occur is in the case of joint custody and, say, their incomes just happen to be equal. They therefore need to issue a payment to the other every month for the exact same amount, and so the two payments just happen to cancel each other out.

      While double income families are becoming more and more common, there is a LOT of incentive for one partner to become a stay-at-home-parent if they have no moral or ethical qualms about turning their partner into a potential slave. Rather than look at it as: the parent who worked made their own sacrifice by working harder (in some cases two or more jobs) in order to give the stay-at-home parent the opportunity to be with their children all day, "society" tends to take the view that having kids is a major sacrifice (how nice for the kids, huh?) and if someone stays home to "raise your kids" then you owe them (the parent, not the children) individual financial (spousal) support ON TOP OF child support.

      Two friends of mine lived together for some years as common-law spouses, never legally married, but they had children when they broke up. The female sought legal counsel and later explained to me that her lawyer was baffled that she would actually want to seek work and earn her keep. The lawyer took it as her job to achieve a state where my friend would not have to work thanks to the spousal support (in addition to child support) that she could expect to collect from her ex on top of various government programs.

      We hear a lot about misogyny, but I'm starting to witness more and more misandry over the years. The misogyny card almost seems like an excuse or a red herring these days. Women may have been treated unfairly in marriage and that needed to be remedied, but I don't see any equality to be found anywhere. Instead I see giving women more and more advantages by taking them away from men.

  6. I have the perfect drug for male contraception by Tastecicles · · Score: 5, Funny

    it's called try being married for twelve years.

    --
    Operation Guillotine is in effect.
  7. There's an option that's much closer to approval by guises · · Score: 4, Informative

    Have a look at RISUG:

    https://en.wikipedia.org/wiki/Reversible_inhibition_of_sperm_under_guidance

    Development is much further along than this drug, RISUG could be available within the next five-ten years. It's available right now if you're in India and willing to be a guinea pig. No testicle shrinkage, though the Wikipedia article say there might be other drawbacks. The article says that there's no evidence for adverse effects though... which makes me wonder why it brings that up at all.

  8. Re:Beats paying child support! by Anonymous Coward · · Score: 5, Interesting

    You see, that's why male contraceptives are a big deal. Currently, the only way for a man to have sex and have any say in whether the woman gets pregnant is either irreversible with some significant probability or ineffective with some significant probability: You can get snipped or use a condom. That's it. Woman can use the pill, and since that's a relatively reliable contraceptive that also doesn't prevent the woman from getting pregnant later when she wants to, it's the most widely used method of birth control. It's however 100% in the control of the woman, who can therefore basically unilaterally decide to get pregnant. So yes, it does take two, but the realities are such that women can and do get pregnant to get a commitment out of men, even if it ends up being just financial commitment.

  9. Relative size by trout007 · · Score: 4, Funny

    By making your balls smaller it will make other things in that area appear larger.

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    I love Jesus, except for his foreign policy.
  10. Re:But, why? by c0lo · · Score: 4, Funny

    On the downside, however, the compound 'shrank the mice's testes

    Without commercial potential, what is this going to be used for?

    This didn't stop FaceBook going public, did it?

    --
    Questions raise, answers kill. Raise questions to stay alive.
  11. Re:But, why? by rossdee · · Score: 5, Funny

    "Have you ever seen mice balls?!"

    Yes, back in the day before optical mice we had to clean them (and the rollers) regularly if you want a smooth moving pointer.

    Of course this was before most people on this forum were born
    now get off my lawn

  12. Does anyone realize the consequences? by Sqreater · · Score: 5, Insightful

    Women, who now have essentially the ability to get pregnant when they want to, will have to ask a man for permission to become pregnant, maybe even beg for permission to be a mother. Do they actually understand the shift in reproductive power that unthinking feminists have been pushing for for so long? Do they realize they lose control of their own pregancies? No more Tom Brady and Giselle kinda thing. No more babies by philandering pretty-boy candidates. No more rock star accidents. No more (oops) having that second child because you want one and hubby maybe isn't so keen. And can a silly woman who depends on a man to take his pill trust him to do so? No. Think of pregnancy as revenge etc., an act of aggression. Male contraception empowers men in a way that women may not find so "fair." Nobody really knew the society-wide changes female contraception would bring starting in the 1960s. Perhaps we are not really projecting the changes easy male contraception in pill form will bring in the future as its benefits to men become widely perceived by them.

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    E Proelio Veritas.
  13. Re:Beats paying child support! by hazah · · Score: 4, Informative

    OK, then perhaps you shouldn't stick your pecker into things it can get pregnant. Grasping that?

  14. Re:Wishful thinking by tylernt · · Score: 4, Interesting

    Try being a sixth grade girl with D-cups then get back to me.

    This isn't the first time I've heard reports of negative social feedback from early large breasts. I'm not disputing your experience, but I don't get it. I thought men were obsessed with the-larger-the-better breasts, hence the popularity of padded bras and implants. Is it the girls that tease the ones who develop large/early? You'd think the guys would all want to be your best friend (maybe that's exactly the unwanted attention you refer to).

    I can tell you, though, that not all early/large girls find it a liability. I remember one in my high school that used them to get guys to do her schoolwork for her.

    --
    DRM 'manages access' in the same way that a prison 'manages freedom'
  15. Re:Wishful thinking by Daniel+Dvorkin · · Score: 5, Insightful

    So what's your standard for manhood, then? Mine involves concepts like "keeping your word," "standing up for what's right," and "taking care of your family," and it's hard to see how a minivan or a vasectomy interferes with any of those things. But maybe you're using some different set of criteria.

    --
    The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
  16. Re:Wishful thinking by Daniel+Dvorkin · · Score: 5, Insightful

    Try being a man in a job interview and having to rely solely on merit and get back to me. Try being a man and getting out of a traffic ticket and get back to me. Try being a man and actually having to take some risk and do some work just to have a relationship, let alone a good one.

    Despite presumably being a biologically adult male human being, you've clearly never actually been a man yourself. Why don't you try it and get back to us before you start telling others what it's like.

    --
    The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
  17. How long till we can get this added to all alcohol by drhank1980 · · Score: 5, Funny

    I think it might make the world a better place.

  18. Re:Beats paying child support! by epyT-R · · Score: 4, Insightful

    If he wasn't, then he needs to re-enroll in his sixth grade health class to learn that when you stick your junk in a vagina, it may produce a pregnancy.

    Seriously. This argument is so old and so tiresome. If you get a woman pregnant, that's your kid. You need to take care of your kid. Is that too hard a concept to grasp?

    That's just it. He didn't 'get her pregnant.' Both of them got her pregnant. So, if she's going to have the unilateral say in taking the fetus to term, then, by default, she should be solely responsible for it. With power comes responsibility, with no power, comes none. Ideally, she should have to enter into a contract with him (or get married) for financial support/fatherhood, but otherwise he should have the same right of refusal she does. This keeps the table balanced and encourages children only when both parents are truly ready to be parents, financially and mentally. It prevents her from using the kid as a battering ram to get him to commit when he's clearly not ready to, which happens a lot in today's society. This would eliminate a ton of highschoolesque melodrama that surrounds pregnancy today. Dr Phil would go out of business which would be a benefit to everyone..

    The rules you're conforming to come from a time when women didn't have a choice. It was fair as women, especially pregnant ones, weren't allowed to work all that much and were very dependent on men for support. Today, things are very different, and it's about time that women gave up the privileges of chattel status if they want out of it.

    sorry, I shouldn't have broken my statement into two posts, but it happens.. there's another reply somewhere on this poor excuse for code

  19. Re:Beats paying child support! by Cazekiel · · Score: 4, Insightful

    I don't see how my saying that a man should support his child means that I think total absolutes about women getting everything they want with no accountability. I'm honestly trying to find the words to say to this, because I'd said I wasn't going to say anything else (I've raped this topic comments-wise today), so I want to make everything clear in these "final words". Or what I HOPE are final...

    Never once have I said anything about women getting everything and men getting nothing, but that doesn't seem to matter; to some men, it seems that anytime someone brings up a disadvantage in the 'Woman's World', they jump up and start pointing fingers, saying "we have it bad, too!" What's funny is that while I have a small feminist side, I see the bullshit that goes on on my side of the court. I could give examples, but I've been too wordy already. Fact is, I try my best to be a reasonable, well-rounded and deep-thinking individual. I can shoot off the mouth and be opinionated, but if no one did that, there wouldn't be anything interesting on the internet.

    We DO have a little more responsibility. And in a lot of cases, that's what fucks us up the ass without the benny of a reach-around. We're damned if we do, damned if we don't. If you're a pregnant teenager, some schools will try to bar you from attending but let the baby-daddy (gah, hate using that, but it seems right here, dunno why) roam the halls without repercussion. If we choose to abort when the man doesn't want us to, we're baby-killing bitches. If we choose to keep the baby, we're money-hungry bitches. If we choose to not have sex on the first or second date, we're labelled prudes. If we DO have sex on the first or second date, we're sluts. We do have options, and we DON'T have options, simply because we can be vilified for any one of them. Saying this, I'm not trying to play the tearful, "WOE IS ME, I'M A WOMAN!" card, it is what it is. How do we win? Give the man the decision entirely? Compromise, when it's already too hot to touch? What about the families on both sides, do they have a say? I DO side with women on this issue a little more, yes, because the products of both abortion and pregnancy will stay with her forever. I know the latter well; I had to have a c-section, because my son was born at 11.6 pounds, no lie. I've never recovered from it, even when I joined a gym and went through serious fitness and dieting routines. I'd never take it back, however. All this doesn't mean the man doesn't get a say in what happens, but it IS hard to say how it's finalized, as yes, the woman is the most affected. Sorry... you might not like it as a man, but it's just fact. Sometimes I don't like it either, because I'm a person who wants to be completely impartial, even in things like this. But I always keep coming back to the "who's affected the most by this?" point.

    The best solution is what a lot of men (and some women) do not want to hear: this can allllll be avoided in NOT having sex with someone on the first, second or even third date. This goes for both sexes. If Jane and Joe have sex on the first date and Jane gets pregnant, neither one of them can bitch about the decisions being made on either side, whether or not the woman's insisting on it being her way. If Jane got to know Joe, she'd learn he didn't want kids and would want an abortion be done and nothing but. If Joe got to know Jane, he'd learn that she didn't want an abortion, even if it was with some guy she just met. Would this seriously kill anyone? I'm not talking "Wait for marriage," crap, just KNOW the person you're going to sleep with before you sleep with them. Neither side can feign ignorance. And it doesn't even have to be a two-hour lecture on 'Why Joe Doesn't Want Kids: Part VII, Money'... just, "Not without a condom--too young for kids *wink*" or the like.

    It's not hard. In the end, it's 50/50, because someone else isn't responsible for another person, no matter how deceitful the man or woman may be. If a man has sex (especially unprotected sex, taking her word tha

    --
    You want to know how to help your kids? LEAVE THEM THE F*&K ALONE. --George Carlin